Neurodevelopmental Liabilities in Schizophrenia and Affective Disorders

References

• Akbarian , S. , Bunney , W.E. Jr , Potkin , S.G. , Wigal , S.B. , Hagman , J.O. , Sandman , C.A. and Jones , E.G. 1993 . "Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development" . Arch. Gen. Psychiatry , 50 : 169 – 177 .
   PubMed Web of Science ®Google Scholar
• Altshuler , L.L. , Bartzokis , G. , Grieder , T. , Curran , J. and Mintz , J. 1998 . "Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity" . Arch. Gen. Psychiatry , 55 : 663 – 664 .
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association . 1994 . Diagnostic and Statistical Manual of Mental Disorders, , 4th Ed. , Washington, DC : American Psychiatric Association . DSM-IV
   Google Scholar
• Andreason , N.C. , Nasrallah , H.A. , Dunn , V. , Ehrhardt , J.C. , Grove , W.M. , Olson , S.C. , Coffman , J.A. and Crossett , J.H. 1986 . "Structureal abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study" . Arch. Gen. Psychiatry , 43 : 136 – 144 .
   PubMed Web of Science ®Google Scholar
• Angst , J. , Scharfetter , C. and Stassen , H.H. 1983 . "Classification of schizo-affective patients by multidimensional scaling and cluster analysis" . Psychiatr. Clin. , 16 : 254 – 264 .
   PubMedGoogle Scholar
• Archer , T. , Beninger , R.J. , Järbe , T.U.C. and Seiden , L.S. 1990 . "Exploratory behaviour and latent learning in a radial arm maze following neonatal dopamine depletion" . Behav. Pharmacol. , 1 : 191 – 200 .
   Google Scholar
• Archer , T. , Palomo , T. and Fredriksson , A. 2002 . "Functional deficits following neonatal dopamine depletion and isolation housing: circular water maze acquisition under pre-exposure conditions and motor activity" . Neurotoxicity Res. , 4 : 503 – 522 .
   PubMed Web of Science ®Google Scholar
• Arias , B. , Rosa , A. and Far˜anás , L. 2002 . "Human Genetic variation and mental disorders" . Neurotoxicity Res. , 4 : 523 – 530 .
   PubMed Web of Science ®Google Scholar
• Bakshi , V.P. and Geyer , M.A. 1999 . "Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats" . Physiol. Behav. , 67 : 385 – 392 .
   PubMed Web of Science ®Google Scholar
• Bakshi , V.P. , Swerdlow , N.R. , Braff , D.L. and Geyer , M.A. 1998 . "Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine" . Biol. Psychiatry , 43 : 436 – 445 .
   PubMed Web of Science ®Google Scholar
• Baxter , L.R. Jr , Schwartz , J.M. , Phelps , M.E. , Mazziotta , J.C. , Guze , B.H. , Selin , C.E. , Gerner , R.H. and Sumida , R.M. 1989 . "Reduction of prefrontal cortex glucose metabolism common to three types of depression" . Arch. Gen. Psychiatry , 46 : 243 – 250 .
   PubMed Web of Science ®Google Scholar
• Bayer , S.A. 1980 . "Development of the hippocampal formation in the rat. I. Neurogenesis examined with 3H-thymidine autoradiography" . J. Comp. Neurol. , 190 : 87 – 114 .
   PubMed Web of Science ®Google Scholar
• Benes , F.M. and Berretta , S. 2001 . "GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder" . Neuropsychopharmacology , 25 : 1 – 27 .
   PubMed Web of Science ®Google Scholar
• Beninger , R.J. 1983 . "The role of dopamine in locomotor activity and learning" . Brain Res. Rev. , 6 : 173 – 196 .
   Web of Science ®Google Scholar
• Beninger , R.J. and Miller , R. 1998 . "Dopamine D1-like receptors and reward-related incentive learning" . Neurosci. Biobehav. Rev. , 22 : 335 – 345 .
   PubMed Web of Science ®Google Scholar
• Beninger , R.J. , Jhamandas , A. , Aujla , H. , Xue , L. , Dagnone , R.V. , Boegman , R. and Jhamandas , K. 2002 . "Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats" . Neurotoxicity Res. , 4 : 477 – 488 .
