Cerebrolysin provides effective protection on high glucose-induced neuropathy in cultured rat dorsal root ganglion neurons

References

• Hammi C, Yeung B. Neuropathy. In: statPearls. Treasure Island (FL): StatPearls Publishing; 2022.
   Google Scholar
• Hicks CW, Selvin E. Epidemiology of peripheral neuropathy and lower extremity disease in diabetes. Curr Diab Rep. 2019;19(10):86. doi: 10.1007/s11892-019-1212-8.
   PubMed Web of Science ®Google Scholar
• Tracy JA, Dyck PJ. The spectrum of diabetic neuropathies. Phys Med Rehabil Clin N Am. 2008;19(1):1–26. doi: 10.1016/j.pmr.2007.10.010.
   PubMed Web of Science ®Google Scholar
• Iqbal Z, Azmi S, Yadav R, et al. Diabetic peripheral neuropathy: epidemiology, diagnosis, and pharmacotherapy. Clin Ther. 2018;40(6):828–849. doi: 10.1016/j.clinthera.2018.04.001.
   PubMed Web of Science ®Google Scholar
• Jensen TS, Karlsson P, Gylfadottir SS, et al. Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management. Brain. 2021;144(6):1632–1645. doi: 10.1093/brain/awab079.
   PubMedGoogle Scholar
• Krames ES. The role of the dorsal root ganglion in the development of neuropathic pain. Pain Med. 2014;15(10):1669–1685. doi: 10.1111/pme.12413.
   PubMed Web of Science ®Google Scholar
• Guha D, Shamji MF. The dorsal root ganglion in the pathogenesis of chronic neuropathic pain. Neurosurgery. 2016;63(Supplement 1):118–126. doi: 10.1227/NEU.0000000000001255.
   PubMedGoogle Scholar
• Malcangio M. Role of the immune system in neuropathic pain. Scand J Pain. 2019;20(1):33–37. doi: 10.1515/sjpain-2019-0138.
   PubMed Web of Science ®Google Scholar
• Ozcan M, Ayar A, Alcin E, et al. Effects of levobupivacaine and bupivacaine on intracellular calcium signaling in cultured rat dorsal root ganglion neurons. J Recept Signal Transduct Res. 2010;30(2):115–120. doi: 10.3109/10799891003630614.
   PubMed Web of Science ®Google Scholar
• Melli G, Höke A. Dorsal root ganglia sensory neuronal cultures: a tool for drug discovery for peripheral neuropathies. Expert Opin Drug Discov. 2009;4(10):1035–1045. doi: 10.1517/17460440903266829.
   PubMed Web of Science ®Google Scholar
• Sharma HS, Feng L, Chen L, et al. Cerebrolysin attenuates exacerbation of neuropathic pain, blood-spinal cord barrier breakdown and cord pathology following chronic intoxication of engineered ag, cu or al (50–60 nm) nanoparticles. Neurochem Res. 2023;48(6):1864–1888. doi: 10.1007/s11064-023-03861-8.
   PubMed Web of Science ®Google Scholar
• Muresanu DF, Sharma A, Sahib S, et al. Diabetes exacerbates brain pathology following a focal blast brain injury: new role of a multimodal drug Cerebrolysin and nanomedicine. Prog Brain Res. 2020;258:285–367. doi: 10.1016/bs.pbr.2020.09.004.
   PubMed Web of Science ®Google Scholar
• Ziganshina LE, Abakumova T, Hoyle CH. Cerebrolysin for acute ischaemic stroke. Cochrane Database Syst Rev. 2020;7(7):CD007026. doi: 10.1002/14651858.CD007026.pub6.
   PubMedGoogle Scholar
• Morales-Medina JC, Flores G, Vallelunga A, et al. Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity. Drug Dev Res. 2019;80(4):513–518. doi: 10.1002/ddr.21528.
   PubMed Web of Science ®Google Scholar
• Aguilar-Hernández L, Gómez-Villalobos MJ, Flores G. Cerebrolysin ameliorates prefrontal cortex and hippocampus neural atrophy of spontaneous hypertensive rats with hyperglycemia. Synapse. 2020;74(9):e22156. doi: 10.1002/syn.22156.
   PubMed Web of Science ®Google Scholar
• Sanchez-Vega L, Juárez I, Gomez-Villalobos Mde J, et al. Cerebrolysin reverses hippocampal neural atrophy in a mice model of diabetes mellitus type 1. Synapse. 2015;69(6):326–335. doi: 10.1002/syn.21819.
   PubMed Web of Science ®Google Scholar
• Biesenbach G, Grafinger P, Eichbauer-Sturm G, et al. Cerebrolysin in der behandlung der schmerzhaften diabetischen neuropathie [Cerebrolysin in treatment of painful diabetic neuropathy]. Wien Med Wochenschr. 1997;147(3):63–66.
   PubMedGoogle Scholar
• Bogdanov EI, Sakovets TG. Efficiency of Cerebrolysin in the diabetic polyneuropathy in patients with insulin-dependency diabetes mellitus. Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2):35–39.
   PubMedGoogle Scholar
• Lehmann HC, Staff NP, Hoke A. Modeling chemotherapy induced peripheral neuropathy (CIPN) in vitro: prospects and limitations. Exp Neurol. 2020;326:113140. doi: 10.1016/j.expneurol.2019.113140.
