Progress in the development of stabilization strategies for nanocrystal preparations

References

• Afolabi A, Akinlabi O, Bilgili E. (2014). Impact of process parameters on the breakage kinetics of poorly water-soluble drugs during wet stirred media milling: a microhydrodynamic view. Eur J Pharm Sci 51:75–86.
   PubMed Web of Science ®Google Scholar
• Ahire E, Thakkar S, Darshanwad M, et al. (2018). Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications. Acta Pharm Sin B 8:733–55.
   PubMed Web of Science ®Google Scholar
• Alexis F, Pridgen E, Molnar LK, et al. (2008). Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5:505–15.
   PubMed Web of Science ®Google Scholar
• Anhalt K, Geissler S, Harms M, et al. (2012). Development of a new method to assess nanocrystal dissolution based on light scattering. Pharm Res 29:2887–901.
   PubMed Web of Science ®Google Scholar
• Bao Y, Zhang Q, Wu W. (2017). Evaluation method and application of correlation in vitro and in vivo. Chin J Pharm 48:638–43.
   Google Scholar
• Barle EL, Cerne M, Peternel L, et al. (2013). Reduced intravenous toxicity of amiodarone nanosuspension in mice and rats. Drug Chem Toxicol 36:263–9.
   PubMed Web of Science ®Google Scholar
• Bartos C, Szabó-Révész P, Bartos C, et al. (2016). The effect of an optimized wet milling technology on the crystallinity, morphology and dissolution properties of micro- and nanonized meloxicam. Molecules 21:507
   PubMed Web of Science ®Google Scholar
• Bartzoka ED, Lange H, Mosesso P, et al. (2017). Synthesis of nano- and microstructures from proanthocyanidins, tannic acid and epigallocatechin-3-O-gallate for active delivery. Green Chem 19:5074–91.
   Web of Science ®Google Scholar
• Berre FL, Chauveteau G, Pefferkorn E. (1998). Perikinetic and orthokinetic aggregation of hydrated colloids. J Colloid Interface Sci 199:1–12.
   Web of Science ®Google Scholar
• Bhakay A, Azad M, Bilgili E, et al. (2014). Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs. Int J Pharm 461:367–79.
   PubMed Web of Science ®Google Scholar
• Bhakay A, Davé R, Bilgili E. (2013). Recovery of BCS Class II drugs during aqueous redispersion of core–shell type nanocomposite particles produced via fluidized bed coating. Powder Technol 236:221–34.
   Web of Science ®Google Scholar
• Bilgili E, Afolabi A. (2012). A combined microhydrodynamics-polymer adsorption analysis for elucidation of the roles of stabilizers in wet stirred media milling. Int J Pharm 439:193–206.
   PubMed Web of Science ®Google Scholar
• Cai H, Dai X, Wang X, et al. (2020). A nanostrategy for efficient imaging-guided antitumor therapy through a stimuli-responsive branched polymeric prodrug. Adv Sci (Weinh) 7:1903243.
   PubMedGoogle Scholar
• Cerdeira AM, Mazzotti M, Gander B. (2010). Miconazole nanosuspensions: influence of formulation variables on particle size reduction and physical stability. Int J Pharm 396:210–8.
   PubMed Web of Science ®Google Scholar
• Chan HK, Kwok PC. (2011). Production methods for nanodrug particles using the bottom-up approach. Adv Drug Deliv Rev 63:406–16.
   PubMed Web of Science ®Google Scholar
• Chaubal MV, Popescu C. (2008). Conversion of nanosuspensions into dry powders by spray drying: a case study. Pharm Res 25:2302–8.
   PubMed Web of Science ®Google Scholar
• Chen K, Liao S, Guo S, et al. (2020). Multistimuli-responsive PEGylated polymeric bioconjugate-based nano-aggregate for cancer therapy. Chem Eng J 391:123543.
   Web of Science ®Google Scholar
• Choi JY, Park CH, Lee J. (2008). Effect of polymer molecular weight on nanocomminution of poorly soluble drug. Drug Deliv 15:347–53.
