Characteristics of Cannabis and Opioid Users Among Older U.S. Veterans and Their Health Outcomes: A Longitudinal Perspective

References

• Aviram, J., D. Pud, T. Gershoni, B. Schiff-Keren, M. Ogintz, S. Vulfsons, T. Yashar, H.-M. Adahan, S. Brill, H. Amital, et al. 2021. Medical cannabis treatment for chronic pain: Outcomes and prediction of response. European Journal of Pain 25 (2):359–74. doi:10.1002/EJP.1675.
   PubMed Web of Science ®Google Scholar
• Barrowclough, C., L. Gregg, F. Lobban, S. Bucci, and R. Emsley. 2015. The impact of cannabis use on clinical outcomes in recent onset psychosis. Schizophrenia Bulletin 41 (2):382–90. doi:10.1093/SCHBUL/SBU095.
   PubMed Web of Science ®Google Scholar
• Boersma, P., L. I. Black, and B. W. Ward. 2020. Prevalence of multiple chronic conditions among US adults, 2018. Preventing Chronic Disease 17:200130. doi:10.5888/pcd17.200130.
   Web of Science ®Google Scholar
• Bonn-Miller, M. O., M. Brunstetter, A. Simonian, M. J. Loflin, R. Vandrey, K. A. Babson, and H. Wortzel. 2022. The long-term, prospective, therapeutic impact of cannabis on post-traumatic stress disorder. Cannabis and Cannabinoid Research 7 (2):214–23. doi:10.1089/can.2020.0056.
   PubMedGoogle Scholar
• Breivik, H., P. C. Borchgrevink, S. M. Allen, L. A. Rosseland, L. Romundstad, E. K. Breivik Hals, G. Kvarstein, and A. Stubhaug. 2008. Assessment of pain. British Journal of Anaesthesia 101 (1):17–24. doi:10.1093/bja/aen103.
   PubMed Web of Science ®Google Scholar
• Bricker, J. B., J. Russo, M. B. Stein, C. Sherbourne, M. Craske, T. J. Schraufnagel, and P. Roy-Byrne. 2007. Does occasional cannabis use impact anxiety and depression treatment outcomes?: Results from a randomized effectiveness trial. Depression and Anxiety 24 (6):392–98. doi:10.1002/DA.20248.
   PubMed Web of Science ®Google Scholar
• Campbell, L. M., B. Tang, C. W. M. Watson, M. Higgins, M. Cherner, B. L. Henry, and R. C. Moore. 2020. Cannabis use is associated with greater total sleep time in middle-aged and older adults with and without HIV: A preliminary report utilizing digital health technologies. Cannabis 3 (2):180. doi:10.26828/CANNABIS.2020.02.005.
   PubMedGoogle Scholar
• Choi, N. G., D. M. DiNitto, C. N. Marti, and B. Y. Choi. 2016. Association of traffic injuries, substance use disorders, and ED visit outcomes among individuals aged 50+ years. Journal of Psychoactive Drugs 48 (5):369–76. doi:10.1080/02791072.2016.1240838.
   PubMed Web of Science ®Google Scholar
• Compton, W. M., B. Han, C. M. Jones, C. Blanco, and A. Hughes. 2016. Marijuana use and use disorders in adults in the USA, 2002–14: Analysis of annual cross-sectional surveys. The Lancet Psychiatry 3 (10):954–64. doi:10.1016/S2215-0366(16)30208-5.
   PubMed Web of Science ®Google Scholar
• Davis, A. K., E. E. Bonar, M. A. Ilgen, M. A. Walton, B. E. Perron, and S. T. Chermack. 2016. Factors associated with having a medical marijuana card among veterans with recent substance use in VA outpatient treatment. Addictive Behaviors 63 (December):132–36. doi:10.1016/J.ADDBEH.2016.07.006.
   PubMed Web of Science ®Google Scholar
• Davis, A. K., L. A. Lin, M. A. Ilgen, and K. M. Bohnert. 2018. Recent cannabis use among veterans in the United States: Results from a national sample. Addictive Behaviors 76:223–28. doi:10.1016/j.addbeh.2017.08.010.
   PubMed Web of Science ®Google Scholar
• De Aquino, J. P., M. Sofuoglu, E. Stefanovics, and R. Rosenheck. 2019. Adverse consequences of co-occurring opioid use disorder and cannabis use disorder compared to opioid use disorder only. The American Journal of Drug and Alcohol Abuse 45 (5):527–37. doi:10.1080/00952990.2019.1607363.
   PubMed Web of Science ®Google Scholar
• Englund, A., T. P. Freeman, R. M. Murray, and P. McGuire. 2017. Can we make cannabis safer? The Lancet Psychiatry 4 (8):643–48. doi:10.1016/S2215-0366(17)30075-5.