   PubMed Web of Science ®Google Scholar
• Ozcan M, Ayar A. Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons. J Recept Signal Transduct Res. 2012;32(3):156–162. doi: 10.3109/10799893.2012.672993.
   PubMed Web of Science ®Google Scholar
• Yazar U, Ayar A. Cortexin® ameliorates high glucose-induced neuropathy in cultured rat sensory neurons. Neuroendocrinology. 2023;113(9):924–929. doi: 10.1159/000530766.
   PubMedGoogle Scholar
• Ke N, Wang X, Xu X, et al. The xCELLigence system for real-time and label-free monitoring of cell viability. Methods Mol Biol. 2011;740:33–43. doi: 10.3109/10799893.2012.672993.
   PubMedGoogle Scholar
• Hattangady NG, Rajadhyaksha MS. A brief review of in vitro models of diabetic neuropathy. Int J Diabetes Dev Ctries. 2009;29(4):143–149. doi: 10.4103/0973-3930.57344.
   PubMed Web of Science ®Google Scholar
• Pajak B, Siwiak E, Sołtyka M, et al. 2-Deoxy-d-glucose and its analogs: from diagnostic to therapeutic agents. Int J Mol Sci. 2019;21(1):234. doi: 10.3390/ijms21010234.
   PubMed Web of Science ®Google Scholar
• Kleman AM, Yuan JY, Aja S, et al. Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. J Neurosci Methods. 2008;167(2):292–301. doi: 10.1016/j.jneumeth.2007.08.028.
   PubMed Web of Science ®Google Scholar
• Varier P, Raju G, Madhusudanan P, et al. A brief review of in vitro models for injury and regeneration in the peripheral nervous system. Int J Mol Sci. 2022;23(2):23–816. doi: 10.3390/ijms23020816.
   Web of Science ®Google Scholar
• Peeraer E, Van Lutsenborg A, Verheyen A, et al. Pharmacological evaluation of rat dorsal root ganglion neurons as an in vitro model for diabetic neuropathy. J Pain Res. 2011;4:55–65. doi: 10.2147/JPR.S15452.
   PubMedGoogle Scholar
• Georgy GS, Nassar NN, Mansour HA, et al. Cerebrolysin ameloriates cognitive deficits in type III diabetic rats. PLOS One. 2013;8(6):e64847. doi: 10.1371/journal.pone.0064847.
   PubMed Web of Science ®Google Scholar
• Morales-Medina JC, Griffiths NH, Flores G, et al. Cerebrolysin reduces mechanical allodynia in a rodent model of peripheral inflammation. Neurosci Lett. 2017;642:27–30. doi: 10.1016/j.neulet.2017.01.058.
   PubMed Web of Science ®Google Scholar
• Schauer E, Wronski R, Patockova J, et al. Neuroprotection of Cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window. J Neural Transm. 2006;113(7):855–868. doi: 10.1007/s00702-005-0384-3.
   PubMed Web of Science ®Google Scholar
• Keilhoff G, Lucas B, Pinkernelle J, et al. Effects of Cerebrolysin on motor-neuron-like NSC-34 cells. Exp Cell Res. 2014;327(2):234–255. doi: 10.1016/j.yexcr.2014.06.020.
   PubMed Web of Science ®Google Scholar
• Hartwig K, Fackler V, Jaksch-Bogensperger H, et al. Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling. Int J Dev Neurosci. 2014;38(1):52–58. doi: 10.1016/j.ijdevneu.2014.07.005.
   PubMedGoogle Scholar
• Satou T, Itoh T, Tamai Y, et al. Neurotrophic effects of FPF-1070 (Cerebrolysin) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm. 2000;107(11):1253–1262. doi: 10.1007/s007020070015.
   PubMed Web of Science ®Google Scholar
• Kurkin DV, Bakulin DA, Morkovin EI, et al. Neuroprotective action of cortexin, Cerebrolysin and actovegin in acute or chronic brain ischemia in rats. PLOS One. 2021;16(7):e0254493. doi: 10.1371/journal.pone.0254493.
   PubMed Web of Science ®Google Scholar
• Schmidt BZ, Lehmann M, Gutbier S, et al. In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities. Arch Toxicol. 2017;91(1):1–33. doi: 10.1007/s00204-016-1805-9.
   PubMed Web of Science ®Google Scholar
• Haberberger RV, Barry C, Dominguez N, et al. Human dorsal root ganglia. Front Cell Neurosci. 2019;13:271. doi: 10.3389/fncel.2019.00271.
   PubMed Web of Science ®Google Scholar
• McRoberts JA, Li J, Ennes HS, et al. Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons. Neuroscience. 2007;148(4):1015–1020. doi: 10.1016/j.neuroscience.2007.07.006.
   PubMed Web of Science ®Google Scholar
• Ahlström FHG, Mätlik K, Viisanen H, et al. Spared nerve ınjury causes sexually dimorphic mechanical allodynia and differential gene expression in spinal cords and dorsal root ganglia in rats. Mol Neurobiol. 2021;58(10):5396–5419. doi: 10.1007/s12035-021-02447-1.
   PubMed Web of Science ®Google Scholar