The role of lysosomal ion channels in lysosome dysfunction

References

• Appelqvist H, Sandin L, Björnström K, Saftig P, Garner B, Öllinger K, Kågedal, K. 2012. Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content. PLoS ONE. 7(11).
   Google Scholar
• Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson M P, Haughey N J. 2014. Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection. J. Neurosci. 34(34):11485–11503. doi:10.1523/JNEUROSCI.0210-14.2014.
   PubMed Web of Science ®Google Scholar
• Bajaj L, Lotfi P, Pal R, Ronza A. di, Sharma J, Sardiello M. 2019. Lysosome biogenesis in health and disease. J Neurochem. 148(5):573–589.
   PubMed Web of Science ®Google Scholar
• Ballabio A, Bonifacino JS. 2020. Lysosomes as dynamic regulators of cell and organismal homeostasis. Nat Rev Mol Cell Biol. 21(2):101–118.
   PubMed Web of Science ®Google Scholar
• Barnes H, Goh NSL, Leong TL, Hoy R. 2019. Silica-associated lung disease: an old-world exposure in modern industries. Respirology. 24(12):1165–1175.
   PubMed Web of Science ®Google Scholar
• Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J, et al. 2014. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 15(8):738–748.
   PubMed Web of Science ®Google Scholar
• Biswas R, Hamilton R F, Holian A. 2014. Role of lysosomes in silica-induced inflammasome activation and inflammation in absence of MARCO. J Immunol Res. 2014:304180.
   PubMed Web of Science ®Google Scholar
• Biswas R, Trout KL, Jessop F, Harkema JR, Holian A. 2017. Imipramine blocks acute silicosis in a mouse model. Part Fibre Toxicol. 14(1):36.
   PubMedGoogle Scholar
• Bonam SR, Wang F, Muller S. 2019. Lysosomes as a therapeutic target. Nat Rev Drug Discov. 18(12):923–948.
   PubMed Web of Science ®Google Scholar
• Borkowska M, Siek M, Kolygina DV, Sobolev YI, Lach S, Kumar S, Cho Y-K, Kandere-Grybowska K, Grzybowski BA. 2020. Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells. Nat Nanotechol. 15(4):1–11.
   Web of Science ®Google Scholar
• Boya P, Andreau K, Poncet D, Zamzami N, Perfettini J-L, Metivier D, Ojcius D M, Jäättelä M, Kroemer G. 2003. Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion. Journal of Experimental Medicine. 197(10):1323–1334.
   PubMed Web of Science ®Google Scholar
• Boya P. 2012. Lysosomal function and dysfunction: mechanism and disease. Antioxid Redox Signal. 17(5):766–774.
   PubMed Web of Science ®Google Scholar
• Boya P, Kroemer G. 2008. Lysosomal membrane permeabilization in cell death. Oncogene. 27(50):6434–6451.
   PubMed Web of Science ®Google Scholar
• Brady OA, Martina JA, Puertollano R. 2018. Emerging roles for TFEB in the immune response and inflammation. Autophagy. 14(2):181–189.
   PubMed Web of Science ®Google Scholar
• Brunner JD, Jakob RP, Schulze T, Neldner Y, Moroni A, Thiel G, Maier T, Schenck S. 2020. Structural basis for ion selectivity in TMEM175 K + channels. ELife. 9:1–24.
   Web of Science ®Google Scholar
• Bunderson-Schelvan M, Holian A, Hamilton RF. 2017. Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. J Toxicol Environ Health - B Crit Rev. 20(4):230–248.
   PubMed Web of Science ®Google Scholar
• Bunderson-Schelvan M, Hamilton RF, Trout KL, Jessop F, Gulumian M, Holian A. 2016. Approaching a unified theory for particle-induced inflammation. In: Otsuki T, Yoshioka Y, Holian A, editors. Biological effects of fibrous and particulate substances. Japan, Tokyo: Springer; p. 51–76.
   Google Scholar
• Buratta S, Tancini B, Sagini K, Delo F, Chiaradia E, Urbanelli L, Emiliani C. 2020. Lysosomal exocytosis, exosome release and secretory autophagy: the autophagic- and endo-lysosomal systems go extracellular. IJMS. 21(7):2576.
   Google Scholar
• Burmeister R, Rhoderick JF, Holian A. 2019. Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine. Inhal Toxicol. 31(7):274–284.
