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Research Article

Enhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks

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Pages 826-843 | Received 24 Jan 2021, Accepted 15 Mar 2021, Published online: 30 Apr 2021

References

  • Abdel-Salam FS, Mahmoud AA, Ammar HO, Elkheshen SA. (2017). Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. J Liposome Res 27:41–55.
  • Abdеlaziz RR, Еlmahdy MK, Suddek GM. (2018). Flavocoxid attenuates airway inflammation in ovalbumin-induced mouse asthma model. Chem Biol Interact 292:15–23.
  • Aburahma MH, El-Laithy HM, Hamza YE. (2010). Oral bioavailability enhancement of vinpocetine using self-microemulsifying drug delivery system containing long chain triglycerides: preparation and in vitro/in vivo evaluation. Clin Res Regul Aff 27:97–107.
  • Alam T, Khan S, Gaba B, et al. (2018). Adaptation of quality by design-based development of isradipine nanostructured–lipid carrier and its evaluation for in vitro gut permeation and in vivo solubilization fate. J Pharm Sci 107:2914–26.
  • Ali M. (2010). Pulmonary drug delivery. Kulkarni VS. Handbook of non-invasive drug delivery systems. Amsterdam: Elsevier, 209–46.
  • Almousallam M, Moia C, Zhu H. (2015). Development of nanostructured lipid carrier for dacarbazine delivery. Int Nano Lett 5:241–8.
  • Anarjan N, Jaberi N, Yeganeh-Zare S, et al. (2014). Optimization of mixing parameters for α-tocopherol nanodispersions prepared using solvent displacement method. J Am Oil Chem Soc 91:1397–405.
  • Anarjan N, Jafarizadeh-Malmiri H, Nehdi IA, et al. (2015). Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique. Int J Nanomedicine 10:1109–18.
  • Arbain NH, Basri M, Salim N, et al. (2018). Development and characterization of aerosol nanoemulsion system encapsulating low water soluble quercetin for lung cancer treatment. Mater Today Proc 5:S137–S42.
  • Athas JC, Jun K, McCafferty C, et al. (2014). An effective dispersant for oil spills based on food-grade amphiphiles. Langmuir 30:9285–94.
  • Banerjee P, Geng T, Mahanty A, et al. (2019). Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors. Int J Pharm 557:374–89.
  • Bao Z-S, Hong L, Guan Y, et al. (2011). Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma. Int Immunopharmacol 11:899–906.
  • Barnes P. (2010). Inhaled corticosteroids. Pharmaceuticals (Basel) 3:514–40.
  • Barnes PJ. (2016). Glucocorticosteroids. Handb Exp Pharmacol 237:93–115.
  • Beloqui A, Solinís MÁ, Rodríguez-Gascón A, et al. (2016). Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomedicine 12:143–61.
  • Berry M, Hargadon B, Morgan A, et al. (2005). Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma. Eur Respir J 25:986–91.
  • Bharatwaj B, Wu L, Whittum-Hudson JA, da Rocha SRP. (2010). The potential for the noninvasive delivery of polymeric nanocarriers using propellant-based inhalers in the treatment of chlamydial respiratory infections. Biomaterials 31:7376–85.
  • Boulet L-P, Bateman ED, Voves R, et al. (2007). A randomized study comparing ciclesonide and fluticasone propionate in patients with moderate persistent asthma. Respir Med 101:1677–86.
  • Boulet L-P, Drollmann A, Magyar P, et al. (2006). Comparative efficacy of once-daily ciclesonide and budesonide in the treatment of persistent asthma. Respir Med 100:785–94.
  • Chana J, Forbes B, Jones SA. (2015). Triggered-release nanocapsules for drug delivery to the lungs. Nanomedicine 11:89–97.
  • Cheng M, Pan H, Dai Y, et al. (2018). Phosphatidylcholine regulates NF-κB activation in attenuation of LPS-induced inflammation: evidence from in vitro study. Animal Cells Syst (Seoul) 22:7–14.
  • Choudhary V, Uaratanawong R, Patel RR, et al. (2019). Phosphatidylglycerol inhibits toll-like receptor-mediated inflammation by danger-associated molecular patterns. J Invest Dermatol 139:868–77.