   PubMed Web of Science ®Google Scholar
• Choi JY, Yoo JY, Kwak H-S, et al. (2005). Role of polymeric stabilizers for drug nanocrystal dispersions. Curr Appl Phys 5:472–4.
   Web of Science ®Google Scholar
• Crisp MT, Tucker CJ, Rogers TL, et al. (2007). Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals. J Control Release 117:351–9.
   PubMed Web of Science ®Google Scholar
• Dai W-G, Dong LC, Song Y-Q. (2007). Nanosizing of a drug/carrageenan complex to increase solubility and dissolution rate. Int J Pharm 342:201–7.
   PubMed Web of Science ®Google Scholar
• Dan J, Ma Y, Yue P, et al. (2016). Microcrystalline cellulose-carboxymethyl cellulose sodium as an effective dispersant for drug nanocrystals: a case study. Carbohydr Polym 136:499–506.
   PubMed Web of Science ®Google Scholar
• Deng J, Huang L, Liu F. (2010). Understanding the structure and stability of paclitaxel nanocrystals. Int J Pharm 390:242–9.
   PubMed Web of Science ®Google Scholar
• Doyle WM. (1992). Principles and applications of fourier transform infrared (FTIR) process analysis. Process Control Qual 2:11–41.
   Google Scholar
• Du J, Li X, Zhao H, et al. (2015). Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies. Int J Pharm 495:738–49.
   PubMed Web of Science ®Google Scholar
• Ferrar JA, Sellers BD, Chan C, et al. (2020). Towards an improved understanding of drug excipient interactions to enable rapid optimization of nanosuspension formulations. Int J Pharm 578:119094.
   PubMed Web of Science ®Google Scholar
• Gao Y, Li ZG, Sun M, et al. (2011). Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv 18:131–42.
   PubMed Web of Science ®Google Scholar
• Geng T, Banerjee P, Lu Z, et al. (2017). Comparative study on stabilizing ability of food protein, non-ionic surfactant and anionic surfactant on BCS type II drug carvedilol loaded nanosuspension: physicochemical and pharmacokinetic investigation. Eur J Pharm Sci 109:200–8.
   PubMed Web of Science ®Google Scholar
• George M, Ghosh I. (2013). Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology. Eur J Pharm Sci 48:142–52.
   PubMed Web of Science ®Google Scholar
• Ghosh I, Bose S, Vippagunta R, et al. (2011). Nanosuspension for improving the bioavailability of a poorly soluble drug and screening of stabilizing agents to inhibit crystal growth. Int J Pharm 409:260–8.
   PubMed Web of Science ®Google Scholar
• Ghosh I, Schenck D, Bose S, et al. (2012). Optimization of formulation and process parameters for the production of nanosuspension by wet media milling technique: effect of Vitamin E TPGS and nanocrystal particle size on oral absorption. Eur J Pharm Sci 47:718–28.
   PubMed Web of Science ®Google Scholar
• Gol D, Thakkar S, Misra M. (2018). Nanocrystal-based drug delivery system of risperidone: lyophilization and characterization. Drug Dev Ind Pharm 44:1458–66.
   PubMed Web of Science ®Google Scholar
• Gong X, Wang Y, Kuang T. (2017). ZIF-8-based membranes for carbon dioxide capture and separation. ACS Sustainable Chem Eng 5:11204–14.
   Web of Science ®Google Scholar
• Gonzalez-Garcia I, Mangas-Sanjuan V, Merino-Sanjuan M, et al. (2015). In vitro-in vivo correlations: general concepts, methodologies and regulatory applications. Drug Dev Ind Pharm 41:1935–47.
   PubMed Web of Science ®Google Scholar
• Gora S, Mustafa G, Sahni JK, et al. (2016). Nanosizing of valsartan by high pressure homogenization to produce dissolution enhanced nanosuspension: pharmacokinetics and pharmacodyanamic study. Drug Deliv 23:940–50.
   PubMed Web of Science ®Google Scholar
• Guo Y, Wang Y, Xu L. (2015). Enhanced bioavailability of rebamipide nanocrystal tablets: formulation and in vitro/in vivo evaluation. Asian J Pharm Sci 10:223–9.
