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Expert Opinion on Biological Therapy Volume 10, 2010 - Issue 2
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Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines

Dae-Sun Kim The Catholic University of Korea, Department of Biotechnology, 43-1 yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyunggi-do 420-743, Republic of Korea +82 2 2164 4852; +82 2 2164 4865; [email protected]
&
Jae-Hwan Nam The Catholic University of Korea, Department of Biotechnology, 43-1 yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyunggi-do 420-743, Republic of Korea +82 2 2164 4852; +82 2 2164 4865; [email protected]
, PhD
Pages 179-190 | Published online: 21 Jan 2010
 
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Abstract

Coxsackievirus strain CVB3 is widespread in the human population and causes myocarditis or pancreatitis. However, despite its clinical impact, there is no commercially available and clinically applicable prophylactic vaccine. This study examines the characteristics of attenuated CVB3 strains developed so far and their application as live-attenuated CVB3 vaccines, and discusses problems to be overcome in the development of live-attenuated vaccines.

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