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Expert Opinion on Biological Therapy Volume 9, 2009 - Issue 7
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Drug Evaluations

Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery- a systematic review

Andreas Rickenbacher These authors contributed equally to this work; University Hospital Zurich, Department of Visceral and Transplantation Surgery, Zurich, Switzerland
, MD,
Stefan Breitenstein These authors contributed equally to this work; University Hospital Zurich, Department of Visceral and Transplantation Surgery, Zurich, Switzerland
, MD,
Mickael Lesurtel University Hospital Zurich, Department of Visceral and Transplantation Surgery, Zurich, Switzerland; University Paris VII, Beaujon Hospital, Department of Hepatobiliary and Pancreatic Surgery, Paris, France
, MD PhD &
Andrea Frilling University Hospital Zurich, Department of Visceral and Transplantation Surgery, Zurich, Switzerland; University Hospital Essen, Department of General, Visceral and Transplantation Surgery, Hufelandstrasse 55, 45122 Essen, Germany +49 177 4597104; +49 211 9559489; [email protected]
, MD
Pages 897-907 | Published online: 15 Jun 2009
 
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Abstract

Background: Proper haemostasis is an important prerequisite for a successful outcome in all operative fields. TachoSil® is used in many surgical specialties, especially for diffuse bleeding. However, TachoSil is not only used for haemostasis but also for closure of other anatomical structures. Objective: To review the literature concerning the efficacy of TachoSil, a topical fibrin-based haemostat. Methods: PubMed was searched for data on TachoSil and TachoComb from clinical trials and basic research. Results/conclusion: TachoSil is used in many surgical specialties and has proven to be a valuable tool for several indications. It also seems to be cost effective. Solid data from randomized controlled trials are available for liver surgery, thoracic surgery and urology where a positive value is clearly documented.

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