Global air pollution exposure and congenital anomalies: an updated systematic review and meta-analysis of epidemiological studies

References

• Agay-Shay K, Friger M, Linn S, Peled A, Amitai Y, Peretz C. 2013. Air pollution and congenital heart defects. Environ Res. 124:28–34. doi: 10.1016/j.envres.2013.03.005.
   PubMed Web of Science ®Google Scholar
• Al Noaimi G, Yunis K, El Asmar K, Abu Salem FK, Afif C, Ghandour LA, Hamandi A, Dhaini HR. 2021. Prenatal exposure to criteria air pollutants and associations with congenital anomalies: a Lebanese national study. Environ Pollut. 281:117022. doi: 10.1016/j.envpol.2021.117022.
   PubMed Web of Science ®Google Scholar
• Botto LD, Lin AE, Riehle-Colarusso T, Malik S, Correa A, National Birth Defects Preventions. 2007. Seeking causes: classifying and evaluating congenital heart defects in etiologic studies. Birth Defect Res A query. 79(10):714–727. doi: 10.1002/bdra.20403.
   PubMedGoogle Scholar
• Chen EK, Zmirou-Navier D, Padilla C, Deguen S. 2014. Effects of air pollution on the risk of congenital anomalies: a systematic review and meta-analysis. Int J Env Res Pub He. 11(8):7642–7668. doi: 10.3390/ijerph110807642.
   PubMed Web of Science ®Google Scholar
• Dadvand P, Rankin J, Hodgson S, Rushton S. 2009. Socioeconomic inequality and congenital anomalies: a small-area analysis. Epidemiology. 20(6):S29–S29. doi: 10.1097/01.ede.0000362265.40079.6c.
   Web of Science ®Google Scholar
• Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. 2011a. Ambient air pollution and congenital heart disease: a register-based study. Environ Res. 111(3):435–441. doi: 10.1016/j.envres.2011.01.022.
   PubMed Web of Science ®Google Scholar
• Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. 2011b. Association between maternal exposure to ambient air pollution and congenital heart disease: a register-based spatiotemporal analysis. Am J Epidemiol. 173(2):171–182. doi: 10.1093/aje/kwq342.
   PubMed Web of Science ®Google Scholar
• Doi SA, Barendregt JJ, Khan S, Thalib L, Williams GM. 2015. Simulation comparison of the quality effects and random effects methods of meta-analysis. Epidemiology. 26(4):e42–44. doi: 10.1097/EDE.0000000000000289.
   PubMed Web of Science ®Google Scholar
• Dolk H, Armstrong B, Lachowycz K, Vrijheid M, Rankin J, Abramsky L, Boyd PA, Wellesley D. 2010. Ambient air pollution and risk of congenital anomalies in England, 1991-1999. Occup Environ Med. 67(4):223–227. doi: 10.1136/oem.2009.045997.
   PubMed Web of Science ®Google Scholar
• Duan HF, Deng T, Chen YW, Zhao ZJ, Wen YA, Chen YD, Li XH, Zeng GH. 2018. Association between vasectomy and risk of testicular cancer: a systematic review and meta-analysis. PLoS One. 13(3):e0194606. doi: 10.1371/journal.pone.0194606.
   PubMed Web of Science ®Google Scholar
• Egger M, Smith GD, Schneider M, Minder C. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ-Brit Med J. 315(7109):629–634. doi: 10.1136/bmj.315.7109.629.
   Web of Science ®Google Scholar
• Fan SJ, Heinrich J, Bloom MS, Zhao TY, Shi TX, Feng WR, Sun Y, Shen JC, Yang ZC, Yang BY, et al. 2020. Ambient air pollution and depression: a systematic review with meta-analysis up to 2019. Sci Total Environ. 701:701. doi: 10.1016/j.scitotenv.2019.134721.
   Web of Science ®Google Scholar
• Farhi A, Boyko V, Almagor J, Benenson I, Segre E, Rudich Y, Stern E, Lerner-Geva L. 2014. The possible association between exposure to air pollution and the risk for congenital malformations. Environ Res. 135:173–180. doi: 10.1016/j.envres.2014.08.024.
