1,583
Views
0
CrossRef citations to date
0
Altmetric
Review Article

Anti-cancer perspectives of resveratrol: a comprehensive review

, , , , , , , , , , ORCID Icon, & show all
Article: 2265686 | Received 08 Jun 2023, Accepted 27 Sep 2023, Published online: 08 Nov 2023

References

  • Abdelaziz, H. M., Elzoghby, A. O., Helmy, M. W., Samaha, M. W., Fang, J.-Y., & Freag, M. S. (2019). Liquid crystalline assembly for potential combinatorial chemo–herbal drug delivery to lung cancer cells. International Journal of Nanomedicine, 14, 499–517. https://doi.org/10.2147/IJN.S188335
  • Abdel-Latif, G. A., Al-Abd, A. M., Tadros, M. G., Al-Abbasi, F. A., Khalifa, A. E., & Abdel-Naim, A. B. (2015). The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines. Scientific Reports, 5(1), 1–13. https://doi.org/10.9734/JSRR/2015/14076
  • Adla, D., Reddy, G. V. R., Nayak, P., & Karuna, G. (2022). Deep learning-based computer aided diagnosis model for skin cancer detection and classification. Distributed and Parallel Databases, 40(4), 717–736. https://doi.org/10.1007/s10619-021-07360-z
  • Ahmadi, R., & Ebrahimzadeh, M. A. (2020). Resveratrol–A comprehensive review of recent advances in anticancer drug design and development. European Journal of Medicinal Chemistry, 200, Article 112356. https://doi.org/10.1016/j.ejmech.2020.112356
  • Aires, V., Brassart, B., Carlier, A., Scagliarini, A., Mandard, S., Limagne, E., Solary, E., Martiny, L., Tarpin, M., & Delmas, D. (2014). A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis. Molecular Nutrition & Food Research, 58(9), 1785–1794. https://doi.org/10.1002/mnfr.201300962
  • Al Fatease, A., Shah, V., Nguyen, D. X., Cote, B., Leblanc, N., Rao, D. A., & Alani, A. W. (2019). Chemosensitization and mitigation of adriamycin-induced cardiotoxicity using combinational polymeric micelles for co-delivery of quercetin/resveratrol and resveratrol/curcumin in ovarian cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 19, 39–48. https://doi.org/10.1016/j.nano.2019.03.011
  • Almeida, T. C., Da Silva, G. N., De Souza, D. V., De Moraes Malinverni, A. C., Aguiar, O., Estadella, D., & Ribeiro, D. A. (2021). Resveratrol effects in oral cancer cells: A comprehensive review. Medical Oncology, 38(8), 1–10. https://doi.org/10.1007/s12032-021-01548-0
  • Angellotti, G., Di Prima, G., Belfiore, E., Campisi, G., & De Caro, V. (2023). Chemopreventive and anticancer role of resveratrol against oral squamous cell carcinoma. Pharmaceutics, 15(1), Article 275. https://doi.org/10.3390/pharmaceutics15010275
  • Annaji, M., Poudel, I., Boddu, S. H., Arnold, R. D., Tiwari, A. K., & Babu, R. J. (2021). Resveratrol-loaded nanomedicines for cancer applications. Cancer Reports, 4(3), Article e1353. https://doi.org/10.1002/cnr2.1353
  • Ashrafizadeh, M., Rafiei, H., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2021). Anti-tumor activity of resveratrol against gastric cancer: A review of recent advances with an emphasis on molecular pathways. Cancer Cell International, 21(1), 1–10. https://doi.org/10.1186/s12935-021-01773-7
  • Baby, J., Devan, A. R., Kumar, A. R., Gorantla, J. N., Nair, B., Aishwarya, T. S., & Nath, L. R. (2021). Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review. Journal of Food Biochemistry, 45(7), Article e13761. https://doi.org/10.1111/jfbc.13761
  • Banaszewska, B., Wrotyńska-Barczyńska, J., Spaczynski, R. Z., Pawelczyk, L., & Duleba, A. J. (2016). Effects of resveratrol on polycystic ovary syndrome: A double-blind, randomized, placebo-controlled trial. The Journal of Clinical Endocrinology & Metabolism, 101(11), 4322–4328. https://doi.org/10.1210/jc.2016-1858
  • Barani, M., Bilal, M., Sabir, F., Rahdar, A., & Kyzas, G. Z. (2021). Nanotechnology in ovarian cancer: Diagnosis and treatment. Life Sciences, 266, Article 118914. https://doi.org/10.1016/j.lfs.2020.118914
  • Barata, P. C., & Rini, B. I. (2017). Treatment of renal cell carcinoma: Current status and future directions. CA: A Cancer Journal for Clinicians, 67(6), 507–524. https://doi.org/10.3322/caac.21411
  • Baribeau, S., Chaudhry, P., Parent, S., & Asselin, É. (2014). Resveratrol inhibits cisplatin-induced epithelial-to-mesenchymal transition in ovarian cancer cell lines. PLoS One, 9(1), Article e86987. https://doi.org/10.1371/journal.pone.0086987
  • Capitanio, U., Bensalah, K., Bex, A., Boorjian, S. A., Bray, F., Coleman, J., Gore, J. L., Sun, M., Wood, C., & Russo, P. (2019). Epidemiology of renal cell carcinoma. European Urology, 75(1), 74–84. https://doi.org/10.1016/j.eururo.2018.08.036
  • Carletto, B., Berton, J., Ferreira, T. N., Dalmolin, L. F., Paludo, K. S., Mainardes, R. M., Farago, P. V., & Favero, G. M. (2016). Resveratrol-loaded nanocapsules inhibit murine melanoma tumor growth. Colloids and Surfaces B: Biointerfaces, 144, 65–72. https://doi.org/10.1016/j.colsurfb.2016.04.001
  • Chang, W. S., Tsai, C. W., Yang, J. S., Hsu, Y. M., Shih, L. C., Chiu, H. Y., Bau, D. T., & Tsai, J. T. (2021). Resveratrol inhibited the metastatic behaviors of cisplatin-resistant human oral cancer cells via phosphorylation of ERK/p-38 and suppression of MMP-2/9. Journal of Food Biochemistry, 45, Article e13666.
