Trust in research physicians as a key dimension of randomized controlled trial participation in clinical addictions research

References

• Bothwell LE, Greene JA, Podolsky SH, Jones DS. Assessing the gold standard-lessons from the history of RCTs. N Engl J Med. 2016;374(22):2175–2181.
   PubMed Web of Science ®Google Scholar
• Ross S, Grant A, Counsell C, Gillespie W, Russell I, Prescott R. Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol. 1999;52(12):1143–1156.
   PubMed Web of Science ®Google Scholar
• Volkmann ER, Claiborne D, Currier JS. Determinants of participation in HIV clinical trials: the importance of patients' trust in their provider. HIV Clin Trials. 2009;10(2):104–109.
   PubMed Web of Science ®Google Scholar
• Robiner WN, Yozwiak JA, Bearman DL, Strand TD, Strasburg KR. Barriers to clinical research participation in a diabetes randomized clinical trial. Soc Sci Med. 2009;68(6):1069–1074.
   PubMed Web of Science ®Google Scholar
• Townsend A, Cox SM. Accessing health services through the back door: a qualitative interview study investigating reasons why people participate in health research in Canada. BMC Med Ethics. 2013;14(1):40.
   PubMedGoogle Scholar
• Trauth JM, Jewell IK, Ricci E, Musa D, Siminoff L. Public attitudes regarding willingness to participate in medical research studies. J Health Soc Policy. 2000;12(2):23–43.
   PubMedGoogle Scholar
• Sellars B, Garza MA, Fryer CS, Thomas SB. Utilization of health care services and willingness to participate in future medical research: the role of race and social support. J Natl Med Assoc. 2010;102(9):776–786.
   PubMed Web of Science ®Google Scholar
• Guillemin M, Barnard E, Allen A, et al. Do research participants trust researchers or their institution? J Empir Res Hum Res Ethics. 2018;13(3):285–294.
   PubMed Web of Science ®Google Scholar
• Smirnoff M, Wilets I, Ragin DF, et al. A paradigm for understanding trust and mistrust in medical research: The Community VOICES study. AJOB Empir Bioeth. 2018;9(1):39–47.
   PubMedGoogle Scholar
• Bonevski B, Randell M, Paul C, et al. Reaching the hard-to-reach: a systematic review of strategies for improving health and medical research with socially disadvantaged groups. BMC Med Res Methodol. 2014;14(1):42
   PubMedGoogle Scholar
• Braunstein JB, Sherber NS, Schulman SP, Ding EL, Powe NR. Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trials. Medicine. 2008;87(1):1–9.
   PubMed Web of Science ®Google Scholar
• Paquette CE, Syvertsen JL, Pollini RA. Stigma at every turn: health services experiences among people who inject drugs. Int J Drug Policy. 2018;57:104–110.
   PubMed Web of Science ®Google Scholar
• Cockroft JD, Adams SM, Bonnet K, Matlock D, McMillan J, Schlundt D. “A scarlet letter”: stigma and other factors affecting trust in the health care system for women seeking substance abuse treatment in a community setting. Subst Abus. 2019;40(2):170–177.
   PubMed Web of Science ®Google Scholar
• Fisher CB, Oransky M, Mahadevan M, Singer M, Mirhej G. Marginalized populations and drug addiction research: realism, mistrust, and misconception. IRB Ethics Hum Res. 2008;30(3):1–9.
   PubMedGoogle Scholar
• Bell K, Salmon A. What women who use drugs have to say about ethical research: findings of an exploratory qualitative study. J Empir Res Hum Res Ethics. 2011;6(4):84–98.
   PubMed Web of Science ®Google Scholar
• Treloar C, Byron P, McCann P, Maher L. "Fitness for duty": social, organisational and structural influences on the design and conduct of candidate hepatitis C vaccine trials involving people who inject drugs. Vaccine. 2010;28(32):5228–5236.
   PubMed Web of Science ®Google Scholar
• Welch MJ, Lally R, Miller JE, et al. The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials. Clin Trials. 2015;12(5):503–510.
   PubMed Web of Science ®Google Scholar
• Abadie R, Goldenberg S, Welch-Lazoritz M, Fisher CB. Establishing trust in HIV/HCV research among people who inject drugs (PWID): insights from empirical research. PLoS One. 2018;13(12):e0208410–15.
   PubMed Web of Science ®Google Scholar
• Neale J, Tompkins CNE, McDonald R, Strang J. Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study. Addiction. 2018;113(6):1066–1076.
   PubMed Web of Science ®Google Scholar
• Hall MA, Dugan E, Zheng B, Mishra AK. Trust in physicians and medical institutions: what is it, can it be measured, and does it matter? Milbank Q. 2001;79(4):613–639.