   PubMed Web of Science ®Google Scholar
• Gruber, S. A., R. T. Smith, M. K. Dahlgren, A. M. Lambros, and K. A. Sagar. 2021. No pain, all gain? Interim analyses from a longitudinal, observational study examining the impact of medical cannabis treatment on chronic pain and related symptoms. Experimental and Clinical Psychopharmacology 29 (2):147–56. doi:10.1037/PHA0000435.
   PubMed Web of Science ®Google Scholar
• Guillouard, M., N. Authier, B. Pereira, M. Soubrier, and S. Mathieu. 2021. Cannabis use assessment and its impact on pain in rheumatologic diseases: A systematic review and meta-analysis. Rheumatology 60 (2):549–56. doi:10.1093/RHEUMATOLOGY/KEAA534.
   PubMed Web of Science ®Google Scholar
• Han, B. H., and J. J. Palamar. 2020. Trends in cannabis use among older adults in the United States, 2015-2018. JAMA Internal Medicine 180 (4):609–11. doi:10.1001/JAMAINTERNMED.2019.7517.
   PubMed Web of Science ®Google Scholar
• Harris, P. A., R. Taylor, R. Thielke, J. Payne, N. Gonzalez, and J. G. Conde. 2009. Research Electronic Data Capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. Journal of Biomedical Informatics 42 (2):377–81. doi:10.1016/J.JBI.2008.08.010.
   PubMed Web of Science ®Google Scholar
• Hartman, R. L., and M. A. Huestis. 2013. Cannabis effects on driving skills. Clinical Chemistry 59 (3):478–92. doi:10.1373/CLINCHEM.2012.194381.
   PubMed Web of Science ®Google Scholar
• Hasin, D., and C. Walsh. 2021. Trends over time in adult cannabis use: A review of recent findings. Current Opinion in Psychology 38 (April):80–85. doi:10.1016/J.COPSYC.2021.03.005.
   PubMed Web of Science ®Google Scholar
• Hill, M. L., M. Loflin, B. Nichter, S. B. Norman, and R. H. Pietrzak. 2021a. Prevalence of cannabis use, disorder, and medical card possession in U.S. military veterans: Results from the 2019–2020 national health and resilience in veterans study. Addictive Behaviors 120 (September):106963. doi:10.1016/J.ADDBEH.2021.106963.
   PubMed Web of Science ®Google Scholar
• Hill, M., M. Loflin, K. Browne, and S. D. Norman. 2021b. Cannabis use and PTSD among veterans. U.S. Department of Veterans Affairs. https://www.ptsd.va.gov/professional/treat/cooccurring/marijuana_ptsd_vets.asp.
   Google Scholar
• Illinois Department of Public Health. 2019. Debilitating Conditions. https://dph.illinois.gov/topics-services/prevention-wellness/medical-cannabis/debilitating-conditions.html.
   Google Scholar
• Kang, H., J. Hunniecutt, L. Quintero Silva, B. Kaskie, and J. Bobitt. 2021. Biopsychosocial factors and health outcomes associated with cannabis, opioids and benzodiazepines use among older veterans. The American Journal of Drug and Alcohol Abuse 47 (4):497–507. doi:10.1080/00952990.2021.1903479.
   PubMed Web of Science ®Google Scholar
• Kaufmann, C. N., A. Kim, M. Miyoshi, and B. H. Han. 2020. Patterns of medical cannabis use among older adults from a cannabis dispensary in New York State. Cannabis and Cannabinoid Research November. doi:10.1089/CAN.2020.0064.
   PubMedGoogle Scholar
• Krediet, E., D. G. Janssen, E. R. Heerdink, T. C. Egberts, and E. Vermetten. 2020. Experiences with medical cannabis in the treatment of veterans with PTSD: Results from a focus group discussion. European Neuropsychopharmacology 36 (July):244–54. doi:10.1016/J.EURONEURO.2020.04.009.
   PubMed Web of Science ®Google Scholar
• Kuhathasan, N., A. Dufort, J. MacKillop, R. Gottschalk, L. Minuzzi, and B. N. Frey. 2019. The use of cannabinoids for sleep: A critical review on clinical trials. Experimental and Clinical Psychopharmacology 27 (4):383–401. doi:10.1037/PHA0000285.
   PubMed Web of Science ®Google Scholar
• Lake, S., Z. Walsh, T. Kerr, Z. D. Cooper, J. Buxton, E. Wood, M. A. Ware, and M. J. Milloy. 2019. Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis. PLoS Medicine 16 (11):e1002967. doi:10.1371/JOURNAL.PMED.1002967.
   PubMed Web of Science ®Google Scholar
• Longo, R., A. Oudshoorn, and D. Befus. 2021. Cannabis for chronic pain: A rapid systematic review of randomized control trials. Pain Management Nursing 22 (2):141–49. doi:10.1016/J.PMN.2020.11.006.
