Fundamental Efforts toward the Development of a Therapeutic Cocktail with a Manifold Ameliorative Effect on Hepatic Ischemia/Reperfusion Injury

References

• Arnault I, Bao Y, Dimicoli J, Lemoine A, Sebagh M, Adam R. Combined effects of fasting and alanine on liver function recovery after cold ischemia. Transpl Int 2002; 15: 89–95
   Google Scholar
• Astarcioglu I, Adam R, Dimicoli JL, Gigou M, Patry J, Sebagh M, et al. Protective effect of alanine against graft failure of transplanted livers from fasted donor rats. Transpl Proc 1995; 27: 507–508
   Google Scholar
• Bergmeyer HU. Methods of Enzymatic Analysis. Academic Press, New York 1988
   Google Scholar
• Biberthaler P, Luchting B, Massberg S, Teupse D, Langer S, Leiderer R, et al. The influence of organ temperature on hepatic ischemia-reperfusion injury. Transplantation 2001; 72: 1486–1490
   PubMed Web of Science ®Google Scholar
• Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG, Brenner DA. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Liver Transpl Surg 1999; 5: 282–293
   PubMedGoogle Scholar
• Cottart C, Do L, Blanc M, Vaubourdollw M, Descamps G, Durand D, et al. Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat. Hepatology 1999; 29: 809–813
   PubMed Web of Science ®Google Scholar
• Cywes R, Greig PD, Sanabria JR, Clavien P, Levy GA, Harvey PRC, et al. Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg 1992; 216: 235–247
   Google Scholar
• Dimopoulou I, Tsagarakis S, Anthi A, Milou E, Ilias I, Stavrakaki K, et al. High prevalence of decreased cortisol reserve in brain-dead potential organ donors. Crit Care Med 2003; 31: 1113–1117
   Google Scholar
• Glanemann M, Strenziok R, Kuntze R, Münchow S, Dikopoulos N, Lippek F, et al. Ischemic preconditioning and methylprednisolone both equally reduce hepatic ischemia/reperfusion injury. Surgery 2004; 135: 203–214
   PubMed Web of Science ®Google Scholar
• Guan X, Dei-Anane G, Liang R, Gross ML, Nickkholgh A, Kern M, et al. Donor preconditioning with taurine protects kidney grafts from injury after experimental transplantation. J Surg Res 2008; 146: 127–134
   Web of Science ®Google Scholar
• Huxtable RJ. Physiological actions of taurine. Physiol Rev 1992; 72: 101–163
   PubMed Web of Science ®Google Scholar
• Ikejima K, Qu W, Stacklewitz RF, Thurman RG. Kupffer cells contain a glycine-gated chloride channel. Am J Physiol 1997; 272: G1581–G1586
   PubMed Web of Science ®Google Scholar
• Jaeschke H. Molecular mechanisims of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol 2003; 284: G15–G26
   PubMed Web of Science ®Google Scholar
• Jahnke C, Mehrabi A, Golling M, von Frankenberg M, Kashfi A, Nentwich H, et al. Evaluation of microperfusion disturbances in the transplanted liver after Kupffer cell destruction using GdCl3: an experimental porcine study. Transpl Proc 2006; 38: 1588–1595
   PubMedGoogle Scholar
• Kincius M, Liang R, Nickkholgh A, Hoffmann K, Flechtenmacher C, Ryschich E, et al. Taurine protects from liver injury after warm ischemia in rats: the role of Kupffer cells. Eur Surg Res 2007; 39: 275–283
   Web of Science ®Google Scholar
• Koeppel TA, Thies JC, Schemmer P, Trauner M, Gebhard MM, Otto G, Post S. Inhibition of nitric oxide synthesis in ischemia/reperfusion of the rat liver is followed by impairment of hepatic microvascular blood flow. J Hepatol 1997; 27: 163–169
   PubMed Web of Science ®Google Scholar
• Koo A, Komatsu H, Tao G, Inoue M, Guth PH, Kaplowitz N. Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role of superoxide anion. Hepatology 1991; 15: 507–514
   Web of Science ®Google Scholar
• Kristensen LO. Associations between transports of alanine and cations across cell membrane in rat hepatocytes. Am J Physiol 1986; 251: 575–584
   PubMed Web of Science ®Google Scholar
• Kurz AK, Schliess F, Häussinger D. Osmotic regulation of the heat shock response in primary hepatocytes. Hepatology 1998; 28: 774–781
   PubMed Web of Science ®Google Scholar
• Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 1997; 37: 327–338
   PubMed Web of Science ®Google Scholar
• Liang R, Nickkholgh A, Hoffmann K, Kern M, Schneider H, Sobirey M, et al. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J Pineal Res 2009; 46: 8–14
   PubMed Web of Science ®Google Scholar
• Lidofsky SD, Roman RM. Alanine uptake activates hepatocellular chloride channels. Am J Physiol 1997; 273: 849–853
   Google Scholar
• Marzi I, Walcher F, Buhren V. Macrophage activation and leukocyte adhesion after liver transplantation. Am J Physiol 1993; 265: G172–G177
   Google Scholar
• McCuskey RS. Morpological mechanisims for regulating blood flow through hepatic sinusoids. Liver 2000; 20: 3–7
   PubMedGoogle Scholar