   PubMed Web of Science ®Google Scholar
• Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang K-T, et al. 2009. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 459(7246):596–600.
   PubMed Web of Science ®Google Scholar
• Cang C, Aranda K, Seo YJ, Gasnier B, Ren D. 2015. TMEM175 Is an organelle K(+) Channel Regulating Lysosomal Function. Cell. 162(5):1101–1112.
   PubMed Web of Science ®Google Scholar
• Cang C, Bekele B, Ren D. 2014. The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol. 10(6):463–469.
   PubMed Web of Science ®Google Scholar
• Cang C, Zhou Y, Navarro B, Seo Y-J, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. 2013. MTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 152(4):778–790.
   PubMed Web of Science ®Google Scholar
• Cao F, Hu L-Q, Yao S-R, Hu Y, Wang D-G, Fan Y-G, Pan G-X, Tao S-S, Zhang Q, Pan H-F, et al. 2019b. P2X7 receptor: a potential therapeutic target for autoimmune diseases. Autoimmun Rev. 18(8):767–777.
   PubMed Web of Science ®Google Scholar
• Cao Q, Zhong XZ, Zou Y, Zhang Z, Toro L, Dong XP. 2015. BK channels alleviate lysosomal storage diseases by providing positive feedback regulation of lysosomal Ca2+ release. Dev Cell. 33(4):427–441.
   PubMed Web of Science ®Google Scholar
• Cao Z, Wang Y, Long Z, He G. 2019a. Interaction between autophagy and the NLRP3 inflammasome. Acta Biochim Biophys Sin (Shanghai). 51(11):1087–1095.
   PubMed Web of Science ®Google Scholar
• Castranova V, Vallyathan V. 2000. Silicosis and coal worker’s pneumoconiosis. Environ Health Perspect. 108(4):637–644.
   Google Scholar
• Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, et al. 2013. An extended proteome map of the lysosomal membrane reveals novel potential transporters. Mol Cell Proteomics. 12(6):1572–1588.
   PubMed Web of Science ®Google Scholar
• Chevriaux A, Pilot T, Derangère V, Simonin H, Martine P, Chalmin F, Ghiringhelli F, Rébé C. 2020. Cathepsin B Is required for NLRP3 inflammasome activation in macrophages, through NLRP3 interaction. Front Cell Dev Biol. 8:167.
   PubMed Web of Science ®Google Scholar
• Colacurcio DJ, Nixon RA. 2016. Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev. 32:75–88.
   PubMed Web of Science ®Google Scholar
• Corrotte M, Castro-Gomes T. 2019. Lysosomes and plasma membrane repair. In: Andrade LO, editor. Current topics in membranes. Vol. 84. Cambridge, Massachusetts: Elsevier Inc.; p. 1–16.
   Google Scholar
• Cotter K, Stransky L, McGuire C, Forgac M. 2015. Recent insights into the structure, regulation, and function of the V-ATPases. Trends Biochem Sci. 40(10):611–622.
   PubMed Web of Science ®Google Scholar
• Dayam RM, Saric A, Shilliday RE, Botelho RJ. 2015. The phosphoinositide-gated lysosomal Ca2+ channel, TRPML1, is required for phagosome maturation. Traffic. 16(9):1010–1026.
   PubMed Web of Science ®Google Scholar
• de Duve C. 2005. The lysosome turns fifty. Nat Cell Biol. 7(9):847–849.
   PubMed Web of Science ®Google Scholar
• Deng D, Jiang N, Hao SJ, Sun H, Zhang G j. 2009. Loss of membrane cholesterol influences lysosomal permeability to potassium ions and protons. Biochim Biophys Acta - Biomembranes. 1788(2):470–476.
   Web of Science ®Google Scholar
• Di Paola S, Scotto-Rosato A, Medina DL. 2018. TRPML1: the Ca(2+)retaker of the lysosome. Cell Calcium. 69:112–121.
   PubMed Web of Science ®Google Scholar
• Dopico AM, Bukiya AN, Singh AK. 2012. Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol. Pharmacol Ther. 135(2):133–150.
