158
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

The association between glyphosate exposure and metabolic syndrome among U.S. adults

, , , , , & show all
Pages 1212-1225 | Received 18 Apr 2023, Accepted 28 Aug 2023, Published online: 16 Nov 2023

References

  • Ahluwalia N, Dwyer J, Terry A, Moshfegh A, Johnson C. 2016. Update on NHANES dietary data: Focus on collection, release, analytical considerations, and uses to inform public policy. Adv Nutr. 7(1):121–134. doi: 10.3945/an.115.009258.
  • Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S. 2013. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010. J Am Coll Cardiol. 62(8):697–703. doi: 10.1016/j.jacc.2013.05.064.
  • Benbrook CM. 2019. How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides? Environ Sci Eur. 31(1):2. doi: 10.1186/s12302-018-0184-7.
  • Boudreau DM, Malone DC, Raebel MA, Fishman PA, Nichols GA, Feldstein AC, Boscoe AN, Ben-Joseph RH, Magid DJ, Okamoto LJ. 2009. Health care utilization and costs by metabolic syndrome risk factors. Metab Syndr Relat Disord. 7(4):305–314. doi: 10.1089/met.2008.0070.
  • Brookes G, Taheripour F, Tyner WE. 2017. The contribution of glyphosate to agriculture and potential impact of restrictions on use at the global level. GM Crops Food. 8(4):216–228. doi: 10.1080/21645698.2017.1390637.
  • Contardo-Jara V, Klingelmann E, Wiegand C. 2009. Bioaccumulation of glyphosate and its formulation Roundup Ultra in Lumbriculus variegatus and its effects on biotransformation and antioxidant enzymes. Environ Pollut. 157(1):57–63. doi: 10.1016/j.envpol.2008.07.027.
  • Egusquiza RJ, Blumberg B. 2020. Environmental obesogens and their impact on susceptibility to obesity: New mechanisms and chemicals. Endocrinology. 161(3). doi: 10.1210/endocr/bqaa024.
  • Eskenazi B, Gunier Robert B, Rauch S, Kogut K, Perito Emily R, Mendez X, Limbach C, Holland N, Bradman A, Harley Kim G, et al. 2023. Association of lifetime exposure to glyphosate and aminomethylphosphonic acid (AMPA) with liver inflammation and metabolic syndrome at young adulthood: Findings from the CHAMACOS study. Environ Health Perspect. 131-144(3):37001. doi: 10.1289/EHP11721.
  • Gillezeau C, van Gerwen M, Shaffer RM, Rana I, Zhang L, Sheppard L, Taioli E. 2019. The evidence of human exposure to glyphosate: A review. Environ Health. 18(1):2. doi: 10.1186/s12940-018-0435-5.
  • Glover F, Barr D, Eatman J, Muncey W, Del Giudice F, Belladelli F, Seranio N, Eisenberg ML. 2023. Evaluation of glyphosate exposure on testosterone among U.S. adult men. Hum Ecol Risk Assess. 29(5–6):902–915. doi: 10.1080/10807039.2023.2195005.
  • Glover F, Steenland K, Eisenberg ML, Belladelli F, Mulloy E, Del Giudice F, Caudle WM. 2022. The association between organophosphate insecticides, blood pressure dysregulation, and metabolic syndrome among U.S. Adults: NHANES 2015-2016. Hyg Environ Health Adv. 4:100035. doi: 10.1016/j.heha.2022.100035.
  • Gomes ECZ, Teleken JL, Vargas R, Alegre-Maller ACP, Amorim JPA, Bonfleur ML, Balbo SL. 2022. Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. Einstein (Sao Paulo). 20:eAO6778. doi: 10.31744/einstein_journal/2022AO6778.
  • Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C, National Heart, Lung, and Blood Institute. 2004. Definition of metabolic syndrome. Circulation. 109(3):433–438. doi: 10.1161/01.CIR.0000111245.75752.C6.
  • Hanke I, Wittmer I, Bischofberger S, Stamm C, Singer H. 2010. Relevance of urban glyphosate use for surface water quality. Chemosphere. 81(3):422–429. doi: 10.1016/j.chemosphere.2010.06.067.
  • Haverinen E, Fernandez MF, Mustieles V, Tolonen H. 2021. Metabolic syndrome and endocrine disrupting chemicals: An overview of exposure and health effects. Int J Environ Res Public Health. 18(24):13047.
  • Huang PL. 2009. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2(5–6):231–237. doi: 10.1242/dmm.001180.
  • Intayoung U, Wunnapuk K, Kohsuwan K, Sapbamrer R, Khacha-Ananda S. 2021. Effect of occupational exposure to herbicides on oxidative stress in sprayers. Saf Health Work. 12(1):127–132. doi: 10.1016/j.shaw.2020.09.011.
  • Jeffrey M E, James L G. 2002. Soybean (Glycine max) and Cotton (Gossypium hirsutum) response to simulated drift of glyphosate and glufosinate. Weed Technol. 16(3):580–586. doi: 10.1614/0890-037X(2002)016[0580:SGMACG]2.0.CO;2.