   Web of Science ®Google Scholar
• Harris KR. (2009). The fractional Stokes–Einstein equation: application to Lennard-Jones, molecular, and ionic liquidsa. J Chem Phys 131:1165.
   Web of Science ®Google Scholar
• He S, Yang H, Zhang R, et al. (2015). Preparation and in vitro-in vivo evaluation of teniposide nanosuspensions. Int J Pharm 478:131–7.
   PubMed Web of Science ®Google Scholar
• He W, Lu Y, Qi J, et al. (2013). Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. Int J Pharm 441:269–78.
   PubMed Web of Science ®Google Scholar
• Ho H, Lee J. (2012). Redispersible drug nanoparticles prepared without dispersant by electro-spray drying. Drug Dev Ind Pharm 38:744–51.
   PubMed Web of Science ®Google Scholar
• Hong C, Dang Y, Lin G, et al. (2014). Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation. Int J Pharm 477:251–60.
   PubMed Web of Science ®Google Scholar
• Hui W, Pan Q, Rempel GL. (2011). Micellar nucleation differential microemulsion polymerization. Eur Polym J 47:973–80.
   Web of Science ®Google Scholar
• Imono M, Uchiyama H, Yoshida S, et al. (2020). The elucidation of key factors for oral absorption enhancement of nanocrystal formulations: in vitro-in vivo correlation of nanocrystals. Eur J Pharm Biopharm 146:84–92.
   PubMed Web of Science ®Google Scholar
• Jablonka L, Ashtikar M, Gao G, et al. (2019). Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans. J Control Release 308:57–70.
   PubMed Web of Science ®Google Scholar
• Jermain SV, Brough C, Williams RO, 3rd. (2018). Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – an update. Int J Pharm 535:379–92.
   PubMed Web of Science ®Google Scholar
• Jog R, Burgess DJ. (2019). Comprehensive quality by design approach for stable nanocrystalline drug products. Int J Pharm 564:426–60.
   PubMed Web of Science ®Google Scholar
• Kakran M, Shegokar R, Sahoo NG, et al. (2012). Long-term stability of quercetin nanocrystals prepared by different methods. J Pharm Pharmacol 64:1394–402.
   PubMed Web of Science ®Google Scholar
• Kalvakuntla S, Deshpande M, Attari Z, et al. (2016). Preparation and characterization of nanosuspension of aprepitant by H96 process. Adv Pharm Bull 6:83–90.
   PubMed Web of Science ®Google Scholar
• Karakucuk A, Celebi N, Teksin ZS. (2016). Preparation of ritonavir nanosuspensions by microfluidization using polymeric stabilizers: I. A design of experiment approach. Eur J Pharm Sci 95:111–21.
   PubMed Web of Science ®Google Scholar
• Karakucuk A, Teksin ZS, Eroglu H, et al. (2019). Evaluation of improved oral bioavailability of ritonavir nanosuspension. Eur J Pharm Sci 131:153–8.
   PubMed Web of Science ®Google Scholar
• Keck CM. (2010). Particle size analysis of nanocrystals: improved analysis method. Int J Pharm 390:3–12.
   PubMed Web of Science ®Google Scholar
• Knieke C, Azad MA, Davé RN, et al. (2013). A study of the physical stability of wet media-milled fenofibrate suspensions using dynamic equilibrium curves. Chem Eng Res Des 91:1245–58.
   Web of Science ®Google Scholar
• Knieke C, Azad MA, To D, et al. (2015). Sub-100 micron fast dissolving nanocomposite drug powders. Powder Technol 271:49–60.
   Web of Science ®Google Scholar
• Kumar S, Burgess DJ. (2014). Wet milling induced physical and chemical instabilities of naproxen nano-crystalline suspensions. Int J Pharm 466:223–32.
   PubMed Web of Science ®Google Scholar
• Kumar S, Gokhale R, Burgess DJ. (2014). Sugars as bulking agents to prevent nano-crystal aggregation during spray or freeze-drying. Int J Pharm 471:303–11.
