Sodium butyrate alleviates potential Alzheimer’s disease in vitro by suppressing Aβ and tau activation and ameliorates Aβ-induced toxicity

References

• Al Mijan, M., Kim, J. Y., Moon, S.-Y., Choi, S.-H., Nah, S.-Y., & Yang, H.-J. (2019). Gintonin enhances proliferation, late stage differentiation, and cell survival from endoplasmic reticulum stress of oligodendrocyte lineage cells. Frontiers in Pharmacology, 10, 1211. https://doi.org/10.3389/fphar.2019.01211
   PubMed Web of Science ®Google Scholar
• Alpino, G. D. C. Á., Pereira-Sol, G. A., Dias, M. D. M. E., Aguiar, A. S. D., & Peluzio, M. D. C. G. (2022). Beneficial effects of butyrate on brain functions: A view of epigenetic. Critical Reviews in Food Science and Nutrition, 1–10. https://doi.org/10.1080/10408398.2022.2137776
   PubMed Web of Science ®Google Scholar
• Awada, R., Parimisetty, A., & Lefebvre d’Hellencourt, C. (2013). Influence of obesity on neurodegenerative diseases. In U. Kishore (Ed.), Neurodegenerative diseases (pp. 381–401). IntechOpen.
   Google Scholar
• Bayazid, A. B., & Jang, Y. A. (2021). The role of andrographolide on skin inflammations and modulation of skin barrier functions in human keratinocyte. Biotechnology and Bioprocess Engineering, 26(5), 804–813. https://doi.org/10.1007/s12257-020-0289-x
   Web of Science ®Google Scholar
• Bayazid, A. B., Jang, Y. A., Kim, Y. M., Kim, J. G., & Lim, B. O. (2021). Neuroprotective effects of sodium butyrate through suppressing neuroinflammation and modulating antioxidant enzymes. Neurochemical Research, 46(9), 2348–2358. https://doi.org/10.1007/s11064-021-03369-z
   PubMed Web of Science ®Google Scholar
• Bayazid, A. B., Jeong, S. A., Park, C. W., Kim, D. H., & Lim, B. O. (2022). The anti-inflammatory activities of fermented curcuma that contains butyrate mitigate DSS-induced colitis in mice. Molecules, 27(15), 4745. https://doi.org/10.3390/molecules27154745
   PubMed Web of Science ®Google Scholar
• Bayazid, A. B., Kim, J. G., Azam, S., Jeong, S. A., Kim, D. H., Park, C. W., & Lim, B. O. (2022). Sodium butyrate ameliorates neurotoxicity and exerts anti-inflammatory effects in high fat diet-fed mice. Food and Chemical Toxicology, 159, 112743. https://doi.org/10.1016/j.fct.2021.112743
   PubMed Web of Science ®Google Scholar
• Bayazid, A. B., & Lim, B. O. (2022). Quercetin is an active agent in berries against neurodegenerative diseases progression through modulation of Nrf2/HO1. Nutrients, 14(23), 5132. https://doi.org/10.3390/nu14235132
   PubMed Web of Science ®Google Scholar
• Bayazid, A. B., Park, C., Jeong, S., Jang, Y., Lee, J., & Lim, B. (2022). FB alleviates fine dust-induced inflammation in SH-SY5Y cells and improves cognitive impairment of intranasal instillation of PM2.5 in mice. The Korean Society of Medicinal Crop Science.
   Google Scholar
• Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., … Sánchez-Arjona, M. B. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412–436. https://doi.org/10.1038/s41588-022-01024-z
   PubMed Web of Science ®Google Scholar
• Carmona, S., Zahs, K., Wu, E., Dakin, K., Bras, J., & Guerreiro, R. (2018). The role of TREM2 in Alzheimer’s disease and other neurodegenerative disorders. The Lancet Neurology, 17(8), 721–730. https://doi.org/10.1016/S1474-4422(18)30232-1
   PubMed Web of Science ®Google Scholar
• Chételat, G. (2013). Aβ-independent processes – Rethinking preclinical AD. Nature Reviews Neurology, 9(3), 123–124. https://doi.org/10.1038/nrneurol.2013.21
   PubMed Web of Science ®Google Scholar
• Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin, S. P., Li, X., Han, X., Wang, Q., Peng, J., Zhang, B., & Yue, Z. (2023). Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence. Nature Cell Biology, 25(7), 963–974. https://doi.org/10.1038/s41556-023-01158-0
   PubMed Web of Science ®Google Scholar
• Dong, Y., & Cui, C. (2022). The role of short-chain fatty acids in central nervous system diseases. Molecular and Cellular Biochemistry, 477(11), 2595–2607. https://doi.org/10.1007/s11010-022-04471-8
   PubMed Web of Science ®Google Scholar
