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Research Article

Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model

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Pages 884-893 | Received 14 Feb 2021, Accepted 30 Mar 2021, Published online: 07 May 2021

References

  • Aderibigbe BA, Buyana B. (2018). Alginate in wound dressings. Pharmaceutics 10:42.
  • Alizadeh R, Bagher Z, Kamrava SK, et al. (2019a). Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: a comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs. J Chem Neuroanat 96:126–33.
  • Alizadeh R, Zarrintaj P, Kamrava SK, et al. (2019b). Conductive hydrogels based on agarose/alginate/chitosan for neural disorder therapy. Carbohydr Polym 224:115161.
  • Atoufi Z, Kamrava SK, Davachi SM, et al. (2019). Injectable PNIPAM/hyaluronic acid hydrogels containing multipurpose modified particles for cartilage tissue engineering: synthesis, characterization, drug release and cell culture study. Int J Biol Macromol 139:1168–81.
  • Chang J, DeLillo N, Khan M, Nacinovich M. (2013). Review of small intestine submucosa extracellular matrix technology in multiple difficult-to-treat wound types. Wounds 25:113–20.
  • Cooper D, Wang C, Patel R, et al. (2018). Human adipose-derived stem cell conditioned media and exosomes containing MALAT1 promote human dermal fibroblast migration and ischemic wound healing. Adv Wound Care (New Rochelle) 7:299–308.
  • Ferreira ADF, Gomes DA. (2018). Stem cell extracellular vesicles in skin repair. Bioengineering (Basel) 6:4.
  • Fitzsimmons REB, Mazurek MS, Soos A, Simmons CA. (2018). Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering. Stem Cells Int 2018:8031718.
  • Gantwerker EA, Hom DB. (2012). Skin: histology and physiology of wound healing. Clin Plast Surg 39:85–97.
  • Ha DH, Kim HK, Lee J, et al. (2020). Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration. Cells 9:1157.
  • Hsu L-C, Peng B-Y, Chen M-S, et al. (2019). The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: in vitro and in vivo evaluation. J Biomed Mater Res B Appl Biomater 107:278–85.
  • Hu L, Wang J, Zhou X, et al. (2016). Exosomes derived from human adipose mesenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep 6:32993.
  • Kaisang L, Siyu W, Lijun F, et al. (2017). Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing. J Surg Res 217:63–74.
  • Kasuya A, Tokura Y. (2014). Attempts to accelerate wound healing. J Dermatol Sci 76:169–72.
  • Kazeminava F, Arsalani N, Akbari A. (2018). POSS nanocrosslinked poly (ethylene glycol) hydrogel as hybrid material support for silver nanocatalyst. Appl Organometal Chem 32:e4359.
  • Khanmohammadi M, Sakai S, Taya M. (2017). Impact of immobilizing of low molecular weight hyaluronic acid within gelatin-based hydrogel through enzymatic reaction on behavior of enclosed endothelial cells. Int J Biol Macromol 97:308–16.
  • Lai RC, Yeo RWY, Lim SK. (2015). Mesenchymal stem cell exosomes. Semin Cell Dev Biol 40:82–8.
  • Leijten J, Seo J, Yue K, et al. (2017). Spatially and temporally controlled hydrogels for tissue engineering. Mater Sci Eng R Rep 119:1–35.
  • Li D, Hu N, Yu Y, et al. (2017). Trajectories of multidimensional caregiver burden in Chinese informal caregivers for dementia: evidence from exploratory and confirmatory factor analysis of the Zarit Burden Interview. J Alzheimers Dis 59:1317–25.
  • Li M, Liang Y, He J, et al. (2020). Two-pronged strategy of biomechanically active and biochemically multifunctional hydrogel wound dressing to accelerate wound closure and wound healing. Chem Mater 32:9937–53.
  • Li M, Tao S-C, Ke Q-F, et al. (2016). Fabrication of hydroxyapatite/chitosan composite hydrogels loaded with exosomes derived from miR-126-3p overexpressed synovium mesenchymal stem cells for diabetic chronic wound healing. J Mater Chem B 4:6830–41.
  • Li P, Kaslan M, Lee SH, et al. (2017). Progress in exosome isolation techniques. Theranostics 7:789–804.
  • Liang X, Zhang L, Wang S, et al. (2016). Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a. J Cell Sci 129:2182–9.
  • Liang Y, Zhao X, Hu T, et al. (2019). Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing. Small 15:e1900046.
  • Liu H, Wang C, Li C, et al. (2018). A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Adv 8:7533–49.
  • Newberry CI, Thomas JR, Cerrati EW. (2018). Facial scar improvement procedures. Facial Plast Surg 34:448–57.