  • Chung KF, Marwick JA. (2010). Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 1203:85–91.
  • Comhair SAA, Ricci KS, Arroliga M, et al. (2005). Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. Am J Respir Crit Care Med 172:306–13.
  • Corren J, Tashkin DP. (2003). Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthma. Clin Ther 25:776–98.
  • Da Cunha AA, Nuñez NK, De Souza RH, et al. (2016). Recombinant human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model. Exp Lung Res 42:66–74.
  • Danaei M, Dehghankhold M, Ataei S, et al. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics 10:57.
  • Dhand R, Dolovich M, Chipps B, et al. (2012). The role of nebulized therapy in the management of COPD: evidence and recommendations. J Chronic Obstr Pulm Dis 9:58–72.
  • Douafer H, Andrieu V, Wafo E, Brunel JM. (2020). Characterization of a new aerosol antibiotic/adjuvant combination for the treatment of P. aeruginosa lung infections. Int J Pharm 586:1–10.
  • Drollmann A, Nave R, Steinijans VW, et al. (2006). Equivalent pharmacokinetics of the active metabolite of ciclesonide with and without use of the AeroChamber PlusTM spacer for inhalation. Clin Pharmacokinet 45:729–36.
  • Durán-Lobato M, Martín-Banderas L, Lopes R, et al. (2016). Lipid nanoparticles as an emerging platform for cannabinoid delivery: physicochemical optimization and biocompatibility. Drug Dev Ind Pharm 42:190–8.
  • Elena Fernández Fernández BS-C, Santi Cd, Ramsey JM, et al. (2018). Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies. Materials (Basel) 11:122.
  • El-Housiny S, Shams Eldeen MA, El-Attar YA, et al. (2018). Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study. Drug Deliv 25:78–90.
  • Elkady EF, Fouad MA. (2011). Forced degradation study to develop and validate stability-indicating RP-LC method for the determination of ciclesonide in bulk drug and metered dose inhalers. Talanta 87:222–9.
  • Elkady OA, Tadros MI, El-Laithy HM. (2020). QbD approach for novel crosslinker-free ionotropic gelation of risedronate sodium – chitosan nebulizable microspheres: optimization and characterization. AAPS PharmSciTech 21:1–18.
  • El-Kamel AH, Al-Fagih IM, Alsarra IA. (2007). Testosterone solid lipid microparticles for transdermal drug delivery. Formulation and physicochemical characterization. J Microencapsul 24:457–75.
  • El-Kashef DH, Serrya MS. (2019). Sitagliptin ameliorates thioacetamide-induced acute liver injury via modulating TLR4/NF-KB signaling pathway in mice. Life Sci 228:266–73.
  • El-Kashef DH. (2018). Nicorandil alleviates ovalbumin-induced airway inflammation in a mouse model of asthma. Environ Toxicol Pharmacol 59:132–7.
  • El-Laithy HM, Badawi A, Abdelmalak NS, Elsayyad NME. (2019). Stabilizing excipients for engineered clopidogrel bisulfate procubosome derived in situ cubosomes for enhanced intestinal dissolution: stability and bioavailability considerations. Eur J Pharm Sci 136:104954.
  • El-laithy HM, Badawi A, Abdelmalak S, El-Sayyad N. (2018). Cubosomes as oral drug delivery systems: a promising approach for enhancing the release of clopidogrel bisulphate in the intestine. Chem Pharm Bull 66:1–10.
  • Elmowafy M, Ibrahim HM, Ahmed MA, et al. (2017). Atorvastatin-loaded nanostructured lipid carriers (NLCs): strategy to overcome oral delivery drawbacks. Drug Deliv 24:932–41.
  • Elmowafy M, Shalaby K, Badran MM, et al. (2018). Multifunctional carbamazepine loaded nanostructured lipid carrier (NLC) formulation. Int J Pharm 550:359–71.
  • Erõs G, Varga G, Váradi R, et al. (2009). Anti-inflammatory action of a phosphatidylcholine, phosphatidylethanolamine and N-acylphosphatidylethanolamine-enriched diet in carrageenan-induced pleurisy. Eur Surg Res 42:40–8.
  • Evans DF, Wennerstrom H. The colloidal domain: where physics, chemistry, biology, and technology meet. New York: Wiley-VCH; 2001.
