104
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation

, , , , & ORCID Icon
Pages 122-129 | Received 26 Sep 2020, Accepted 16 Nov 2020, Published online: 14 Apr 2021

References

  • Stewart B, Wild CP. World Cancer Report 2014; International Agency for Research on Cancer (IARC): Lyon, France. 2014. https://www.who.int/cancer/publications/WRC_2014/en/
  • Levin B, DA L, McFarland B. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps. CA Cancer J Clin. 2008;58:130–160.
  • Martinez-Useros J, Garcia-Foncillas J. Obesity and colorectal cancer: molecular features of adipose tissue. J Transl Med. 2016;14:21.
  • Pabla B, Bissonnette M, VJ K. Colon cancer and the epidermal growth factor receptor: current treatment paradigms, the importance of diet, and the role of chemoprevention. World J Clin Oncol. 2015;6:133–141.
  • Li JL, Lin SH, Chen HQ. Clinical significance of HER2 and EGFR expression in colorectal cancer patients with ovarian metastasis. BMC Clin Pathol. 2019;19:3.
  • NE H, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol. 2009;21:177–184.
  • Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer. 2012;12:553–563.
  • MS W, CJ W. STAT3 the oncogene – still eluding therapy? Febs J. 2015;282:2600–2611.
  • Zhang C, Xu H, Zhou Z. Blocking of the EGFR-STAT3 signaling pathway through afatinib treatment inhibited the intrahepatic cholangiocarcinoma. Exp Ther Med. 2018;15:4995–5000.
  • HL Z, Hong H, LL Z. Nifuratel, a novel STAT3 inhibitor with potent activity against human gastric cancer cells. Cancer Manag Res. 2017;9:565–571.
  • Waller P, AD B. Non-coding RNAs – A primer for the laboratory scientist. Br J Biomed Sci. 2019;76:157–165.
  • Wang C, DZ H, JZ L. Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis. Genet Mol Res. 2015;14:5485–5495.1
  • Chen Y, Zhang Y, He J. MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. Oncol Rep. 2017;37:1646–1652.
  • Paraskevopoulou MD, Hatzigeorgiou AG. Analyzing MiRNA- LncRNA interactions. Methods Mol Biol. 2016;1402:271–286.
  • Fan C, Tang Y, Wang J. Role of long non-coding RNAs in glucose metabolism in cancer. Mol Cancer. 2017;16:130.
  • HL Q, CS L, CW Q. The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma. Tumuor Biol. 2016;37:1079–1089.
  • OH L, NJ R, AL F. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193265–193275. PMID:14907713
  • KJ L, TD S. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408
  • Kountourakis P, Pavlakis K, Psyrri A. Clinicopathologic significance of EGFR and Her-2/neu inn colorectal adenocarcinomas. Cancer J. 2006;12:229–236.
  • Arnold M, MS S, Laversanne M. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691.
  • KK T, CW T, Wu M. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside. World J Gastroenterol. 2018;21; 24:2949–2973.
  • Bărbălan A, AC N, AV M. Immunohistochemistry predictive markers for primary colorectal cancer tumors: where are we and where are we going?”. Rom J Morphol Embryol. 2018;59:29–42.
  • Segatto O, Anastasi S, Alemà S. Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors. J Cell Sci. 2011;124.11:1785–1793.
  • HL Q, CS L, CW Q. The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma. Tumor Biol. 2016;37:1079–1089.
  • Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21:1253.
  • Yuan S, Luan X, Chen H, et al. Long non-coding RNA EGFR-AS1 sponges micorRNA-381 to upregulate ROCK2 in bladder cancer. Oncol Lett. 2020;19:1899–1905.
  • Wang A, Bao Y, Wu Z. Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer. Cell Death Dis. 2019;10:1–14.
  • Hu J, Qian Y, Peng L. Long noncoding RNA EGFR-AS1 promotes cell proliferation by increasing EGFR mRNA stability in gastric cancer. Cell Physiol Biochem. 2018;49:322–334.
  • Zeng W, JF Z, JY L. miR-133b inhibits cell proliferation, migration and invasion of esophageal squamous cell carcinoma by targeting EGFR. Biomed Pharmacother. 2019;111:476–484.
  • Agustoni F, Suda K, Yu H. EGFR-directed monoclonal antibodies in combination with chemotherapy for treatment of non-small-cell lung cancer: an updated review of clinical trials and new perspectives in biomarkers analysis. Cancer Treat Rev. 2018;72:15–27.
  • Fang B. Genetic interactions of STAT3 and anticancer drug development. Cancers. 2014;6:494–525.
  • Wang Y, Lu Z, Wang N. MicroRNA-1299 is a negative regulator of STAT3 in colon cancer. Oncol Rep. 2017;37:3227–3234.
  • Song X, Liu Z, Yu Z. EGFR Promotes the Development of Triple Negative Breast Cancer Through JAK/STAT3 Signaling. Cancer Manag Res. 2020;30:703–717.
  • Yang N, Zhao Y, Wang Z. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Mol Med Rep. 2017;15:929–935.
  • ZQ D, ZY G, Xie J. The lncRNA EGFR-AS1 is linked to migration, invasion and apoptosis in glioma cells by targeting miR-133b/RACK1. Biomed Pharmacother. 2019;118:109292.
  • Zhou W, Bi X, Gao G. miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. Biomed Pharmacother. 2016;84:722–729.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.