Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro, and in-vivo assessment

References

• Abou El Ela AESF, Khatib MME. (2014). Formulation and evaluation of new long acting metoprolol tartrate ophthalmic gels. Saudi Pharm J 22:555–63.
   PubMed Web of Science ®Google Scholar
• Alhakamy NA, Hosny KM. (2019). Nano-vesicular delivery system loaded by bifonazole: preparation, optimization, and assessment of pharmacokinetic and antifungal activity. J Drug Deliv Sci Technol 49:316–22.
   Web of Science ®Google Scholar
• Alharbi WS, Hosny KM. (2020). Development and optimization of ocular in situ gels loaded with ciprofloxacin cubic liquid crystalline nanoparticles. J Drug Deliv Sci Technol 57:101710.
   Web of Science ®Google Scholar
• Ansari Z, Miller D, Galor A. (2013). Current thoughts in fungal keratitis: diagnosis and treatment. Curr Fungal Infect Rep 7:209–18.
   PubMedGoogle Scholar
• Barriga HMG, Holme MN, Stevens MM. (2019). Cubosomes: the next generation of smart lipid nanoparticles? Angew Chem Int Ed Engl 58:2958–78.
   PubMed Web of Science ®Google Scholar
• Barry BW, Meyer MC. (1979). The rheological properties of carbopol gels I. Continuous shear and creep properties of carbopol gels. Int J Pharm 2:1–25.
   Web of Science ®Google Scholar
• Bessone CDV, Akhlaghi SP, Tártara LI, et al. (2021). Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma. Eur J Pharm Sci 160:105748.
   PubMed Web of Science ®Google Scholar
• Chang C, Meikle TG, Drummond CJ, et al. (2021). Comparison of cubosomes and liposomes for the encapsulation and delivery of curcumin. Soft Matter 17:3306–13.
   PubMed Web of Science ®Google Scholar
• Dubashynskaya N, Poshina D, Raik S, et al. (2019). Polysaccharides in ocular drug delivery. Pharmaceutics 12:22.
   PubMed Web of Science ®Google Scholar
• El-Enin HA, AL-Shanbari AH. (2018). Nanostructured liquid crystalline formulation as a remarkable new drug delivery system of anti-epileptic drugs for treating children patients. Saudi Pharm J 26:790–800.
   PubMed Web of Science ®Google Scholar
• Elfaky MA, Sirwi A, Tolba HH, et al. (2021). Development, optimization, and antifungal assessment of ocular gel loaded with ketoconazole cubic liquid crystalline nanoparticles. J Pharm Sci 110:2210–20.
   PubMed Web of Science ®Google Scholar
• ElMeshad AN, Mohsen AM. (2016). Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle. Drug Deliv 23:2115–23.
   PubMed Web of Science ®Google Scholar
• El-Nabarawi MA, Abd El Rehem RT, Teaima M, Abary M, et al. (2019). Natamycin niosomes as a promising ocular nanosized delivery system with ketorolac tromethamine for dual effects for treatment of candida rabbit keratitis; in vitro/in vivo and histopathological studies. Drug Dev Ind Pharm 45:922–36.
   PubMed Web of Science ®Google Scholar
• El-Nabarawi MA, Bendas ER, El Rehem RTA, Abary MYS. (2013). Transdermal drug delivery of paroxetine through lipid-vesicular formulation to augment its bioavailability. Int J Pharm 443:307–17.
   PubMed Web of Science ®Google Scholar
• Gilhotra RM, Nagpal K, Mishra DN. (2011). Azithromycin novel drug delivery system for ocular application. Int J Pharm Investig 1:22–8.
   PubMedGoogle Scholar
• Gorantla S, Rapalli VK, Waghule T, et al. (2020). Nanocarriers for ocular drug delivery: current status and translational opportunity. RSC Adv 10:27835–55.
