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British Journal of Biomedical Science Volume 78, 2021 - Issue 4
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Case Report

Management of mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a kidney recipient: a case report

F Boixa Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3926-7920View further author information
ORCID Icon,
J Feitob Department of Clinical Pathology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, SpainORCID Iconhttps://orcid.org/0000-0003-2667-5332View further author information
ORCID Icon,
A Rodríguez-Campónc Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, SpainView further author information
,
MC Chillóna Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, SpainORCID Iconhttps://orcid.org/0000-0003-1624-6059View further author information
ORCID Icon,
S García-Sáncheza Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, SpainORCID Iconhttps://orcid.org/0000-0002-8306-8478View further author information
ORCID Icon,
G Taberneroc Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, SpainView further author information
,
P Frailec Department of Nephrology, University Hospital of Salamanca (HUS-IBSAL), Salamanca, SpainView further author information
&
R García-Sanza Department of Haematology, University Hospital of Salamanca (HUS-IBSAL), CIBERONC, and Cancer Research Institute of Salamanca-IBMCC (CSIC-USAL University), Salamanca, SpainORCID Iconhttps://orcid.org/0000-0003-4120-2787View further author information
ORCID Icon show all
Pages 244-247 | Received 11 Apr 2021, Accepted 04 May 2021, Published online: 27 Aug 2021

References

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  • Lefaucheur C, Loupy A, Vernerey D, et al. Antibody-mediated vascular rejection of kidney allografts: a population-based study. Lancet. 2013;381:313–319.
  • Haas M, Loupy A, Lefaucheur C, et al. The Banff 2017 kidney meeting report: revised diagnostic criteria for chronic active T cell–mediated rejection, antibody‐mediated rejection, and prospects for integrative endpoints for next‐generation clinical trials. Am J Transplant. 2018;18:293–307.
  • Haas M, Mirocha J, Reinsmoen NL, et al. Differences in pathologic features and graft outcomes in antibody-mediated rejection of renal allografts due to persistent/recurrent versus de novo donor-specific antibodies. Kidney Int. 2017;91:729–737.
  • Lefaucheur C, Viglietti D, Bentlejewski C, et al. IgG donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury. J Am Soc Nephrol. 2016;27:293–304.
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  • Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant. 2012;12:1157–1167.
  • Djamali A, Kaufman DB, Ellis TM, et al. Diagnosis and management of antibody-mediated rejection: current status and novel approaches. Am J Transplant. 2014;14:255–271.
  • Leino A, Lichvar A, Abu-Jawdeh B, et al. Randomized controlled trial of mixed acute rejection therapy in renal allografts: 3 year follow up. Am J Transplant. 2016;16:601.
  • Sun Q, Liu Z-H, Yin G, et al. Tacrolimus combined with mycophenolate mofetil can effectively reverse C4d-positive steroid-resistant acute rejection in Chinese renal allograft recipients. Nephrol Dial Transplant. 2006;21:510–517.

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