   PubMed Web of Science ®Google Scholar
• Berrettini , W.H. 2000 . "The search for susceptibility genes in bipolar disorder" ” . In Genetic Influences on Neural and Behavioral Functions , Edited by: Pfaff , D.W. , Berrettini , W.H. , Joh , T.H. and Maxson , S.C. 31 – 45 . Boca Raton, FL : CRC Press .
   Google Scholar
• Binder , E.B. , Kinkead , B. , Owens , M.J. , Kilts , C.D. and Nemeroff , C.B. 2001 . "Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating" . J. Neurosci. , 21 : 601 – 608 .
   PubMed Web of Science ®Google Scholar
• Boksa , P. , Krishnamurthy , A. and Sharma , S. 1996 . "Hippocampal and hypothalamic type I corticosteroid receptor affinities are reduced in adult rats born by a Caesarean procedure with or without an added period of anoxia" . Neuroendocrinology , 64 : 25 – 34 .
   PubMed Web of Science ®Google Scholar
• Braff , D.L. , Stone , C. , Callaway , E. , Geyer , M. , Glick , I. and Bali , L. 1978 . "Prestimulus effects on human startle reflex in normals and schizophrenics" . Psychophysiology , 15 : 339 – 343 .
   PubMed Web of Science ®Google Scholar
• Bremmer , J.D. , Narayan , M. , Anderson , E.R. , Staib , L.H. , Miller , H.L. and Charney , D.S. 2000 . "Hippocampal volume reduction in major depression" . Am. J. Psychiatry , 157 : 115 – 117 .
   PubMed Web of Science ®Google Scholar
• Bullmore , E.T. , O'Connell , P. , Frangou , S. and Murray , R.M. 1997 . "Schizophrenia as a developmental disorder of neural network integrity: the dysplastic net hypothesis" ” . In Neurodevelopment and Adult Psychopathology , Edited by: Keshaven , M.S. and Murray , R.M. 253 – 266 . Cambridge, , UK : Cambridge University Press .
   Google Scholar
• Burd , L. , Severud , R. , Kerbeshian , J. and Klug , M.G. 1999 . "Prenatal and perinatal risk factors for autism" . J. Perinat. Med. , 27 : 441 – 450 .
   PubMed Web of Science ®Google Scholar
• Butler , A.B. and Hodos , W. 1996 . Comparative Vertebrate Neuroanatomy: Evolution and Adaptation , New York : Wiley-Liss .
   Google Scholar
• Caldji , C. , Tannenbaum , B. , Sharma , S. , Francis , D. , Plotsky , P.M. and Meaney , M.J. 1998 . "Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat" . Proc. Natl Acad. Sci. USA , 95 : 5335 – 5340 .
   PubMed Web of Science ®Google Scholar
• Cardno , A.G. , Marshall , E.J. , Coid , B. , Macdonald , A.M. , Ribchester , T.R. , Davies , N.J. , Venturi , P. , Jones , L.A. , Lewis , S.W. , Sham , P.C. , Gottesman , I.I. , Farmer , A.E. , McGuffin , P. , Reveley , A.M. and Murray , R.M. 1999 . "Heritability estimates for psychotic disorders: the Maudsley twin psychosis series" . Arch. Gen. Psychiatry , 56 : 162 – 168 .
   PubMed Web of Science ®Google Scholar
• Carroll , B.J. 1982 . "The dexamethasone suppression test for melancholia" . J. Psychiatry , 140 : 292 – 304 .
   PubMed Web of Science ®Google Scholar
• Celada , P. , Puig , M.V. , Martin-Ruiz , R. , Casanovas , J.M. and Artigas , F. 2000 . "Control of the serotonergic system by the medial prefrontal cortex: potential role in the etiology of PTSD and depressive disorders" . Neurotoxicity Res. , 4 : 409 – 419 .
   Web of Science ®Google Scholar
• Cilia , J. , Reavill , C. , Hagan , J.J. and Jones , D.N.C. 2001 . "Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats" . Psychopharmacology , 156 : 327 – 337 .