   PubMed Web of Science ®Google Scholar
• Safran DG, Kosinski M, Tarlov AR, et al. The Primary Care Assessment Survey: tests of data quality and measurement performance. Med Care. 1998;36(5):728–739.
   PubMed Web of Science ®Google Scholar
• Hall MA, Camacho F, Lawlor JS, Depuy V, Sugarman J, Weinfurt K. Measuring trust in medical researchers. Med Care. 2006;44(11):1048–1053.
   PubMed Web of Science ®Google Scholar
• Sherber NS, Powe NR, Braunstein JB. Personal physicians as study investigators: impact on patients’ willingness to participate in clinical trials. Contemp Clin Trials. 2009;30(3):227–232.
   PubMed Web of Science ®Google Scholar
• Barata PC, Gucciardi E, Ahmad F, Stewart DE. Cross-cultural perspectives on research participation and informed consent. Soc Sci Med. 2006;62(2):479–490.
   PubMed Web of Science ®Google Scholar
• McDonald M, Townsend A, Cox SM, Paterson ND, Lafrenière D. Trust in health research relationships: accounts of human subjects. J Empir Res Hum Res Ethics. 2008;3(4):35–47.
   PubMed Web of Science ®Google Scholar
• Corbie-Smith G, Thomas SB, St. George DMM. Distrust, Race, and Research. Arch Intern Med. 2002;162(21):2458.
   PubMed Web of Science ®Google Scholar
• Farmer DF, Jackson SA, Camacho F, Hall MA. Attitudes of African American and low socioeconomic status white women toward medical research. J Health Care Poor Underserved. 2007;18(1):85–99.
   PubMed Web of Science ®Google Scholar
• Slomka J, Ratliff E, McCurdy S, Timpson S, Williams ML. Decisions to participate in research: views of underserved minority drug users with or at risk for HIV. AIDS Care. 2008;20(10):1224–1232.
   PubMed Web of Science ®Google Scholar
• Svensson K, Ramírez OF, Peres F, Barnett M, Claudio L. Socioeconomic determinants associated with willingness to participate in medical research among a diverse population. Contemp Clin Trials. 2012;33(6):1197–1205.
   PubMed Web of Science ®Google Scholar
• Haynes-Maslow L, Godley P, Dimartino L, et al. African American women's perceptions of cancer clinical trials. Cancer Med. 2014;3(5):1430–1439.
   PubMed Web of Science ®Google Scholar
• Park JN, White B, Bates A, Enriquez J, Liao L, Maher L. Motivators and barriers influencing willingness to participate in candidate HCV vaccine trials: perspectives of people who inject drugs. Drug Alcohol Depend. 2012;123(1–3):35–40.
   PubMed Web of Science ®Google Scholar
• Oviedo-Joekes E, Nosyk B, Marsh DC, et al. Scientific and political challenges in North America's first randomized controlled trial of heroin-assisted treatment for severe heroin addiction: rationale and design of the NAOMI study. Clin Trials. 2009;6(3):261–271.
   PubMed Web of Science ®Google Scholar
• Alsan M, Wanamaker M. Tuskegee and the health of black men. Q J Econ. 2018;133(1):407–455.
   PubMed Web of Science ®Google Scholar
• Castells X, Cunill R, Pérez-Mañá C, Vidal X, Capellà D. Psychostimulant drugs for cocaine dependence. Cochrane Database Syst Rev. 2016;9(9):CD007380.
   PubMedGoogle Scholar
• Fischer B, Kuganesan S, Gallassi A, Malcher-Lopes R, van den Brink W, Wood E. Addressing the stimulant treatment gap: a call to investigate the therapeutic benefits potential of cannabinoids for crack-cocaine use. Int J Drug Policy. 2015;26(12):1177–1182.
   PubMed Web of Science ®Google Scholar
• Brincks AM, Shiu-Yee K, Metsch LR, et al. Physician mistrust, medical system mistrust, and perceived discrimination: associations with HIV care engagement and viral load. AIDS Behav. 2019;23(10):2859–2869.
   PubMed Web of Science ®Google Scholar
• Uhlmann S, Milloy MJ, Ahamad K, et al. Factors associated with willingness to participate in a pharmacologic addiction treatment clinical trial among people who use drugs. Am J Addict. 2015;24(4):368–373.
   PubMed Web of Science ®Google Scholar
• Halpern SD, Metzger DS, Berlin JA, Ubel PA. Who will enroll? Predicting participation in a Phase II AIDS Vaccine Trial. J Acquir Immune Defic Syndr. 2001;27:281–288.
   PubMed Web of Science ®Google Scholar