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Inhalation Toxicology
International Forum for Respiratory Research
Volume 33, 2021 - Issue 4
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Research Articles

Inhalation dosimetry of nasally inhaled respiratory aerosols in the human respiratory tract with locally remodeled conducting lungs

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Pages 143-159 | Received 26 Jan 2021, Accepted 30 Mar 2021, Published online: 18 Apr 2021

References

  • Adair BM. 2009. Nanoparticle vaccines against respiratory viruses. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 1(4):405–414.
  • Allen MD, Raabe OG. 1985. Slip correction measurements of spherical solid aerosol particles in an improved Millikan apparatus. Aerosol Sci Technol. 4(3):269–286.
  • Bates JH, Suki B. 2008. Assessment of peripheral lung mechanics. Respir Physiol Neurobiol. 163(1–3):54–63.
  • Belyi VA, Muthukumar M. 2006. Electrostatic origin of the genome packing in viruses. Proc Natl Acad Sci U S A. 103(46):17174–17178.
  • Borgstrom L, Olsson B, Thorsson L. 2006. Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. J Aerosol Med. 19(4):473–483.
  • Bryan R, Nair PB, Taylor M. 2009. Use of a statistical model of the whole femur in a large scale, multi-model study of femoral neck fracture risk. J Biomech. 42(13):2171–2176.
  • Byron PR, Peart J, Staniforth JN. 1997. Aerosol electrostatics I: properties of fine powders before and after aerosolization by dry powder inhalers. Pharm Res. 14(6):698–705.
  • Castro-Mateos I, Pozo JM, Cootes TF, Wilkinson JM, Eastell R, Frangi AF. 2014. Statistical shape and appearance models in osteoporosis. Curr Osteoporos Rep. 12(2):163–173.
  • Chandra SS, Xia Y, Engstrom C, Crozier S, Schwarz R, Fripp J. 2014. Focused shape models for hip joint segmentation in 3D magnetic resonance images. Med Image Anal. 18(3):567–578.
  • Chang KK, Kim KB, McQuilling MW, Movahed R. 2018. Fluid structure interaction simulations of the upper airway in obstructive sleep apnea patients before and after maxillomandibular advancement surgery. Am J Orthod Dentofacial Orthop. 153(6):895–904.
  • Choi J, Hoffman EA, Lin C-L, Milhem MM, Tessier J, Newell JD. 2017. Quantitative computed tomography determined regional lung mechanics in normal nonsmokers, normal smokers and metastatic sarcoma subjects. PLoS One. 12(7):e0179812.
  • Choi S, Miyawaki S, Lin C-L. 2018. A feasible computational fluid dynamics study for relationships of structural and functional alterations with particle depositions in severe asthmatic lungs. Comput Math Methods Med. 2018:6564854.
  • Choi S, Yoon S, Jeon J, Zou C, Choi J, Tawhai MH, Hoffman EA, Delvadia R, Babiskin A, Walenga R, et al. 2019. 1D network simulations for evaluating regional flow and pressure distributions in healthy and asthmatic human lungs. J Appl Physiol (1985). 127(1):122–133.
  • Corley RA, Kabilan S, Kuprat AP, Carson JP, Minard KR, Jacob RE, Timchalk C, Glenny R, Pipavath S, Cox T, et al. 2012. Comparative computational modeling of airflows and vapor dosimetry in the respiratory tracts of rat, monkey, and human. Toxicol Sci. 128(2):500–516.
  • De Backer JW, Vos WG, Burnell P, Verhulst SL, Salmon P, De Clerck N, De Backer W. 2009. Study of the variability in upper and lower airway morphology in Sprague-Dawley rats using modern micro-CT scan-based segmentation techniques. Anat Rec (Hoboken). 292(5):720–727.
  • Fitzpatrick C, FitzPatrick D, Lee J, Auger D. 2007. Statistical design of unicompartmental tibial implants and comparison with current devices. Knee. 14(2):138–144.
  • Frans JW, Alan JW. 2020. Synthetic lung surfactant treatment for Covid-19 pneumonia. Coronaviruses. 1:1–3.
  • Garcia GJM, Schroeter JD, Segal RA, Stanek J, Foureman GL, Kimbell JS. 2009a. Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability. Inhal Toxicol. 21(7):607–618.
  • Garcia GJM, Tewksbury EW, Wong BA, Kimbell JS. 2009b. Interindividual variability in nasal filtration as a function of nasal cavity geometry. J Aerosol Med Pulm Drug Deliv. 22(2):139–155.