   PubMed Web of Science ®Google Scholar
• Ciruili , F. , Gottlieb , S.L. , Rosenfeld , P. and Levine , S. 1992 . "Maternal factors regulate stress responsiveness in the neonatal rat" . Psychobiology , 20 : 143 – 152 .
   Google Scholar
• Clarke , A.S. , Wittwer , D.J. , Abbott , D.H. and Schneider , M.L. 1994 . "Long term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys" . Dev. Psychobiol. , 27 : 257 – 269 .
   PubMed Web of Science ®Google Scholar
• Coplan , J.D. , Andrews , M.W. , Rosenblum , L.A. , Owens , M.J. , Friedman , S. , Gorman , J.M. and Nemeroff , C.B. 1996 . "Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders" . Proc. Natl Acad. Sci. USA , 93 : 1619 – 1623 .
   PubMed Web of Science ®Google Scholar
• Crow , T.J. 1990a . "Nature of the genetic contribution to psychotic illness: a continuum viewpoint" . Acta Psychiatry Scand. , 81 : 401 – 408 .
   PubMed Web of Science ®Google Scholar
• Crow , T.J. 1990b . "The continuum of psychosis and its genetic origins: the sixty-fifth Maudsley lecture" . Br. J. Psychiatry , 156 : 788 – 797 .
   PubMed Web of Science ®Google Scholar
• Crow , T.J. 1995 . "A continuum of psychosis, one human gene, and not much else--the case for homogeneity" . Schizophr. Res. , 17 : 135 – 145 .
   PubMed Web of Science ®Google Scholar
• De Bellis , M.D. , Baum , A.S. , Birmaher , B. , Keshavan , M.S. , Eccard , C.H. , Boring , A.M. , Jenkins , F.J. and Ryan , N.D. 1999 . "Developmental traumatology part I: biological stress systems" . Biol. Psychiatry , 45 : 1259 – 1270 .
   PubMed Web of Science ®Google Scholar
• De Wied , D. and Sigling , H. 2002 . "Neuropeptides involved in the pathophysiology of schizophrenia and major depression" . Neurotoxicity Res. , 4 : 453 – 452 .
   PubMed Web of Science ®Google Scholar
• Deuschle , M. , Schweiger , U. , Standhardt , H. , Weber , B. and Heuser , I. 1996 . "Corticosteroid-binding globulin is not decreased in depressed patients" . Psychoneuroendocrinology , 21 : 645 – 649 .
   PubMed Web of Science ®Google Scholar
• Diamond , M.C. 1967 . "Extensive cortical depth measures and neuron size increases in the cortex of environmentally enriched rats" . J. Comp. Neurol. , 131 : 357 – 364 .
   Web of Science ®Google Scholar
• Du , L. , Bakish , D. , Lapierre , Y.D. , Ravindran , A.V. and Hrdina , P.D. 2000 . "Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder" . Am. J. Med. Genet. (Neuropsychiatry Genet.) , 96 : 56 – 60 .
   PubMed Web of Science ®Google Scholar
• Duncan , G.E. , Leipzig , J.N. , Mailman , R.B. and Lieberman , J.A. 1998 . "Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation" . Brain Res. , 812 : 65 – 75 .
   PubMed Web of Science ®Google Scholar
• Einon , D.F. and Morgan , M.J. 1978 . "Early isolation produces enduring hyperactivity in the rat, but no effect upon spontaneous alternation" . Q. J. Exp. Psychol. , 30 : 151 – 156 .
   PubMed Web of Science ®Google Scholar
• Ekman , R. , Persson , R. and Niellon , C.L. 2002 . "Neurodevelopmental influence on the immune system reflecting brain pathology" . Neurotoxicity Res. , 4 : 565 – 572 .
   PubMed Web of Science ®Google Scholar
• Foerster , A. , Lewis , S.W. , Owen , M.J. and Murray , R.M. 1991 . "Premorbid personality and psychosis: effects of sex and diagnosis" . Br. J. Psychiatry , 158 : 171 – 176 .
   PubMed Web of Science ®Google Scholar
• Gentsch , C. , Lichtsteiner , M. , Frischknecht , H.R. , Feer , H. and Siegfried , B. 1988 . "Isolation-induced locomotor hyperactivity and hypoalgesia in rats are prevented by handling and reversed by resocialization" . Physiol. Behav. , 43 : 13 – 16 .