   PubMed Web of Science ®Google Scholar
• Lum, H. D., K. Arora, J. A. Croker, S. H. Qualls, M. Schuchman, J. Bobitt, G. Milavetz, and B. Kaskie. 2019. Patterns of marijuana use and health impact: A survey among older coloradans. Gerontology & Geriatric Medicine 5 (April):2333721419843707. doi:10.1177/2333721419843707.
   Web of Science ®Google Scholar
• Mok, J., M. J. Milloy, C. Grant, S. Lake, K. DeBeck, K. Hayashi, and M. E. Socías. 2021. Use of cannabis for harm reduction among people at high risk for overdose in Vancouver, Canada (2016-2018). American Journal of Public Health 111 (5):969–72. doi:10.2105/AJPH.2021.306168.
   PubMed Web of Science ®Google Scholar
• Mosher, H. J., E. E. Krebs, M. Carrel, P. J. Kaboli, M. W. V. Weg, and B. C. Lund. 2015. Trends in prevalent and incident opioid receipt: An observational study in veterans health administration 2004–2012. Journal of General Internal Medicine 30 (5):597–604. doi:10.1007/s11606-014-3143-z.
   PubMed Web of Science ®Google Scholar
• Nahin, R. L. 2017. Severe pain in veterans: The effect of age and sex, and comparisons with the general population. The Journal of Pain 18 (3):247–54. doi:10.1016/j.jpain.2016.10.021.
   PubMed Web of Science ®Google Scholar
• National Academies of Sciences, Engineering, and Medicine. 2017. The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research. Washington, DC: The National Academies Press. doi:10.17226/24625.
   Google Scholar
• National Conference of State Legislatures. 2021. State medical marijuana laws. https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx.
   Google Scholar
• National Institute on Drug Abuse. 2019. Substance use and military life DrugFacts. https://nida.nih.gov/publications/drugfacts/substance-use-military-lifeon2022.
   Google Scholar
• Nugent, S. M., B. J. Yarborough, N. X. Smith, S. K. Dobscha, R. A. Deyo, C. A. Green, and B. J. Morasco. 2018. Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy. General Hospital Psychiatry 50 (January):104–10. doi:10.1016/J.GENHOSPPSYCH.2017.11.001.
   PubMed Web of Science ®Google Scholar
• Olfson, M., M. M. Wall, S. M. Liu, and C. Blanco. 2018. Cannabis use and risk of prescription opioid use disorder in the United States. The American Journal of Psychiatry 175 (1):47–53. doi:10.1176/appi.ajp.2017.17040413.
   PubMed Web of Science ®Google Scholar
• Palace, Z. J., and D. A. Reingold. 2019. Medical cannabis in the skilled nursing facility: A novel approach to improving symptom management and quality of life. Journal of the American Medical Directors Association 20 (1):94–98. doi:10.1016/J.JAMDA.2018.11.013.
   PubMed Web of Science ®Google Scholar
• Pocuca, N., T. J. Walter, A. Minassian, J. W. Young, M. A. Geyer, and W. Perry. 2021. The effects of cannabis use on cognitive function in healthy aging: A systematic scoping review. Archives of Clinical Neuropsychology 36 (5):673–85. doi:10.1093/ARCLIN/ACAA105.
   PubMed Web of Science ®Google Scholar
• Reddon, H., K. DeBeck, M. E. Socias, S. Lake, H. Dong, M. Karamouzian, K. Hayashi, T. Kerr, and M. J. Milloy. 2020. Frequent cannabis use and cessation of injection of opioids, Vancouver, Canada, 2005-2018. American Journal of Public Health 110 (10):1553–60. doi:10.2105/AJPH.2020.305825.
   PubMed Web of Science ®Google Scholar
• Reynolds, I. R., D. R. Fixen, B. L. Parnes, H. D. Lum, P. Shanbhag, S. Church, S. A. Linnebur, and G. Orosz. 2018. Characteristics and patterns of marijuana use in community-dwelling older adults. Journal of the American Geriatrics Society 66 (11):2167–71. doi:10.1111/JGS.15507.
   PubMed Web of Science ®Google Scholar
• Rogers, A. H., J. Bakhshaie, J. D. Buckner, M. F. Orr, D. J. Paulus, J. W. Ditre, and M. J. Zvolensky. 2019. Opioid and cannabis co-use among adults with chronic pain: Relations to substance misuse, mental health, and pain experience. Journal of Addiction Medicine 13 (4):287–94. doi:10.1097/ADM.0000000000000493.