  • Fu T-T, Zhao Y, Yang F-F, et al. (2018). Ciclesonide and budesonide suspensions for nebulization delivery: an in vivo inhalation biopharmaceutics investigation. Int J Pharm 549:21–30.
  • Gartziandia O, Herrán E, Pedraz JL, et al. (2015). Chitosan coated nanostructured lipid carriers for brain delivery of proteins by intranasal administration. Colloids Surf B Biointerfaces 134:304–13.
  • Gonzalez-Mira E, Egea MA, Souto EB, et al. (2011). Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery. Nanotechnology 22:045101.
  • Granja A, Vieira AC, Chaves LL, et al. (2017). Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate. Food Chem 237:803–10.
  • Griffiths HR, Gao D, Pararasa C. (2017). Redox regulation in metabolic programming and inflammation. Redox Biol 12:50–7.
  • Guilherme VA, Ribeiro LNM, Alcântara ACS, de castro SR. (2019). Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration. Sci Rep 9:1–11.
  • Hamdani J, Moës AJ, Amighi K. (2003). Physical and thermal characterisation of Precirol® and Compritol® as lipophilic glycerides used for the preparation of controlled-release matrix pellets. Int J Pharm 260:47–57.
  • Han F, Li S, Yin R, et al. (2008). Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: nanostructured lipid carriers. Colloids Surf A Physicochem Eng Aspects 315:210–6.
  • Hartmann P, Szabó A, Eros G, et al. (2009). Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats. Eur J Pharmacol 622:58–64.
  • Hassanzadeh P, Arbabi E, Rostami F, et al. (2017). Aerosol delivery of ferulic acid-loaded nanostructured lipid carriers: a promising treatment approach against the respiratory disorders. Physiol Pharmacol Physiol 21:331–42.
  • Hsu J, Qin X, Beavers SF, Mirabelli MC. (2016). Asthma-related school absenteeism, morbidity, and modifiable factors. Am J Prev Med 51:23–32.
  • Huang Z, Hua S, Yang Y, Fang J. (2008). Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion. Acta Pharmacol Sin 29:1094–102.
  • Huang J, Wang Q, Li T, et al. (2017). Nanostructured lipid carrier (NLC) as a strategy for encapsulation of quercetin and linseed oil: preparation and in vitro characterization studies. J Food Eng 215:1–12.
  • Huguet-Casquero A, Moreno-Sastre M, López-Méndez TB, et al. (2020). Encapsulation of oleuropein in nanostructured lipid carriers: biocompatibility and antioxidant efficacy in lung epithelial cells. Pharmaceutics 12:429–2.
  • Hussain SM, Ayesha Farhana S, Alnasser SM. (2018). Time trends and regional variation in prevalence of asthma and associated factors in Saudi Arabia: a systematic review and meta-analysis. Biomed Res Int 2018:8102527.
  • Ibrahim M, Verma R, Garcia-Contreras L. (2015). Inhalation drug delivery devices: technology update. Med Devices 8:131–9.
  • Impellizzeri D, Di Paola R, Esposito E, et al. (2011). CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. Eur J Pharmacol 668:305–16.
  • Ioachimescu OC, Desai NS. (2019). Nonallergic triggers and comorbidities in asthma exacerbations and disease severity. Clin Chest Med 40:71–85.
  • Jana P, Sabrina W, Hans P, et al. (2016). Itraconazole-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons. Eur J Pharm Biopharm 108:269–76.
  • Joshi M, Patravale V. (2006). Formulation and evaluation of nanostructured lipid carrier (NLC)-based gel of valdecoxib. Drug Dev Ind Pharm 32:911–8.
  • Jung YY, Nam Y, Park YS, et al. (2013). Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury. Korean J Physiol Pharmacol 17:209–16.
  • Kallakunta VR, Tiwari R, Sarabu S, et al. (2018). Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: a comparative study. Eur J Pharm Sci 121:126–38.
  • Kamimura M, Izumi S, Hamamoto Y, et al. (2012). Superiority of nebulized corticosteroids over dry powder inhalers in certain patients with cough variant asthma or cough-predominant asthma. Allergol Int 61:411–7.
  • Kenyon NJ, Bratt JM, Lee J, et al. (2013). Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. PLoS One 8:e77730.