   PubMed Web of Science ®Google Scholar
• Kumar S, Shen J, Zolnik B, et al. (2015). Optimization and dissolution performance of spray-dried naproxen nano-crystals. Int J Pharm 486:159–66.
   PubMed Web of Science ®Google Scholar
• Kumar S, Xu X, Gokhale R, et al. (2014). Formulation parameters of crystalline nanosuspensions on spray drying processing: a DoE approach. Int J Pharm 464:34–45.
   PubMed Web of Science ®Google Scholar
• Kurakula M, El-Helw AM, Sobahi TR, et al. (2015). Chitosan based atorvastatin nanocrystals: effect of cationic charge on particle size, formulation stability, and in-vivo efficacy. Int J Nanomedicine 10:321–34.
   PubMed Web of Science ®Google Scholar
• Lee J, Choi JY, Park CH. (2008). Characteristics of polymers enabling nano-comminution of water-insoluble drugs. Int J Pharm 355:328–36.
   PubMed Web of Science ®Google Scholar
• Lee J, Lee SJ, Choi JY, et al. (2005). Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion. Eur J Pharm Sci 24:441–9.
   PubMed Web of Science ®Google Scholar
• Li X, Gu L, Xu Y, et al. (2009). Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats. Drug Dev Ind Pharm 35:827–33.
   PubMed Web of Science ®Google Scholar
• Lindfors L, Skantze P, Skantze U, et al. (2007). Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth. Langmuir 23:9866–74.
   PubMed Web of Science ®Google Scholar
• Litou C, Patel N, Turner DB, et al. (2019). Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states. Eur J Pharm Sci 138:105031.
   PubMed Web of Science ®Google Scholar
• Liu P, Rong X, Laru J, et al. (2011). Nanosuspensions of poorly soluble drugs: preparation and development by wet milling. Int J Pharm 411:215–22.
   PubMed Web of Science ®Google Scholar
• Liu T, Yu X, Yin H. (2020). Study of top-down and bottom-up approaches by using design of experiment (DoE) to produce meloxicam nanocrystal capsules. AAPS PharmSciTech 21:79.
   PubMed Web of Science ®Google Scholar
• Liu YF, Wang YJ, Zhou YM, et al. (2019). Advances in the study of drug release in vitro and in vivo correlation evaluation in nano drug delivery system. China Pharm 30:548–53.
   Google Scholar
• Lo CL, Lin SJ, Tsai HC, et al. (2009). Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery. Biomaterials 30:3961–70.
   PubMed Web of Science ®Google Scholar
• Luo RF, Lin MS, Zhang C, et al. (2020). Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis. Food Chem 330:127241.
   PubMed Web of Science ®Google Scholar
• Martínez NA, Fernández-Álvarez F, Delgado ÁV, et al. (2020). First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications. Pharm Dev Technol 25:892–8.
   PubMed Web of Science ®Google Scholar
• McKee J, Rabinow B, Cook C, et al. (2010). Nanosuspension formulation of itraconazole eliminates the negative inotropic effect of SPORANOX in dogs. J Med Toxicol 6:331–6.
   PubMedGoogle Scholar
• Medarević D, Ibrić S, Vardaka E, et al. (2020). Insight into the formation of glimepiride nanocrystals by wet media milling. Pharmaceutics 12:53.
   PubMed Web of Science ®Google Scholar
• Medarević D, Djuriš J, Ibrić S, et al. (2018). Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling. Int J Pharm 540:150–61.
   PubMed Web of Science ®Google Scholar
• Milewski M, Yerramreddy TR, Ghosh P, et al. (2010). In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. J Control Release 146:37–44.
   PubMed Web of Science ®Google Scholar
• Möschwitzer JP. (2013). Drug nanocrystals in the commercial pharmaceutical development process. Int J Pharm 453:142–56.
   PubMed Web of Science ®Google Scholar
• Niwa T, Miura S, Danjo K. (2011). Design of dry nanosuspension with highly spontaneous dispersible characteristics to develop solubilized formulation for poorly water-soluble drugs. Pharm Res 28:2339–49.
