Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 12, 2000 - Issue 1-2
376
Views
133
CrossRef citations to date
0
Altmetric
Research Article

THE RELEVANCE OF THE RAT LUNG RESPONSE TO PARTICLE OVERLOAD FOR HUMAN RISK ASSESSMENT: A Workshop Consensus Report

Pages 1-17 | Published online: 01 Oct 2008

References

  • Clean Air Scientific Advisory Committee. 1995. EPA Science Advisory Board Review of the Diesel Health Assessment Document May 4-5, 1995 Meeting. EPA-SAB-CASAC-LTR-95-003. EPA Science Advisory Board, Washington, DC: EPA.
  • Commission on Risk Assessment and Risk Management. 1997. Risk assessment and risk management in regulatory decision-making. Final report, vol. 2, pp. 64–68. Washington, DC: U.S. Govern-ment Printing Office.
  • Donaldson, K. 1999. Nonneoplastic lung responses induced in experimental animals by exposure to poorly soluble nonfibrous particles. Inhal. Toxicol. 12:121–139.
  • Green, F. H. Y. 1999. Pulmonary responses to inhaled poorly soluble particulate in the human. Inhal. Toxicol. 12:59–95.
  • Health Effects Institute. 1995. Diesel exhaust: A critical analysis of emissions, exposure, and health effects. Cambridge, MA: NEI.
  • Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., Fuhst, R., Mohr, U., Pott, F., and Stöber, W. 1986. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J. AppL Toxicol. 6:383–395.
  • Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, 0., Belman, B., Koch, W., and Levsen, K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 7: 533–556.
  • International Agency for Research on Cancer. 1987–1997. ARC Monogr. Eval. Carcinogen. Risk Chem. Hum.: Suppl 7 (1987), pp. 349–350 [talc]. Vol. 47 (1989), pp. 309–326 [titanium di-oxide]. Vol. 65 (1996), pp. 149–262 [carbon black]. Vol. 68 (1997), pp. 337–406 [coal dust]. Lyon, France: ARC.
  • Kanematsu, N., Hara, M., and Kada, T. 1980. REC assay and mutagenicity studies on metal com-pounds. Mutat. Res. 77:109–116.
  • Klonne, D. R., Burns, J. M., Haider, C. A., Holdsworth, C. E., and Ulrich, C. E. 1987. Two-year inhalation toxicity study of petroleum coke in rats and monkeys. Am.]. Ind. Med. 11:375–389.
  • Lee, K. P., Trichimowicz, H. J., and Reinhardt, C. F. 1985. Pulmonary response of rats exposed to titanium dioxide (Ti02) by inhalation for two years. Toxicol. Appl. PharmacoL 79:179-192.MacFarland, H. N., Coate, W. B., Disbennett, D. B., and Ackerman, L. J. 1982. Long-term inhalation studies with raw and processed shale dusts. Ann. Occup. Hyg. 26:213–224.
  • Mauderly, J. L. 1994. Contribution of inhalation bioassays to the assessment of human health risks from solid airborne particles. In Toxic and carcinogenic effects of solid particles in the respiratory tract, eds. U. Mohr, D. L. Dungworth, J. L. Mauderly, and G. Oberdörster, pp. 43–56. Washing-ton, DC: ILSI.
  • Mauderly, J. L., Jones, R. K., Griffith, W. C., Henderson, R. F., and McClellan, R. 0. 1987. Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. AppL Toxicol. 9:208–221.
  • Mauderly, J. L., Snipes, M. B., Barr, E. B., Belinsky, S. A., Bond, J. A., Brooks, A. L., Chang, I.-Y., Cheng, Y. S., Gillett, N. A., Griffith, W., Henderson, R. F., Mitchell, C. F., Nikula, K. J., and Thomassen, D. G. 1994. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically-exposed rats. Health Effects Research Report No. 68. Cambridge, MA: Health Effects Institute.
  • Mauderly, J. L., Banas, D. A., Griffith, W. C., Hahn, F. H., Henderson, R. F., and McClellan, R. 0. 1996. Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats. Fundam. AppL Toxicol. 30:233–242.
  • Miller, F. J. 1999. Dosimetry of particles in laboratory animals and humans in relationship to issues surrounding lung overload and human health risk assessment: A critical review. Inhal. Toxicol. 12:19–57.
  • Mossman, B. T. 1999. Mechanisms of action of poorly soluble particulates in overload-related lung pathology. Inhal. Toxicol. 12:141–148.
  • Nikula, K. J. 1999. Rat lung tumors induced by exposure to selected poorly soluble nonfibrous parti-cles. Inhal. Toxicol. 12:97–119.
  • Nikula, K. J., Snipes, M. B., Griffith, W. C., Henderson, R. F., and Mauderly, J. L. 1995. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. AppL Toxicol. 25:80–94.
  • Nikula, K. J., Avila, K. J., Griffith, W. C., and Mauderly, J. L. 1997. Lung tissue responses and sites of particle retention differ between rats and cynomolgus monkeys exposed chronically to diesel and coal dust. Fundam. AppL Toxicol. 37:37–53.
  • National Toxicology Program. 1993. Toxicology and Carcinogenesis Studies of Talc in F344 rats and B6C3F1 Mice. NTP-TR 421; NIH Publ. No. 93–3152. Washington, DC: DHHS/NIH.
  • Oberdörster, G. 1994. Extrapolation of results from animal inhalation studies with particles to humans. In Toxic and carcinogenic effects of solid particles in the respiratory tract, eds. U. Mohr, D. L. Dungworth, J. L. Mauderly, and G. Oberdörster, pp. 57–73. Washington, DC: ILSI.
  • Periera, M. A. 1982. Genotoxicity of diesel exhaust emissions in laboratory animals. Dev. Toxicol. Environ. Sci. 10:265–276.
  • Schlesinger, R. B. 1995. Deposition and clearance of inhaled particles. In Concepts in inhalation toxi-cology, 2nd ed., eds. R. 0. McClellan and R. F. Henderson, pp. 191–224. Washington, DC: Taylor & Francis.
  • Snipes, M. B. 1989. Long-term retention and clearance of particles inhaled by mammalian species. CRC Crit. Rev. Toxicol. 20:175–211.
  • Watson, A. Y., and Valberg, P. A. 1996. Particle-induced lung tumors in rats: Evidence for species specificity in mechanisms. lnhal. Toxicol. 8:227–257.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.