  • Kanissery R, Gairhe B, Kadyampakeni D, Batuman O, Alferez F. 2019. Glyphosate: Its environmental persistence and impact on crop health and nutrition. Plants (Basel). 8(11). doi: 10.3390/plants8110499.
  • Malik J, Barry G, Kishore G. 1989. The herbicide glyphosate. Biofactors. 2(1):17–25.
  • Marangos PJ, Okamoto LJ, Caro JJ. 2010. Economic burden of the components of the metabolic syndrome. In: Preedy VR, Watson RR, editors. Handbook of disease burdens and quality of life measures. New York: Springer; p. 1135–1149. doi: 10.1007/978-0-387-78665-0_64.
  • Meloni F, Satta G, Padoan M, Montagna A, Pilia I, Argiolas A, Piro S, Magnani C, Gambelunghe A, Muzi G, et al. 2021. Occupational exposure to glyphosate and risk of lymphoma:results of an Italian multicenter case-control study. Environ Health. 20(1):49. doi: 10.1186/s12940-021-00729-8.
  • Moore JX, Chaudhary N, Akinyemiju T. 2017. Metabolic syndrome prevalence by race/ethnicity and sex in the United States, National Health and Nutrition Examination Survey, 1988-2012. Prev Chronic Dis. 14: e24. doi: 10.5888/pcd14.160287.
  • Muñoz JP, Bleak TC, Calaf GM. 2021. Glyphosate and the key characteristics of an endocrine disruptor: A review. Chemosphere. 270:128619. doi: 10.1016/j.chemosphere.2020.128619.
  • National Health and Nutrition Examination Survey. 1997. NHANES III plan and operations procedures manuals CD-ROM: Draft. Atlanta (GA): National Centers for Disease Control and Prevention.
  • Ospina M, Schütze A, Morales-Agudelo P, Vidal M, Wong LY, Calafat AM. 2022. Exposure to glyphosate in the United States: Data from the 2013-2014 National Health and Nutrition Examination Survey. Environ Int. 170:107620. doi: 10.1016/j.envint.2022.107620.
  • Prasad M, Gatasheh MK, Alshuniaber MA, Krishnamoorthy R, Rajagopal P, Krishnamoorthy K, Periyasamy V, Veeraraghavan VP, Jayaraman S. 2022. Impact of glyphosate on the development of insulin resistance in experimental diabetic rats: Role of NFκB signalling pathways. Antioxidants (Basel). 11(12). doi: 10.3390/antiox11122436.
  • Puigbò P, Leino LI, Rainio MJ, Saikkonen K, Saloniemi I, Helander M. 2022. Does glyphosate affect the human microbiota? Life (Basel). 12(5). doi: 10.3390/life12050707.
  • Regnier SM, Sargis RM. 2014. Adipocytes under assault: Environmental disruption of adipose physiology. Biochim Biophys Acta. 1842(3):520–533. doi: 10.1016/j.bbadis.2013.05.028.
  • Richmond ME. 2018. Glyphosate: A review of its global use, environmental impact, and potential health effects on humans and other species. J Environ Stud Sci. 8(4):416–434. doi: 10.1007/s13412-018-0517-2.
  • Sargis RM, Johnson DN, Choudhury RA, Brady MJ. 2010. Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation. Obesity (Silver Spring). 18(7):1283–1288. doi: 10.1038/oby.2009.419.
  • Swarup S, Goyal A, Grigorova Y, Zeltser R. 2022. Metabolic syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing.
  • Talbot D, Massamba VK. 2019. A descriptive review of variable selection methods in four epidemiologic journals: There is still room for improvement. Eur J Epidemiol. 34(8):725–730. doi: 10.1007/s10654-019-00529-y.
  • Tarazona JV, Court-Marques D, Tiramani M, Reich H, Pfeil R, Istace F, Crivellente F. 2017. Glyphosate toxicity and carcinogenicity: A review of the scientific basis of the European Union assessment and its differences with IARC. Arch Toxicol. 91(8):2723–2743. doi: 10.1007/s00204-017-1962-5.
  • Van Stempvoort D, Roy J, Brown S, Bickerton G. 2014. Residues of the herbicide glyphosate in riparian groundwater in urban catchments. Chemosphere. 95:455–463. doi: 10.1016/j.chemosphere.2013.09.095.
  • van Vliet-Ostaptchouk JV, Nuotio M-L, Slagter SN, Doiron D, Fischer K, Foco L, Gaye A, Gögele M, Heier M, Hiekkalinna T, et al. 2014. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr Disord. 14(1):9. doi: 10.1186/1472-6823-14-9.
  • Zheng X-Y, Tang S-L, Liu T, Wang Y, Xu X-J, Xiao N, Li C, Xu Y-J, He Z-X, Ma S-L, et al. 2022. Effects of long-term PM2.5 exposure on metabolic syndrome among adults and elderly in Guangdong, China. Environ Health. 21(1):84. doi: 10.1186/s12940-022-00888-2.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.