Palliative sedation in the treatment of existential suffering in end-of-life patients: protocol for an integrative review

References

• Vehling S, Kissane DW. Existential distress in cancer: alleviating suffering from fundamental loss and change. Psycho-Oncol 2018;27(11):2525–30. doi:10.1002/pon.4872.
   PubMed Web of Science ®Google Scholar
• Kissane DW. Demoralization: a life-preserving diagnosis to make for the severely medically ill. J Palliat Care 2014;30(4):255–8.
   PubMed Web of Science ®Google Scholar
• Roze des Ordons AL, Sinuff T, Stelfox HT, Kondejewski J, Sinclair S. Spiritual distress within inpatient settings—A scoping review of patients' and families' experiences. J Pain Symptom Manag 2018;56(1):122–45. doi:10.1016/j.jpainsymman.2018.03.009
   PubMed Web of Science ®Google Scholar
• Robinson S, Kissane DW, Brooker J, Burney S. A systematic review of the demoralization syndrome in individuals with progressive disease and cancer: a decade of research. J Pain Symptom Manag 2015;49(3):595–610.
   PubMed Web of Science ®Google Scholar
• Best M, Aldridge L, Butow P, Olver I, Price M, Webster F. Assessment of spiritual suffering in the cancer context: a systematic literature review. Palliat Supp Care 2015;13(5):1335–61. doi:10.1017/S1478951514001217.
   PubMed Web of Science ®Google Scholar
• Saunders C. A personal therapeutic journey. BMJ 1996;313:1599–601.
   PubMedGoogle Scholar
• Schipper S, Nigam K, Piechotta V, Ljuslin M, Beaussant Y, Schwarzer G, et al. Psychedelic/entactogen-assisted therapy for treatment of anxiety, depression and existential distress in adult palliative care. Cochrane Database Syst Rev 2022;2022(11):CD015383. Published 2022 Nov 21. doi:10.1002/14651858.CD015383
   Google Scholar
• Boston P, Bruce A, Schreiber R. Existential suffering in the palliative care setting: an integrated literature review. J Pain Symptom Manag 2011;41(3):604–18. doi:10.1016/j.jpainsymman.2010.05.010.
   PubMed Web of Science ®Google Scholar
• Grech A, Marks A. Existential suffering part 1: definition and diagnosis #319. J Palliat Med 2017;20(1):93–4. doi:10.1089/jpm.2016.0422.
   PubMed Web of Science ®Google Scholar
• Mesquita AC, Caldeira S, Chaves E, Carvalho EC. An analytical overview of spirituality in NANDA-I taxonomies. Int J Nurs Knowledge 2018;29(3):200–5. doi:10.1111/2047-3095.12172.
   PubMed Web of Science ®Google Scholar
• Yalom ID. Existential psychotherapy. New York, NY: Yalom Family Trust; 1980.
   Google Scholar
• Yalom ID. The yalom reader: selections from the work of a master therapist and storyteller. New York, NY: Basic Books; 1998.
   Google Scholar
• Yalom I. Religion and psychiatry. Am J Psychoth 2002;56(3):301–16.
   PubMedGoogle Scholar
• Sullivan D, Palitsky R. An existential psychological perspective on the human essence. In: van Zomeren M, Dovidio JF, editors. The Oxford handbook of the human essence. NewYork: Oxford University Press; 2018. p. 21–34.
   Google Scholar
• Palitsky R, Kaplan DM, Peacock C, Zarrabi AJ, Maples-Keller JL, Grant GH, et al. Importance of integrating spiritual, existential, religious, and theological components in psychedelic-assisted therapies. Jama Psychiat. 2023;80(7):743–9.
   PubMed Web of Science ®Google Scholar
• Breitbart W, Gibson C, Poppito SR, Berg A. Psychotherapeutic interventions at the end of life: a focus on meaning and spirituality. Canad J Psychiat 2004;49(6):366–72. doi:10.1177/070674370404900605.
   PubMed Web of Science ®Google Scholar
• Gaignard ME, Pautex S, Hurst S. Existential suffering as a motive for assisted suicide: difficulties, acceptability, management and roles from the perspectives of Swiss professionals. PLoS One 2023;18(4):e0284698. Published 2023 Apr 21. doi:10.1371/journal.pone.0284698
   PubMed Web of Science ®Google Scholar
• Kissane DW, Clarke DM, Street AF. Demoralization syndrome — a relevant psychiatric diagnosis for palliative care. J Palliat Care 2001;17(1):12–21.
   PubMed Web of Science ®Google Scholar
• Woźniewicz A, Cosci F. Clinical utility of demoralization: a systematic review of the literature. Clin Psychol Rev 2023;99:102227. doi:10.1016/j.cpr.2022.102227.
   PubMed Web of Science ®Google Scholar
• Gan LL, Gong S, Kissane DW. Mental state of demoralisation across diverse clinical settings: a systematic review, meta-analysis and proposal for its use as a ‘specifier’ in mental illness. Aust N Z J Psychiat 2022;56(9):1104–29. doi:10.1177/00048674211060746.
   PubMed Web of Science ®Google Scholar
• Wang Y, Sun H, Wu JQ, Wei Q, Zhu J, Prevalence P. Prevalence, associated factors and adverse outcomes of demoralization in cancer patients: a decade of systematic review. Am J Hospice Palliat Med 2023;40(11):1216–30. doi:10.1177/10499091231154887.