  • Hauser R, Smoliński J, Gos T. 2005. The estimation of stature on the basis of measurements of the femur. Forensic Sci Int. 147(2–3):185–190.
  • Heimann T, Meinzer HP. 2009. Statistical shape models for 3D medical image segmentation: a review. Med Image Anal. 13(4):543–563.
  • Hernando-Pérez M, Cartagena-Rivera AX, Lošdorfer Božič A, Carrillo PJP, San Martín C, Mateu MG, Raman A, Podgornik R, de Pablo PJ. 2015. Quantitative nanoscale electrostatics of viruses. Nanoscale. 7(41):17289–17298.
  • Hofmann W, Asgharian B, Winkler-Heil R. 2002. Modeling intersubject variability of particle deposition in human lungs. J Aerosol Sci. 33(2):219–235.
  • Jakab A, Blanc R, Berenyi EL, Szekely G. 2012. Generation of individualized thalamus target maps by using statistical shape models and thalamocortical tractography. AJNR Am J Neuroradiol. 33(11):2110–2116.
  • Kim T, Cho HB, Kim WJ, Lee CH, Chae KJ, Choi S-H, Lee KE, Bak SH, Kwon SO, Jin GY, et al. 2020. Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects. Respir Res. 21(1):133.
  • Kim J, Xi J, Si X, Berlinski A, Su WC. 2014. Hood nebulization: effects of head direction and breathing mode on particle inhalability and deposition in a 7-month-old infant model. J Aerosol Med Pulm Drug Deliv. 27(3):209–218.
  • Kitaoka H, Koc S, Tetsumoto S, Koumo S, Hirata H, Kijima T. 2013. 4D model generator of the human lung, "Lung4Cer". Conf Proc IEEE Eng Med Biol Soc. 2013:453–456.
  • Kitaoka H, Takaki R, Suki B. 1999. A three-dimensional model of the human airway tree. J Appl Physiol (1985). 87(6):2207–2217.
  • Koombua K, Pidaparti RM, Longest PW, Ward KR. 2008. Computational analysis of fluid characteristics in rigid and flexible human respiratory airway models. Eng Appl Comput Fluid Mech. 2(2):185–194.
  • Krishan K, Chatterjee PM, Kanchan T, Kaur S, Baryah N, Singh RK. 2016. A review of sex estimation techniques during examination of skeletal remains in forensic anthropology casework. Forensic Sci Int. 261:165.e1–165.e8.
  • Labiris NR, Dolovich MB. 2003. Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol. 56(6):588–599.
  • Lambert AR, O'Shaughnessy PT, Tawhai MH, Hoffman EA, Lin C-L. 2011. Regional deposition of particles in an image-based airway model: large-eddy simulation and left-right lung ventilation asymmetry. Aerosol Sci Technol. 45(1):11–25.
  • Li C, Jiang J, Dong H, Zhao K. 2017. Computational modeling and validation of human nasal airflow under various breathing conditions. J Biomech. 64:59–68.
  • Liu Y, Mitchell J, Chen Y, Yim W, Chu W, Wang RC. 2018. Study of the upper airway of obstructive sleep apnea patient using fluid structure interaction. Respir Physiol Neurobiol. 249:54–61.
  • Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, Sun L, Duan Y, Cai J, Westerdahl D, et al. 2020. Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature. 582(7813):557–560.
  • Longest PW, Xi J. 2007. Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways. Aerosol Sci Technol. 41(4):380–397.
  • Lourenço RV, Loddenkemper R, Carton RW. 1972. Patterns of distribution and clearance of aerosols in patients with bronchiectasis. Am Rev Respir Dis. 106(6):857–866.
  • Lumb AB. 2000. Nunn's applied respiratory physiology. Oxford: Butterworth Heinemann.
  • Macdonald-Wallis C. 2014. Statistical analysis of human growth and development. Int J Epidemiol. 43(2):635–636.
  • Maghari AYA, Liao IY, Belaton B. 2012. Quantitative analysis on PCA-based statistical 3D face shape modeling. In: Giamberardino D, editor. Computational modelling of objects represented in images: fundamentals, methods and applications III. London: Taylor & Francis Group; p. 13–18.
  • Mardia KV, Kent JT, Walder AN. 1991. Statistical shape models in image analysis. In: Keramidas E, Kaufman S, editors. Computer science and statistics: proceedings of the 23rd Symposium on the Interface. Fairfax Station (VA): Interface Foundation of North America; p. 550–557.
  • Mason RJ. 2020a. Pathogenesis of COVID-19 from a cell biology perspective. Eur Respir J. 55(4):2000607.