  • Khames A, Khaleel MA, El-Badawy MF, El-Nezhawy AOH. (2019). Natamycin solid lipid nanoparticles – sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization. Int J Nanomedicine 14:2515–31.
  • Kovacevic A, Savic S, Vuleta G, et al. (2011). Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure. Int J Pharm 406:163–72.
  • Kovačević AB, Müller RH, Keck CM. (2020). Formulation development of lipid nanoparticles: improved lipid screening and development of tacrolimus loaded nanostructured lipid carriers (NLC). Int J Pharm 576:118918.
  • Kumar S, Meena VK, Hazari PP, Sharma RK. (2016). FITC-dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications. Int J Pharm 506:242–52.
  • Labiris NR, Dolovich MB. (2003). Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56:600–12.
  • Lavorini F, Pedersen S, Usmani OS. (2017). Dilemmas, confusion, and misconceptions related to small airways directed therapy. Chest 151:1345–55.
  • Leung SY, Eynott P, Nath P, Chung KF. (2005). Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. J Allergy Clin Immunol 115:989–96.
  • Levy GK, Kafri A, Ventura Y, Leon A. (2019). Surface stabilization treatment enhances initial cell viability and adhesion for biodegradable zinc alloys. Mater Lett 248:130–3.
  • Li-Blatter X, Nervi P, Seelig A. (2009). Detergents as intrinsic P-glycoprotein substrates and inhibitors. Biochim Biophys Acta 1788:2335–44.
  • Lim WM, Rajinikanth PS, Mallikarjun C, Kang YB. (2014). Formulation and delivery of itraconazole to the brain using a nanolipid carrier system. Int J Nanomedicine 9:2117–26.
  • Luo X, Zhou Y, Bai L, et al. (2017). Production of highly concentrated oil-in-water emulsions using dual-channel microfluidization: use of individual and mixed natural emulsifiers (saponin and lecithin). Food Res Int 96:103–12.
  • Manconi M, Manca ML, Valenti D, et al. (2017). Chitosan and hyaluronan coated liposomes for pulmonary administration of curcumin. Int J Pharm 525:203–10.
  • Marklund S, Marklund G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469–74.
  • Marques MRC, Loebenberg R, Almukainzi M. (2011). Simulated biological fluids with possible application in dissolution testing. Dissolution Technol 18:15–28.
  • Matsuo Y, Ishihara T, Ishizaki J, et al. (2009). Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model. Cell Immunol 260:33–8.
  • Mendes IT, Ruela ALM, Carvalho FC, et al. (2019). Development and characterization of nanostructured lipid carrier-based gels for the transdermal delivery of donepezil. Colloids Surf B Biointerfaces 177:274–81.
  • Mendes AI, Silva AC, Catita JAM, et al. (2013). Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity. Colloids Surf B Biointerfaces 111:755–63.
  • Moreno-Sastre M, Pastor M, Esquisabel A, et al. (2016). Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm 498:263–73.
  • Morrison ID. (2002). Colloidal dispersions: suspensions, emulsions, and foams. New York: Wiley-VCH.
  • Mubarak AB, Mohamed HK. (2018). Fabrication and evaluation of phytomenadione as a nanostructure lipid carrier for enhancement of bioavailability. Pharm Dev Technol 23:382–6.
  • Myrdal PB, Sheth P, Stein SW. (2014). Advances in metered dose inhaler technology: formulation development. AAPS PharmSciTech 15:434–55.
  • Nadeem A, Raj HG, Chhabra SK. (2005). Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. Inflammation 29:23–32.
  • Nasab ME, Takzaree N, Saffaria PM, Partoazar A. (2019). In vitro antioxidant activity and in vivo wound-healing effect of lecithin liposomes: a comparative study. J Comp Eff Res 8:633–43.
  • Nave R, Mueller H. (2013). From inhaler to lung: clinical implications of the formulations of ciclesonide and other inhaled corticosteroids. Int J Gen Med 6:99–107.
  • Newman S, Salmon A, Nave R, Drollmann A. (2006). High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 100:375–84.
  • Ong CYD, Raja SS, Ridhima W, et al. (2019). Preparation, characterization and in-vitro efficacy of quercetin loaded liquid crystalline nanoparticles for the treatment of asthma. J Drug Deliv Sci Technol 54:101297.