   PubMed Web of Science ®Google Scholar
• Gupta S, Samanta MK, Raichur AM. (2010). Dual-drug delivery system based on in situ gel-forming nanosuspension of forskolin to enhance antiglaucoma efficacy. AAPS PharmSciTech 11:322–35.
   PubMed Web of Science ®Google Scholar
• Han S, Shen J, Gan Y, et al. (2010). Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability. Acta Pharmacol Sin 31:990–8.
   PubMed Web of Science ®Google Scholar
• Hartnett TE, O'Connor AJ, Ladewig K. (2015). Cubosomes and other potential ocular drug delivery vehicles for macromolecular therapeutics. Expert Opin Drug Deliv 12:1513–26.
   PubMed Web of Science ®Google Scholar
• Janga KY, Tatke A, Balguri SP, et al. (2018). Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation. Artif Cells Nanomed Biotechnol 46:1039–50.
   PubMed Web of Science ®Google Scholar
• Janga KY, Tatke A, Dudhipala N, et al. (2019). Gellan gum based sol-to-gel transforming system of natamycin transfersomes improves topical ocular delivery. J Pharmacol Exp Ther 370:814–22.
   PubMed Web of Science ®Google Scholar
• Kazi M, Dhakne R, Dehghan MH. (2020). Ocular delivery of natamycin based on monoolein/span 80/poloxamer 407 nanocarriers for the effectual treatment of fungal keratitis. JRP 24:251–63.
   Google Scholar
• Khames A, Khaleel MA, El-Badawy MF, El-Nezhawy AOH. (2019). Natamycin solid lipid nanoparticles – sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization. Int J Nanomedicine 14:2515–31.
   PubMed Web of Science ®Google Scholar
• Khare A, Grover K, Pawar P, Singh I. (2014). Mucoadhesive polymers for enhancing retention in ocular drug delivery: a critical review. Rev Adhes Adhesives 2:467–502.
   Google Scholar
• Klotz SA, Penn CC, Negvesky GJ, Butrus SI. (2000). Fungal and parasitic infections of the eye. Clin Microbiol Rev 13:662–85.
   PubMed Web of Science ®Google Scholar
• Lai X, Ding Y, Wu C-M, et al. (2020). Phytantriol-based cubosome formulation as an antimicrobial against lipopolysaccharide-deficient gram-negative bacteria. ACS Appl Mater Interfaces 12:44485–98.
   PubMed Web of Science ®Google Scholar
• Li R, Jiang S, Liu D, et al. (2011). A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide. J Microencapsul 28:134–41.
   PubMed Web of Science ®Google Scholar
• Luechtefeld T, Maertens A, Russo DP, et al. (2016). Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008–2014 REACH data. ALTEX 33:123–34.
   PubMedGoogle Scholar
• Magaldi S, Mata-Essayag S, Hartung de Capriles C, et al. (2004). Well diffusion for antifungal susceptibility testing. Int J Infect Dis 8:39–45.
   PubMed Web of Science ®Google Scholar
• Makwana SB, Patel VA, Parmar SJ. (2016). Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Results Pharma Sci 6:1–6.
   PubMedGoogle Scholar
• Mei L, Xie Y, Jing H, et al. (2017). A novel design for stable self-assembly cubosome precursor-microparticles enhancing dissolution of insoluble drugs. Drug Dev Ind Pharm 43:1239–43.
   PubMed Web of Science ®Google Scholar
• Müller G, Kara-José N, Castro R. (2013). Antifungals in eye infections: drugs and routes of administration. Rev Brasoftalmol 72:132–41.
   Google Scholar
• Muthumanikandar R, Edavalath S, Robert JH, et al. (2011). Development and in-vitro evaluation of buccoadhesive tablets of losartan potassium. Int J Drug Deliv 3:465–71.
   Google Scholar
• Nasr M, Teiama M, Ismail A, et al. (2020). In vitro and in vivo evaluation of cubosomal nanoparticles as an ocular delivery system for fluconazole in treatment of keratomycosis. Drug Deliv Transl Res 10:1841–52.
