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Original article: Nose/Sinus

Expression of Na+/H+ exchanger isoforms in normal human nasal epithelial cells and functional activity of Na+/H+ exchanger 1 in intracellular pH regulation

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Pages 286-292 | Received 12 Jan 2004, Accepted 01 Jul 2004, Published online: 08 Jul 2009

References

  • Jeffery PK, Li D. Airway mucosa: secretory cells, mucus and mucin genes. Eur Respir J 1997;10:1655–62.
  • Dudeja PK, Hafez N, Tyagi S, Gailey CA, Toofanfard M, Alrefai WA, et al. Expression of the Na +/H+ and HCO exchanger isoforms in proximal and distal human airways. Am J Physiol 1999;276:L971–8.
  • Welsh MJ. Electrolyte transport by airway epithelia. Physiol Rev 1987;67:1143–84.
  • Orlowski J, Grinstein S. Na +/H+ exchangers of mammalian cells. J Biol Chem 1997;272:22373–6.
  • Yoon JH, Gray T, Guzman K, Koo JS, Netteshein P. Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracel-lular matrix. Am J Respir Cell Mol Biol 1997;16:724–31.
  • Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG, Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2000;278: G197–206.
  • Avkiran M. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. Am J Cardiol 1999;83:10G–7G.
  • Counillon L, Scholz W, Lang HJ, Pouyssegur J. Pharmaco-logical characterization of stably transfected Na +/H+ anti-porter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 1993;44:1041–5.
  • Bhaskar KR, Gong DH, Bansil R, Pajevic S, Hamilton JA, Turner BS, et al. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol 1991;261:G827–32.
  • Al-Bazzaz FJ, Hafez N, Tyagi S, Gailey CA, Toofanfard M, Alrefai WA, et al. Detection of ci--Fico and Na + -H+ exchangers in human airways epithelium. J Pancreas 2001;2:285–90.
  • Lee SH, Seok YS, Jung HH, Oh BH, Lee HM, Kwon SY, et al. Expression of mRNA transcripts of the Na +/H+ and C1—/HCO exchanger isoforms in human nasal mucosa. Acta Otolaryngol 2002;122:866–71.
  • Reilly RF, Hildebrandt F, Biemesderfer D, Sardet C, Pouyssegur J, Aronson PS, et al. cDNA cloning and immunolocalization of a Na(±)-H+ exchanger in LLC-PK1 renal epithelial cells. Am J Physiol 1991;261:F1088–94.
  • Helmle-Kolb C, Counillon L, Roux D, Pouyssegur J, Mrkic B, Murer H. Na/H exchange activities in NHE1 -transfected OK-cells: cell polarity and regulation. Pflugers Arch 1993;425: 34–40.
  • Granger D, Marsolais M, Burry J, Laprade R. Na + /H+ exchangers in the human eccrine sweat duct. Am J Physiol Cell Physiol 2003;285:C1047–58.
  • Lee MG, Ahn W, Choi JY, Luo X, Seo JT, Schultheis PJ, et al. Na(+)-dependent transporters mediate HCO(3)(-) sal-vage across the luminal membrane of the main pancreatic duct. J Chin Invest 2000;105:1651–8.
  • Paradiso AM. ATP-activated basolateral Na +/H+ exchange in the human normal and cystic fibrosis airway epithelium. Am J Physiol 1997;273:L148–58.
  • Choi JY, Cho KN, Yoon JH. Effect of uridine 5'-triphos-phate on mucin and lysozyme expression in human middle ear epithelial cells. Acta Otolaryngol 2003;123: 362–6.
  • Choi JY, Namkung W, Shin JH, Yoon JH. Uridine-5'-triphosphate and adenosine triphosphate gamma S induce mucin secretion via Ca2 +-dependent pathways in human nasal epithelial cells. Acta Otolaryngol 2003;123: 1080–6.
  • Busa WB. Mechanisms and consequences of pH-mediated cell regulation. Annu Rev Physiol 1986;48:389–402.
  • Hwang J, Pouyssegur J, Willingham MC, Pastan I. The role of intracellular pH in ligand internalization. J Cell Physiol 1986;128:18–22.

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