   PubMed Web of Science ®Google Scholar
• Geyer , M.A. , Wilkinson , L.S. , Humby , T. and Robbins , T.W. 1993 . "Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia" . Biol. Psychiatry , 34 : 361 – 372 .
   PubMed Web of Science ®Google Scholar
• Geyer , M.A. , Krebs-Thomson , K. , Braff , D.L. and Swerdlow , N.R. 2001 . "Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review" . Psychopharmacology , 156 : 117 – 154 .
   PubMed Web of Science ®Google Scholar
• Gilvarry , C. , Noriyoshi , T. , Russell , A. , Rushe , T. , Hemsley , D. and Murray , R.M. 2000 . "Premorbid IQ in patients with functional psychosis and their first degree relatives" . Schizophr. Res. , 41 : 417 – 429 .
   PubMed Web of Science ®Google Scholar
• Greengard , P. 2001 . "The neurobiology of slow synaptic transmission" . Science , 294 : 1024 – 1030 .
   PubMed Web of Science ®Google Scholar
• Greenough , W.T. and Volkmar , F.R. 1973 . "Pattern of dendritic branching in rat occipital cortex after rearing in complex environments" . Exp. Neurol. , 40 : 491 – 504 .
   PubMed Web of Science ®Google Scholar
• Harkness , K.L. and Tucker , D.M. 2000 . "Adaptive organization of corticolimbic networks" ” . In Emotion, Development, and Self-Organization , Edited by: Lewis , M.D. and Granic , I. 186 – 208 . Cambridge, , UK : Cambridge University Press .
   Google Scholar
• Harvey , I. , Persaud , R. , Ron , M.A. , Baker , G. and Murray , R.M. 1994 . "Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls" . Psychol. Med. , 24 : 689 – 699 .
   PubMed Web of Science ®Google Scholar
• Herman , J.P. and Cullinan , W.E. 1997 . "Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis" . Trends Neurosci. , 20 : 78 – 84 .
   PubMed Web of Science ®Google Scholar
• Ikonomidou , C. , Bosch , F. , Miksa , M. , Bittigau , P. , Vöckler , J. , Dikranian , K. , Tenkova , T.I. , Stefovska , V. , Turski , L. and Olney , J.W. 1999 . "Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain" . Science , 283 : 70 – 71 .
   PubMed Web of Science ®Google Scholar
• Izquierdo , I. , Vianna , M.R.M. , Izquierdo , L.A. , Barros , D.M. , Szapiro , G. , Coitinho , A.S. , Muller , L. and Medina , J.H. 2002 . "Memory retrieval and its lasting consequences" . Neurotoxicity Res. , 4 : 573 – 593 .
   PubMed Web of Science ®Google Scholar
• Jones , P. and Done , D.J. 1997 . "From birth to onset: a developmental perspective of schizophrenia in two national birth cohorts" ” . In Neurodevelopment and Adult Psychopathology , Edited by: Keshaven , M.S. and Murray , R.M. 119 – 136 . Cambridge, , UK : Cambridge University Press .
   Google Scholar
• Jones , G.H. , Hernandez , T.D. , Marsden , C.A. and Robbins , T.W. 1988 . "Enhanced striatal response to d -amphetamne as revealed by intracerebral dialysis following social isolation in rats" . Br. J. Pharmacol. , 94 : 349
   Web of Science ®Google Scholar
• Jones , G.H. , Hernandez , T.D. , Kendall , D.A. , Marsden , C.A. and Robbins , T.W. 1992 . "Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry" . Pharmacol. Biochem. Behav. , 43 : 17 – 35 .
   PubMed Web of Science ®Google Scholar
• Jones , P. , Rodgers , B. , Murray , R. and Marmot , M. 1994 . "Child development risk factors for adult schizophrenia in the British 1946 birth cohort" . Lancet , 344 : 1398 – 1402 .
   PubMed Web of Science ®Google Scholar
• Kandel , E.R. 2001 . "The molecular biology of memory storage: a dialogue between genes and synapses" . Science , 294 : 1030 – 1038 .