   PubMed Web of Science ®Google Scholar
• Nasr M, Younes H, Abdel-Rashid RS. (2020). Formulation and evaluation of cubosomes containing colchicine for transdermal delivery. Drug Deliv Transl Res 10:1302–13.
   PubMed Web of Science ®Google Scholar
• Navarro-Partida J, Castro-Castaneda CR, Santa Cruz-Pavlovich FJ, et al. (2021). Lipid-based nanocarriers as topical drug delivery systems for intraocular diseases. Pharmaceutics 13(5):678.
   Web of Science ®Google Scholar
• O'Day DM, Head WS, Robinson RD, Clanton JA. (1986). Corneal penetration of topical amphotericin B and natamycin. Curr Eye Res 5:877–82.
   PubMed Web of Science ®Google Scholar
• Patil A, Lakhani P, Majumdar S. (2017). Current perspectives on natamycin in ocular fungal infections. J Drug Deliv Sci Technol 41:206–12.
   Web of Science ®Google Scholar
• Patil A, Lakhani P, Taskar P, et al. (2018). Formulation development, optimization, and in vitro-in vivo characterization of natamycin-loaded PEGylated nano-lipid carriers for ocular applications. J Pharm Sci 107:2160–71.
   PubMed Web of Science ®Google Scholar
• Perugini P, Pavanetto F. (1998). Liposomes containing boronophenylalanine for boron neutron capture therapy. J Microencapsul 15:473–83.
   PubMed Web of Science ®Google Scholar
• Qi H, Chen W, Huang C, et al. (2007). Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. Int J Pharm 337:178–87.
   PubMed Web of Science ®Google Scholar
• Qiu S, Zhao G-Q, Lin J, et al. (2015). Natamycin in the treatment of fungal keratitis: a systematic review and meta-analysis. Int J Ophthalmol 8:597–602.
   PubMed Web of Science ®Google Scholar
• Rammohan R, Suneetha V, Sen S, et al. (2020). Fungal infections of the eye. Curr Clin Micro Rep 7:39–50.
   Web of Science ®Google Scholar
• Rizwan SB, Assmus D, Boehnke A, et al. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. Eur J Pharm Biopharm 79:15–22.
   PubMed Web of Science ®Google Scholar
• Sheu SJ. (2017). Endophthalmitis. Korean J Ophthalmol 31:283–9.
   PubMedGoogle Scholar
• Terreni E, Chetoni P, Tampucci S, et al. (2020). Assembling surfactants-mucoadhesive polymer nanomicelles (ASMP-nano) for ocular delivery of cyclosporine-A. Pharmaceutics 12:253.
   PubMed Web of Science ®Google Scholar
• Thakkar R, Patil A, Mehraj T, et al. (2019). Updates in ocular antifungal pharmacotherapy: formulation and clinical perspectives. Curr Fungal Infect Rep 13:45–58.
   Web of Science ®Google Scholar
• Thomas PA. (2003). Fungal infections of the cornea. Eye 17:852–62.
   PubMed Web of Science ®Google Scholar
• Wu Y, Liu Y, Li X, et al. (2019). Research progress of in-situ gelling ophthalmic drug delivery system. Asian J Pharm Sci 14:1–15.
   PubMed Web of Science ®Google Scholar
• Xu Q, Kambhampati SP, Kannan RM. (2013). Nanotechnology approaches for ocular drug delivery. Middle East Afr J Ophthalmol 20:26–37.
   PubMedGoogle Scholar
• Zhang L, Li J, Tian D, et al. (2020). Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells. Cell Death Dis 11:1.
   PubMed Web of Science ®Google Scholar
• Zhou H-Y, Hao J-L, Wang S, et al. (2013). Nanoparticles in the ocular drug delivery. Int J Ophthalmol 6:390–6.
   PubMed Web of Science ®Google Scholar