   PubMed Web of Science ®Google Scholar
• Nothnagel L, Wacker MG. (2018). How to measure release from nanosized carriers? Eur J Pharm Sci 120:199–211.
   PubMed Web of Science ®Google Scholar
• Oktay AN, Ilbasmis-Tamer S, Celebi N. (2019). The effect of critical process parameters of the high pressure homogenization technique on the critical quality attributes of flurbiprofen nanosuspensions. Pharm Dev Technol 24:1278–86.
   PubMed Web of Science ®Google Scholar
• Oktay AN, Ilbasmis-Tamer S, Karakucuk A, et al. (2020). Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design. J Drug Deliv Sci Technol 57:101690.
   Web of Science ®Google Scholar
• Oktay AN, Karakucuk A, Ilbasmis-Tamer S, et al. (2018). Dermal flurbiprofen nanosuspensions: optimization with design of experiment approach and in vitro evaluation. Eur J Pharm Sci 122:254–63.
   PubMed Web of Science ®Google Scholar
• Pan D, Zheng X, Zhang Q, et al. (2020). Dendronized-polymer disturbing cells’ stress protection by targeting metabolism leads to tumor vulnerability. Adv Mater 32:e1907490.
   PubMed Web of Science ®Google Scholar
• Pardeike J, Müller RH. (2010). Nanosuspensions: a promising formulation for the new phospholipase A2 inhibitor PX-18. Int J Pharm 391:322–9.
   PubMed Web of Science ®Google Scholar
• Parmentier J, Tan EH, Low A, et al. (2017). Downstream drug product processing of itraconazole nanosuspension: Factors influencing drug particle size and dissolution from nanosuspension-layered beads. Int J Pharm 524:443–53.
   PubMed Web of Science ®Google Scholar
• Pasquali RC, Taurozzi MP, Bregni C. (2008). Some considerations about the hydrophilic-lipophilic balance system. Int J Pharm 356:44–51.
   PubMed Web of Science ®Google Scholar
• Patel PJ, Gajera BY, Dave RH. (2018). A quality-by-design study to develop Nifedipine nanosuspension: examining the relative impact of formulation variables, wet media milling process parameters and excipient variability on drug product quality attributes. Drug Dev Ind Pharm 44:1942–52.
   PubMed Web of Science ®Google Scholar
• Peltonen L, Hirvonen J. (2010). Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods. J Pharm Pharmacol 62:1569–79.
   PubMed Web of Science ®Google Scholar
• Pi J, Wang S, Li W, et al. (2019). A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein. Asian J Pharm Sci 14:154–64.
   PubMed Web of Science ®Google Scholar
• Pyo SM, Hespeler D, Keck CM, et al. (2017). Dermal miconazole nitrate nanocrystals – formulation development, increased antifungal efficacy & skin penetration. Int J Pharm 531:350–9.
   PubMed Web of Science ®Google Scholar
• Rachmawati H, Rahma A, Al Shaal L, et al. (2016). Destabilization mechanism of ionic surfactant on curcumin nanocrystal against electrolytes. Sci Pharm 84:685–93.
   PubMed Web of Science ®Google Scholar
• Rangel-Yagui CO, Pessoa A, Jr., Tavares LC. (2005). Micellar solubilization of drugs. J Pharm Pharm Sci 8:147–65.
   PubMed Web of Science ®Google Scholar
• Rettig H, Mysicka J. (2008). IVIVC: Methods and applications in modified-release product development. Dissolution Technol 15:6–8.
   Web of Science ®Google Scholar
• Roos C, Dahlgren D, Sjogren E, et al. (2018). Jejunal absorption of aprepitant from nanosuspensions: role of particle size, prandial state and mucus layer. Eur J Pharm Biopharm 132:222–30.
   PubMed Web of Science ®Google Scholar
• Salazar J, Ghanem A, Muller RH, et al. (2012). Nanocrystals: comparison of the size reduction effectiveness of a novel combinative method with conventional top-down approaches. Eur J Pharm Biopharm 81:82–90.