   PubMed Web of Science ®Google Scholar
• Feng Y, Zhang HH 2021. Systematic review and meta-analysis of the association between air pollution and birth defects. PROSPERO2021 CRD42021265955. https://www.crd.york.ac.uk/PROSPERO/#myprospero.
   Google Scholar
• Gianicolo EA, Mangia C, Cervino M, Bruni A, Andreassi MG, Latini G. 2014. Congenital anomalies among live births in a high environmental risk area--a case-control study in Brindisi (southern Italy). Environ Res. 128:9–14. doi: 10.1016/j.envres.2013.11.002.
   PubMed Web of Science ®Google Scholar
• Gilboa SM, Mendola P, Olshan AF, Langlois PH, Savitz DA, Loomis D, Herring AH, Fixler DE. 2005. Relation between ambient air quality and selected Birth Defects, Seven County study, Texas, 1997–2000. Am J Epidemiol. 162(3):238–252. doi: 10.1093/aje/kwi189.
   PubMed Web of Science ®Google Scholar
• Girguis MS, Strickland MJ, Hu X, Liu Y, Bartell SM, Vieira VM. 2016. Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environ Res. 146:1–9. doi: 10.1016/j.envres.2015.12.010.
   PubMed Web of Science ®Google Scholar
• Hall KC, Robinson JC, Cooke WH, Parnell AS, Zhang L, Northington L. 2022. Relationship between environmental air quality and congenital heart Defects. Nurs Res. 71(4):266–274. doi: 10.1097/NNR.0000000000000590.
   PubMed Web of Science ®Google Scholar
• Hansen CA, Barnett AG, Jalaludin BB, Morgan GG, Pan X. 2009. Ambient air pollution and birth defects in Brisbane, Australia. PLoS One. 4(4):e5408. doi: 10.1371/journal.pone.0005408.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Green S 2011. Cochrane handbook for systematic reviews of interventions, version 5.1.0. The Cochrane Collaboration. [accessed 2014 July 21]. www.cochrane-handbook.org
   Google Scholar
• Higgins JP, Thompson SG. 2002. Quantifying heterogeneity in a meta-analysis. Stat Med. 21(11):1539–1558. doi: 10.1002/sim.1186.
   PubMed Web of Science ®Google Scholar
• Huang CC, Chen BY, Pan SC, Ho YL, Guo YL. 2019. Prenatal exposure to PM2.5 and Congenital Heart Diseases in Taiwan. Sci Total Environ. 655:880–886. doi: 10.1016/j.scitotenv.2018.11.284.
   PubMed Web of Science ®Google Scholar
• Huang X, Chen J, Zeng D, Lin Z, Herbert C, Cottrell L, Liu L, Ash A, Wang B. 2021. The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China. BMC Pediatr. 21(1):232. doi: 10.1186/s12887-021-02687-z.
   PubMed Web of Science ®Google Scholar
• Hu C-Y, Huang K, Fang Y, Yang X-J, Ding K, Jiang W, Hua X-G, Huang D-Y, Jiang Z-X, Zhang X-J. 2020. Maternal air pollution exposure and congenital heart defects in offspring: a systematic review and meta-analysis. Chemosphere. 253:253. doi: 10.1016/j.chemosphere.2020.126668.
   Web of Science ®Google Scholar
• Hwang B-F, Jaakkola JJK. 2008. Ozone and other air pollutants and the risk of oral clefts. Environ Health Perspect. 116(10):1411–1415. doi: 10.1289/ehp.11311.
   PubMed Web of Science ®Google Scholar
• Hwang BF, Lee YL, Jaakkola JJ. 2015. Air Pollution and the Risk of Cardiac Defects: A Population-Based Case-Control Study. Med. 94(44):e1883. doi: 10.1097/md.0000000000001883.
   PubMed Web of Science ®Google Scholar
• Jiang W, Xie W, Ni B, Zhou H, Liu Z, Li X. 2021. First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case–control study in Changsha, China. BMC Oral Health. 21(1):530. doi: 10.1186/s12903-021-01876-7.