  • Mason RJ. 2020b. Thoughts on the alveolar phase of COVID-19. Am J Physiol Lung Cell Mol Physiol. 319(1):L115–L120.
  • Mirastschijski U, Dembinski R, Maedler K. 2020. Lung surfactant for pulmonary barrier restoration in patients with COVID-19 pneumonia. Front Med (Lausanne). 7:254–254.
  • Miyawaki S, Hoffman EA, Wenzel SE, Lin C-L. 2019. Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: a feasibility study. Clin Biomech (Bristol, Avon). 66:81–87.
  • Montaudon M, Desbarats P, Berger P, de Dietrich G, Marthan R, Laurent F. 2007. Assessment of bronchial wall thickness and lumen diameter in human adults using multi-detector computed tomography: comparison with theoretical models. J Anat. 211(5):579–588.
  • Montesantos S, Katz I, Fleming J, Majoral C, Pichelin M, Dubau C, Piednoir B, Conway J, Texereau J, Caillibotte G, et al. 2013. Airway morphology from high resolution computed tomography in healthy subjects and patients with moderate persistent asthma. Anat Rec (Hoboken). 296(6):852–866.
  • Morsi SA, Alexander AJ. 1972. An investigation of particle trajectories in two-phase flow systems. J Fluid Mech. 55(2):193–208.
  • Oakes JM, Marsden AL, Grandmont C, Darquenne C, Vignon-Clementel IE. 2015. Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies. J Biomech. 48(6):1147–1157.
  • Oakes JM, Marsden AL, Grandmont C, Shadden SC, Darquenne C, Vignon-Clementel IE. 2014. Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments. Ann Biomed Eng. 42(4):899–914.
  • Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C. 2012. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol (1985). 112(11):1921–1931.
  • Pavia D, Thomson ML, Clarke SW, Shannon HS. 1977. Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. Thorax. 32(2):194–197.
  • Pramod K, Kotta S, Jijith US, Aravind A, Abu Tahir M, Manju CS, Gangadharappa HV. 2020. Surfactant-based prophylaxis and therapy against COVID-19: a possibility. Med Hypotheses. 143:110081.
  • Schaefer I-M, Padera RF, Solomon IH, Kanjilal S, Hammer MM, et al. 2020. In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19. Mod Pathol.
  • Schroeter JD, Garcia GJM, Kimbell JS. 2010. A computational fluid dynamics approach to assess interhuman variability in hydrogen sulfide nasal dosimetry. Inhal Toxicol. 22(4):277–286.
  • Segal RA, Kepler GM, Kimbell JS. 2008. Effects of differences in nasal anatomy on airflow distribution: a comparison of four individuals at rest. Ann Biomed Eng. 36(11):1870–1882.
  • Sella G, Hirsh AE. 2005. The application of statistical physics to evolutionary biology. Proc Natl Acad Sci USA. 102(27):9541–9546.
  • Shukla RK, Srivastav VK, Paul AR, Jain A. 2020. Fluid structure interaction studies of human airways. Sādhanā. 45(1):229.
  • Slice DE. 2007. Geometric morphometrics. Annu Rev Anthropol. 36(1):261–281.
  • Su W-C, Cheng Y-S. 2006. Deposition of fiber in a human airway replica. J Aerosol Sci. 37(11):1429–1441.
  • Talaat K, Xi J. 2017. Computational modeling of aerosol transport, dispersion, and deposition in rhythmically expanding and contracting terminal alveoli. J Aerosol Sci. 112:19–33.
  • Thekedar B, Oeh U, Szymczak W, Hoeschen C, Paretzke HG. 2011. Influences of mixed expiratory sampling parameters on exhaled volatile organic compound concentrations. J Breath Res. 5(1):016001.
  • Tian L, Ahmadi G. 2013. Fiber transport and deposition in human upper tracheobronchial airways. J Aerosol Sci. 60:1–20.
  • Troeger C, Forouzanfar M, Rao PC, Khalil I, Brown A, Swartz S, Fullman N, Mosser J, Thompson RL, Reiner RC, et al. 2017. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis. 17(11):1133–1161.
  • Verma S, Bednar V, Blount A, Hogue BG. 2006. Identification of functionally important negatively charged residues in the carboxy end of mouse hepatitis coronavirus A59 nucleocapsid protein. J Virol. 80(9):4344–4355.
  • Vijverberg SJH, Koenderman L, Koster ES, van der Ent CK, Raaijmakers JAM, Maitland-van der Zee A-H. 2011. Biomarkers of therapy responsiveness in asthma: pitfalls and promises. Clin Exp Allergy. 41(5):615–629.
