Targeted therapy of rheumatoid arthritis via macrophage repolarization

References

• Avina-Zubieta JA, Thomas J, Sadatsafavi M, et al. (2012). Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 71:1524–9.
   PubMed Web of Science ®Google Scholar
• Cao X, Zhou X, Wang Y, et al. (2016). Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo. J Mater Chem B 4:3216–24.
   PubMed Web of Science ®Google Scholar
• Crielaard BJ, Rijcken CJF, Quan L, et al. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angew Chem Int Ed Engl 51:7254–8.
   PubMed Web of Science ®Google Scholar
• Du B, Han S, Li H, et al. (2015). Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy. Nanoscale 7:5411–26.
   PubMed Web of Science ®Google Scholar
• Ebel AV, O’Dell JR. (2021). Clinical features, diagnosis, and treatment of rheumatoid arthritis. Phys Assist Clin 6:41–60.
   Web of Science ®Google Scholar
• Emery P, Breedveld F, Dougados CM, et al. (2002). Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis 61:290–7.
   PubMed Web of Science ®Google Scholar
• Feng N, Guo F. (2020). Nanoparticle-siRNA: a potential strategy for rheumatoid arthritis therapy? J Control Release 325:380–93.
   PubMed Web of Science ®Google Scholar
• Fu J, Zang Y, Zhou Y, et al. (2020). A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype. Biomed Pharmacother 126:110084.
   PubMed Web of Science ®Google Scholar
• Fu Y, Lin Q, Gong T, et al. (2016). Renal-targeting triptolide–glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats. Acta Pharmacol Sin 37:1467–80.
   PubMed Web of Science ®Google Scholar
• Hu J, He J, Cao D, et al. (2015). Core cross-linked polyphosphoester micelles with folate-targeted and acid-cleavable features for pH-triggered drug delivery. Polym Chem 6:3205–16.
   Web of Science ®Google Scholar
• Jain S, Tran T-H, Amiji M. (2015). Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis. Biomaterials 61:162–77.
   PubMed Web of Science ®Google Scholar
• Jia M, Deng C, Luo J, et al. (2018). A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats. Int J Pharm 540:57–64.
   PubMed Web of Science ®Google Scholar
• Kapoor B, Gulati M, Singh SK, et al. (2021). Fail-safe nano-formulation of prodrug of sulfapyridine: preparation and evaluation for treatment of rheumatoid arthritis. Mater Sci Eng C Mater Biol Appl 118:111332.
   PubMed Web of Science ®Google Scholar
• Kottarath SK, Bhat M, Verma C, et al. (2020). Folate receptor-β targeted cholesterol-chitosan nanocarrier for treatment of rheumatoid arthritis: an animal study. J Drug Deliv Sci Technol 60:101946.
   Web of Science ®Google Scholar
• Law ST, Taylor PC. (2019). Role of biological agents in treatment of rheumatoid arthritis. Pharmacol Res 150:104497.
   PubMed Web of Science ®Google Scholar
• Li H, Fu Y, Zhang T, et al. (2015). Rational design of polymeric hybrid micelles with highly tunable properties to co-deliver MicroRNA-34a and vismodegib for melanoma therapy. Adv Funct Mater 25:7457–69.
   Web of Science ®Google Scholar
• Li P, Yang X, Yang Y, et al. (2020). Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. J Control Release 319:87–103.
   PubMed Web of Science ®Google Scholar
• Liaw K, Sharma R, Sharma A, et al. (2021). Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma. J Control Release 329:434–44.
   PubMed Web of Science ®Google Scholar
• Liu Y, Jin J, Xu H, et al. (2021). Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy. Acta Biomater 121:541–53.
   PubMed Web of Science ®Google Scholar
• Maity S, Misra A, Wairkar S. (2021). Novel injectable carrier based corticosteroid therapy for treatment of rheumatoid arthritis and osteoarthritis. J Drug Deliv Sci Technol 61:102309.
   Web of Science ®Google Scholar
• McInnes IB, Schett G. (2017). Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389:2328–37.
   PubMed Web of Science ®Google Scholar
• Mohammadi M, Li Y, Abebe DG, et al. (2016). Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. J Control Release 244:269–79.
   PubMed Web of Science ®Google Scholar
• Naerr GW, Rein P, Saely CH, Drexel H. (2016). Effects of synthetic and biological disease modifying antirheumatic drugs on lipid and lipoprotein parameters in patients with rheumatoid arthritis. Vascul Pharmacol 81:22–30.
   PubMed Web of Science ®Google Scholar
• Nigro A, Frattaruolo L, Fava M, et al. (2020). Bortezomib-loaded mesoporous silica nanoparticles selectively alter metabolism and induce death in multiple myeloma cells. Cancers 12:2709.
   PubMed Web of Science ®Google Scholar
• Nogueira E, Gomes AC, Preto A, Cavaco-Paulo A. (2016). Folate-targeted nanoparticles for rheumatoid arthritis therapy. Nanomedicine 12:1113–26.
   PubMed Web of Science ®Google Scholar
• Nogueira E, Lager F, Le Roux D, et al. (2015). Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice. J Biomed Nanotechnol 11:2243–52.
   PubMed Web of Science ®Google Scholar
• Paulos CM, Turk MJ, Breur GJ, Low PS. (2004). Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev 56:1205–17.