  • Osama H, Sayed OM, Hussein RRS, et al. (2019). Design, optimization, characterization, and in vivo evaluation of sterosomes as a carrier of metformin for treatment of lung cancer. J Liposome Res 2104:1–13.
  • Pan Y, Tikekar RV, Nitin N. (2013). Effect of antioxidant properties of lecithin emulsifier on oxidative stability of encapsulated bioactive compounds. Int J Pharm 450:129–37.
  • Pardeike J, Weber S, Haber T, et al. (2011). Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. Int J Pharm 419:329–38.
  • Pastor M, Moreno-Sastre M, Esquisabel A, et al. (2014). Sodium colistimethate loaded lipid nanocarriers for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm 477:485–94.
  • Patil-Gadhe A, Kyadarkunte A, Patole M, Pokharkar V. (2014). Montelukast-loaded nanostructured lipid carriers: part II. Pulmonary drug delivery and in vitro–in vivo aerosol performance. Eur J Pharm Biopharm 88:169–77.
  • Patlolla RR, Chougule M, Patel AR, et al. (2010). Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release 144:233–41.
  • Pérez-Rosés R, Risco E, Vila R, et al. (2015). Antioxidant activity of Tween-20 and Tween-80 evaluated through different in-vitro tests. J Pharm Pharmacol 67:666–72.
  • Price D, Roche N, Christian Virchow J, et al. (2011). Device type and real-world effectiveness of asthma combination therapy: an observational study. Respir Med 105:1457–66.
  • Qutubuddin M, Singh SM, Nayak C, et al. (2018). Efficacy of individualized homeopathy in bronchial asthma in adults: double-blind, randomized, placebo-controlled, clinical trial in the context of usual care. Adv Integr Med
  • Rashid J, Patel B, Nozik-Grayck E, et al. (2017). Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH). J Control Release 250:96–106.
  • Ricciardolo FLM. (2003). Multiple roles of nitric oxide in the airways. Thorax 58:175–82.
  • Ritger PL, Peppas NA. (1987). A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release 5:37–42.
  • Sabater J, Masclans JR, Sacanell J, et al. (2011). Effects of an omega-3 fatty acid-enriched lipid emulsion on eicosanoid synthesis in acute respiratory distress syndrome (ARDS): a prospective, randomized, double-blind, parallel group study. Nutr Metab 8:1–7.
  • Said-Elbahr R, Nasr M, Alhnan MA, et al. (2016). Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer. Eur J Pharm Biopharm 103:1–12.
  • Salem LH, El-Feky GS, Fahmy RH, et al. (2020). Coated lipidic nanoparticles as a new strategy for enhancing nose-to-brain delivery of a hydrophilic drug molecule. J Pharm Sci 109:2237–51.
  • Salminen H, Helgason T, Aulbach S, et al. (2014). Influence of co-surfactants on crystallization and stability of solid lipid nanoparticles. J Colloid Interface Sci 426:256–63.
  • Sanad RA, Abdelmalak NS, Elbayoomy TS, Badawi AA. (2010). Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs). AAPS PharmSciTech 11:1684–94.
  • Sanchis J, Corrigan C, Levy ML, et al. (2013). Inhaler devices – from theory to practice. Respir Med 107:495–502.
  • Sanna V, Kirschvink N, Gustin P, et al. (2004). Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration. AAPS PharmSciTech 5:17.
  • Sasse SK, Altonsy MO, Kadiyala V, et al. (2016). Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol 311:L421–L32.
  • Severino P, Helena M, Santana A, Souto EB. (2012). Optimizing SLN and NLC by 2(2) full factorial design: effect of homogenization technique. Mater Sci Eng C Mater Biol Appl 32:1375–9.
  • Shchipunov YA, Schmiedel P. (1996). Phase behavior of lecithin at the oil/water interface. Langmuir 12:6443–5.
  • Shchipunov YA, Shumilina EV. (1995). Lecithin bridging by hydrogen bonds in the organogel. Mater Sci Eng 3:43–50.
  • Sherkawy MM, Abo-Youssef AM, Salama AAA, Ismaiel IE. (2018). Fluoxetine protects against OVA induced bronchial asthma and depression in rats. Eur J Pharmacol 837:25–32.
