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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 8
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Review

Biologics in Crohn's disease: searching indicators for outcome

C Janneke van der Woude Erasmus MC, Department of Gastroenterology and Hepatology, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands +31 10 463 5946; +31 10 463 4682; [email protected]
, MD PhD &
Daniel W Hommes LUMC, Department of Gastroenterology and Hepatology, Leiden, The Netherlands
Pages 1233-1243 | Published online: 14 Aug 2007
 
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Abstract

New insights into the underlying mechanism of Crohn's disease is enabling the development of new therapies. Even though the mechanisms of these drugs have been studied extensively, reliable indicators for implementation of new biologic drugs are still needed. This review presents biologics in Crohn's disease focusing on efficacy, steroid sparing, mucosal healing and safety, including immunogenicity.

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