Immunosuppressive effect of PLGA-FK506-NPs in treatment of acute cardiac rejection via topical subcutaneous injection

References

• Alshamsan A, Binkhathlan Z, Kalam MA, et al. (2020). Mitigation of tacrolimus-associated nephrotoxicity by PLGA nanoparticulate delivery following multiple dosing to mice while maintaining its immunosuppressive activity. Sci Rep 10:6675.
   PubMed Web of Science ®Google Scholar
• Azzi J, Yin Q, Uehara M, et al. (2016). Targeted delivery of immunomodulators to lymph nodes. Cell Rep 15:1202–13.
   PubMed Web of Science ®Google Scholar
• Bahmani B, Uehara M, Jiang L, et al. (2018). Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. J Clin Invest 128:4770–86.
   PubMed Web of Science ®Google Scholar
• Bittner B, Richter W, Schmidt J. (2018). Subcutaneous administration of biotherapeutics: an overview of current challenges and opportunities. BioDrugs 32:425–40.
   PubMed Web of Science ®Google Scholar
• Booth AJ, Grabauskiene S, Wood SC, et al. (2011). IL-6 promotes cardiac graft rejection mediated by CD4+ cells. J Immunol 187:5764–71.
   PubMed Web of Science ®Google Scholar
• Chiang PC, Nagapudi K, Fan PW, Liu J. (2019). Investigation of drug delivery in rats via subcutaneous injection: case study of pharmacokinetic modeling of suspension formulations. J Pharm Sci 108:109–19.
   PubMed Web of Science ®Google Scholar
• Collins DS, Sánchez-Félix M, Badkar AV, Mrsny R. (2020). Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics. J Control Release 321:475–82.
   PubMed Web of Science ®Google Scholar
• Danhier F, Ansorena E, Silva JM, et al. (2012). PLGA-based nanoparticles: an overview of biomedical applications. J Control Release 161:505–22.
   PubMed Web of Science ®Google Scholar
• Deng C, Chen Y, Zhang L, et al. (2020). Delivery of FK506-loaded PLGA nanoparticles prolongs cardiac allograft survival. Int J Pharm 575:118951.
   PubMedGoogle Scholar
• Dogra P, Adolphi NL, Wang Z, et al. (2018). Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics. Nat Commun 9:4551.
   PubMed Web of Science ®Google Scholar
• Gajanayake T, Olariu R, Leclère FM, et al. (2014). A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. Sci Transl Med 6:249ra110.
   PubMedGoogle Scholar
• Gao GF, Ashtikar M, Kojima R, et al. (2021). Predicting drug release and degradation kinetics of long-acting microsphere formulations of tacrolimus for subcutaneous injection. J Control Release 329:372–84.
   PubMed Web of Science ®Google Scholar
• Jiang H, Wang Q, Sun X. (2017). Lymph node targeting strategies to improve vaccination efficacy. J Control Release 267:47–56.
   PubMed Web of Science ®Google Scholar
• Jordan SC, Ammerman N, Choi J, et al. (2020). Interleukin-6: an important mediator of allograft injury. Transplantation 104:2497–506.
   PubMed Web of Science ®Google Scholar
• Jordan SC, Choi J, Kim I, et al. (2017). Interleukin-6, a cytokine critical to mediation of inflammation, autoimmunity and allograft rejection: therapeutic implications of IL-6 receptor blockade. Transplantation 101:32–44.
   PubMed Web of Science ®Google Scholar
• Kalam MA, Alshamsan A. (2017). Poly (d,l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. Biomed Pharmacother 94:402–11.
   PubMed Web of Science ®Google Scholar
• Khan S, Shaharyar M, Fazil M, et al. (2016). Tacrolimus-loaded nanostructured lipid carriers for oral delivery—in vivo bioavailability enhancement. Eur J Pharm Biopharm 109:149–57.
   PubMed Web of Science ®Google Scholar
• Lee KW, Kim TH, Lee JB, et al. (2019). Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: investigating optimal dosing regimens. J Pharmacol Sci 139:65–71.
   PubMed Web of Science ®Google Scholar
• Liu M, Li H, Luo G, et al. (2008). Pharmacokinetics and biodistribution of surface modification polymeric nanoparticles. Arch Pharm Res 31:547–54.
   PubMed Web of Science ®Google Scholar
• Martins C, Sousa F, Araújo F, Sarmento B. (2018). Functionalizing PLGA and PLGA derivatives for drug delivery and tissue regeneration applications. Adv Healthcare Mater 7:1701035.
   Google Scholar
• McDonald TA, Zepeda ML, Tomlinson MJ, et al. (2010). Subcutaneous administration of biotherapeutics: current experience in animal models. Curr Opin Mol Ther 12:461–70.
   PubMedGoogle Scholar
• Mitragotri S, Burke PA, Langer R. (2014). Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov 13:655–72.
   PubMed Web of Science ®Google Scholar
• Miyamoto Y, Uno T, Yamamoto H, et al. (2004). Pharmacokinetic and immunosuppressive effects of tacrolimus-loaded biodegradable microspheres. Liver Transpl 10:392–6.
   PubMed Web of Science ®Google Scholar
• Mohanan D, Slütter B, Henriksen-Lacey M, et al. (2010). Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems. J Control Release 147:342–9.
   PubMed Web of Science ®Google Scholar
• Niu L, Chu LY, Burton SA, et al. (2019). Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response. J Control Release 294:268–78.