   PubMed Web of Science ®Google Scholar
• Jin L, Qiu J, Zhang Y, Qiu W, He X, Wang Y, Sun Q, Li M, Zhao N, Cui H, et al. 2015. Ambient air pollution and congenital heart defects in Lanzhou, China. Environ Res Lett ERL [Web site]. 10(7):074005. doi: 10.1088/1748-9326/10/7/074005.
   PubMed Web of Science ®Google Scholar
• Kim OJ, Ha EH, Kim BM, Seo JH, Park HS, Jung WJ, Lee BE, Suh YJ, Kim YJ, Lee JT, et al. 2007. PM10 and pregnancy outcomes: a hospital-based cohort study of pregnant women in Seoul. J Occup Environ Med. 49(12):1394–1402. doi: 10.1097/JOM.0b013e3181594859.
   PubMed Web of Science ®Google Scholar
• Landau D, Novack L, Yitshak-Sade M, Sarov B, Kloog I, Hershkovitz R, Grotto I, Karakis I. 2015. Nitrogen dioxide pollution and hazardous household environment: what impacts more congenital malformations. Chemosphere. 139:340–348. doi: 10.1016/j.chemosphere.2015.06.091.
   PubMed Web of Science ®Google Scholar
• Landrigan PJ, Fuller R, Acosta NJR, Adeyi O, Arnold R, Basu N, Baldé AB, Bertollini R, Bose-O’Reilly S, Boufford JI, et al. 2018. The lancet commission on pollution and health. Lancet. 391(10119):462–512. doi: 10.1016/s0140-6736(17)32345-0.
   PubMed Web of Science ®Google Scholar
• Li H, Huang YH, Li J, Liu S, Chen YL, Li LL, Jiang CZ, Chen ZJ, Li N. 2021. Maternal PM(10) exposure Increases risk for spina bifida: a population-based Case-control study. Front Public Health. 9:695192. doi: 10.3389/fpubh.2021.695192.
   PubMed Web of Science ®Google Scholar
• Lin HC, Guo JM, Ge P, Ou P. 2021. Association between prenatal exposure to ambient particulate matter and risk of hypospadias in offspring: a systematic review and meta-analysis. Environ Res. 192. doi: 10.1016/j.envres.2020.110190.
   Google Scholar
• Liu FF, Chen GB, Huo WQ, Wang CJ, Liu SY, Li N, Mao SY, Hou YT, Lu YA, Xiang H. 2019. Associations between long-term exposure to ambient air pollution and risk of type 2 diabetes mellitus: a systematic review and meta-analysis. Environ Pollut. 252:1235–1245. doi: 10.1016/j.envpol.2019.06.033.
   PubMed Web of Science ®Google Scholar
• Liu CB, Hong XR, Shi M, Chen XQ, Huang HJ, Chen JH, Yang K, Chen SQ, Chen HQ, Kan HD, et al. 2017. Effects of prenatal PM10 exposure on fetal cardiovascular malformations in Fuzhou, China: A retrospective case-control study. Environ Health Perspect. 125(5). doi:10.1289/EHP289.
   Web of Science ®Google Scholar
• Liu F-H, Xing Z, Gong T-T, Zhang J-Y, Huang Y-H, Li J, Liu S, Chen Y-L, Li L-L, Jiang C-Z, et al. 2021. Maternal exposure to sulfur dioxide and the risk of oral clefts in Liaoning Province, China: a population-based case-control study. Environ Sci Pollut R. 28(29):39101–39109. doi: 10.1007/s11356-021-13461-0.
   PubMed Web of Science ®Google Scholar
• Li D, Xu W, Qiu Y, Pan F, Lou H, Li J, Jin Y, Wu T, Pan L, An J, et al. 2022. Maternal air pollution exposure and neonatal congenital heart disease: A multi-city cross-sectional study in eastern China. Int J Hyg Envir Heal. 240:113898. doi: 10.1016/j.ijheh.2021.113898.