  • Che, Y., Shi, X., Zhong, X., Zhang, Y., Si, R., Li, Y., & Shi, Y. (2020). Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription. The Journal of Nutritional Biochemistry, 82, Article 108400. https://doi.org/10.1016/j.jnutbio.2020.108400
  • Chen, P., Bai, P., Luo, G., Su, H., Shen, R., Liu, Z., Zhang, N., Fang, L., & Liu, C. (2016). Role of anti-apoptotic activity of antioxidants in conferring protection against prostate cancer. International Journal of Pharmacology, 12(4), 304–316. https://doi.org/10.3923/ijp.2016.304.316
  • Chen, Y.-R., Chen, Y.-S., Chin, Y.-T., Li, Z.-L., Shih, Y.-J., Yang, Y.-C. S., Changou, C. A., Su, P.-Y., Wang, S.-H., & Wu, Y.-H. (2019). Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. Food and Chemical Toxicology, 132, Article 110693. https://doi.org/10.1016/j.fct.2019.110693
  • Çınar Ayan, İ, Güçlü, E., Vural, H., & Dursun, H. G. (2022). Piceatannol induces apoptotic cell death through activation of caspase-dependent pathway and upregulation of ROS-mediated mitochondrial dysfunction in pancreatic cancer cells. Molecular Biology Reports, 49(12), 11947–11957.
  • Corradetti, B., Pisano, S., Conlan, R. S., & Ferrari, M. (2019). Nanotechnology and immunotherapy in ovarian cancer: Tracing new landscapes. Journal of Pharmacology and Experimental Therapeutics, 370(3), 636–646. https://doi.org/10.1124/jpet.118.254979
  • Cosco, D., Paolino, D., Maiuolo, J., Di Marzio, L., Carafa, M., Ventura, C. A., & Fresta, M. (2015). Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery. International Journal of Pharmaceutics, 489(1-2), 1–10. https://doi.org/10.1016/j.ijpharm.2015.04.056
  • D'arcy, M. S., Pike, C. V., & Coussons, P. J. (2021). A novel combined resveratrol/berberine phytochemotheraputic using the HePG2 cell line as a model for the treatment of hepatocarcinoma. Cell Biology International, 45(12), 2499–2509. https://doi.org/10.1002/cbin.11695
  • De, A., De, A., Papasian, C., Hentges, S., Banerjee, S., Haque, I., & Banerjee, S. K. (2013). Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors. PloS one, 8(8), Article e72748. https://doi.org/10.1371/journal.pone.0072748
  • Decastro, G. J., & Mckiernan, J. M. (2008). Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urologic Clinics of North America, 35(4), 581–592. https://doi.org/10.1016/j.ucl.2008.07.005
  • Ekremoglu, O., & Koc, A. (2021). The role of SIRT5 and p53 proteins in the sensitivity of colon cancer cells to chemotherapeutic agent 5-fluorouracil. Molecular Biology Reports, 48(7), 5485–5495. https://doi.org/10.1007/s11033-021-06558-9
  • El-Far, S. W., Helmy, M. W., Khattab, S. N., Bekhit, A. A., Hussein, A. A., & Elzoghby, A. O. (2018). Phytosomal bilayer-enveloped casein micelles for codelivery of monascus yellow pigments and resveratrol to breast cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(5), 481–499. https://doi.org/10.2217/nnm-2017-0301
  • El-Melegy, M. G., Eltaher, H. M., Gaballah, A., & EL-Kamel, A. H. (2021). Enhanced oral permeability of trans-resveratrol using nanocochleates for boosting anticancer efficacy; in-vitro and ex-vivo appraisal. European Journal of Pharmaceutics and Biopharmaceutics, 168, 166–183. https://doi.org/10.1016/j.ejpb.2021.08.020
  • Elshaer, M., Chen, Y., Wang, X. J., & Tang, X. (2018). Resveratrol: An overview of its anti-cancer mechanisms. Life Sciences, 207, 340–349. https://doi.org/10.1016/j.lfs.2018.06.028
  • Engelke, L. H., Hamacher, A., Proksch, P., & Kassack, M. U. (2016). Ellagic acid and resveratrol prevent the development of cisplatin resistance in the epithelial ovarian cancer cell line A2780. Journal of Cancer, 7(4), 353–363. https://doi.org/10.7150/jca.13754
  • Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359–E386. https://doi.org/10.1002/ijc.29210
  • Ferraresi, A., Phadngam, S., Morani, F., Galetto, A., Alabiso, O., Chiorino, G., & Isidoro, C. (2017). Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy. Molecular Carcinogenesis, 56(3), 1164–1181. https://doi.org/10.1002/mc.22582
  • Ferraresi, A., Titone, R., Follo, C., Castiglioni, A., Chiorino, G., Dhanasekaran, D. N., & Isidoro, C. (2017). The protein restriction mimetic resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Molecular Carcinogenesis, 56(12), 2681–2691. https://doi.org/10.1002/mc.22711
  • Fu, J., Shrivastava, A., Shrivastava, S. K., Srivastava, R. K., & Shankar, S. (2019). Triacetyl resveratrol upregulates miRNA-200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent. International Journal of Oncology, 54, 1306–1316.
  • Fudhaili, A., Yoon, N., Kang, S., Ryu, J., Jeong, J. Y., Lee, D. H., & Kang, S. S. (2019). Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non-small cell lung cancer cell lines. Oncology Reports, 41, 1377–1386.
  • Fukuda, M., Ogasawara, Y., Hayashi, H., Inoue, K., & Sakashita, H. (2022). Resveratrol inhibits proliferation and induces autophagy by blocking SREBP1 expression in oral cancer cells. Molecules, 27(23), Article 8250. https://doi.org/10.3390/molecules27238250
  • Gao, H., Ye, G., Lin, Y., Chi, Y., & Dong, S. (2020). Benzo [a] pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling. Journal of Applied Toxicology, 40(8), 1087–1098. https://doi.org/10.1002/jat.3969
  • Gaona-Luviano, P., Medina-Gaona, L. A., & Magaña-Pérez, K. (2020). Epidemiology of ovarian cancer. Chinese Clinical Oncology, 9(4), Article 47. https://doi.org/10.21037/cco-20-34
  • Gatti, A., Plotti, F., Montera, R., Terranova, C., & Nardone, C. (2021). Paraneoplastic arthritis in advanced ovarian cancer and its correlation with CA125 and HE4 levels: A case report. Annals of Case Reports, 6, Article 608.
  • Ghosh, S., Kumar, V., Mukherjee, H., Lahiri, D., & Roy, P. (2021). Nutraceutical regulation of miRNAs involved in neurodegenerative diseases and brain cancers. Heliyon, 7, Article e07262.
