Advanced search
Publication Cover
Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 8
Submit an article Journal homepage
662
Views
43
CrossRef citations to date
0
Altmetric
Drug Evaluation

CPG-7909 (PF-3512676, ProMune®): toll-like receptor-9 agonist in cancer therapy

Yanal M Murad Duke University Medical Center, Department of Surgery, Program in Molecular Therapeutics, Comprehensive Cancer Center, 401 MSRB, Research Drive, Durham, NC 27710, USA [email protected]
, PhD,
Timothy M Clay Duke University Medical Center, Department of Surgery, Program in Molecular Therapeutics, Comprehensive Cancer Center, 401 MSRB, Research Drive, Durham, NC 27710, USA [email protected]
, PhD,
H Kim Lyerly Duke University Medical Center, Duke Comprehensive Cancer Center, Departments of Surgery, Pathology and Immunology, Program in Molecular Therapeutics, 401 MSRB, Research Drive, Durham, NC 27710, USA
, MD &
Michael A Morse Duke University Medical Center, Department of Medicine, Program in Molecular Therapeutics, Comprehensive Cancer Center, Box 3233, 401 MSRB, Research Drive, Durham, NC 27710, USA
, MD
Pages 1257-1266 | Published online: 14 Aug 2007
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Stimulation of toll-like receptor (TLR)9 activates human plasmacytoid dendritic cells and B cells, and induces potent innate immune responses in preclinical tumor models and in patients. CpG oligodeoxynucleotides (ODNs) are TLR9 agonists that show promising results as vaccine adjuvants and in the treatment of cancers, infections, asthma and allergy. PF-3512676 (ProMune®) was developed as a TLR9 agonist for the treatment of cancer as monotherapy and as an adjuvant in combination with chemo- and immunotherapy. Phase I and II trials have tested this drug in several hematopoietic and solid tumors. Pfizer has initiated Phase III trials to test PF-3512676 in combination with standard chemotherapy for non-small-cell lung cancer.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 960.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.