• Ming Z, Han C, Lautt WW. Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constricton. Am J Physiol Gastrointest Liver Physiol 1999; 277: 1200–1206
   Google Scholar
• Morgan GR, Sanabria JR, Clavien PA, Phillips MJ, Edwards C, Harvey PRC, et al. Correlation of donor nutritional status with sinusoidal lining cell viability and liver function in the rat. Transplantation 1991; 51: 1176–1183
   Google Scholar
• Post S, Gonzalez AP, Palma P, Rentsch M, Stiehl A, Menger MD. Assessment of hepatic phagocytic activity by in vivo microscopy after liver transplantation in the rat. Hepatology 1992; 16: 803–809
   PubMed Web of Science ®Google Scholar
• Rosendale JD, Kauffman HM, McBride MA, Chabalewski FL, Zaroff JG, Garrity ER, et al. Hormonal resuscitation yields more transplanted hearts, with improved early function. Transplantation 2003; 27: 1336–1341
   Google Scholar
• Roth E. The impact of L-arginine–nitric oxide metabolism on ischemia/reperfusion injury. Curr Opin Clin Nutr Metab Care 1998; 1: 97–99
   Google Scholar
• Schemmer P, Schoonhoven R, Swenberg JA, Bunzendahl H, Thurman RG. Gentle in situ liver manipulation during organ harvest decreases survival after rat liver transplantation: role of Kupffer cells. Transplantation 1998; 65: 1015–1020
   PubMed Web of Science ®Google Scholar
• Schemmer P, Bunzendahl H, Raleigh JA, Thurman RG. Graft survival is improved by hepatic denervation prior to organ harvest. Transplantation 1999; 67: 1–7
   Google Scholar
• Schemmer P, Liang R, Kincius M, Flechtenmacher C, Bunzendahl H, Gutt CN, et al. Taurine improves graft survival after experimental liver transplantation. Transplantation 2005; 11: 950–959
   Google Scholar
• Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125: 917–936
   PubMed Web of Science ®Google Scholar
• Schemmer P, Bradford BU, Bunzedahl H, Raleigh JA, Lemasters JJ, Thurmann RG. Intravenous glycine improves survival in rat liver transplantation. Am J Physiol 1999; 276: G924–G932
   PubMedGoogle Scholar
• Schemmer P, Connor HD, Arteel GE, Raleigh JA, Bunzendahl H, Mason RP, et al. Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals. J Pharmacol Exp Ther 1999; 290: 1–6
   Google Scholar
• Schemmer P, Enomoto N, Bradford BU, Bunzendahl H, Raleigh JA, Lemasters JJ, et al. Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats. Am J Physiol 2001; 280: G1076–G1082
   Google Scholar
• Schemmer P, Golling M, Kraus T, Mayatepek E, Herfarth C, Klar E. Extended experience with glycine for prevention of reperfusion injury after human liver transplantation. Transpl Proc 2002; 34: 2307–2309
   Google Scholar
• Santiago-Delpin EA, Figueroa I, Lopez R, Vazquez J. Protective effects of steroids on liver ischemia. Am Surg 1975; 45: 683–695
   Google Scholar
• Sumimoto R, Southard JH, Belzer FO. Livers from fasted rats acquire resistance to warm and cold ischemia injury. Transplantation 1993; 55: 728–732
   Google Scholar
• Sumimoto R, Fukuda Y, Gamniez L, Oshiro H, Dohi K, Southard JH, et al. Successful 48-hour liver preservation by controlling nutritional status by donor and recipient. Transpl Int 1994; 7: 499–502
   Google Scholar
• Serafin A, Rosello-Catafau J, Prats N, Xaus C, Gelpi E, Peralta C. Ischemia preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat. Am J Pathol 2002; 161: 587–597
   PubMedGoogle Scholar
• Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia-reperfusion injury. Am J Surg 2001; 181: 160–166
   PubMed Web of Science ®Google Scholar
• Shiraishi M, Hiroyasu S, Nagahama M, et al. Role of exogenous L-arginine in hepatic ischemia-reperfusion injury. J Surg Res 1997; 69: 429–434
   PubMed Web of Science ®Google Scholar
• Thies JC, Koeppel TA, Lehmann T, Schemmer P, Otto G, Post S. Efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation: an experimental study. Transpl Proc 1997; 29: 1326–1327
   Google Scholar
• Vollmar B, Glasz J, Leiderer R, Post S, Menger MD. Hepatic microcirculatory perfusion failure is a determinant for liver dysfunction in warm ischemia-reperfusion. Am J Pathol 1994; 145: 1–11
   Google Scholar
• Wang Y, Vodovotz Y, Kim PK, Zamora R, Billiar TR. Mechanisms of hepatoprotection by nitric oxide. Ann N Y Acad Sci 2002; 962: 415–422
   Google Scholar
• Yamashita Y, Shimada M, Hamatsu T, Rikimaru T, Tanaka S, Shirabe K, et al. Effects of preoperative steroid administration on surgical stress in hepatic resection. Arch Surg 2001; 136: 328–333
   Google Scholar
• Yancey PH. Organic osmolytes as compatible, metabolic, and counteracting cytoprotectants in high osmolarity and other stresses. J Exp Biol 2005; 208: 2819–2830
   PubMed Web of Science ®Google Scholar
• Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yim M, et al. L-glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care 2003; 6: 229–240
   PubMed Web of Science ®Google Scholar