2,991
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis

ORCID Icon, ORCID Icon, , , ORCID Icon, ORCID Icon, , , , ORCID Icon, , , , , & show all
Pages 1043-1054 | Received 16 Apr 2021, Accepted 10 May 2021, Published online: 01 Jun 2021

References

  • Alghaith AF, Alshehri S, Alhakamy NA, Hosny KM. (2021). Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea. Drug Deliv 28:343–56. ‏
  • Altaei T, Ahmed SA. (2012). Topical treatment of herpes simplex lesion by lavender cream. J Bagh Coll Dent 24:70–6.
  • Aslani A, Zolfaghari B, Davoodvandi F. (2016). Design, formulation and evaluation of an oral gel from Punica Granatum flower extract for the treatment of recurrent Aphthous stomatitis. Adv Pharm Bull 6:391–8.
  • Balakrishnan P, Lee BJ, Oh DH, et al. (2009). Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm 374:66–72.
  • Bandara HMHN, Samaranayake LP. (2019). Viral, bacterial, and fungal infections of the oral mucosa: types, incidence, predisposing factors, diagnostic algorithms, and management. Periodontol 2000 80:148–76.
  • Białoń M, Krzyśko-Łupicka T, Nowakowska-Bogdan E, Wieczorek PP. (2019). Chemical composition of two different lavender essential oils and their effect on facial skin microbiota. Molecules 24:3270.
  • Billard A, Pourchet L, Malaise S, et al. (2015). Liposome-loaded chitosan physical hydrogel: toward a promising delayed-release biosystem. Carbohydr Polym 115:651–7..
  • Charman WN, Rogge MC, Boddy AW, Berger BM. (1993). Effect of food and a monoglyceride emulsion formulation on danazol bioavailability. J Clin Pharmacol 33:381–6.
  • Cherniakov I, Domb AJ, Hoffman A. (2015). Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects. Expert Opin Drug Deliv 12:1121–33.
  • de Matos SP, Teixeira HF, de Lima ÁAN, et al. (2019). Essential oils and isolated terpenes in nanosystems designed for topical administration: a review. Biomolecules 9:138.
  • Dong G, Bai X, Aimila A, et al. (2020). Study on lavender essential oil chemical compositions by GC-MS and improved pGC. Molecules 25:3166.
  • Eid AM, El-Enshasy HA, Aziz R, Elmarzugi NA. (2014). The preparation and evaluation of self-nanoemulsifying systems containing Swietenia oil and an examination of its anti-inflammatory effects. Int J Nanomedicine 9:4685–95.
  • El-Leithy ES, Shaker DS, Ghorab MK, Abdel-Rashid RS. (2010). Evaluation of mucoadhesive hydrogels loaded with diclofenac sodium-chitosan microspheres for rectal administration. AAPS PharmSciTech 11:1695–702.
  • Ghelardini C, Galeotti N, Salvatore G, Mazzanti G. (1999). Local anaesthetic activity of the essential oil of Lavandula angustifolia. Planta Med 65:700–3.
  • Ghica MV, Hîrjău M, Lupuleasa D, Dinu-Pîrvu CE. (2016). Flow and thixotropic parameters for rheological characterization of hydrogels. Molecules 21:786.
  • Gurram AK, Deshpande PB, Kar SS, et al. (2015). Role of components in the formation of self-microemulsifying drug delivery systems. Indian J Pharm Sci 77:249–57.
  • Hosny KM, Aldawsari HM, Bahmdan RH, et al. (2019). Preparation, optimization, and evaluation of hyaluronic acid-based hydrogel loaded with miconazole self-nanoemulsion for the treatment of oral thrush. AAPS PharmSciTech 20:1–12. ‏
  • Hosny KM, Bahmdan RH, Alhakamy NA, et al. (2020). Physically optimized nano-lipid carriers augment raloxifene and vitamin d oral bioavailability in healthy humans for management of osteoporosis. J Pharm Sci 109:2145–55. 2020‏
  • Hosny KM, Sindi AM, Alkhalidi HM, et al. (2021a). Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain. Drug Deliv 28:741–51. ‏
  • Hosny KM, Sindi AM, Bakhaidar RB, et al. (2021b). Formulation and optimization of neomycin Sulfate–Thioctic acid loaded in a eucalyptus oil self-nanoemulsion to enhance the beneficial activity of the substances and limit the side effects associated with the treatment of hepatic coma. J Drug Delivery Sci Technol 61:102108. ‏
  • Isailović TM, Todosijević MN, Đorđević SM, Savić SD. (2017). Chapter 7 - Natural surfactants-based micro/nanoemulsion systems for NSAIDs—practical formulation approach, physicochemical and biopharmaceutical characteristics/performances. Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs. In: Čalija BBT-M, NC for NA-ID, editor. Boston (MA): Academic Press, 179–217..
  • Jakab G, Fülöp V, Bozó T, et al. (2018). Optimization of quality attributes and atomic force microscopy imaging of reconstituted nanodroplets in baicalin loaded self-nanoemulsifying formulations. Pharmaceutics 10:275.
  • Jeong SW. (2019). Shear rate-dependent rheological properties of mine tailings: determination of dynamic and static yield stresses. Appl Sci 9:4744.
  • Kamatou GPP, Viljoen AM. (2008). Linalool – a review of a biologically active compound of commercial importance. Nat Prod Commun 3:1934578X0800300.