  • Gong, G., Lin, T., & Yuan, Y. (2020). Integrated analysis of gene expression and DNA methylation profiles in ovarian cancer. Journal of Ovarian Research, 13(1), 1–10. https://doi.org/10.1186/s13048-019-0602-5
  • González-Sarrías, A., Espín-Aguilar, J. C., Romero-Reyes, S., Puigcerver, J., Alajarín, M., Berná, J., Selma, M. V., & Espín, J. C. (2022). Main determinants affecting the antiproliferative activity of stilbenes and their Gut microbiota metabolites in colon cancer cells: A structure–activity relationship study. International Journal of Molecular Sciences, 23(23), Article 15102. https://doi.org/10.3390/ijms232315102
  • Grau, L., Soucek, R., & Pujol, M. D. (2023). Resveratrol derivatives: Synthesis and their biological activities. European Journal of Medicinal Chemistry, 246, Article 114962. https://doi.org/10.1016/j.ejmech.2022.114962
  • Gu, S., Chen, C., Jiang, X., & Zhang, Z. (2016). ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction underlie apoptosis induced by resveratrol and arsenic trioxide in A549 cells. Chemico-biological Interactions, 245, 100–109. https://doi.org/10.1016/j.cbi.2016.01.005
  • Gwak, H., Kim, S., Dhanasekaran, D. N., & Song, Y. S. (2016). Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Letters, 371(2), 347–353. https://doi.org/10.1016/j.canlet.2015.11.032
  • Han, Y., Jo, H., Cho, J. H., Dhanasekaran, D. N., & Song, Y. S. (2019). Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer. International Journal of Molecular Sciences, 20(4), Article 925. https://doi.org/10.3390/ijms20040925
  • Hao, Y., Huang, W., Liao, M., Zhu, Y., Liu, H., Hao, C., Liu, G., Zhang, G., Feng, H., & Ning, X. (2013). The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice. Fitoterapia, 86, 84–91. https://doi.org/10.1016/j.fitote.2013.02.005
  • Hayakawa, S., Ohishi, T., Oishi, Y., Isemura, M., & Miyoshi, N. (2022). Contribution of non-coding RNAs to anticancer effects of dietary polyphenols: Chlorogenic acid, curcumin, epigallocatechin-3-gallate, genistein, quercetin and resveratrol. Antioxidants, 11(12), Article 2352. https://doi.org/10.3390/antiox11122352
  • Henley, S. J., Peipins, L. A., Rim, S. H., Larson, T. C., & Miller, J. W. (2020). Geographic co-occurrence of mesothelioma and ovarian cancer incidence. Journal of Women's Health, 29(1), 111–118. https://doi.org/10.1089/jwh.2019.7752
  • Heo, J. R., Kim, S. M., Hwang, K. A., Kang, J. H., & Choi, K. C. (2018). Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line. International Journal of Molecular Medicine, 42, 1427–1435.
  • Hosein Farzaei, M., Bahramsoltani, R., & Rahimi, R. (2016). Phytochemicals as adjunctive with conventional anticancer therapies. Current Pharmaceutical Design, 22(27), 4201–4218. https://doi.org/10.2174/1381612822666160601100823
  • Hosseini, A., & Ghorbani, A. (2015). Cancer therapy with phytochemicals: Evidence from clinical studies. Avicenna Journal of Phytomedicine, 5, Article 84.
  • Hsieh, M. T., Huang, L. J., Wu, T. S., Lin, H. Y., Morris-Natschke, S. L., Lee, K. H., & Kuo, S. C. (2018). Synthesis and antitumor activity of bis (hydroxymethyl) propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. Bioorganic & Medicinal Chemistry, 26(14), 3909–3916. https://doi.org/10.1016/j.bmc.2018.06.011
  • Hsieh, T. C. (2009). Antiproliferative effects of resveratrol and the mediating role of resveratrol targeting protein NQO2 in androgen receptor-positive, hormone-non-responsive CWR22Rv1 cells. Anticancer Research, 29, 3011–3017.
  • Hu, Y., Wang, Z., Qiu, Y., Liu, Y., Ding, M., & Zhang, Y. (2019). Anti-miRNA21 and resveratrol-loaded polysaccharide-based mesoporous silica nanoparticle for synergistic activity in gastric carcinoma. Journal of Drug Targeting, 27(10), 1135–1143. https://doi.org/10.1080/1061186X.2019.1610766
  • Innets, B., Thongsom, S., Petsri, K., Racha, S., Yokoya, M., Moriue, S., Chaotham, C., & Chanvorachote, P. (2022). Akt/mTOR targeting activity of resveratrol derivatives in non-small lung cancer. Molecules, 27(23), Article 8268. https://doi.org/10.3390/molecules27238268
  • Iqubal, M. K., Iqubal, A., Anjum, H., Gupta, M. M., Ali, J., & Baboota, S. (2021). Determination of in vivo virtue of dermal targeted combinatorial lipid nanocolloidal based formulation of 5-fluorouracil and resveratrol against skin cancer. International Journal of Pharmaceutics, 610, Article 121179. https://doi.org/10.1016/j.ijpharm.2021.121179
  • Irshad, K., Rehman, K., Akash, M. S. H., & Hussain, I. (2021). Biochemical investigation of therapeutic potential of resveratrol against arsenic intoxication. Dose-Response, 19(4). https://doi.org/10.1177/15593258211060941
  • Islam, S. U., Shehzad, A., Sonn, J. K., & Lee, Y. S. (2017). PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. Oncotarget, 8(34), 56659–56671. https://doi.org/10.18632/oncotarget.17855
  • Jain, S., Garg, T., Kushwah, V., Thanki, K., Agrawal, A. K., & Dora, C. P. (2017). α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer. Journal of Drug Targeting, 25(6), 554–565. https://doi.org/10.1080/1061186X.2017.1298603
  • Jang, Y. G., Go, R. E., Hwang, K. A., & Choi, K. C. (2019). Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway. The Journal of Steroid Biochemistry and Molecular Biology, 192, Article 105406. https://doi.org/10.1016/j.jsbmb.2019.105406
  • Jardim, F. R., de Rossi, F. T., Nascimento, M. X., da Silva Barros, R. G., Borges, P. A., Prescilio, I. C., & de Oliveira, M. R. (2018). Resveratrol and brain mitochondria: A review. Molecular Neurobiology, 55(3), 2085–2101. https://doi.org/10.1007/s12035-017-0448-z
  • Jenkins, G., Cronin, J., Alhamdani, A., Rawat, N., D'Souza, F., Thomas, T., Eltahir, Z., Griffiths, A., & Baxter, J. (2008). The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-κB activation in oesophageal cells, with a mechanism of action involving ROS. Mutagenesis, 23(5), 399–405. https://doi.org/10.1093/mutage/gen029