  • Nooshabadi VT, Khanmohamadi M, Valipour E, et al. (2020). Impact of exosome-loaded chitosan hydrogel in wound repair and layered dermal reconstitution in mice animal model. J Biomed Mater Res A 108:2138–49.
  • Qu J, Zhao X, Liang Y, et al. (2018). Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. Biomaterials 183:185–99.
  • Rani S, Ritter T. (2016). The exosome – a naturally secreted nanoparticle and its application to wound healing. Adv Mater 28:5542–52.
  • Rice JJ, Martino MM, De Laporte L, et al. (2013). Engineering the regenerative microenvironment with biomaterials. Adv Healthc Mater 2:57–71.
  • Rosca A, Tutuianu R, Titorencu I. (2018). Mesenchymal stromal cells derived exosomes as tools for chronic wound healing therapy. Roman J Morphol Embryol 59:655–662.
  • Shabbir A, Cox A, Rodriguez-Menocal L, et al. (2015). Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro. Stem Cells Dev 24:1635–47.
  • Shafei S, Khanmohammadi M, Heidari R, et al. (2020). Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: an in vivo study. J Biomed Mater Res A 108:545–56.
  • Shi Q, Qian Z, Liu D, et al. (2017). GMSC-derived exosomes combined with a chitosan/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model. Front Physiol 8:904.
  • Shi Y, Shu B, Yang R, et al. (2015). Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. Stem Cell Res Ther 6:120.
  • Simorgh S, Alizadeh R, Eftekharzadeh M, et al. (2019). Olfactory mucosa stem cells: an available candidate for the treatment of the Parkinson's disease. J Cell Physiol 234:23763–73.
  • Soleymani M, Akbari A, Mahdavinia G. (2019). Magnetic PVA/laponite RD hydrogel nanocomposites for adsorption of model protein BSA. Polym Bull 76:2321–40.
  • Tao S-C, Guo S-C, Li M, et al. (2017). Chitosan wound dressings incorporating exosomes derived from microRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model. Stem Cells Transl Med 6:736–47.
  • Tricarico C, Clancy J, D'Souza-Schorey C. (2017). Biology and biogenesis of shed microvesicles. Small GTPases 8:220–32.
  • Trkov S, Eng G, Di Liddo R, et al. (2010). Micropatterned three-dimensional hydrogel system to study human endothelial–mesenchymal stem cell interactions. J Tissue Eng Regen Med 4:205–15.
  • Wang C, Liang C, Wang R, et al. (2019). The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing. Biomater Sci 8:313–24.
  • Wang L, Gu Z, Zhao X, et al. (2016). Extracellular vesicles released from human umbilical cord-derived mesenchymal stromal cells prevent life-threatening acute graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation. Stem Cells Dev 25:1874–83.
  • Wang C, Wang M, Xu T, et al. (2019). Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration. Theranostics 9:65–76.
  • Wang W, Li P, Li W, et al. (2017). Osteopontin activates mesenchymal stem cells to repair skin wound. PLoS One 12:e0185346.
  • Xu H, Huang S, Wang J, et al. (2019). Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells. Int J Biol Macromol 137:433–41.
  • Xu Q, Sigen A, Gao Y, et al. (2018). A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing. Acta Biomater 75:63–74.
  • Yim N, Ryu SW, Choi K, et al. (2016). Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module. Nat Commun 7:12277.
  • Zhang J, Guan J, Niu X, et al. (2015). Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med 13:49.
  • Zhang K, Zhao X, Chen X, et al. (2018). Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS Appl Mater Interfaces 10:30081–91.
  • Zhang X, Li J, Ye P, et al. (2017). Coculture of mesenchymal stem cells and endothelial cells enhances host tissue integration and epidermis maturation through AKT activation in gelatin methacryloyl hydrogel-based skin model. Acta Biomater 59:317–26.
  • Zhao X, Liang Y, Huang Y, et al. (2020). Physical double‐network hydrogel adhesives with rapid shape adaptability, fast self‐healing, antioxidant and NIR/pH stimulus‐responsiveness for multidrug‐resistant bacterial infection and removable wound dressing. Adv Funct Mater 30:1910748.
  • Zhang Y, Chopp M, Meng Y, et al. (2015). Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg 122:856–67.
  • Zhou Y, Nie W, Zhao J, Yuan X. (2013). Rapidly in situ forming adhesive hydrogel based on a PEG-maleimide modified polypeptide through Michael addition. J Mater Sci Mater Med 24:2277–2286.