   PubMed Web of Science ®Google Scholar
• Krystal , J.H. , Karper , L.P. , Seibyl , J.P. , Freeman , G.K. , Delany , R. , Bremmer , J.D. , Heninger , G.R. , Bowers , M.B. and Crarney , D.S. 1994 . "Subanasthetic effects of the noncompetitive NMDA antagonist ketamine in humans" . Arch. Gen. Psychiatry , 51 : 199 – 214 .
   PubMed Web of Science ®Google Scholar
• Ladd , C.O. , Owens , M.J. and Nemeroff , C.B. 1996 . "Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation" . Endocrinology , 137 : 1212 – 1218 .
   PubMed Web of Science ®Google Scholar
• Lahti , A.C. , Holcomb , H.H. , Medoff , D.R. and Tamminga , C.A. 1995 . "Ketamine activates psychosis and alters blood blow in schizophrenia" . NeuroReport , 6 : 869 – 872 .
   PubMed Web of Science ®Google Scholar
• Lamaire , V. , Koehl , M. , LeMoal , M. and Abrous , N. 2000 . "Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus" . Proc. Natl Acad. Sci. USA , 97 : 11032 – 11037 .
   PubMed Web of Science ®Google Scholar
• Levine , S. 2002 . "Regulation of the hypothalamic-pituitary-adrenal axis in the neonatal rat: the role of maternal behavior" . Neurotoxicity Res. , 4 : 557 – 564 .
   PubMed Web of Science ®Google Scholar
• Levine , S. , Lyons , D.M. and Schatzberg , A.F. 1997 . "Psychobiological consequences of social relationships" . Ann. N.Y. Acad. Sci. , 807 : 210 – 218 .
   PubMed Web of Science ®Google Scholar
• Levinson , D.F. and Mowry , B.J. 2000 . "Genetics of schizophrenia" ” . In Genetic Influences on Neural and Behavioral Functions , Edited by: Pfaff , D.W. , Berrettini , W.H. , Joh , T.H. and Maxson , S.C. 47 – 82 . Boca Raton, FL : CRC Press .
   Google Scholar
• Lipska , B.K. and Weinberger , D.R. 1993 . "Delayed effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in rats" . Dev. Brain Res. , 75 : 213 – 222 .
   PubMedGoogle Scholar
• Lipska , B.K. and Weinberger , D.R. 2002 . "A neurodevelopmental model of schizophrenia: neonatal disconnection of the hippocampus" . Neurotoxicity Res. , 4 : 469 – 475 .
   PubMed Web of Science ®Google Scholar
• Lipska , B.K. , Jaskiw , G.E. and Weinberger , D.R. 1993 . "Postpubertal emergence of hyperresponsiveness to stress and amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia" . Neuropsychopharmacology , 9 : 67 – 75 .
   PubMed Web of Science ®Google Scholar
• Lipska , B.K. , Swerdlow , N.R. , Geyer , M.A. , Jaskiw , G.E. , Braff , D.L. and Weinberger , D.R. 1995 . "Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine" . Psychopharmacology , 122 : 35 – 43 .
   PubMed Web of Science ®Google Scholar
• Lipska , B.K. , Halim , N.D. , Segal , P.N. and Weinberger , D.R. 2002 . "Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat" . J. Neurosci. , 22 : 2835 – 2842 .
   PubMed Web of Science ®Google Scholar
• Liu , D. , Diorio , J. , Tannenbaum , B. , Caldji , C. , Francis , D. , Freedman , A. , Sharma , S. , Pearson , D. , Plotsky , P.M. and Meaney , M.J. 1997 . "Maternal care hippocampal glucocorticoid receptors, and hypothalamic pituitary-adrenal responses to stress" . Science , 277 : 1659 – 1662 .
   PubMed Web of Science ®Google Scholar
• McEwen , B.S. and Sapolsky , R.M. 1995 . "Stress and cognitive function" . Curr. Opin. Neurobiol. , 5 : 205 – 216 .
   PubMed Web of Science ®Google Scholar
• Meaney , M.J. , Aitken , D.H. , Bhatnagar , S. , Van Berkel , C. and Sapolsky , R.M. 1988 . "Effect of neonatal handling on age-related impairments associated with the hippocampus" . Science , 239 : 766 – 768 .