   PubMed Web of Science ®Google Scholar
• Shen Q, Wang J, Yuan Z, et al. (2019). Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis. Int Immunopharmacol 77:105959.
   PubMed Web of Science ®Google Scholar
• Song X, Zhang Y, Dai E, et al. (2020). Prediction of triptolide targets in rheumatoid arthritis using network pharmacology and molecular docking. Int Immunopharmacol 80:106179.
   PubMed Web of Science ®Google Scholar
• Tardito S, Martinelli G, Soldano S, et al. (2019). Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review. Autoimmun Rev 18:102397.
   PubMed Web of Science ®Google Scholar
• van den Hoven JM, Hofkens W, Wauben MHM, et al. (2011). Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis. Int J Pharm 416:471–7.
   PubMed Web of Science ®Google Scholar
• Varghese B, Haase N, Low PS. (2007). Depletion of folate-receptor-positive macrophages leads to alleviation of symptoms and prolonged survival in two murine models of systemic lupus erythematosus. Mol Pharm 4:679–85.
   PubMed Web of Science ®Google Scholar
• Wang Q, Jiang H, Li Y, et al. (2017). Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy. Biomaterials 122:10–22.
   PubMed Web of Science ®Google Scholar
• Wang Q, Jiang J, Chen W, et al. (2016). Targeted delivery of low-dose dexamethasone using PCL-PEG micelles for effective treatment of rheumatoid arthritis. J Control Release 230:64–72.
   PubMed Web of Science ®Google Scholar
• Wang Q, Qin X, Fang J, Sun X. (2021). Nanomedicines for the treatment of rheumatoid arthritis: state of art and potential therapeutic strategies. Acta Pharm Sin B 11:1158–74.
   PubMed Web of Science ®Google Scholar
• Wang Y, Han C-C, Cui D, et al. (2017). Is macrophage polarization important in rheumatoid arthritis? Int Immunopharmacol 50:345–52.
   PubMed Web of Science ®Google Scholar
• Xi C, Peng S, Wu Z, et al. (2017). Toxicity of triptolide and the molecular mechanisms involved. Biomed Pharmacother 90:531–41.
   PubMed Web of Science ®Google Scholar
• Xia W, Hilgenbrink AR, Matteson EL, et al. (2009). A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 113:438–46.
   PubMed Web of Science ®Google Scholar
• Xie L, Zhao Y, Duan J, et al. (2020). Integrated proteomics and metabolomics reveal the mechanism of nephrotoxicity induced by triptolide. Chem Res Toxicol 33:1897–906.
   PubMed Web of Science ®Google Scholar
• Xue L, Wang D, Zhang X, et al. (2020). Targeted and triple therapy-based liposomes for enhanced treatment of rheumatoid arthritis. Int J Pharm 586:119642.
   PubMed Web of Science ®Google Scholar
• Yang M, Ding J, Zhang Y, et al. (2016). Activated macrophage-targeted dextran-methotrexate/folate conjugate prevents deterioration of collagen-induced arthritis in mice. J Mater Chem B 4:2102–13.
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo L, Wang Z, et al. (2021). Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and re-polarization. Biomaterials 264:120390.
   PubMed Web of Science ®Google Scholar
• Yu Y, Cai W, Zhou J, et al. (2020). Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/HIF-1α pathway. Int Immunopharmacol 87:106830.
   PubMed Web of Science ®Google Scholar
• Yuan F, Quan L-d, Cui L, et al. (2012). Development of macromolecular prodrug for rheumatoid arthritis. Adv Drug Deliv Rev 64:1205–19.
   PubMed Web of Science ®Google Scholar
• Yuan Z, Hasnat M, Liang P, et al. (2019). The role of inflammasome activation in Triptolide-induced acute liver toxicity. Int Immunopharmacol 75:105754.
   PubMed Web of Science ®Google Scholar
• Zhang T, Zheng Y, Peng Q, et al. (2013). A novel submicron emulsion system loaded with vincristine-oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies. Int J Nanomedicine 8:1185–96.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xu W, Li H, et al. (2013). Therapeutic effects of total alkaloids of Tripterygium wilfordii Hook F. on collagen-induced arthritis in rats. J Ethnopharmacol 145:699–705.
   PubMed Web of Science ®Google Scholar
• Zhou P, Sun X, Gong T, et al. (2014). Conjugating glucosamine to triptolide to enhance its protective effect against renal ischemia–reperfusion injury and reduce its toxicity. J Drug Target 22:200–10.
   PubMed Web of Science ®Google Scholar
• Zhou X, Cao X, Tu H, et al. (2019). Inflammation-targeted delivery of celastrol via neutrophil membrane-coated nanoparticles in the management of acute pancreatitis. Mol Pharm 16:1397–405.
   PubMed Web of Science ®Google Scholar
• Zhou X, Qin X, Gong T, et al. (2017). d-Fructose modification enhanced internalization of mixed micelles in breast cancer cells via GLUT5 transporters. Macromol Biosci 17:1600529.
   Web of Science ®Google Scholar
• Zhu X, Zhu Y, Ding C, et al. (2021). LncRNA H19 regulates macrophage polarization and promotes Freund's complete adjuvant-induced arthritis by upregulating KDM6A. Int Immunopharmacol 93:107402.
   PubMed Web of Science ®Google Scholar