   PubMed Web of Science ®Google Scholar
• Eugenia Schroeder M, Russo S, Costa C, Hori J, Tiscornia I, Bollati-Fogolín M, Zamboni DS, Ferreira G, Cairoli E, Hill M. 2017. Pro-inflammatory Ca++-activated K + channels are inhibited by hydroxychloroquine. Sci Rep. 7(1):1892.
   PubMedGoogle Scholar
• Filippini A, D’Amore A, Palombi F, Carpaneto A. 2020. Could the inhibition of endo-lysosomal two-pore channels (TPCs) by the natural flavonoid naringenin represent an option to fight SARS-CoV-2 infection? Front Microbiol. 11(970):970.
   PubMedGoogle Scholar
• Funk RS, Krise JP. 2012. Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: Implications for an intracellular distribution-based drug interaction. Mol Pharm. 9(5):1384–1395.
   PubMedGoogle Scholar
• Ge W, Li D, Gao Y, Cao X. 2015. The roles of lysosomes in inflammation and autoimmune diseases. Int Rev Immunol. 34(5):415–431.
   PubMed Web of Science ®Google Scholar
• Gottesfeld P, Andrew D, Dalhoff J. 2015. Silica exposures in artisanal small-scale gold mining in Tanzania and implications for tuberculosis prevention. J Occup Environ Hyg. 12(9):647–653.
   PubMed Web of Science ®Google Scholar
• Graves AR, Curran PK, Smith CL, Mindell JA. 2008. The Cl−/H + antiporter ClC-7 is the primary chloride permeation pathway in lysosomes. Nature. 453(7196):788–792.
   PubMed Web of Science ®Google Scholar
• Grimm C, Tang R. 2020. Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2? Cell Calcium. 88(May):102212.
   PubMedGoogle Scholar
• Grimm C, Holdt LM, Chen C-C, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, et al. 2014. High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun. 5(4699):4699.
   PubMedGoogle Scholar
• Gulbins E, Kolesnick RN. 2013. It takes a CAD to kill a tumor cell with a LMP. Cancer Cell. 24(3):279–281.
   PubMed Web of Science ®Google Scholar
• Guo J, Zeng W, Jiang Y. 2017. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci U S A. 114(5):1009–1014.
   PubMed Web of Science ®Google Scholar
• Hamilton R F, Thakur S A, Holian A. 2008. Silica binding and toxicity in alveolar macrophages. Free Radic Biol Med. 44(7):1246–1258.
   Google Scholar
• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol. 9(8):847–856.
   PubMed Web of Science ®Google Scholar
• Hoy RF, Chambers DC. 2020. Silica-related diseases in the modern world. Allergy. 0:1–13.
   Google Scholar
• Jessop F, Hamilton RF, Rhoderick JF, Fletcher P, Holian A. 2017. Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity. Toxicol Appl Pharmacol. 318:58–68.
   PubMed Web of Science ®Google Scholar
• Jinn S, Drolet RE, Cramer PE, Wong AH-K, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, et al. 2017. TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proc Natl Acad Sci USA. 114(9):2389–2394.
   PubMed Web of Science ®Google Scholar
• Jo E-K, Kim JK, Shin D-M, Sasakawa C. 2016. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 13(2):148–159.
   PubMed Web of Science ®Google Scholar
• Joris F, De Backer L, Van de Vyver T, Bastiancich C, De Smedt SC, Raemdonck K. 2018. Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells. J Control Release. 269:266–276.
   PubMed Web of Science ®Google Scholar
• Kelley N, Jeltema D, Duan Y, He Y. 2019. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. IJMS. 20(13):3328–3324.
   Google Scholar
• Kesavardhana S, Kanneganti T-D. 2017. Mechanisms governing inflammasome activation, assembly and pyroptosis induction. Int Immunol. 29(5):201–210. doi:10.1093/intimm/dxx018. 28531279
   PubMed Web of Science ®Google Scholar
• Khan N, Lakpa KL, Halcrow PW, Afghah Z, Miller NM, Geiger JD, Chen X. 2019. BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep. 9(1):12285.
   PubMedGoogle Scholar
• Kissing S, Saftig P, Haas A. 2018. Vacuolar ATPase in phago(lyso)some biology. Int J Med Microbiol. 308(1):58–67.
   PubMed Web of Science ®Google Scholar
• Kuzu O F, Toprak M, Noory M A, Robertson G P. 2017. Effect of lysosomotropic molecules on cellular homeostasis. Pharmacol. Res. 117:177–184.