  • Shevalkar G, Vavia P. (2019). Solidified nanostructured lipid carrier (S-NLC) for enhancing the oral bioavailability of ezetimibe. J Drug Deliv Sci Technol 53:101211.
  • Silva M, Silva A, Fernandez-Lodeiro J, et al. (2017). Supercritical CO2-assisted spray drying of strawberry-like gold-coated magnetite nanocomposites in chitosan powders for inhalation. Materials (Basel) 10:74.
  • Silveira JS, Antunes GL, Kaiber DB, et al. (2019). Reactive oxygen species are involved in eosinophil extracellular traps release and in airway inflammation in asthma. J Cell Physiol 234:23633–46.
  • Singh A, Neupane YR, Mangla B, Kohli K. (2019). Nanostructured lipid carriers for oral bioavailability enhancement of exemestane: formulation design, in vitro, ex vivo, and in vivo studies. J Pharm Sci 108:3382–95.
  • Smithmaitrie P, Tangudomkit K. (2018). Multiphysics finite element modeling and validation of transient aerosol generation in an ultrasonic nebulizer drug delivery device. J Aerosol Sci 126:110–21.
  • Soleimanian Y, Amir S, Goli H, Sahafi SM. (2018). Formulation and characterization of novel nanostructured lipid carriers made from beeswax, propolis wax and pomegranate seed oil. Food Chem 244:83–92.
  • Treede I, Braun A, Jeliaskova P, et al. (2009). TNF-α-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. BMC Gastroenterol 9:11–53.
  • Ungaro F, d'Angelo I, Coletta C, et al. (2012). Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers. J Control Release 157:149–59.
  • Usmani OS. (2015). Small-airway disease in asthma: pharmacological considerations. Curr Opin Pulm Med 21:55–67.
  • van Wijck Y, Hiemstra PS, Taube C. (2018). Therapeutic application of an extract of helicobacter pylori ameliorates the development of allergic airway disease. J Immunol 200:1570–9.
  • Vogelmeier CF, Hering T, Lewin T, et al. (2011). Efficacy and safety of ciclesonide in the treatment of 24,037 asthmatic patients in routine medical care. Respir Med 105:186–94.
  • Weber S, Zimmer A, Pardeike J. (2014). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharm Biopharm 86:7–22.
  • Wijerathne CUB, Seob SC, Won SJ, et al. (2017). Isoimperatorin attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma. Int Immunopharmacol 49:67–76.
  • Xu W, Meng K, Tu Y, et al. (2017). Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells. Eur J Pharmacol 807:102–8.
  • Xu W, Hu M, Zhang Q, et al. (2018). Effects of anthraquinones from Cassia occidentalis L. on ovalbumin-induced airways inflammation in a mouse model of allergic asthma. J Ethnopharmacol 221:1–9.
  • Yoshihiko C, Kumiko G, Misawa M. (2012). Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells. Pharmacol Rep 64:454–8.
  • Yousry C, Elkheshen SA, El-Laithy HM, et al. (2017). Studying the influence of formulation and process variables on vancomycin-loaded polymeric nanoparticles as potential carrier for enhanced ophthalmic delivery. Eur J Pharm Sci 100:142–54.
  • Yu S, Go G, Kim W. (2019). Medium chain triglyceride (MCT) oil affects the immunophenotype via reprogramming of mitochondrial respiration in murine macrophages. Foods 8:1–13.
  • Yuting H, Kan X, Yao W, et al. (2019). AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway. Exp Gerontol 125:1–10.
  • Zeng M, Li Y, Jiang Y, et al. (2013). Local and systemic oxidative stress and glucocorticoid receptor levels in chronic obstructive pulmonary disease patients. Can Respir J 20:35–41.
  • Zhang H, Huang X, Mi J, et al. (2014). Improvement of pulmonary absorptions of poorly absorbable drugs using gelucire 44/14 as an absorption enhancer. J Pharm Pharmacol 66:1410–20.
  • Zhao J, Stenzel MH. (2018). Entry of nanoparticles into cells: the importance of nanoparticle properties. Polym Chem 9:259–72.
  • Zhu B, Traini D, Young P, et al. (2015). Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition. Pharm Dev Technol 20:897–910.