   PubMed Web of Science ®Google Scholar
• Salazar J, Müller RH, Möschwitzer JP. (2013). Application of the combinative particle size reduction technology H 42 to produce fast dissolving glibenclamide tablets. Eur J Pharm Sci 49:565–77.
   PubMed Web of Science ®Google Scholar
• Sauron R, Wilkins M, Jessent V, et al. (2006). Absence of a food effect with a 145 mg nanoparticle fenofibrate tablet formulation. Int J Clin Pharmacol Ther 44:64–70.
   PubMed Web of Science ®Google Scholar
• Shah SMH, Ullah F, Khan S, et al. (2017). Fabrication and evaluation of smart nanocrystals of artemisinin for antimalarial and antibacterial efficacy. Afr J Tradit Complement Altern Med 14:251–62.
   PubMedGoogle Scholar
• Shi HQG, Farber L, Michaels JN, et al. (2003). Characterization of crystalline drug nanoparticles using atomic force microscopy and complementary techniques. Pharm Res 20:479–84.
   PubMed Web of Science ®Google Scholar
• Sievens-Figueroa L, Pandya N, Bhakay A, et al. (2012). Using USP I and USP IV for discriminating dissolution rates of nano- and microparticle-loaded pharmaceutical strip-films. AAPS PharmSciTech 13:1473–82.
   PubMed Web of Science ®Google Scholar
• Singare DS, Marella S, Gowthamrajan K, et al. (2010). Optimization of formulation and process variable of nanosuspension: an industrial perspective. Int J Pharm 402:213–20.
   PubMed Web of Science ®Google Scholar
• Singh SK, Srinivasan KK, Gowthamarajan K, et al. (2011). Investigation of preparation parameters of nanosuspension by top-down media milling to improve the dissolution of poorly water-soluble glyburide. Eur J Pharm Biopharm 78:441–6.
   PubMed Web of Science ®Google Scholar
• Singh SK, Vaidya Y, Gulati M, et al. (2016). Nanosuspension: principles, perspectives and practices. Curr Drug Deliv 13:1222–46.
   PubMed Web of Science ®Google Scholar
• Su JQ, Guo Q, Chen YL, et al. (2020). Utilization of beta-lactoglobulin- (-)-Epigallocatechin-3-gallate(EGCG) composite colloidal nanoparticles as stabilizers for lutein pickering emulsion. Food Hydrocoll 98:105293.
   Web of Science ®Google Scholar
• Teeranachaideekul V, Junyaprasert VB, Souto EB, et al. (2008). Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology. Int J Pharm 354:227–34.
   PubMed Web of Science ®Google Scholar
• Toziopoulou F, Malamatari M, Nikolakakis I, et al. (2017). Production of aprepitant nanocrystals by wet media milling and subsequent solidification. Int J Pharm 533:324–34.
   PubMed Web of Science ®Google Scholar
• Tuomela A, Hirvonen J, Peltonen L. (2016). Stabilizing agents for drug nanocrystals: effect on bioavailability. Pharmaceutics 8:16.
   PubMed Web of Science ®Google Scholar
• Van Eerdenbrugh B, Froyen L, Van Humbeeck J, et al. (2008). Drying of crystalline drug nanosuspensions-the importance of surface hydrophobicity on dissolution behavior upon redispersion. Eur J Pharm Sci 35:127–35.
   PubMed Web of Science ®Google Scholar
• Van Eerdenbrugh B, Van den Mooter G, Augustijns P. (2008). Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm 364:64–75.
   PubMed Web of Science ®Google Scholar
• Van Eerdenbrugh B, Vermant J, Martens JA, et al. (2009). A screening study of surface stabilization during the production of drug nanocrystals. J Pharm Sci 98:2091–103.
   PubMed Web of Science ®Google Scholar
• Verma S, Gokhale R, Burgess DJ. (2009). A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int J Pharm 380:216–22.
   PubMed Web of Science ®Google Scholar
• Verma S, Huey BD, Burgess DJ. (2009). Scanning probe microscopy method for nanosuspension stabilizer selection. Langmuir 25:12481–7.