  • Kazi M, Shahba AA, Alrashoud S, Alwadei M, et al. (2020). Bioactive self-nanoemulsifying drug delivery systems (bio-SNEDDS) for combined oral delivery of curcumin and piperine. Molecules 25:1703.
  • Khan M, Nadhman A, Sehgal SA, et al. (2018). Formulation and characterization of a self-emulsifying drug delivery system (SEDDS) of curcumin for the topical application in cutaneous and mucocutaneous leishmaniasis. Curr Top Med Chem 18:1603–9.
  • Kienzle-Sterzer CA, Rodriguez-Sanchez D, Rha CK. (1985). Flow behavior of a cationic biopolymer: chitosan. Polym Bull 13:1–6.
  • Kim YH, Ghim JL, Jung JA, et al. (2015). Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers. Drug Des Devel Ther 9:3571–7.
  • Koulivand PH, Khaleghi Ghadiri M, Gorji A. (2013). Lavender and the nervous system. Evid Based Complement Alternat Med 2013:681304.
  • Król SK, Skalicka-Woźniak K, Kandefer-Szerszeń M, Stepulak A. (2013). The biological and pharmacological activity of essential oils in the treatment and prevention of infectious diseases. Postepy Hig Med Dosw 67:1000–7.
  • Lai F, Sinico C, De LA, et al. (2007). SLN as a topical delivery system for Artemisia arborescens essential oil: in vitro antiviral activity and skin permeation study. Int J Nanomedicine 2:419–25.
  • Lee CH, Moturi V, Lee Y. (2009). Thixotropic property in pharmaceutical formulations. J Control Release 136:88–98..
  • Li X, Kolltveit KM, Tronstad L, Olsen I. (2000). Systemic diseases caused by oral infection. Clin Microbiol Rev 13:547–58.
  • Miyazaki S, Takahashi A, Itoh K, et al. (2009). Preparation and evaluation of gel formulations for oral sustained delivery to dysphagic patients. Drug Dev Ind Pharm 35:780–7.
  • N Politis S, Colombo P, Colombo G, M Rekkas D. (2017). Design of experiments (DoE) in pharmaceutical development. Drug Dev Ind Pharm 43:889–901.
  • Niamprem P, Rujivipat S, Tiyaboonchai W. (2014). Development and characterization of lutein-loaded SNEDDS for enhanced absorption in Caco-2 cells. Pharm Dev Technol 19:735–42.
  • Opstelten W, Neven AK, Eekhof J. (2008). Treatment and prevention of herpes labialis. Can Fam Physician 54:1683–7.
  • Padamwar MN, Pokharkar VB. (2006). Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm 320:37–44..
  • Sakeena MHF, Elrashid SM, Munavvar AS, Azmin MN. (2011). Effects of oil and drug concentrations on droplets size of palm oil esters (POEs) nanoemulsion. J Oleo Sci 60:155–8.
  • Salem HF, Kharshoum RM, Sayed OM, Abdel Hakim LF. (2019). Formulation development of self-nanoemulsifying drug delivery system of celecoxib for the management of oral cavity inflammation. J Liposome Res 29:195–205.
  • Santosh A, Muddana K. (2020). Viral infections of oral cavity. J Fam Med Prim Care 9:36–42.
  • Schmid-Wendtner MH, Korting HC. (2004). Penciclovir cream-improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol 17:214–8.
  • Shahba AAW, Mohsin K, Alanazi FK. (2012). Novel self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of cinnarizine: design, optimization, and in-vitro assessment. AAPS PharmSciTech 13:967–77.
  • Sindi AM, Alharbi WS, Alkhalidi HM, et al. (2021). Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel for oral thrush and gingivitis. J Drug Deliv Sci Technol 63:102482..
  • Spruance SL, Rea TL, Thoming C, et al. (1997). Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical penciclovir collaborative study group. 277:1374–9.
  • Thanou M, Verhoef JC, Junginger HE. (2001a). Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev 50:91–101.
  • Thanou M, Verhoef JC, Junginger HE. (2001b). Oral drug absorption enhancement by chitosan and its derivatives. Adv Drug Deliv Rev 52:117–26.
  • Tripathi S, Kushwah V, Thanki K, Jain S. (2016). Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: implication of chemoprevention of breast cancer. Nanomedicine 12:1431–43.
  • Wilkes GL. (1981). An overview of the basic rheological behavior of polymer fluids with an emphasis on polymer melts. J Chem Educ 58:880.
  • Xu H, Shi M, Liu Y, et al. (2014). A novel in situ gel formulation of ranitidine for oral sustained delivery. Biomol Ther (Seoul) 22:161–5.
  • Yang LP, Wang WH. (2005). The influence of liposome on penciclovir penetration through mouse skin. Chin Pharm J 40:289–91.
  • Yoo J, Baskaran R, Yoo BK. (2013). Self-nanoemulsifying drug delivery system of lutein: physicochemical properties and effect on bioavailability of warfarin. Biomol Ther (Seoul) 21:173–9.
  • Zhu W, Guo C, Yu A, et al. (2009). Microemulsion-based hydrogel formulation of penciclovir for topical delivery. Int J Pharm 378:152–8..
  • Zhu W, Yu A, Wang W, et al. (2008). Formulation design of microemulsion for dermal delivery of penciclovir. Int J Pharm 360:184–90.