  • Jeon, D., Jo, M., Lee, Y., Park, S. H., Phan, H. T. L., Nam, J. H., & Namkung, W. (2023). Inhibition of ANO1 by Cis-and trans-resveratrol and their anticancer activity in human prostate cancer PC-3 cells. International Journal of Molecular Sciences, 24(2), Article 1186. https://doi.org/10.3390/ijms24021186
  • Jiang, H., Tang, W., Song, Y., Jin, W., & Du, Q. (2022). Induction of apoptosis by metabolites of Rhei Radix et Rhizoma (Da Huang): A review of the potential mechanism in hepatocellular carcinoma. Frontiers in Pharmacology, 13, 806175. https://doi.org/10.3389/fphar.2022.806175
  • Jiang, L., Yu, H., Wang, C., He, F., Shi, Z., Tu, H., Ning, N., Duan, S., & Zhao, Y. (2022). The anti-cancer effects of mitochondrial-targeted triphenylphosphonium–resveratrol conjugate on breast cancer cells. Pharmaceuticals, 15(10), 1271. https://doi.org/10.3390/ph15101271
  • Jose, S., Anju, S., Cinu, T., Aleykutty, N., Thomas, S., & Souto, E. (2014). In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery. International Journal of Pharmaceutics, 474(1-2), 6–13. https://doi.org/10.1016/j.ijpharm.2014.08.003
  • Juère, E., Florek, J., Bouchoucha, M., Jambhrunkar, S., Wong, K. Y., Popat, A., & Kleitz, F. (2017). In vitro dissolution, cellular membrane permeability, and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles. Molecular Pharmaceutics, 14(12), 4431–4441. https://doi.org/10.1021/acs.molpharmaceut.7b00529
  • Junco, J. J., Mancha, A., Malik, G., Wei, S.-J., Kim, D. J., Liang, H., & Slaga, T. J. (2013). Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid enhancement of ursolic acid tumor cytotoxicity In vitro. Molecular Cancer Research, 11(12), 1521–1529. https://doi.org/10.1158/1541-7786.MCR-13-0237
  • Kanlikilicer, P., Bayraktar, R., Denizli, M., Rashed, M. H., Ivan, C., Aslan, B., Mitra, R., Karagoz, K., Bayraktar, E., & Zhang, X. (2018). Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer. EBioMedicine, 38, 100–112. https://doi.org/10.1016/j.ebiom.2018.11.004
  • Karimi, A., Tutunchi, H., Naeini, F., Vajdi, M., Mobasseri, M., & Najafipour, F. (2022). The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies. Clinical and Experimental Pharmacology and Physiology, 49(9), 935–949. https://doi.org/10.1111/1440-1681.13698
  • Karimkhani, C., Green, A. C., Nijsten, T., Weinstock, M. A., Dellavalle, R. P., Naghavi, M., & Fitzmaurice, C. (2017). The global burden of melanoma: Results from the global burden of disease study 2015. British Journal of Dermatology, 177(1), 134–140. https://doi.org/10.1111/bjd.15510
  • Kataria, R., & Khatkar, A. (2019). Resveratrol in various pockets: A review. Current Topics in Medicinal Chemistry, 19(2), 116–122. https://doi.org/10.2174/1568026619666190301173958
  • Khusbu, F. Y., Zhou, X., Roy, M., Chen, F. Z., Cao, Q., & Chen, H. C. (2020). Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration. The International Journal of Biochemistry & Cell Biology, 118, Article 105644. https://doi.org/10.1016/j.biocel.2019.105644
  • Kim, E. C., Kim, M. K., Leesungbok, R., Lee, S. W., & Ahn, S. J. (2016). Co–Cr dental alloys induces cytotoxicity and inflammatory responses via activation of Nrf2/antioxidant signaling pathways in human gingival fibroblasts and osteoblasts. Dental Materials, 32(11), 1394–1405. https://doi.org/10.1016/j.dental.2016.09.017
  • Kim, J., Oh, J., Averilla, J. N., Kim, H. J., Kim, J. S., & Kim, J. S. (2019). Grape peel extract and resveratrol inhibit wrinkle formation in mice model through activation of Nrf2/HO-1 signaling pathway. Journal of Food Science, 84(6), 1600–1608. https://doi.org/10.1111/1750-3841.14643
  • Knower, K. C., To, S. Q., Leung, Y. K., Ho, S. M., & Clyne, C. D. (2014). Endocrine disruption of the epigenome: A breast cancer link. Endocrine-related Cancer, 21(2), T33–T55. https://doi.org/10.1530/ERC-13-0513
  • Kowalczyk, M. C., Junco, J. J., Kowalczyk, P., Tolstykh, O., Hanausek, M., Slaga, T. J., & Walaszek, Z. (2013). Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. International Journal of Oncology, 43(3), 911–918. https://doi.org/10.3892/ijo.2013.2005
  • Kueck, A., Opipari Jr, A. W., Griffith, K. A., Tan, L., Choi, M., Huang, J., Wahl, H., & Liu, J. R. (2007). Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecologic Oncology, 107(3), 450–457. https://doi.org/10.1016/j.ygyno.2007.07.065
  • Lang, F., Qin, Z., Li, F., Zhang, H., Fang, Z., & Hao, E. (2015). Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PloS one, 10, Article e0129196.
  • Laquerre, J. N. (2020). Intussusception: Sonographic findings to fluoroscopic reduction in pediatrics. Radiologic Technology, 91, 380–384.
  • Lee, M. H., Choi, B. Y., Kundu, J. K., Shin, Y. K., Na, H. K., & Surh, Y. J. (2009). Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: Eukaryotic elongation factor 1A2 as a potential target. Cancer Research, 69(18), 7449–7458. https://doi.org/10.1158/0008-5472.CAN-09-1266
  • Lee, S. H., & Lee, Y. J. (2021). Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells. Nutrition Research and Practice, 15(1), 12–25. https://doi.org/10.4162/nrp.2021.15.1.12
  • Leonard, S. S., Xia, C., Jiang, B. H., Stinefelt, B., Klandorf, H., Harris, G. K., & Shi, X. (2003). Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochemical and Biophysical Research Communications, 309(4), 1017–1026. https://doi.org/10.1016/j.bbrc.2003.08.105
  • Levenson, A. S. (2022). Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy. Seminars in Cancer Biology 80, 107–117. https://doi.org/10.1016/j.semcancer.2020.02.012
  • Li, D., Wang, G., Jin, G., Yao, K., Zhao, Z., Bie, L., Guo, Y., Li, N., Deng, W., & Chen, X. (2019). Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway. International Journal of Molecular Medicine, 43, 630–640.
  • Li, W., Li, C., Ma, L., & Jin, F. (2020). Resveratrol inhibits viability and induces apoptosis in the small-cell lung cancer H446 cell line via the PI3K/Akt/c-Myc pathway. Oncology Reports, 44, 1821–1830.
  • Li, W., Shi, Y., Wang, R., Pan, L., Ma, L., & Jin, F. (2018). Resveratrol promotes the sensitivity of small-cell lung cancer H446 cells to cisplatin by regulating intrinsic apoptosis. International Journal of Oncology, 53, 2123–2130.