• Fernandes, F., Barbosa, M., Pereira, D. M., Sousa-Pinto, I., Valentão, P., Azevedo, I. C., & Andrade, P. B. (2018). Chemical profiling of edible seaweed (Ochrophyta) extracts and assessment of their in vitro effects on cell-free enzyme systems and on the viability of glutamate-injured SH-SY5Y cells. Food and Chemical Toxicology, 116, 196–206. https://doi.org/10.1016/j.fct.2018.04.033
   PubMed Web of Science ®Google Scholar
• Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018). New insights into the role of TREM2 in Alzheimer’s disease. Molecular Neurodegeneration, 13(1), 66. https://doi.org/10.1186/s13024-018-0298-9
   PubMedGoogle Scholar
• Hamilton, A., Vasefi, M., Vander Tuin, C., McQuaid, R. J., Anisman, H., & Ferguson, S. S. G. (2016). Chronic pharmacological mGluR5 inhibition prevents cognitive impairment and reduces pathogenesis in an Alzheimer disease mouse model. Cell Reports, 15(9), 1859–1865. https://doi.org/10.1016/j.celrep.2016.04.077
   PubMed Web of Science ®Google Scholar
• Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., … Kummer, M. P. (2015). Neuroinflammation in Alzheimer’s disease. The Lancet Neurology, 14(4), 388–405. https://doi.org/10.1016/S1474-4422(15)70016-5
   PubMed Web of Science ®Google Scholar
• Henrı́quez, G., Mendez, L., Varela-Ramirez, A., Guerrero, E., & Narayan, M. (2020). Neuroprotective effect of Brazilin on amyloid β (25–35)-induced pathology in a human neuroblastoma model. ACS Omega, 5(23), 13785–13792. https://doi.org/10.1021/acsomega.0c00396
   PubMed Web of Science ®Google Scholar
• Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., Eckert, A., Staufenbiel, M., Hardeman, E., & Götz, J. (2010). Dendritic function of tau mediates amyloid-β toxicity in Alzheimer’s disease mouse models. Cell, 142(3), 387–397. https://doi.org/10.1016/j.cell.2010.06.036
   PubMed Web of Science ®Google Scholar
• Jaradat, N., Abualhasan, M., Hawash, M., Qadi, M., Al-Maharik, N., Abdallah, S., Mousa, A., Zarour, A., Arar, M., Sobuh, S., Hussein, F., Issa, L., Jaber, A., Hamduni, H., & Alshahatit, S. (2023). Chromatography analysis, in light of vitro antioxidant, antidiabetic, antiobesity, anti-inflammatory, antimicrobial, anticancer, and three-dimensional cancer spheroids’ formation blocking activities of Laurus nobilis aromatic oil from Palestine. Chemical and Biological Technologies in Agriculture, 10(1), 25. https://doi.org/10.1186/s40538-023-00396-6
   Web of Science ®Google Scholar
• Jia, G., Diao, Z., Liu, Y., Sun, C., & Wang, C. (2021). Neural stem cell-conditioned medium ameliorates Aβ25–35-induced damage in SH-SY5Y cells by protecting mitochondrial function. Bosnian Journal of Basic Medical Sciences, 21(2), 179–186. https://doi.org/10.17305/bjbms.2020.4570
   PubMed Web of Science ®Google Scholar
• Karaahmet, B., Le, L., Mendes, M. S., Majewska, A. K., & O’Banion, M. K. (2022). Repopulated microglia induce expression of Cxcl13 with differential changes in tau phosphorylation but do not impact amyloid pathology. Journal of Neuroinflammation, 19(1), 173. https://doi.org/10.1186/s12974-022-02532-9
   PubMed Web of Science ®Google Scholar
• Koh, E.-J., Kim, K.-J., Choi, J., Kang, D.-H., & Lee, B.-Y. (2018). Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1–42 (Aβ1–42) induced neurotoxicity in PC12 cells. Neuroscience Letters, 673, 33–38. https://doi.org/10.1016/j.neulet.2018.02.057
   PubMed Web of Science ®Google Scholar
• Lee, A. Y., Lee, M.-H., Lee, S., & Cho, E. J. (2018). Alpha-linolenic acid regulates amyloid precursor protein processing by mitogen-activated protein kinase pathway and neuronal apoptosis in amyloid beta-induced SH-SY5Y neuronal cells. Applied Biological Chemistry, 61(1), 61–71. https://doi.org/10.1007/s13765-017-0334-4
   Web of Science ®Google Scholar
• Lee, J.-H., Yang, D.-S., Goulbourne, C. N., Im, E., Stavrides, P., Pensalfini, A., Chan, H., Bouchet-Marquis, C., Bleiwas, C., Berg, M. J., Huo, C., Peddy, J., Pawlik, M., Levy, E., Rao, M., Staufenbiel, M., & Nixon, R. A. (2022). Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. Nature Neuroscience, 25(6), 688–701. https://doi.org/10.1038/s41593-022-01084-8
   PubMed Web of Science ®Google Scholar