   PubMed Web of Science ®Google Scholar
• Lucena A, Yuguero O. Systematic review of common refractory symptoms in the end-of-life situation and Its relation With euthanasia. OMEGA - J Death Dying 2022. doi:10.1177/00302228221089123
   PubMed Web of Science ®Google Scholar
• Cherny NI, ESMO Guidelines Working Group. ESMO Clinical Practice Guidelines for the management of refractory symptoms at the end of life and the use of palliative sedation. Ann Oncol 2014;25 Suppl 3:iii143–iii152. doi:10.1093/annonc/mdu238
   PubMedGoogle Scholar
• Patel C, Kleinig P, Bakker M, Tait P. Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life. Aust J Gene Pract 2019;48(12):838–45. doi:10.31128/AJGP-05-19-4938.
   PubMed Web of Science ®Google Scholar
• Rodin G, Lo C, Rydall A, Shnall J, Malfitano C, Chiu A, et al. Managing cancer and living meaningfully (CALM): A randomized controlled trial of a psychological intervention for patients With advanced cancer. J Clin Oncol 2018;36(23):2422–32.
   PubMed Web of Science ®Google Scholar
• Ross S, Bossis A, Guss J, Agin-Liebes G, Malone T, Cohen B, et al. Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. J Psychopharmacol 2016;30(12):1165–80. doi:10.1177/0269881116675512.
   PubMed Web of Science ®Google Scholar
• Ross S, Agin-Liebes G, Lo S, Zeifman RJ, Ghazal L, Benville J, et al. Acute and sustained reductions in loss of meaning and suicidal ideation following psilocybin-assisted psychotherapy for psychiatric and existential distress in life-threatening cancer. Acs Pharmacol Transl Sci 2021;4(2):553–62. doi:10.1021/acsptsci.1c00020.
   PubMedGoogle Scholar
• Ciancio AL, Mirza RM, Ciancio AA, Klinger CA. The Use of palliative sedation to treat existential suffering: a scoping review on practices, ethical considerations, and guidelines. J Palliat Care 2020;35(1):13–20. doi:10.1177/0825859719827585.
   PubMed Web of Science ®Google Scholar
• Rodrigues P, Crokaert J, Gastmans C. Palliative sedation for existential suffering: a systematic review of argument-based ethics literature. J Pain Symp Manage 2018;55(6):1577–90.
   PubMed Web of Science ®Google Scholar
• Rodrigues P, Menten J, Gastmans C. Physicians’ perceptions of palliative sedation for existential suffering: a systematic review. Bmj Supp Palliat Care 2020;10(2):136–44. doi:10.1136/bmjspcare-2019-001865.
   PubMed Web of Science ®Google Scholar
• Reich M, Bondenet X, Rambaud L, et al. Refractory psycho-existential distress and continuous deep sedation until death in palliative care: The French perspective. Palliat Supp Care 2020;18(4):486–94. doi:10.1017/S1478951519000816.
   PubMed Web of Science ®Google Scholar
• Whittemore R, Knafl K. The integrative review: updated methodology. J Advan Nurs 2005;52(5):546–53.
   PubMed Web of Science ®Google Scholar
• Broome ME. Integrative literature reviews for the development of concepts. In: Rodgers BL, Knafl KA, editors. Concept development in nursing, 2nd ed. Philadelphia: W.B. Saunders Co.; 1993. pp. 231–50.
   Google Scholar
• Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 2015;4(1):1. doi:10.1186/2046-4053-4-1.
   PubMed Web of Science ®Google Scholar
• Stern C, Jordan Z, McArthur A. Developing the review question and inclusion criteria. Am J Nurs 2014;114(4):53–6. doi:10.1097/01.NAJ.0000445689.67800.86.
   PubMed Web of Science ®Google Scholar
• Jadad AR, Moher D, Klassen TP. Guides for reading and interpreting systematic reviews: II. How did the authors find the studies and assess their quality? Arch Pediatr Adolesc Med 1998;152(8):812–7. doi:10.1001/archpedi.152.8.812.
   PubMedGoogle Scholar
• Dang D, Dearholt S, Bissett K, Ascenzi J, Whalen M. Johns Hopkins evidence-based practice for nurses and healthcare professionals: Model and guidelines. 4th ed. Baltimore (US): Sigma Theta Tau International; 2022.
   Google Scholar
• Bloomer MJ, Hutchinson AM, Brooks L, Botti M. Dying persons’ perspectives on, or experiences of, participating in research: an integrative review. Palliat Med 2018;32(4):851–60. doi:10.1177/0269216317744503.
   PubMed Web of Science ®Google Scholar
• Miles MB, Huberman AM. Qualitative data analysis. Thousand Oaks: Sage Publications; 1994.
   Google Scholar
• Garcia ACM, Isidoro GM, Paiva EMDC, Silva AE, Costa ICP, Bornemann-Cimenti H. Palliative sedation at home: a scoping review. Am J Hosp Palliat Med 2023;40(2):173–82. doi:10.1177/10499091221096412.
   PubMed Web of Science ®Google Scholar
• Robinson KA, Brunnhuber K, Ciliska D, Juhl CB, Christensen R, Lund H. Evidence-Based research series-paper 1: what evidence-based research is and why is it important? J Clin Epidemiol 2021;129:151–7. doi:10.1016/j.jclinepi.2020.07.020.
   PubMed Web of Science ®Google Scholar