   PubMed Web of Science ®Google Scholar
• Li SS, Zhang R, Lan X, Qu PF, Dang SN, Chen FY, Yan H. 2017. Prenatal exposure to ambient air pollution and congenital heart disease: a meta-analysis]. Zhonghua Liu xing Bing Xue za zhi =. Zhonghua Liuxingbingxue Zazhi. 38(8):1121–1126. doi: 10.3760/cma.j.issn.0254-6450.2017.08.025.
   Google Scholar
• Ma Z, Cao X, Chang Y, Li W, Chen X, Tang NJ. 2021. Association between gestational exposure and risk of congenital heart disease: a systematic review and meta-analysis. Environ Res. 197:197. doi: 10.1016/j.envres.2021.111014.
   Web of Science ®Google Scholar
• Marshall EG, Harris G, Wartenberg D. 2010. Oral cleft defects and maternal exposure to ambient air pollutants in New Jersey. Birth Defects Research Part A. Clinical and Molecular Teratology. 88(4):205–215. doi: 10.1002/bdra.20650.
   PubMedGoogle Scholar
• Miri M, Nazarzadeh M, Alahabadi A, Ehrampoush MH, Rad A, Lotfi MH, Sheikhha MH, Sakhvidi MJZ, Nawrot TS, Dadvand P. 2019. Air pollution and telomere length in adults: a systematic review and meta-analysis of observational studies. Environ Pollut. 244:636–647. doi:10.1016/j.envpol.2018.09.130.
   PubMed Web of Science ®Google Scholar
• Morgan RL, Whaley P, Thayer KA, Schunemann HJ. 2018. Identifying the PECO: a framework for formulating good questions to explore the association of environmental and other exposures with health outcomes. Environ Int. 121(Pt 1):1027–1031. doi: 10.1016/j.envint.2018.07.015.
   PubMed Web of Science ®Google Scholar
• OHAT. 2015. Translation (OHAT) Division Of The National Toxicology. Program National Institute of Environmental Health Sciences. https://wwwniehsnihgov/research/atniehs/dntp/assoc/ohat/indexcfm.
   Google Scholar
• Padula AM, Tager IB, Carmichael SL, Hammond SK, Yang W, Lurmann F, Shaw GM. 2013. Ambient air pollution and traffic exposures and congenital heart defects in the San Joaquin Valley of California. Paediatr Perinat Epidemiol. 27(4):329–339. doi: 10.1111/ppe.12055.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol. 134:178–189. doi: 10.1016/j.jclinepi.2021.03.001.
   PubMed Web of Science ®Google Scholar
• Pedersen M, Garne E, Hansen-Nord N, Hjortebjerg D, Ketzel M, Raaschou-Nielsen O, Nybo Andersen AM, Sørensen M. 2017. Exposure to air pollution and noise from road traffic and risk of congenital anomalies in the Danish National Birth Cohort. Environ Res. 159:39–45. doi: 10.1016/j.envres.2017.07.031.
   PubMed Web of Science ®Google Scholar
• Rankin J, Chadwick T, Natarajan M, Howel D, Pearce MS, Pless-Mulloli T. 2009. Maternal exposure to ambient air pollutants and risk of congenital anomalies. Environ Res. 109(2):181–187. doi: 10.1016/j.envres.2008.11.007.
   PubMed Web of Science ®Google Scholar
• Rao A, Ahmed MK, Taub PJ, Mamoun JS. 2016. The correlation between Maternal exposure to air pollution and the risk of orofacial clefts in infants: a systematic review and meta-analysis. J oral & maxillofacial res. 7(1):e2. doi: 10.5037/jomr.2016.7102.
   PubMedGoogle Scholar
• Ravindra K, Chanana N, Mor S. 2020. Exposure to air pollutants and risk of congenital anomalies: a systematic review and metaanalysis. Sci Total Environ. 765:142772. doi: 10.1016/j.scitotenv.2020.142772.