  • Liang, Y., Xu, M. L., Gao, X., Wang, Y., Zhang, L. N., Li, Y. C., & Guo, Q. (2023). Resveratrol improves ovarian state by inhibiting apoptosis of granulosa cells. Gynecological Endocrinology, 39(1), Article 2181652. https://doi.org/10.1080/09513590.2023.2181652
  • Lin, T. A., Lin, W. S., Chou, Y. C., Nagabhushanam, K., Ho, C. T., & Pan, M. H. (2021). Oxyresveratrol inhibits human colon cancer cell migration through regulating epithelial–mesenchymal transition and microRNA. Food & Function, 12(20), 9658–9668. https://doi.org/10.1039/D1FO01920A
  • Lin, Y.-S., Hsieh, C.-Y., Kuo, T.-T., Lin, C.-C., Lin, C.-Y., & Sher, Y.-P. (2020). Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy. American Journal of Cancer Research, 10, Article 3828.
  • Lipworth, L., Morgans, A. K., Edwards, T. L., Barocas, D. A., Chang, S. S., Herrell, S. D., Penson, D. F., Resnick, M. J., Smith, J. A., & Clark, P. E. (2016). Renal cell cancer histological subtype distribution differs by race and sex. BJU International, 117(2), 260–265. https://doi.org/10.1111/bju.12950
  • Long, Z., Dai, J., Hu, Q., Wang, Q., Zhen, S., Zhao, Z., Liu, Z., Hu, J.-J., Lou, X., & Xia, F. (2020). Nanococktail based on AIEgens and semiconducting polymers: A single laser excited image-guided dual photothermal therapy. Theranostics, 10(5), 2260–2272. https://doi.org/10.7150/thno.41317
  • Losa, G. (2003). Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells. European Journal of Clinical Investigation, 33(9), 818–823. https://doi.org/10.1046/j.1365-2362.2003.01219.x
  • Ma, F., Ma, Y., Liu, K., Gao, J., Li, S., Sun, X., & Li, G. (2023). Resveratrol induces DNA damage-mediated cancer cell senescence through the DLC1–DYRK1A–EGFR axis. Food & Function, 14(3), 1484–1497.
  • Mohammadhosseinpour, S., Weaver, A., Sudhakaran, M., Ho, L.-C., Le, T., Doseff, A. I., & Medina-Bolivar, F. (2023). Arachidin-1, a prenylated stilbenoid from peanut, enhances the anticancer effects of paclitaxel in triple-negative breast cancer cells. Cancers, 15(2), Article 399. https://doi.org/10.3390/cancers15020399
  • Momchilova, A., Pankov, R., Staneva, G., Pankov, S., Krastev, P., Vassileva, E., Hazarosova, R., Krastev, N., Robev, B., & Nikolova, B. (2022). Resveratrol affects sphingolipid metabolism in A549 lung adenocarcinoma cells. International Journal of Molecular Sciences, 23(18), Article 10870. https://doi.org/10.3390/ijms231810870
  • Moreira, H., Szyjka, A., Grzesik, J., Pelc, K., Żuk, M., Kulma, A., Emhemmed, F., Muller, C. D., Gąsiorowski, K., & Barg, E. (2022). Celastrol and resveratrol modulate SIRT genes expression and exert anticancer activity in colon cancer cells and cancer stem-like cells. Cancers, 14(6), Article 1372. https://doi.org/10.3390/cancers14061372
  • Msaouel, P., Hong, A. L., Mullen, E. A., Atkins, M. B., Walker, C. L., Lee, C. H., Carden, M. A., Genovese, G., Linehan, W. M., & Rao, P. (2019). Updated recommendations on the diagnosis, management, and clinical trial eligibility criteria for patients with renal medullary carcinoma. Clinical Genitourinary Cancer, 17(1), 1–6. https://doi.org/10.1016/j.clgc.2018.09.005
  • Muhanmode, Y., Wen, M. K., Maitinuri, A., & Shen, G. (2022). Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway. Human & Experimental Toxicology, 41. https://doi.org/10.1177/09603271221095929
  • Nabi, S., Kessler, E. R., Bernard, B., Flaig, T. W., & Lam, E. T. (2018). Renal cell carcinoma: a review of biology and pathophysiology. F1000Research, 7, 307. https://doi.org/10.12688/f1000research.13179.1
  • Nassir, A. M., Shahzad, N., Ibrahim, I. A., Ahmad, I., Md, S., & Ain, M. R. (2018). Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells. Saudi Pharmaceutical Journal, 26(6), 876–885. https://doi.org/10.1016/j.jsps.2018.03.009
  • Olas, B., Wachowicz, B., Bald, E., & Głowacki, R. (2004). The protective effects of resveratrol against changes. Journal of Physiology and Pharmacology, 55, 467–476.