   PubMed Web of Science ®Google Scholar
• Mednick , S.A. , Machon , R.A. , Huttumen , M.O. and Bonnett , D. 1988 . "Adult schizophrenia following prenatal exposure to an influenza epidemic" . Arch. Gen. Psychiatry , 45 : 189 – 192 .
   PubMed Web of Science ®Google Scholar
• Molina , V. , Reig , S. , Desco , M. , Gispert , J.D. , Sanz , J. , Luque , R. , Aragues , M. , Misiego , J.M. , Corral , I.L. and Palomo , T. 2002 . "Multimodal neuroimaging studies and the neurodevelopmental hypothesis of schizophrenia" . Neurotoxicity Res. , 4 : 437 – 451 .
   PubMed Web of Science ®Google Scholar
• Nasrallah , H.A. 1997 . "Neurodevelopmental models of affective disorders" ” . In Neurodevelopment and Adult Psychopathology , Edited by: Keshaven , M.S. and Murray , R.M. 199 – 205 . Cambridge, , UK : Cambridge University Press .
   Google Scholar
• Nemeroff , C.B. , Widerlov , E. , Bissette , G. , Walleus , H. , Karlsson , I. , Eklund , K. , Kilts , C.D. , Loosen , P.T. and Vale , W. 1984 . "Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients" . Science , 226 : 1342 – 1344 .
   PubMed Web of Science ®Google Scholar
• Nopoulos , P. , Torres , I. , Flaum , M. , Andreasen , N.C. , Ehrhardt , J.C. and Yuh , W.T. 1995 . "Brain morphology in first-episode schizophrenia" . Am. J. Psychiatry , 152 : 1721 – 1723 .
   PubMed Web of Science ®Google Scholar
• Olney , J.W. and Farber , N.B. 1995 . "Glutamate receptor dysfunction and schizophrenia" . Arch. Gen. Psychiatry , 52 : 998 – 1007 .
   PubMed Web of Science ®Google Scholar
• Oreland , L. , Damberg , M. , Hallman , J. , Berggard , C. and Garpenstrand , H. 2002 . "Risk factors for the neurohumoral alterations underlying personality disturbances" . Neurotoxicity Res. , 4 : 421 – 426 .
   PubMed Web of Science ®Google Scholar
• Orr , S.T. , James , S.A. , Miller , C.A. , Barakat , B. , Daikoku , N. , Pupkin , M. , Engsstrom , K. and Huggins , G. 1996 . "Psyhosocial stressors and low birthweight in an urban population" . Am. J. Prev. Med. , 12 : 459 – 466 .
   PubMed Web of Science ®Google Scholar
• Peacock , J.L. , Bland , J.M. and Anderson , H.R. 1995 . "Preterm delivery--effects of socioeconomic factors, psychological stress, smoking, alcohol, and caffeine" . Br. Med. J. , 311 : 531 – 535 .
   PubMed Web of Science ®Google Scholar
• Plotsky , P. and Meany , M. 1993 . "Early postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content, and stress-induced release in adult rats" . Brain Res. , 18 : 195 – 200 .
   Web of Science ®Google Scholar
• Powell , S.B. and Geyer , M.A. 2002 . "Developmental markers of psychiatric disorders as identified by sensorimotor gating" . Neurotoxicity Res. , : 489 – 502 .
   PubMed Web of Science ®Google Scholar
• Raadsheer , F.C. , Van Heerikhuize , J.J. , Lucassen , P.J. , Hoogendijk , W.J. , Tilders , F.J. and Swaab , D.F. 1995 . "Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression" . Am. J. Psychiatry , 152 : 1372 – 1376 .
   PubMed Web of Science ®Google Scholar
• Rosenfeld , P. , Suchecki , D. and Levine , S. 1992 . "Multifactorial regulation of the hypothalamic-pituitary-adrenal axis during development" . Neurosci. Biobehav. Rev. , 16 : 553 – 568 .