   PubMed Web of Science ®Google Scholar
• Verma S, Kumar S, Gokhale R, et al. (2011). Physical stability of nanosuspensions: investigation of the role of stabilizers on Ostwald ripening. Int J Pharm 406:145–52.
   PubMed Web of Science ®Google Scholar
• Wang Y, Gong X. (2017a). Special oleophobic and hydrophilic surfaces: approaches, mechanisms, and applications. J Mater Chem A 5:3759–73.
   Web of Science ®Google Scholar
• Wang Y, Gong X. (2017b). Superhydrophobic coatings with periodic ring structured patterns for self-cleaning and oil-water separation. Adv Mater Interfaces 4:1700190.
   Web of Science ®Google Scholar
• Wang Y, Liu Z, Zhang D, et al. (2011). Development and in vitro evaluation of deacety mycoepoxydiene nanosuspension. Colloids Surf B Biointerfaces 83:189–97.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zheng Y, Zhang L, et al. (2013). Stability of nanosuspensions in drug delivery. J Control Release 172:1126–41.
   PubMed Web of Science ®Google Scholar
• Wei Q, Keck CM, Muller RH. (2018). Solidification of hesperidin nanosuspension by spray drying optimized by design of experiment (DoE). Drug Dev Ind Pharm 44:1–12.
   PubMed Web of Science ®Google Scholar
• Xia D, Cui F, Piao H, et al. (2010). Effect of crystal size on the in vitro dissolution and oral absorption of nitrendipine in rats. Pharm Res 27:1965–76.
   PubMed Web of Science ®Google Scholar
• Xie Y, Ma Y, Xu J, et al. (2016). Panax notoginseng saponins as a novel nature stabilizer for poorly soluble drug nanocrystals: a case study with baicalein. Molecules 21:1149.
   PubMed Web of Science ®Google Scholar
• Xie YB, Yue PF, Dan JX, et al. (2016). Research progress of in vitro release evaluation methods for nano preparation. Chin Pharmaceutical J 51:861–6.
   Google Scholar
• Yue PF, Li G, Dan JX, et al. (2014). Study on formability of solid nanosuspensions during solidification: II novel roles of freezing stress and cryoprotectant property. Int J Pharm 475:35–48.
   PubMed Web of Science ®Google Scholar
• Yue PF, Li Y, Wan J, et al. (2013). Study on formability of solid nanosuspensions during nanodispersion and solidification: I. Novel role of stabilizer/drug property. Int J Pharm 454:269–77.
   PubMed Web of Science ®Google Scholar
• Zhai Z, Xu P, Yao J, et al. (2020). Erythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy. Drug Deliv 27:387–99.
   PubMed Web of Science ®Google Scholar
• Zhang D, Tan T, Gao L, et al. (2007). Preparation of azithromycin nanosuspensions by high pressure homogenization and its physicochemical characteristics studies. Drug Dev Ind Pharm 33:569–75.
   PubMed Web of Science ®Google Scholar
• Zhang H, Meng Y, Wang X, et al. (2014). Pharmaceutical and pharmacokinetic characteristics of different types of fenofibrate nanocrystals prepared by different bottom-up approaches. Drug Deliv 21:588–94.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wu Y, Li Z, et al. (2020). Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy. Carbohydr Polym 247:116749.
   PubMed Web of Science ®Google Scholar
• Zhang XY, Li Q, Sun JX, et al. (2014). Influences of nanometer effects on the characters of water-insoluble drug aprepitant in vivo and in vitro. Chin Pharmaceutical J 49:1226–32.
   Google Scholar
• Zhou Y, Du J, Wang L, et al. (2016). State of the art of nanocrystals technology for delivery of poorly soluble drugs. J Nanopart Res 18:257.
   Web of Science ®Google Scholar
• Zuo B, Sun Y, Li H, et al. (2013). Preparation and in vitro/in vivo evaluation of fenofibrate nanocrystals. Int J Pharm 455:267–75.
   PubMed Web of Science ®Google Scholar
• Zwanzig R, Harrison AK. (1985). Modifications of the Stokes–Einstein formula. J Chem Phys 83:5861–2.
   Web of Science ®Google Scholar