   PubMed Web of Science ®Google Scholar
• Ren S, Haynes E, Hall E, Hossain M, Chen A, Muglia L, Lu L, DeFranco E. 2018. Periconception exposure to air pollution and risk of congenital malformations. J Pediatr. 193:76–84 e76. doi: 10.1016/j.jpeds.2017.09.076.
   PubMed Web of Science ®Google Scholar
• Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA. 2002. Ambient air pollution and risk of birth defects in Southern california. Am J Epidemiol. 155(1):17–25. doi: 10.1093/aje/155.1.17.
   PubMed Web of Science ®Google Scholar
• Schembari A, Nieuwenhuijsen MJ, Salvador J, de Nazelle A, Cirach M, Dadvand P, Beelen R, Hoek G, Basagana X, Vrijheid M. 2014. Traffic-related air pollution and congenital anomalies in Barcelona. Environ Health Perspect. 122(3):317–323. doi: 10.1289/ehp.1306802.
   PubMed Web of Science ®Google Scholar
• Simmons W, Lin S, Luben TJ, Sheridan SC, Langlois PH, Shaw GM, Reefhuis J, Romitti PA, Feldkamp ML, Nembhard WN, et al. 2022. Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects: A U.S. population-based case-control study in the National Birth Defects Prevention Study. Sci Total Environ. 808. doi:10.1016/j.scitotenv.2021.152150.
   PubMed Web of Science ®Google Scholar
• Stieb DM, Chen L, Eshoul M, Judek S. 2012. Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis. Environ Res. 117:100–111. doi: 10.1016/j.envres.2012.05.007.
   PubMed Web of Science ®Google Scholar
• Strickland MJ, Klein M, Correa A, Reller MD, Mahle WT, Riehle-Colarusso TJ, Botto LD, Flanders WD, Mulholland JA, Siffel C, et al. 2009. Ambient air pollution and cardiovascular malformations in Atlanta, Georgia, . Am J EpidemiolVol. 169(8):pp. 1004–1014. 10.1093/aje/kwp011.
   Google Scholar
• Tang H, Cheng Z, Li N, Mao S, Ma R, He H, Niu Z, Chen X, Xiang H. 2020. The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: a meta-analysis. Environ Pollut. 267:115630. doi: 10.1016/j.envpol.2020.115630.
   PubMed Web of Science ®Google Scholar
• Tanner JP, Salemi JL, Stuart AL, Yu H, Jordan MM, DuClos C, Cavicchia P, Correia JA, Watkins SM, Kirby RS. 2015. Associations between exposure to ambient benzene and PM(2.5) during pregnancy and the risk of selected birth defects in offspring. Environ Res. 142:345–353. doi: 10.1016/j.envres.2015.07.006.
   PubMed Web of Science ®Google Scholar
• Varela MM, Nohr EA, Llopis-Gonzalez A, Andersen AM, Olsen J. 2009. Socio-occupational status and congenital anomalies. Eur J Public Health. 19(2):161–167. doi: 10.1093/eurpub/ckp003.
   PubMed Web of Science ®Google Scholar
• Vinceti M, Malagoli C, Malavolti M, Cherubini A, Maffeis G, Rodolfi R, Heck JE, Astolfi G, Calzolari E, Nicolini F. 2016. Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study. Sci Total Environ. 541:444–450. doi: 10.1016/j.scitotenv.2015.09.051.
   PubMed Web of Science ®Google Scholar
• Vinikoor-Imler LC, Davis JA, Meyer RE, Luben TJ. 2013. Early prenatal exposure to air pollution and its associations with birth defects in a state-wide birth cohort from North Carolina. Birth Defects Research Part A. Clinical and Molecular Teratology. 97(10):696–701. doi: 10.1002/bdra.23159.
   PubMedGoogle Scholar
• Vinikoor-Imler LC, Stewart TG, Luben TJ, Davis JA, Langlois PH. 2015. An exploratory analysis of the relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas. Environ Pollut. 202:1–6. doi: 10.1016/j.envpol.2015.03.001.
   PubMed Web of Science ®Google Scholar
• Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J, Nieuwenhuijsen M. 2011. Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis. Environ Health Perspect. 119(5):598–606. doi: 10.1289/ehp.1002946.