   PubMed Web of Science ®Google Scholar
• Rubin , R.T. , Poland , R.E. , Lesser , I.M. , Winston , R.A. and Blodgett , N.A. 1987 . "Neuroendocrine aspects of primary endogenous depression: cortisol secretory dynamics in patients and matched controls" . Gen. Psychiatry , 44 : 328 – 336 .
   PubMed Web of Science ®Google Scholar
• Sachar , E. , Hellman , L. , Fukushima , D.K. and Gallagher , T.F. 1970 . "Cortisol production in depressive illness. A clinical and biochemical clarification" . Arch. Gen. Psychiatry , 23 : 289 – 298 .
   PubMed Web of Science ®Google Scholar
• Sahakian , B.J. , Robbins , T.W. , Morgan , M.J. and Iversen , S.D. 1975 . "The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats" . Brain Res. , 84 : 195 – 205 .
   PubMed Web of Science ®Google Scholar
• Sahakian , B.J. , Robbins , T.W. and Iversen , S.D. 1977 . "The effects of isolation rearing on exploration in the rat" . Anim. Learn. Behav. , 5 : 193 – 198 .
   Google Scholar
• Sawa , A. and Snyder , S.H. 2002 . "Schizophrenia: diverse approaches to a complex disease" . Science , 296 : 692 – 695 .
   PubMed Web of Science ®Google Scholar
• Schenk , S. , Lacelle , G. , Gorman , K. and Amit , Z. 1987 . "Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse" . Neurosci. Lett. , 81 : 227 – 231 .
   PubMed Web of Science ®Google Scholar
• Smith , M.A. , Kim , S-Y. , Van Oers , H.J.J. and Levine , S. 1997 . "Maternal deprivation and stress induced immediate early genes in the infant rat brain" . Endocrinology , 138 : 4622 – 4628 .
   PubMed Web of Science ®Google Scholar
• Stanton , M.E. and Levine , S. 1988 . "Maternal modulation of infant glucocorticoid stress responses: role of age and maternal deprivation" . Psychobiology , 16 (3) : 223 – 228 .
   Google Scholar
• Stanton , M.E. and Levine , S. 1990 . "Inhibition of infant glucorticoid stress response: specific role of maternal cues" . Dev. Psychobiol. , 23 : 411 – 426 .
   PubMed Web of Science ®Google Scholar
• Stanton , M.E. , Wallstrom , J. and Levine , S. 1987 . "Maternal contact inhibits pituitary-adrenal stress response in preweaning rats" . Dev. Psychobiol. , 20 : 131 – 145 .
   PubMed Web of Science ®Google Scholar
• Strakowski , S.M. , DelBello , M.P. , Sax , K.W. , Zimmerman , M.E. , Shear , P.K. , Hawkins , J.M. and Larson , E.R. 1999 . "Brain magnetic resonance imaging of structural abnormalities in bipolar disorder" . Arch. Gen. Psychiatry , 56 : 254 – 260 .
   PubMed Web of Science ®Google Scholar
• Suchecki , D. , Rosenfeld , P. and Levine , S. 1993 . "Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the role of feeding and stroking" . Dev. Brain Res. , 75 : 185 – 192 .
   PubMedGoogle Scholar
• Takei , N. , O'Callaghan , E. , Sham , P. , Glover , G. , Tamura , A. and Murray , R. 1992 . "Seasonality of admission in the psychoses: effect of diagnosis, sex, and age at onset" . Br. J. Psychiatry , 161 : 506 – 511 .
   PubMed Web of Science ®Google Scholar
• Tamminga , C. 1999 . "Glutamatergic aspects of schizophrenia (Abstract)" . Br. J. Psychiatry , : 12 – 15 .
   PubMed Web of Science ®Google Scholar
• Tanabe , G. 1972 . "Remediating maze deficiencies by the use of environmental enrichment" . Dev. Psychol. , 7 : 224
   Web of Science ®Google Scholar
• Van Londen , L. , Goekoop , J.G. , Van Kempen , G.M. , Frankhuijzen Sierevogel , A.C. , Wiegant , V.M. , Van der Velde , E.A. and De Wied , D. 1997 . "Plasma levels of arginine vasopressin elevated in patients with major depression" . Neuropsychopharmacology , 17 : 284 – 292 .