   PubMed Web of Science ®Google Scholar
• Lagostena L, Festa M, Pusch M, Carpaneto A. 2017. The human two-pore channel 1 is modulated by cytosolic and luminal calcium. Sci Rep. 7(43900):43900.
   PubMedGoogle Scholar
• Lamming DW, Bar-Peled L. 2019. Lysosome: the metabolic signaling hub. Traffic. 20(1):27–38.
   PubMed Web of Science ®Google Scholar
• Lee J-H, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PPY, Mohan P, Coffey EE, Kompella U, et al. 2015. Presenilin 1 maintains lysosomal Ca(2+) homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification. Cell Rep. 12(9):1430–1444.
   PubMed Web of Science ®Google Scholar
• Leso V, Fontana L, Romano R, Gervetti P, Iavicoli I. 2019. Artificial stone associated silicosis: a systematic review. IJERPH. 16(4):568–517.
   Google Scholar
• Leung CC, Yu ITS, Chen W. 2012. Silicosis. The Lancet. 379(9830):2008–2018.
   PubMed Web of Science ®Google Scholar
• Li B, Wang F, Schall N, Muller S. 2018a. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. J Autoimmun. 90:132–145.
   PubMed Web of Science ®Google Scholar
• Li G, Huang D, Hong J, Bhat OM, Yuan X, Li P-L. 2019. Control of lysosomal TRPML1 channel activity and exosome release by acid ceramidase in mouse podocytes. Am J Physiol Cell Physiol. 317:481–491.
   Web of Science ®Google Scholar
• Li Y, Cao F, Li M, Li P, Yu Y, Xiang L, Xu T, Lei J, Tai YY, Zhu J, et al. 2018b. Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages. J Exp Clin Cancer Res. 37:259.
   PubMed Web of Science ®Google Scholar
• Lie PPY, Nixon RA. 2019. Lysosome trafficking and signaling in health and neurodegenerative diseases. Neurobiol Dis. 122:94–105.
   PubMed Web of Science ®Google Scholar
• Lin P-H, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, et al. 2015. Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. J Biol Chem. 290(6):3377–3389.
   PubMed Web of Science ®Google Scholar
• Lloyd-Evans E, Morgan A J, He X, Smith D A, Elliot-Smith E, Sillence D J, Churchill G C, Schuchman E H, Galione A, Platt F M. 2008. Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med. 14(11):1247–1255.
   PubMed Web of Science ®Google Scholar
• Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. 2005. Rheb binds and regulates the mTOR kinase. Curr Biol. 15(8):702–713.
   PubMed Web of Science ®Google Scholar
• Lu F, Liang Q, Abi-Mosleh L, Das A, de Brabander JK, Goldstein JL, Brown MS. 2015. Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection. ELife. 4:e12177.
   PubMed Web of Science ®Google Scholar
• Luzio JP, Pryor PR, Bright NA. 2007. Lysosomes: fusion and function. Nat Rev Mol Cell Biol. 8(8):622–632.
   PubMed Web of Science ®Google Scholar
• Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. 2018. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 17(8):588–606.
   PubMed Web of Science ®Google Scholar
• Marceau F, Bawolak MT, Lodge R, Bouthillier J, Gagné-Henley A, C.-Gaudreault R, Morissette G. 2012. Cation trapping by cellular acidic compartments: beyond the concept of lysosomotropic drugs. Toxicol Appl Pharmacol. 259(1):1–12.
   PubMed Web of Science ®Google Scholar
• Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, et al. 2015. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol. 17(3):288–299.
   PubMed Web of Science ®Google Scholar
• Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, Puri C, Pignata A, Martina JA, Sardiello M, et al. 2011. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell. 21(3):421–430.
   PubMed Web of Science ®Google Scholar
• Menu P, Vince JE. 2011. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol. 166(1):1–15.
   PubMed Web of Science ®Google Scholar
• Miller F W, Alfredsson L, Costenbader K H, Kamen D L, Nelson L M, Norris J M, De Roos A J. 2012. Epidemiology of environmental exposures and human autoimmune diseases: Findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. Journal of Autoimmunity. 39(4):259–271. doi:10.1016/j.jaut.2012.05.002.