  • Oliveira, D. V., Prahm, K. P., Christensen, I. J., Hansen, A., Høgdall, C. K., & Høgdall, E. V. (2021). Gene expression profile association with poor prognosis in epithelial ovarian cancer patients. Scientific Reports, 11(1), Article 5438. https://doi.org/10.1038/s41598-021-84953-9
  • Park, J. W., Choi, W. G., Lee, P. J., Chung, S. W., Kim, B. S., Chung, H. T., Cho, S., Kim, J. H., Kang, B. H., & Kim, H. (2017). The novel resveratrol derivative 3, 5-diethoxy-3′, 4′-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro. Acta Pharmacologica Sinica, 38(11), 1486–1500. https://doi.org/10.1038/aps.2017.106
  • Park, S. Y., Chae, S. Y., Park, J. O., Lee, K. J., & Park, G. (2016). Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. Oncology Reports, 35(6), 3248–3256. https://doi.org/10.3892/or.2016.4716
  • Patra, C. R., Bhattacharya, R., & Mukherjee, P. (2010). Fabrication and functional characterization of goldnanoconjugates for potential application in ovarian cancer. Journal of Materials Chemistry, 20(3), 547–554. https://doi.org/10.1039/B913224D
  • Pradhan, R., Chatterjee, S., Hembram, K. C., Sethy, C., Mandal, M., & Kundu, C. N. (2021). Nano formulated resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages. The Journal of Nutritional Biochemistry, 92, Article 108624. https://doi.org/10.1016/j.jnutbio.2021.108624
  • Pradhan, R., Paul, S., Das, B., Sinha, S., Dash, S. R., Mandal, M., & Kundu, C. N. (2023). Resveratrol nanoparticle attenuates metastasis and angiogenesis by deregulating inflammatory cytokines through inhibition of CAFs in oral cancer by CXCL-12/IL-6-dependent pathway. The Journal of Nutritional Biochemistry, 113, Article 109257. https://doi.org/10.1016/j.jnutbio.2022.109257
  • Qin, T., Cheng, L., Xiao, Y., Qian, W., Li, J., Wu, Z., Wang, Z., Xu, Q., Duan, W., & Wong, L. (2020). NAF-1 inhibition by resveratrol suppresses cancer stem cell-like properties and the invasion of pancreatic cancer. Frontiers in Oncology, 10, Article 1038. https://doi.org/10.3389/fonc.2020.01038
  • Qin, X., Luo, H., Deng, Y., Yao, X., Zhang, J., & He, B. (2022). Resveratrol inhibits proliferation and induces apoptosis via the hippo/YAP pathway in human colon cancer cells. Biochemical and Biophysical Research Communications, 636, 197–204. https://doi.org/10.1016/j.bbrc.2022.10.077
  • Rauf, A., Imran, M., Butt, M. S., Nadeem, M., Peters, D. G., & Mubarak, M. S. (2018). Resveratrol as an anti-cancer agent: A review. Critical Reviews in Food Science and Nutrition, 58(9), 1428–1447. https://doi.org/10.1080/10408398.2016.1263597
  • Rawat, D., Shrivastava, S., Naik, R. A., Chhonker, S. K., & Koiri, R. K. (2020). SIRT1-mediated amelioration of oxidative stress in kidney of alcohol-aflatoxin-B1-induced hepatocellular carcinoma by resveratrol is catalase dependent and GPx independent. Journal of Biochemical and Molecular Toxicology, 34(11), Article e22576. https://doi.org/10.1002/jbt.22576
  • Reid, B. M., Permuth, J. B., & Sellers, T. A. (2017). Epidemiology of ovarian cancer: A review. Cancer Biology & Medicine, 14(1), Article 9. https://doi.org/10.20892/j.issn.2095-3941.2016.0084
  • Reis, J. S., Correa, M. A., Ribeiro, C. A., & Dos Santos, J. L. (2019). Synthesis and evaluation of 1, 3, 5-triazine derivatives as sunscreens useful to prevent skin cancer. Bioorganic & Medicinal Chemistry Letters, 29(24), Article 126755. https://doi.org/10.1016/j.bmcl.2019.126755
  • Ren, C. P., Zhang, Y. N., Wu, Y. L., Xx, D., & Cui, X. L. (2022). Effects of resveratrol on inhibiting pyroptosis of intestinal cancer cells. Zhongguo Ying Yong Sheng li xue za zhi= Zhongguo Yingyong Shenglixue Zazhi= Chinese Journal of Applied Physiology, 38, 326–331.
  • Saralkar, P., & Dash, A. K. (2017). Alginate nanoparticles containing curcumin and resveratrol: Preparation, characterization, and in vitro evaluation against DU145 prostate cancer cell line. AAPS Pharmscitech, 18(7), 2814–2823. https://doi.org/10.1208/s12249-017-0772-7
  • Schmidt, L. S., & Linehan, W. M. (2016). Genetic predisposition to kidney cancer. Seminars in Oncology 43(5), 566–574. https://doi.org/10.1053/j.seminoncol.2016.09.001
  • Seer, C. S. F. (2019). Kidney and renal pelvis cancer. National Cancer Institute.
  • Seino, M., Okada, M., Shibuya, K., Seino, S., Suzuki, S., Takeda, H., Ohta, T., Kurachi, H., & Kitanaka, C. (2015). Differential contribution of ROS to resveratrol-induced cell death and loss of self-renewal capacity of ovarian cancer stem cells. Anticancer Research, 35, 85–96.
  • Selvarajoo, N., Stanslas, J., Islam, M. K., Sagineedu, S. R., Lian, H. K., & Lim, J. C. W. (2022). Pharmacological modulation of apoptosis and autophagy in pancreatic cancer treatment. Mini Reviews in Medicinal Chemistry, 22(20), 2581–2595. https://doi.org/10.2174/1389557522666220324123605
  • Sheng, H., Ogawa, T., Niwano, Y., Sasaki, K., & Tachibana, K. (2018). Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. Journal of Oral Pathology & Medicine, 47(4), 368–374. https://doi.org/10.1111/jop.12685
  • Siegel, R. L., Miller, K. D., & Jemal, A. (2018). Cancer statistics, 2018. CA: A Cancer Journal for Clinicians, 68(1), 7–30. https://doi.org/10.3322/caac.21442
  • Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7–34. https://doi.org/10.3322/caac.21551
  • Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA: A Cancer Journal for Clinicians, 73(1), 17–48. https://doi.org/10.3322/caac.21763
  • Singh, S. K., Lillard Jr, J. W., & Singh, R. (2018). Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer. Cancer Letters, 427, 49–62. https://doi.org/10.1016/j.canlet.2018.04.017
  • Singh, V., Singh, R., Kujur, P. K., & Singh, R. P. (2020). Combination of resveratrol and quercetin causes cell growth inhibition, DNA damage, cell cycle arrest, and apoptosis in oral cancer cells. ASSAY and Drug Development Technologies, 18(5), 226–238. https://doi.org/10.1089/adt.2020.972
  • Singla, R. K., Sharma, P., Kumar, D., Gautam, R. K., Goyal, R., Tsagkaris, C., Dubey, A. K., Bansal, H., Sharma, R., & Shen, B. (2022). The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer. Frontiers in Pharmacology, 13, 987088. https://doi.org/10.3389/fphar.2022.987088
  • Society, T. L. L. (2017). Blood cancer facts 2016–2017.
  • Song, F., Zhang, Y., Pan, Z., Zhang, Q., Lu, X., & Huang, P. (2021). Resveratrol inhibits the migration, invasion and epithelial-mesenchymal transition in liver cancer cells through up-miR-186-5p expression. Zhejiang da xue xue bao. Yi xue ban= Journal of Zhejiang University. Medical Sciences, 50, 582–590.