   PubMed Web of Science ®Google Scholar
• Van Praag , H.M. 2002 . "Crossroads of corticotropin releasing hormone, corticosteroids and monoamines: about a biological interface between stress and depression" . Neurotoxicity Res. , 4 : 531 – 556 .
   PubMed Web of Science ®Google Scholar
• Van Oers , H.J.J. , DeKloet , E.R. , Whelan , T. and Levine , S. 1998 . "Maternal deprivation effect on the infants neural stress markers is reversed by tactile stimulation but not by suppressing corticosterone" . J. Neurosci. , 18 : 10171 – 10179 .
   PubMed Web of Science ®Google Scholar
• Van Os , J. , Jones , P. , Lewis , G. , Wadsworth , M. and Murray , R. 1997 . "Developmental precursors of affective illness in a general population birth cohort" . Arch. Gen. Psychiatry , 54 : 625 – 631 .
   PubMed Web of Science ®Google Scholar
• Varty , G.B. and Higgins , G.A. 1995 . "Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs" . Psychopharmacology , 122 : 15 – 26 .
   PubMed Web of Science ®Google Scholar
• Ventura , J. , Neuchterlein , K. , Lukoff , D. and Hardesty , J. 1989 . "A prospective study of stressful life events in schizophrenic relapse" . J. Abnorm. Psychol. , 98 : 407 – 411 .
   PubMed Web of Science ®Google Scholar
• Virgin , C.E. , Ha , T.P. , Packan , D.R. , Tombaugh , G.C. , Yang , S.H. , Horner , H.C. and Sapolsky , R.M. 1991 . "Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity" . J. Neurochem. , 57 : 1422 – 1428 .
   PubMed Web of Science ®Google Scholar
• Vollenweider , F.X. , Leenders , K.L. , Scharfetter , C. , Antonini , A. , Maguire , P. , Missimer , J. and Angst , J. 1997 . "Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)" . Eur. Neuropsychopharmacol. , 7 : 9 – 24 .
   PubMed Web of Science ®Google Scholar
• Walker , E. and Lewine , R.J. 1990 . "Prediction of adult-onset schizophrenia from childhood home movies of the patients" . Am. J. Psychiatry , 147 : 1052 – 1056 .
   PubMed Web of Science ®Google Scholar
• Walker , C.D. , Perrin , M. , Vale , W. and Rivier , C. 1986 . "Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus" . Endocrinology , 118 : 1445 – 1451 .
   PubMed Web of Science ®Google Scholar
• Walker , J. , Shaw , P. , Curtis , V. and Murray , R.M. 2002 . "Shared genetic susceptibility but differences in neurodevelopment determine the similarities and differences between schizophrenia and bipolar disorder" . Neurotoxicity Res. , 4 (unknown)
   PubMedGoogle Scholar
• Watanabe , Y. , Gould , E. and McEwen , B.S. 1992 . "Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons" . Brain Res. , 588 : 341 – 345 .
   PubMed Web of Science ®Google Scholar
• Weinberger , D.R. 1995 . "Neurodevelopmental perspectives on schizophrenia" ” . In Psychopharmacology: The Fourth Generation of Progress , Edited by: Bloom , F.E. and Kupfer , D.J. 1171 – 1183 . New York : Raven Press .
   Google Scholar
• Weinstock , M. , Fride , E. and Hertzberg , R. 1988 . "Prenatal stress effects on functional development of the offspring" . Prog. Brain Res. , 73 : 319 – 331 .
   PubMed Web of Science ®Google Scholar
• Weiss , I.C. and Feldon , J. 2001 . "Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review" . Psychopharmacology , 156 : 305 – 326 .
   PubMed Web of Science ®Google Scholar
• Wilkinson , L.S. , Killcross , S.S. , Humby , T. , Hall , F.S. , Geyer , M.A. and Robbins , T.W. 1994 . "Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition" . Neuropsychopharmacology , 10 : 61 – 72 .
   PubMed Web of Science ®Google Scholar
• Zhou , A.W. , Li , W.X. and Du , Y.C. 1997 . "Facilitation of AVP(4-8) on gene expression of BDNF and NGF in rat brain" . Peptides , 18 : 1179 – 1187 .
   PubMed Web of Science ®Google Scholar