   PubMed Web of Science ®Google Scholar
• Mindell JA. 2012. Lysosomal Acidification Mechanisms. Annu Rev Physiol. 74(1):69–86.
   PubMedGoogle Scholar
• Monteith AJ, Kang SAh, Scott E, Hillman K, Rajfur Z, Jacobson K, Costello MJ, Vilen BJ. 2016. Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 113(15):E2142–E2151.
   PubMed Web of Science ®Google Scholar
• Mossman BT, Glenn RE. 2013. Bioreactivity of the crystalline silica polymorphs, quartz and cristobalite, and implications for occupational exposure limits (OELs). Crit Rev Toxicol. 43(8):632–660.
   PubMed Web of Science ®Google Scholar
• Muñoz-Planillo R, Kuffa P, Martínez-Colón G, Smith BL, Rajendiran TM, Núñez G. 2013. K + efflux Is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 38(6):1142–1153.
   PubMed Web of Science ®Google Scholar
• Murrell-Lagnado RD. 2018. A role for P2X4 receptors in lysosome function. J Gen Physiol. 150(2):185–187.
   PubMed Web of Science ®Google Scholar
• Napolitano G, Ballabio A. 2016. TFEB at a glance. J Cell Sci. 129(13):2475–2481.
   PubMed Web of Science ®Google Scholar
• Nixon RA. 2013. The role of autophagy in neurodegenerative disease. Nat Med. 19(8):983–997.
   PubMed Web of Science ®Google Scholar
• Oh N, Kim Y, Kweon H-S, Oh W-Y, Park J-H. 2018. Macrophage-mediated exocytosis of elongated nanoparticles improves hepatic excretion and cancer phototherapy. ACS Applied Materials and Interfaces. 10(34):28450–29457.
   PubMed Web of Science ®Google Scholar
• Peng W, Wong YC, Krainc D. 2020. Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1. Proc Natl Acad Sci USA. 117(32):19266–19275.
   PubMed Web of Science ®Google Scholar
• Perera RM, Zoncu R. 2016. The lysosome as a regulatory hub. Annu Rev Cell Dev Biol. 32(1):223–253.
   PubMedGoogle Scholar
• Platt FM, d’Azzo A, Davidson BL, Neufeld EF, Tifft CJ. 2018. Lysosomal storage diseases. Nat Rev Dis Primers. 4(1):27.
   PubMed Web of Science ®Google Scholar
• Pollard KM. 2016. Silica, silicosis, and autoimmunity. Front Immunol. 7:97.
   PubMed Web of Science ®Google Scholar
• Reddy A, Caler EV, Andrews NW. 2001. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes . Cell. 106(2):157–169.
   PubMed Web of Science ®Google Scholar
• Sakurai Y, Kolokoltsov AA, Chen C-C, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA. 2015. Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science. 347(6225):995–998.
   PubMed Web of Science ®Google Scholar
• Salata C, Calistri A, Parolin C, Baritussio A, Palù G. 2017. Antiviral activity of cationic amphiphilic drugs. Expert Rev anti Infect Ther. 15(5):483–492.
   PubMed Web of Science ®Google Scholar
• Sayan M, Mossman BT. 2015. The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases. Part Fibre Toxicol. 13(1):51.
   Google Scholar
• Schrezenmeier E, Dörner T. 2020. Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 16(3):155–166.
   PubMed Web of Science ®Google Scholar
• Schroder K, Sagulenko V, Zamoshnikova A, Richards A A, Cridland J A, Irvine K M, Stacey K J, Sweet M J. 2012. Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology. 217(12):1325–1329.
   PubMed Web of Science ®Google Scholar
• Settembre C, Fraldi A, Medina DL, Ballabio A. 2013. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol. 14(5):283–296.
   PubMed Web of Science ®Google Scholar
• She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC. 2018. Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature. 556(7699):130–134.
   PubMed Web of Science ®Google Scholar
• She J, Zeng W, Guo J, Chen Q, Bai XC, Jiang Y. 2019. Structural mechanisms of phospholipid activation of the human TPC2 channel. ELife. 8:e45222.
   PubMed Web of Science ®Google Scholar
• Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong X-p, Yu T, Lieberman AP, Showalter HD, et al. 2012. Lipid storage disorders block lysosomal trafficking by Inhibiting a TRP channel and lysosomal calcium release. Nat Commun. 3:731.