  • Srivani, G., Behera, S. K., Dariya, B., Aliya, S., Alam, A., & Nagaraju, G. P. (2020). Resveratrol binds and inhibits transcription factor HIF-1α in pancreatic cancer. Experimental Cell Research, 394(1), Article 112126. https://doi.org/10.1016/j.yexcr.2020.112126
  • Stein, C., & Colditz, G. (2004). Modifiable risk factors for cancer. British Journal of Cancer, 90(2), 299–303. https://doi.org/10.1038/sj.bjc.6601509
  • Sudha, T., El-Far, A. H., Mousa, D. S., & Mousa, S. A. (2020). Resveratrol and its nanoformulation attenuate growth and the angiogenesis of xenograft and orthotopic colon cancer models. Molecules, 25(6), Article 1412. https://doi.org/10.3390/molecules25061412
  • Summerlin, N., Qu, Z., Pujara, N., Sheng, Y., Jambhrunkar, S., Mcguckin, M., & Popat, A. (2016). Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144, 1–7. https://doi.org/10.1016/j.colsurfb.2016.03.076
  • Tang, H. M. V., Gao, W. W., Chan, C. P., Cheng, Y., Deng, J. J., Yuen, K. S., Iha, H., & Jin, D. Y. (2015). SIRT1 suppresses human T-cell leukemia virus type 1 transcription. Journal of Virology, 89(16), 8623–8631. https://doi.org/10.1128/JVI.01229-15
  • Tian, B., Hua, S., & Liu, J. (2020). Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review. Carbohydrate Polymers, 232, Article 115805. https://doi.org/10.1016/j.carbpol.2019.115805
  • Tian, B., & Liu, J. (2020). Resveratrol: A review of plant sources, synthesis, stability, modification and food application. Journal of the Science of Food and Agriculture, 100(4), 1392–1404. https://doi.org/10.1002/jsfa.10152
  • Tino, A. B., Chitcholtan, K., Sykes, P. H., & Garrill, A. (2016). Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein. Journal of Ovarian Research, 9(1), 1–12. https://doi.org/10.1186/s13048-016-0211-5
  • Ünver, H. M., & Ayan, E. (2019). Skin lesion segmentation in dermoscopic images with combination of YOLO and grabcut algorithm. Diagnostics, 9(3), Article 72. https://doi.org/10.3390/diagnostics9030072
  • Valentovic, M. A. (2018). Evaluation of resveratrol in cancer patients and experimental models. Advances in Cancer Research, 137, 171–188. https://doi.org/10.1016/bs.acr.2017.11.006
  • Valvona, C. J., Fillmore, H. L., Nunn, P. B., & Pilkington, G. J. (2016). The regulation and function of lactate dehydrogenase a: Therapeutic potential in brain tumor. Brain Pathology, 26(1), 3–17. https://doi.org/10.1111/bpa.12299
  • Varoni, E. M., Lo Faro, A. F., Sharifi-Rad, J., & Iriti, M. (2016). Anticancer molecular mechanisms of resveratrol. Frontiers in Nutrition, 3, Article 8. https://doi.org/10.3389/fnut.2016.00008
  • Verma, N., & Tiku, A. B. (2022). Polydatin-induced direct and bystander effects in a549 lung cancer cell line. Nutrition and Cancer, 74(1), 237–249. https://doi.org/10.1080/01635581.2020.1870705
  • Vidoni, C., Ferraresi, A., Vallino, L., Salwa, A., Ha, J. H., Seca, C., Garavaglia, B., Dhanasekaran, D. N., & Isidoro, C. (2023). Glycolysis inhibition of autophagy drives malignancy in ovarian cancer: Exacerbation by IL-6 and attenuation by resveratrol. International Journal of Molecular Sciences, 24(2), Article 1723. https://doi.org/10.3390/ijms24021723
  • Vladu, A. F., Ficai, D., Ene, A. G., & Ficai, A. (2022). Combination therapy using polyphenols: An efficient way to improve antitumoral activity and reduce resistance. International Journal of Molecular Sciences, 23(18), Article 10244. https://doi.org/10.3390/ijms231810244
  • Wang, J., Li, J., Cao, N., Li, Z., Han, J., & Li, L. (2018). Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK. OncoTargets and Therapy, 11, 7777–7786. https://doi.org/10.2147/OTT.S159095
  • Wang, W., Zhang, L., Chen, T., Guo, W., Bao, X., Wang, D., Ren, B., Wang, H., Li, Y., & Wang, Y. (2017). Anticancer effects of resveratrol-loaded solid lipid nanoparticles on human breast cancer cells. Molecules, 22(11), Article 1814. https://doi.org/10.3390/molecules22111814
  • Wang, X., Parvathaneni, V., Shukla, S. K., Kanabar, D. D., Muth, A., & Gupta, V. (2020). Cyclodextrin complexation for enhanced stability and non-invasive pulmonary delivery of resveratrol—applications in non-small cell lung cancer treatment. Aaps Pharmscitech, 21(1), 1–14. https://doi.org/10.1208/s12249-019-1542-5
  • Wang, Y., Ma, J., Qiu, T., Tang, M., Zhang, X, & Dong, W. (2021). In vitro and in vivo combinatorial anticancer effects of oxaliplatin-and resveratrol-loaded N, O-carboxymethyl chitosan nanoparticles against colorectal cancer. European Journal of Pharmaceutical Sciences, 163, 105864.
  • Wani, A. K., Akhtar, N., Mir, T. U. G., Singh, R., Jha, P. K., Mallik, S. K., Sinha, S., Tripathi, S. K., Jain, A., & Jha, A. (2023). Targeting apoptotic pathway of cancer cells with phytochemicals and plant-based nanomaterials. Biomolecules, 13(2), Article 194. https://doi.org/10.3390/biom13020194
  • Wen, Q., Zhang, Y., Luo, J., Xiong, K., Lu, Y., Wu, Z., Wang, B. Q., Wu, J., Chen, Y., & Fu, S. (2020). Therapeutic efficacy of thermosensitive pluronic hydrogel for codelivery of resveratrol microspheres and cisplatin in the treatment of liver cancer ascites. International Journal of Pharmaceutics, 582, Article 119334. https://doi.org/10.1016/j.ijpharm.2020.119334
  • Wu, J., Wang, Y., Yang, H., Liu, X., & Lu, Z. (2017). Preparation and biological activity studies of resveratrol loaded ionically cross-linked chitosan-TPP nanoparticles. Carbohydrate Polymers, 175, 170–177. https://doi.org/10.1016/j.carbpol.2017.07.058
  • Wu, S. X., Xiong, R. G., Huang, S. Y., Zhou, D. D., Saimaiti, A., Zhao, C. N., Shang, A., Zhang, Y. J., Gan, R. Y., & Li, H. B. (2022). Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review. Critical Reviews in Food Science and Nutrition, 1–19. https://doi.org/10.1080/10408398.2022.2101428
  • Xia, L., Wang, Y., Cai, S., & Xu, M. (2021). DGAT1 expression promotes ovarian cancer progression and is associated with poor prognosis. Journal of Immunology Research, 2021, 1–10.