  • Wilcox DC. 1998. Turbulence modeling for CFD. 2nd ed. California: DCW Industries, Inc.
  • Wu D, Tawhai MH, Hoffman EA, Lin C-L. 2014. A numerical study of heat and water vapor transfer in MDCT-based human airway models. Ann Biomed Eng. 42(10):2117–2131.
  • Xi J, Berlinski A, Zhou Y, Greenberg B, Ou X. 2012. Breathing resistance and ultrafine particle deposition in nasal-laryngeal airways of a newborn, an infant, a child, and an adult. Ann Biomed Eng. 40(12):2579–2595.
  • Xi J, Kim J, Si XA. 2016a. Effects of nostril orientation on airflow dynamics, heat exchange, and particle depositions in human noses. Eur J Mech B Fluids. 55:215–228.
  • Xi J, Kim J, Si XA. 2013a. Transport and absorption of anesthetic vapors in a mouth-lung model extending to G9 bronchioles. Int J Anesthesiol Res. 1:6–19.
  • Xi J, Kim J, Si XA, Zhou Y. 2013b. Diagnosing obstructive respiratory diseases using exhaled aerosol fingerprints: a feasibility study. J Aerosol Sci. 64:24–36.
  • Xi J, Longest PW. 2008. Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. Int J Heat Mass Transf. 51(23–24):5562–5577.
  • Xi J, Longest PW. 2007. Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Ann Biomed Eng. 35(4):560–581.
  • Xi J, Longest PW, Martonen TB. 2008. Effects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airways. J Appl Physiol (1985). 104(6):1761–1777.
  • Xi J, Si XA, Gaide R. 2014c. Electrophoretic particle guidance significantly enhances olfactory drug delivery: a feasibility study. PLoS One. 9(1):e86593.
  • Xi J, Si XA, Kim JW. 2015. Characterizing respiratory airflow and aerosol condensational growth in children and adults using an imaging-CFD approach. In: Becker S, Kuznetsov A, editors. Heat transfer and fluid flow in biological processes. Cambridge (MA): Academic Press; p. 125155.
  • Xi J, Yang T. 2019. Variability in oropharyngeal airflow and aerosol deposition due to changing tongue positions. J Drug Deliv Sci Technol. 49:674–682.
  • Xi J, Zhao W. 2019. Correlating exhaled aerosol images to small airway obstructive diseases: a study with dynamic mode decomposition and machine learning. PLoS ONE. 1:e021141314.
  • Xi J, Si XA, Nagarajan RJPoF. 2020. Effects of mask-wearing on the inhalability and deposition of airborne SARS-CoV-2 aerosols in human upper airway. Phys Fluids (1994). 32:123312.
  • Xi J, Si X, Longest PW. 2013c. Electrostatic charge effects on pharmaceutical aerosol deposition in human nasal–laryngeal airways. Pharmaceutics. 16:26–35.
  • Xi J, Si X, Kim JW, Berlinski A. 2011. Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. J Aerosol Sci. 42:156–173.
  • Xi J, Si X, Kim J, Su G, Dong H. 2014a. Modeling the pharyngeal anatomical effects on breathing resistance and aerodynamically generated sound. Med Biol Eng Comput. 52:567–577.
  • Xi J, Si X, Zhou Y, Kim J, Berlinski A. 2014b. Growth of nasal-laryngeal airways in children and their implications in breathing and inhaled aerosol dynamics. Respir Care. 59:263–273.
  • Xi J, Talaat M, Si XA, Kitaoka H. 2021. Micrometer aerosol deposition in normal and emphysematous subacinar models. Respir Physiol Neurobiol. 283:103556.
  • Xi J, Yuan JE, Si XA. 2016b. Simulation study of electric-guided delivery of 0.4 µm monodisperse and polydisperse aerosols to the ostiomeatal complex. Comput Biol Med. 72:1–12.
  • Xi J, Yuan JE, Yang M, Si X, Zhou Y, Cheng Y-S. 2016c. Parametric study on mouth–throat geometrical factors on deposition of orally inhaled aerosols. J Aerosol Sci. 99:94–106.
  • Yin Y, Choi J, Hoffman EA, Tawhai MH, Lin C-L. 2013. A multiscale MDCT image-based breathing lung model with time-varying regional ventilation. J Comput Phys. 244:168–192.
  • Zhou Y, Xi J, Simpson J, Irshad H, Cheng Y-S. 2013. Aerosol deposition in a nasopharyngolaryngeal replica of a 5-year-old child. Aerosol Sci Technol. 47:275–282.
  • Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, et al. 2020. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 181:1016–1035.e19.

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