   PubMed Web of Science ®Google Scholar
• Rosic, T., R. Kapoor, B. Panesar, L. Naji, D. B. Chai, N. Sanger, D. C. Marsh, A. Worster, L. Thabane, and Z. Samaan. 2021. The association between cannabis use and outcome in pharmacological treatment for opioid use disorder. Harm Reduction Journal 18 (1):1–9. doi:10.1186/s12954-021-00468-6.
   PubMed Web of Science ®Google Scholar
• Sandbrink, F., E. M. Oliva, T. L. McMullen, A. R. Aylor, M. A. Harvey, M. L. Christopher, F. Cunningham, T. Minegishi, T. Emmendorfer, and J. M. Perry. 2020. Opioid prescribing and opioid risk mitigation strategies in the veterans health administration. Journal of General Internal Medicine 35 (3):927–34. doi:10.1007/s11606-020-06258-3.
   PubMed Web of Science ®Google Scholar
• Scott, E. P., E. Brennan, and A. Benitez. 2019. A systematic review of the neurocognitive effects of cannabis use in older adults. Current Addiction Reports 6 (4):443–55. doi:10.1007/S40429-019-00285-9.
   PubMedGoogle Scholar
• Shah, A., J. Craner, and J. L. Cunningham. 2017. Medical cannabis use among patients with chronic pain in an interdisciplinary pain rehabilitation program: Characterization and treatment outcomes. Journal of Substance Abuse Treatment 77 (June):95–100. doi:10.1016/J.JSAT.2017.03.012.
   PubMed Web of Science ®Google Scholar
• Solomon, H. V., A. P. Greenstein, and L. E. Delisi. 2021. Cannabis use in older adults: A perspective. Harvard Review of Psychiatry 29 (3):225–33. doi:10.1097/HRP.0000000000000289.
   PubMed Web of Science ®Google Scholar
• StataCorp. 2017. Stata statistical software: Release 15. College Station, TX.
   Google Scholar
• State of Illinois. 2020. Medical cannabis patient program. https://www2.illinois.gov/sites/mcpp/Pages/default.aspx.
   Google Scholar
• Stewart, M., L. Meredith, J. B. Brown, and J. Galajda. 2000. The influence of older patient-physician communication on health and health-related outcomes. Clinics in Geriatric Medicine 16 (1):25–36. doi:10.1016/S0749-0690(05)70005-7.
   PubMed Web of Science ®Google Scholar
• Stypulkowski, K., and R. E. Thayer. 2021. Long-term recreational cannabis use is associated with lower executive function and processing speed in a pilot sample of older adults. Journal of Geriatric Psychiatry and Neurology 35 (5):740–46. September. doi:10.1177/08919887211049130.
   PubMed Web of Science ®Google Scholar
• Substance Abuse and Mental Health Services Administration (SAMHSA). 2020. 2019 national survey on drug use and health: Veteran adults. https://www.samhsa.gov/data/sites/default/files/reports/rpt31103/2019NSDUH-Veteran/Veterans2019NSDUH.pdf.
   Google Scholar
• U.S. Department of Veterans Affairs. 2019. VA and marijuana – what veterans need to know. https://www.publichealth.va.gov/marijuana.asp.
   Google Scholar
• U.S. Department of Veterans Affairs. 2020. VA reduces prescription opioid use by 64% during past eight years. https://www.va.gov/opa/pressrel/pressrelease.cfm?id=5492.
   Google Scholar
• Vo, K. T., H. Horng, K. Li, R. Y. Ho, A. H. B. Wu, K. L. Lynch, and C. G. Smollin. 2018. Cannabis intoxication case series: The dangers of edibles containing tetrahydrocannabinol. Annals of Emergency Medicine 71 (3):306–13. doi:10.1016/J.ANNEMERGMED.2017.09.008.
   PubMed Web of Science ®Google Scholar
• Walsh, Z., R. Gonzalez, K. Crosby, M. S. Thiessen, C. Carroll, and M. O. Bonn-Miller. 2017. Medical cannabis and mental health: A GUIDED SYSTEMATIC REview. Clinical Psychology Review 51 (February):15–29. doi:10.1016/J.CPR.2016.10.002.
   PubMed Web of Science ®Google Scholar
• Wildes, M., T. L. Bigand, M. E. Layton, and M. Wilson. 2020. Cannabis use and cognition in adults prescribed opioids for persistent pain. Pain Management Nursing 21 (1):94–99. doi:10.1016/J.PMN.2019.06.014.
   PubMed Web of Science ®Google Scholar
• Yang, K. H., C. N. Kaufmann, R. Nafsu, E. T. Lifset, K. Nguyen, M. Sexton, B. H. Han, A. Kim, and A. A. Moore. 2021. Cannabis: An emerging treatment for common symptoms in older adults. Journal of the American Geriatrics Society 69 (1):91–97. doi:10.1111/JGS.16833.
   PubMed Web of Science ®Google Scholar