  • Xia, N., Daiber, A., Förstermann, U., & Li, H. (2017). Antioxidant effects of resveratrol in the cardiovascular system. British Journal of Pharmacology, 174(12), 1633–1646. https://doi.org/10.1111/bph.13492
  • Xiao, Q., Zhu, W., Feng, W., Lee, S. S., Leung, A. W., Shen, J., Gao, L., & Xu, C. (2019). A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy. Frontiers in Pharmacology, 9, Article 1534. https://doi.org/10.3389/fphar.2018.01534
  • Xin, R., Shen, B., Huang, Z. Y., Liu, J. B., Li, S., Jiang, G. X., Zhang, J., Cao, Y. H., Zou, D. Z., Li, W., Li, C. G., Ma, Y. S., & Fu, D. (2023). Research progress in elucidating the mechanisms underlying Resveratrol action on lung cancer. Current Pharmaceutical Biotechnology, 24(3), 427–437.
  • Xu, X., Liu, A., Bai, Y., Li, Y., Zhang, C., Cui, S., Piao, Y., & Zhang, S. (2019). Co-delivery of resveratrol and p53 gene via peptide cationic liposomal nanocarrier for the synergistic treatment of cervical cancer and breast cancer cells. Journal of Drug Delivery Science and Technology, 51, 746–753. https://doi.org/10.1016/j.jddst.2018.05.008
  • Yang, Z., Xie, Q., Chen, Z., Ni, H., Xia, L., Zhao, Q., Chen, Z., & Chen, P. (2019). Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1-mediated epithelial-to-mesenchymal transition. Experimental and Therapeutic Medicine, 17, 1569–1578.
  • Yao, S., Gao, M., Wang, Z., Wang, W., Zhan, L., & Wei, B. (2021). Upregulation of microRNA-34a sensitizes ovarian cancer cells to resveratrol by targeting Bcl-2. Yonsei Medical Journal, 62(8), Article 691. https://doi.org/10.3349/ymj.2021.62.8.691
  • Yee, Y. J., Benson, H. A., Dass, C. R., & Chen, Y. (2022). Evaluation of novel conjugated resveratrol polymeric nanoparticles in reduction of plasma degradation, hepatic metabolism and its augmentation of anticancer activity in vitro and in vivo. International Journal of Pharmaceutics, 615, Article 121499. https://doi.org/10.1016/j.ijpharm.2022.121499
  • Yen, G. C., Duh, P. D., & Lin, C. W. (2003). Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. Free Radical Research, 37(5), 509–514. https://doi.org/10.1080/1071576031000083099
  • Zarain-Herzberg, Á, Izquierdo-Torres, E., Hernández-Oliveras, A., Rodríguez, G., & Lozano-Arriaga, D. (2021). Sarcoplasmic reticulum Ca2+ ATPases genes differential expression in breast cancer cells. Gaceta Medica de Mexico, 157, 343–349.
  • Zayed, D. G., Ebrahim, S. M., Helmy, M. W., Khattab, S. N., Bahey-El-Din, M., Fang, J. Y., Elkhodairy, K. A., & Elzoghby, A. O. (2019). Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin–QDs nano-hybrids: Covalent coupling and phospholipid complexation approaches. Journal of Nanobiotechnology, 17(1), 1–19. https://doi.org/10.1186/s12951-019-0445-7
  • Zeng, Y., Li, F. D., Shi, C. W., Du, J. L., Xue, Y. J., Liu, X. Y., Cao, X., & Wei, N. (2020). Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma. Cancer Gene Therapy, 27(7-8), 619–623. https://doi.org/10.1038/s41417-019-0150-6
  • Zhang, D., Zhang, J., Zeng, J., Li, Z., Zuo, H., Huang, C., & Zhao, X. (2019). Nano-gold loaded with resveratrol enhance the anti-hepatoma effect of resveratrol in vitro and in vivo. Journal of Biomedical Nanotechnology, 15(2), 288–300. https://doi.org/10.1166/jbn.2019.2682
  • Zhang, F., Zhao, R., Hou, T., Ren, F., Liu, X., Zhang, Y., & Zhang, X. (2020, August). Staging of rectal cancer based on radiomics. In H. Meng, T. Lei, M. Li, K. Li, N. Xiong, & L. Wang (Eds.), The international conference on natural computation, fuzzy systems and knowledge discovery (pp. 1017–1024). Springer International Publishing.
  • Zhang, L., Martin, G., Mohankumar, K., Hampton, J. T., Liu, W. R., & Safe, S. (2022). Resveratrol binds nuclear receptor 4A1 (NR4A1) and acts as an NR4A1 antagonist in lung cancer cells. Molecular Pharmacology, 102(2), 80–91. https://doi.org/10.1124/molpharm.121.000481
  • Zhang, Y., Yang, S., Yang, Y., & Liu, T. (2019). Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells. Infectious Agents and Cancer, 14(1), 1–9. https://doi.org/10.1186/s13027-018-0209-2
  • Zhang, Y., Zhang, Z., Mousavi, M., Moliani, A., Bahman, Y., & Bagheri, H. (2023). Resveratrol inhibits glioblastoma cells and chemoresistance progression through blockade P-glycoprotein and targeting AKT/PTEN signaling pathway. Chemico-Biological Interactions, 376, Article 110409. https://doi.org/10.1016/j.cbi.2023.110409
  • Zhao, F., Qin, J., Liang, Y., & Zhou, R. (2021). Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: In silico and verified findings. Bioengineered, 12(2), 9939–9948. https://doi.org/10.1080/21655979.2021.1985328
  • Zhao, Y., Tang, H., Zeng, X., Ye, D., & Liu, J. (2018). Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells. Biomedicine & Pharmacotherapy, 98, 36–44. https://doi.org/10.1016/j.biopha.2017.12.029
  • Zhong, C., Xie, Z., Zeng, L.-H., Yuan, C., & Duan, S. (2022). MIR4435-2HG is a potential pan-cancer biomarker for diagnosis and prognosis. Frontiers in Immunology, 13, Article 855078.
  • Zhong, L. X., Li, H., Wu, M. L., Liu, X. Y., Zhong, M. J., Chen, X. Y., Liu, J., & Zhang, Y. (2015). Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells. Journal of Ovarian Research, 8(1), 1–11. https://doi.org/10.1186/s13048-015-0152-4
  • Zhong, L. X., Nie, J. H., Liu, J., & Lin, L. Z. (2018). Correlation of ARHI upregulation with growth suppression and STAT3 inactivation in resveratrol-treated ovarian cancer cells. Cancer Biomarkers, 21(4), 787–795. https://doi.org/10.3233/CBM-170483
  • Zhu, T., Wang, L., Wang, L. P., & Wan, Q. (2022). Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs. Biomedicine & Pharmacotherapy, 148, Article 112719. https://doi.org/10.1016/j.biopha.2022.112719
  • Zini, R., Morin, C., Bertelli, A., Bertelli, A. A., & Tillement, J. (1999). Effects of resveratrol on the rat brain respiratory chain. Drugs Under Experimental and Clinical Research, 25, 87–97.