   PubMed Web of Science ®Google Scholar
• Wang L, Xiang X, Mi B, Song H, Dong M, Zhang S, Bi Y, Zhao Y, Li Q, Zhang Q, et al. 2019. Association between early prenatal exposure to ambient air pollution and birth defects: evidence from newborns in Xi’an, China. J Public Health (Oxford, England). 41(3):494–501. doi: 10.1093/pubmed/fdy137.
   PubMed Web of Science ®Google Scholar
• Wang L, Xiang X, Song H, Dong M, Zhang S, Mi B, Zhang Q, Zhang L, Yan H, Dang S. 2017. Time-series analysis of air pollution and birth defects during 2010 to 2015 in Xi’an. J Xi’an Jiaotong Uni Med Sci. 38(3):366–370.
   Google Scholar
• Wells G, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P 2013. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
   Google Scholar
• WHO. 2010. World Health assembly report on birth defects. Geneva: World Health Orgnization.
   Google Scholar
• WHO. 2020. World Health Organization: health topics- congenital anomalies. https://www.who.int/health-topics/congenital-anomalies#tab=tab_1.
   Google Scholar
• Xiong L, Xu Z, Wang H, Liu Z, Xie D, Wang A, Kong F. 2019. The association between ambient air pollution and birth defects in four cities in Hunan province, China, from 2014 to 2016. Med. 98(4):e14253. doi: 10.1097/MD.0000000000014253.
   PubMed Web of Science ®Google Scholar
• Yang BY, Fan S, Thiering E, Seissler J, Nowak D, Dong GH, Heinrich J. 2020. Ambient air pollution and diabetes: a systematic review and meta-analysis. Environ Res. 180:108817. doi: 10.1016/j.envres.2019.108817.
   PubMed Web of Science ®Google Scholar
• Yang BY, Qian ZM, Howard SW, Vaughn MG, Fan SJ, Liu KK, Dong GH. 2018. Global association between ambient air pollution and blood pressure: a systematic review and meta-analysis. Environ Pollut. 235:576–588. doi: 10.1016/j.envpol.2018.01.001.
   PubMed Web of Science ®Google Scholar
• Yang BY, Qu Y, Guo Y, Markevych I, Heinrich J, Bloom MS, Bai Z, Knibbs LC, Li S, Chen G, et al. 2021. Maternal exposure to ambient air pollution and congenital heart defects in China. Environ Int. 153:106548. doi: 10.1016/j.envint.2021.106548.
   PubMed Web of Science ®Google Scholar
• Yang Y, Zhou L, Zhang W, Yang Y, Liu Y, Pan L, Huo Y, Wang R, Ba Y, Ren X, et al. 2022. Association between air pollutants and neural tube defects during pregnancy in Lanzhou, China: a time series analysis. Environ Sci Pollut Res Int. 30(2):4826–4836. doi: 10.1007/s11356-022-21962-9.
   PubMed Web of Science ®Google Scholar
• Yao C, Chen Y, Zhu X, Liu Y, Zhang J, Hou L, Xu Y, Zhang C, Cao J. 2016. Air Pollution and the Risk of Birth Defects in Anqing City, China. J Occup Environ Med. 58(4):e124–e127. doi: 10.1097/JOM.0000000000000676.
   PubMed Web of Science ®Google Scholar
• Yu G, Chen Y, Tang J, Lin Z, Zheng F, Zheng C, Zhou J, Su Q, Wu S, Li H. 2021. Meta-analyses of maternal exposure to atmospheric particulate matter and risk of congenital anomalies in offspring. Environ Sci Pollut Res Int. 28(40):55869–55887. doi: 10.1007/s11356-021-16200-7.
   PubMed Web of Science ®Google Scholar
• Zhang JY, Dai HX, Wu QJ, Li J, Huang YH, Chen ZJ, Li LL, Chen YL, Liu S, Jiang CZ. 2021. Maternal exposure to ambient levels of sulfur dioxide and risk of neural tube defects in 14 cities in Liaoning province, China: a population-based case–control study. J Expo Sci Environ Epidemiol. 31(2):266–275. doi: 10.1038/s41370-020-00273-6.