• Lin, C.-I., Chang, Y.-C., Kao, N.-J., Lee, W.-J., Cross, T.-W., & Lin, S.-H. (2020). 1,25(OH)2D3 alleviates Aβ(25–35)-induced tau hyperphosphorylation, excessive reactive oxygen species, and apoptosis through interplay with glial cell line-derived neurotrophic factor signaling in SH-SY5Y cells. International Journal of Molecular Sciences, 21(12), 4215. https://doi.org/10.3390/ijms21124215
   PubMed Web of Science ®Google Scholar
• Long, J. M., & Holtzman, D. M. (2019). Alzheimer disease: An update on pathobiology and treatment strategies. Cell, 179(2), 312–339. https://doi.org/10.1016/j.cell.2019.09.001
   PubMed Web of Science ®Google Scholar
• Luo, Q.-J., Sun, M.-X., Guo, Y.-W., Tan, S.-W., Wu, X.-Y., Abassa, K.-K., Lin, L., Liu, H.-L., Jiang, J., & Wei, X.-Q. (2020). Sodium butyrate protects against lipopolysaccharide-induced liver injury partially via the GPR43/β-arrestin-2/NF-κB network. Gastroenterology Report, 9(2), 154–165. https://doi.org/10.1093/gastro/goaa085
   PubMed Web of Science ®Google Scholar
• Marizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., Coppola, L., Salvatore, M., & Frisoni, G. B. (2020). Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer’s disease. Journal of Alzheimer’s Disease, 78(2), 683–697. https://doi.org/10.3233/JAD-200306
   PubMed Web of Science ®Google Scholar
• Milà-Alomà, M., Ashton, N. J., Shekari, M., Salvadó, G., Ortiz-Romero, P., Montoliu-Gaya, L., Benedet, A. L., Karikari, T. K., Lantero-Rodriguez, J., Vanmechelen, E., Day, T. A., González-Escalante, A., Sánchez-Benavides, G., Minguillon, C., Fauria, K., Molinuevo, J. L., Dage, J. L., Zetterberg, H., Gispert, J. D., … Blennow, K. (2022). Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease. Nature Medicine, 28(9), 1797–1801. https://doi.org/10.1038/s41591-022-01925-w
   PubMed Web of Science ®Google Scholar
• Mirzaei, R., Bouzari, B., Hosseini-Fard, S. R., Mazaheri, M., Ahmadyousefi, Y., Abdi, M., Jalalifar, S., Karimitabar, Z., Teimoori, A., Keyvani, H., Zamani, F., Yousefimashouf, R., & Karampoor, S. (2021). Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomedicine & Pharmacotherapy, 139, 111661. https://doi.org/10.1016/j.biopha.2021.111661
   PubMed Web of Science ®Google Scholar
• Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019). Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. EBioMedicine, 47, 529–542. https://doi.org/10.1016/j.ebiom.2019.08.032
   PubMed Web of Science ®Google Scholar
• Oguchi, T., Ono, R., Tsuji, M., Shozawa, H., Somei, M., Inagaki, M., Mori, Y., Yasumoto, T., Ono, K., & Kiuchi, Y. (2017). Cilostazol suppresses Aβ-induced neurotoxicity in SH-SY5Y cells through inhibition of oxidative stress and MAPK signaling pathway. Frontiers in Aging Neuroscience, 9, 337. https://doi.org/10.3389/fnagi.2017.00337
   PubMed Web of Science ®Google Scholar
• Pang, K., Jiang, R., Zhang, W., Yang, Z., Li, L.-L., Shimozawa, M., Tambaro, S., Mayer, J., Zhang, B., Li, M., Wang, J., Liu, H., Yang, A., Chen, X., Liu, J., Winblad, B., Han, H., Jiang, T., Wang, W., … Lu, B. (2022). An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research, 32(2), 157–175. https://doi.org/10.1038/s41422-021-00582-x
   PubMed Web of Science ®Google Scholar
• Qiu, C., Kivipelto, M., & von Strauss, E. (2009). Epidemiology of Alzheimer’s disease: Occurrence, determinants, and strategies toward intervention. Dialogues in Clinical Neuroscience, 11(2), 111–128. https://doi.org/10.31887/DCNS.2009.11.2/cqiu
   PubMedGoogle Scholar
• Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014). Apoptosis and oxidative stress in neurodegenerative diseases. Journal of Alzheimer’s Disease, 42(Suppl. 3), S125–S152. https://doi.org/10.3233/JAD-132738
   PubMed Web of Science ®Google Scholar
• Riegerová, P., Brejcha, J., Bezděková, D., Chum, T., Mašínová, E., Čermáková, N., Ovsepian, S. V., Cebecauer, M., & Štefl, M. (2021). Expression and localization of AβPP in SH-SY5Y cells depends on differentiation state. Journal of Alzheimer’s Disease, 82(2), 485–491. https://doi.org/10.3233/JAD-201409
   PubMed Web of Science ®Google Scholar
• Wilson, C. A., Doms, R. W., & Lee, V. M.-Y. (1999). Intracellular APP processing and Aβ production in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 58(8), 787–794. https://doi.org/10.1097/00005072-199908000-00001
   PubMed Web of Science ®Google Scholar