   PubMed Web of Science ®Google Scholar
• Olymbios M, Kwiecinski J, Berman DS, Kobashigawa JA. (2018). Imaging in heart transplant patients. JACC Cardiovasc Imaging 11:1514–30.
   PubMed Web of Science ®Google Scholar
• Ono K, Lindsey ES. (1969). Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 57:225–9.
   PubMed Web of Science ®Google Scholar
• Pathak S, Regmi S, Gupta B, et al. (2017). Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice. Drug Deliv 24:1350–9.
   PubMed Web of Science ®Google Scholar
• Pennington CA, Park JM. (2015). Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. Am J Health Syst Pharm 72:277–84.
   PubMed Web of Science ®Google Scholar
• Pietra BA, Wiseman A, Bolwerk A, et al. (2000). CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class II. J Clin Invest 106:1003–10.
   PubMed Web of Science ®Google Scholar
• Rao DA, Forrest ML, Alani AW, et al. (2010). Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery. J Pharm Sci 99:2018–31.
   PubMed Web of Science ®Google Scholar
• Reddy ST, Rehor A, Schmoekel HG, et al. (2006). In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. J Control Release 112:26–34.
   PubMed Web of Science ®Google Scholar
• Schreiber SL, Crabtree GR. (1992). The mechanism of action of cyclosporin A and FK506. Immunol Today 13:136–42.
   PubMedGoogle Scholar
• Shahzad KA, Wan X, Zhang L, et al. (2018). On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation. Drug Deliv 25:703–15.
   PubMed Web of Science ®Google Scholar
• Shin SB, Cho HY, Kim DD, et al. (2010). Preparation and evaluation of tacrolimus-loaded nanoparticles for lymphatic delivery. Eur J Pharm Biopharm 74:164–71.
   PubMed Web of Science ®Google Scholar
• Singh R, Lillard JW Jr. (2009). Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–23.
   PubMed Web of Science ®Google Scholar
• Solari S, Cancino A, Wolff R, et al. (2017). Sublingual tacrolimus administration provides similar drug exposure to per-oral route employing lower doses in liver transplantation: a pilot study. Aliment Pharmacol Ther 45:1225–31.
   PubMed Web of Science ®Google Scholar
• Stehlik J, Kobashigawa J, Hunt SA, et al. (2018). Honoring 50 years of clinical heart transplantation in circulation: in-depth state-of-the-art review. Circulation 137:71–87.
   PubMed Web of Science ®Google Scholar
• Stewart S, Winters GL, Fishbein MC, et al. (2005). Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 24:1710–20.
   PubMed Web of Science ®Google Scholar
• Tanaka T, Narazaki M, Kishimoto T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 6:a016295.
   PubMed Web of Science ®Google Scholar
• Trevaskis NL, Kaminskas LM, Porter CJ. (2015). From sewer to saviour – targeting the lymphatic system to promote drug exposure and activity. Nat Rev Drug Discov 14:781–803.
   PubMed Web of Science ®Google Scholar
• Tung Thanh P, Tiep Tien N, Pathak S, et al. (2018). Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model. Biomaterials 154:182–96.
   PubMed Web of Science ®Google Scholar
• Wang S, Xiong Y, Wang Y, et al. (2020). Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft – an experimental study. Transpl Int 33:450–61.
   PubMed Web of Science ®Google Scholar
• Wu Q, Liu D, Zhang X, et al. (2019). Development and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection. Drug Deliv 26:290–9.
   PubMed Web of Science ®Google Scholar
• Wu Y, Jin Q, Chen Y, et al. (2020). Bioinspired beta-glucan microcapsules deliver FK506 to lymph nodes for treatment of cardiac allograft acute rejection. Biomater Sci 8:5282–92.
   PubMed Web of Science ®Google Scholar
• Xie H, Zhu H, Zhou K, et al. (2020). Target-oriented delivery of self-assembled immunosuppressant cocktails prolongs allogeneic orthotopic liver transplant survival. J Control Release 328:237–50.
   PubMed Web of Science ®Google Scholar
• Xu W, Ling P, Zhang T. (2014). Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(d,l-lactide) nanoparticle with longer survival time. Int J Pharm 460:173–80.
   PubMed Web of Science ®Google Scholar
• Yoshida T, Nakanishi K, Yoshioka T, et al. (2016). Oral tacrolimus oil formulations for enhanced lymphatic delivery and efficient inhibition of T-cell's interleukin-2 production. Eur J Pharm Biopharm 100:58–65.
   PubMed Web of Science ®Google Scholar
• Zamorano-Leon JJ, Hernandez-Fisac I, Guerrero S, et al. (2016). New strategy of tacrolimus administration in animal model based on tacrolimus-loaded microspheres. Transpl Immunol 36:9–13.
   PubMed Web of Science ®Google Scholar
• Zhao L, Zhou Y, Gao Y, et al. (2015). Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. Int J Pharm 483:180–7.
   PubMed Web of Science ®Google Scholar
• Zheng X, Pei G, Qiu Y, et al. (2002). Dynamic observation of serum cytokines in the patients with hand transplantation. Transplant Proc 34:3405–9.
   PubMed Web of Science ®Google Scholar
• Zhou K, Chen X, Zhang L, et al. (2021). Targeting peripheral immune organs with self-assembling prodrug nanoparticles ameliorates allogeneic heart transplant rejection. Am J Transplant 0:1–12.
   Google Scholar