   PubMed Web of Science ®Google Scholar
• Zhang B, Liang S, Zhao J, Qian Z, Bassig BA, Yang R, Zhang Y, Hu K, Xu S, Zheng T, et al. 2016. Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects. J Expo Sci Environ Epidemiol. 26(4):422–427. doi: 10.1038/jes.2016.1.
   PubMed Web of Science ®Google Scholar
• Zhang F, Liu L, Zhang C, Ji S, Mei Z, Li T. 2021. Association of metabolic syndrome and its components with risk of stroke recurrence and mortality: a meta-analysis. Neurology. 97(7):e695–e705. doi: 10.1212/WNL.0000000000012415.
   PubMed Web of Science ®Google Scholar
• Zhang T-N, Li D, Wu Q-J, Xia J, Wen R, Chen X-C, Yang N, Chen Y-L, Huang Y-H, Liu C-F. 2018. Exposure to nitrogen oxide in the first trimester and risk of cardiovascular-related malformations: a dose-response meta-analysis of Observational studies. BioMed Res Int. 2018:1–15. doi: 10.1155/2018/1948407.
   Web of Science ®Google Scholar
• Zhang HH, Wang Q, He SM, Wu KP, Ren M, Dong HT, Di JL, Yu ZL, Huang CR. 2020. Ambient air pollution and gestational diabetes mellitus: a review of evidence from biological mechanisms to population epidemiology. Sci Total Environ. 719:719. doi: 10.1016/j.scitotenv.2020.137349.
   Web of Science ®Google Scholar
• Zhang L, Xiang X, Zhang S. 2019. Influence of air pollution on congenital heart disease in Xi ‘an city: 2009 -2016. China J Public Health. 35(10):1416–1420.
   Google Scholar
• Zhang W, Yang Y, Liu Y, Zhou L, Yang Y, Pan L, Ba Y, Wang R, Huo Y, Ren X, et al. 2022. Associations between congenital heart disease and air pollutants at different gestational weeks: a time-series analysis. Environ Geochem Health. 45(5):2213–2228. doi: 10.1007/s10653-022-01315-8.
   PubMed Web of Science ®Google Scholar
• Zhang J, Yu KF. 1998. What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA. 280(19):1690–1691. doi: 10.1001/jama.280.19.1690.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang X, Wang Q, Xu Y, Feng Y, Yu Z, Huang C. 2021. Ambient air pollution and stillbirth: an updated systematic review and meta-analysis of epidemiological studies. Environ Pollut. 278:116752. doi: 10.1016/j.envpol.2021.116752.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang X, Zhao X, Cheng G, Chang H, Ye X, Wang J, Yu Z, Wang Q, Huang C. 2022. Maternal exposure to air pollution and congenital heart diseases in Henan, China: a register-based case-control study. Ecotoxicol Environ Saf. 229:113070. doi: 10.1016/j.ecoenv.2021.113070.
   PubMed Web of Science ®Google Scholar
• Zhao B, Wang M, C L, Meng H, Fan Q, Guo J, Wang W, Wang H, Zhou H, He J. 2019. Increasing risk of congenital anomalies associated with seasonal pattern of air pollution: differences by maternal comorbidities. Ecotox Environ Safe. 167:317–323. doi: 10.1016/j.ecoenv.2018.10.037.
   PubMed Web of Science ®Google Scholar
• Zhao J, Zhang B, Yang S, Mei H, Qian Z, Liang S, Zhang Y, Hu K, Tan Y, Xian H, et al. 2018. Maternal exposure to ambient air pollutant and risk of oral clefts in Wuhan, China. Environ Pollut. 238:624–630. doi: 10.1016/j.envpol.2018.03.053.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. 2015. Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects. Environ Res. 140:714–720. doi: 10.1016/j.envres.2015.06.002.
   PubMed Web of Science ®Google Scholar