   PubMed Web of Science ®Google Scholar
• Song Q, Meng B, Xu H, Mao Z. 2020. The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases. Transl Neurodegener. 9(1):17.
   PubMed Web of Science ®Google Scholar
• Sterea AM, Almasi S, El Hiani Y. 2018. The hidden potential of lysosomal ion channels: a new era of oncogenes. Cell Calcium. 72:91–103.
   PubMed Web of Science ®Google Scholar
• Sun X, Xu M, Cao X, Huang P, Zhu X, Dong X-P. 2020. A lysosomal K channel regulates large particle phagocytosis by facilitating lysosome Ca2 release. Sci. Rep. 10(1):1–13.
   PubMed Web of Science ®Google Scholar
• Sun A. 2018. Lysosomal storage disease overview. Ann Transl Med. 6(24):476–476.
   PubMed Web of Science ®Google Scholar
• Takenouchi T, Fujita M, Sugama S, Kitani H, Hashimoto M. 2009. The role of the P2X7 receptor signaling pathway for the release of autolysosomes in microglial cells. Autophagy. 5(5):723–724.
   PubMed Web of Science ®Google Scholar
• Trivedi PC, Bartlett JJ, Pulinilkunnil T. 2020. Lysosomal biology and function: modern view of cellular debris bin. Cells. 9(5):1131–1135.
   Web of Science ®Google Scholar
• Wang Z, Zhang S, Xiao Y, Zhang W, Wu S, Qin T, Yue Y, Qian W, Li L. 2020. NLRP3 inflammasome and inflammatory diseases. Oxid. Med. Cell. Longevity. 2020(4063562).
   Google Scholar
• Wang F, Gómez-Sintes R, Boya P. 2018. Lysosomal membrane permeabilization and cell death. Traffic. 19(12):918–931.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang GJ. 2005. Influence of membrane physical state on lysosomal potassium ion permeability. Cell Biol Int. 29(6):393–401.
   PubMed Web of Science ®Google Scholar
• Wang J, Yu Y, Lu K, Yang M, Li Y, Zhou X, Sun Z. 2017a. Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes. Int J Nanomedicine. 12:80
   Web of Science ®Google Scholar
• Wang F, Li B, Schall N, Wilhelm M, & Muller S. 2017b. Assessing autophagy in mouse models and patients with systemic autoimmune diseases. Cells. 6(3):16.
   Web of Science ®Google Scholar
• Wang X, Zhang X, Dong X-P, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, et al. 2012. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151(2):372–383.
   PubMed Web of Science ®Google Scholar
• Weber K, Schilling JD. 2014. Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages. Int J Inflamm. 289(13):9158–9171.
   Google Scholar
• Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U, Jentsch TJ. 2010. Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science. 328(5984):1401–1403.
   PubMed Web of Science ®Google Scholar
• Xiong J, Zhu MX. 2016. Regulation of lysosomal ion homeostasis by channels and transporters. Sci China Life Sci. 59(8):777–791.
   PubMed Web of Science ®Google Scholar
• Xu H, Ren D. 2015. Lysosomal physiology. Annu Rev Physiol. 77(1):57–80.
   PubMedGoogle Scholar
• Yang H, Zhang G, Cui J. 2015. BK channels: multiple sensors, one activation gate. Front Physiol. 6(29):1–16.
   PubMedGoogle Scholar
• Zhang C-S, Jiang B, Li M, Zhu M, Peng Y, Zhang Y-L, Wu Y-Q, Li TY, Liang Y, Lu Z, et al. 2014. The lysosomal v-ATPase-ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metab. 20(3):526–540.
   PubMed Web of Science ®Google Scholar
• Zhang X, Chen W, Li P, Calvo R, Southall N, Hu X, Bryant-Genevier M, Feng X, Geng Q, Gao C, et al. 2019. Agonist-specific voltage-dependent gating of lysosomal two-pore na + channels. ELife. 8:e51423.
   PubMed Web of Science ®Google Scholar
• Zhong XZ, Sun X, Cao Q, Dong G, Schiffmann R, Dong XP. 2016. BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases. Sci Rep. 6(1):1–11.
   PubMedGoogle Scholar
• Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. 2011. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science. 334(6056):678–683.
   PubMed Web of Science ®Google Scholar