274
Views
21
CrossRef citations to date
0
Altmetric
Biochemistry & Molecular Biology

Ginsenoside Rg2 attenuates myocardial fibrosis and improves cardiac function after myocardial infarction via AKT signaling pathway

, & ORCID Icon
Pages 2199-2206 | Received 02 Nov 2019, Accepted 01 Jul 2020, Published online: 24 Jul 2020

References

  • Verma SK. Updated cardiac concerns with rituximab use: a growing challenge. Indian Heart J. 2016;68(Suppl 2):S246–S248.
  • Christia P, Frangogiannis NG. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest. 2013;43:986–995.
  • Galvez-Monton C, Prat-Vidal C, Roura S, et al. Post-infarction scar coverage using a pericardial-derived vascular adipose flap. Pre-clinical results. Int J Cardiol. 2013;166:469–474.
  • Chistiakov DA, Orekhov AN, Bobryshev YV. The role of cardiac fibroblasts in post-myocardial heart tissue repair. Exp Mol Pathol. 2016;101:231–240.
  • Suncion VY, Schulman IH, Hare JM. Concise review: the role of clinical trials in deciphering mechanisms of action of cardiac cell-based therapy. Stem Cells Transl Med. 2012;1:29–35.
  • Kurabayashi M. [Inhibitor of left ventricular remodeling]. Nihon Rinsho. 2011;69(Suppl 9):246–251.
  • Sano M, Fukuda K. [Metabolic remodeling in the ischemic and non-ischemic failing heart]. Nihon Rinsho. 2011;69(Suppl 7):60–68.
  • Yuan CS, Wang CZ, Wicks SM, et al. chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res. 2010;34:160–167.
  • Li XD, Wang JS, Chang B, et al. Panax notoginseng saponins promotes proliferation and osteogenic differentiation of rat bone marrow stromal cells. J Ethnopharmacol. 2011;134:268–274.
  • Zeng P, Li J, Chen Y. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog Mol Biol Transl Sci. 2019;163:423–444.
  • Pi MS, Ru Q, Gong XK, et al. [Effect of ginsenoside Rg2 and its stereoisomers on oxygen-glucose deprivation and reperfusion induced cortical neuronal injury model]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016;36:333–338.
  • Fu W, Sui D, Yu X, et al. Protective effects of ginsenoside Rg2 against H2O2-induced injury and apoptosis in H9c2 cells. Int J Clin Exp Med. 2015;8:19938–19947.
  • Cui J, Wang J, Zheng M, et al. Ginsenoside Rg2 protects PC12 cells against beta-amyloid25-35-induced apoptosis via the phosphoinositide 3-kinase/Akt pathway. Chem Biol Interact. 2017;275:152–161.
  • Cho YS, Kim CH, Ha TS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013;17:133–137.
  • Song J, Zhu Y, Li J, et al. Pellino1-mediated TGF-beta1 synthesis contributes to mechanical stress induced cardiac fibroblast activation. J Mol Cell Cardiol. 2015;79:145–156.
  • Issa ZF. My approach to the patient with ventricular arrhythmia and no structural heart disease. Trends Cardiovasc Med. 2019;29:190.
  • Yang HY, Ahn MJ, Jeong MH, et al. Korea acute myocardial infarction registry I: predictors of in-hospital mortality in Korean patients with acute myocardial infarction. Chonnam Med J. 2019;55:40–46.
  • Gorman RC, Jackson BM. The potential role of ventricular compressive therapy. Surg Clin North Am. 2004;84:45–59.
  • Riaz S, Zeidan A. Myocardial proteases and cardiac remodeling. J Cell Physiol. 2017;232:3244–3250.
  • Nabavi SF, Sureda A, Habtemariam S. Ginsenoside Rd and ischemic stroke; a short review of literatures. J Ginseng Res. 2015;39:299–303.
  • Liu JF, Yan XD, Qi LS, et al. Ginsenoside Rd attenuates Abeta25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons. Chem Biol Interact. 2015;239:12–18.
  • Simonis G, Wiedemann S, Joachim D, et al. Stimulation of adenosine A2b receptors blocks apoptosis in the non-infarcted myocardium even when administered after the onset of infarction. Mol Cell Biochem. 2009;328:119–126.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.