An updated comprehensive review of the therapeutic properties of Chamomile (Matricaria chamomilla L.)

References

• El Joumaa, M. M.; Borjac, J. M. Matricaria Chamomilla: A Valuable Insight into Recent Advances in Medicinal Uses and Pharmacological Activities. Phytochem. Rev. 2022, 21(6), 1913–1940. DOI: 10.1007/s11101-022-09817-0.
   Web of Science ®Google Scholar
• Marković, M.; Pljevljakušić, D.; Kojičić, K.; Cupara, S. Ethnopharmacological Application of Chamomile (Matricaria Chamomilla L.) in the Pirot County of Southeastern Serbia. Arh. Farm. (Belgr). 2020, 70(4), 238–247. DOI: 10.5937/arhfarm2004238M.
   Google Scholar
• Singh, O.; Khanam, Z.; Misra, N.; Srivastava, M. Chamomile (Matricaria chamomilla L.): An overview. Pharmacogn. Rev. 2011, 5(9), 82. DOI: 10.4103/0973-7847.79103.
   PubMedGoogle Scholar
• Sharifi-Rad, M.; Nazaruk, J.; Polito, L.; Morais-Braga, M. F. B.; Rocha, J. E.; Coutinho, H. D. M.; Salehi, B.; Tabanelli, G.; Montanari, C.; Del Mar Contreras, M., et al. Matricaria Genus as a Source of Antimicrobial Agents: From Farm to Pharmacy and Food Applications. Microbiol. Res. 2018, 215, 76–88. DOI: 10.1016/j.micres.2018.06.010.
   PubMed Web of Science ®Google Scholar
• Chauhan, R.; Singh, S.; Kumar, V.; Kumar, A.; Kumari, A.; Rathore, S.; Kumar, R.; Singh, S. A Comprehensive Review on Biology, Genetic Improvement, Agro and Process Technology of German Chamomile (Matricaria Chamomilla L.). Plants. 2021, 11(1), 29. DOI: 10.3390/plants11010029.
   Google Scholar
• Srivastava, J. K.; Shankar, E.; Gupta, S. Chamomile: A Herbal Medicine of the Past with a Bright Future (Review). Mol. Med. Rep. 2010, 3(6), 895–901. DOI: 10.3892/mmr.2010.377.
   PubMed Web of Science ®Google Scholar
• Kyokong, O.; Charuluxananan, S.; Muangmingsuk, V.; Rodanant, O.; Subornsug, K.; Punyasang, W. Efficacy of Chamomile-Extract Spray for Prevention of Post-Operative Sore Throat. J. Med. Assoc. Thai. 2002, 85(1), S180–5.
   PubMedGoogle Scholar
• Togar, B.; Turkez, H.; Hacimuftuoglu, A.; Tatar, A.; Geyikoglu, F. Guaiazulene: biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J. Intercult. Ethnopharmacol. 2015, 4(1), 29. DOI: 10.5455/jice.20141124062203.
   PubMedGoogle Scholar
• Attia, M.; Kim, S.-U.; Ro, D.-K. Molecular Cloning and Characterization of (+)-Epi-α-Bisabolol Synthase, Catalyzing the First Step in the Biosynthesis of the Natural Sweetener, Hernandulcin, in Lippia Dulcis. Arch. Biochem. Biophys. 2012, 527(1), 37–44. DOI: 10.1016/j.abb.2012.07.010.
   PubMed Web of Science ®Google Scholar
• Eddin, L. B.; Jha, N. K.; Goyal, S. N.; Agrawal, Y. O.; Subramanya, S. B.; Bastaki, S. M. A.; Ojha, S. Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. Nutrients. 2022, 14(7), 1370. DOI: 10.3390/nu14071370.
   PubMed Web of Science ®Google Scholar
• Farias, K. S.; Kato, N. N.; Boaretto, A. G.; Weber, J. I.; Brust, F. R.; Alves, F. M.; Tasca, T.; Macedo, A. J.; Silva, D. B.; Carollo, C. A. Nectandra as a Renewable Source for (+)-α-Bisabolol, an Antibiofilm and Anti-Trichomonas Vaginalis Compound. Fitoterapia. 2019, 136, 104179. DOI: 10.1016/j.fitote.2019.104179.
   PubMed Web of Science ®Google Scholar
• Kamatou, G. P. P.; Viljoen, A. M. A Review of the Application and Pharmacological Properties of α -Bisabolol and α -Bisabolol-Rich Oils. J. Am. Oil Chem. Soc. 2010, 87(1), 1–7. DOI: 10.1007/s11746-009-1483-3.
   Web of Science ®Google Scholar
• Aziz, Z. A. A.; Ahmad, A.; Setapar, S. H. M.; Karakucuk, A.; Azim, M. M.; Lokhat, D.; Rafatullah, M.; Ganash, M.; Kamal, M. A.; Ashraf, G. M. Essential Oils: Extraction Techniques, Pharmaceutical And Therapeutic Potential - A Review. Curr. Drug Metab. 2018, 19(13), 1100–1110. DOI: 10.2174/1389200219666180723144850.
   PubMed Web of Science ®Google Scholar
• Deligeorgopoulou, A.; Allemann, R. K. Evidence for Differential Folding of Farnesyl Pyrophosphate in the Active Site of Aristolochene Synthase: A Single-Point Mutation Converts Aristolochene Synthase into an (E)-β-Farnesene Synthase. Biochemistry. 2003, 42(25), 7741–7747. DOI: 10.1021/bi034410m.
   PubMed Web of Science ®Google Scholar
• Amara, U.; Mashwani, Z. U. R.; Khan, A.; Laraib, S.; Wali, R.; Sarwar, U.; Ain, Q. T.; Shakeel, S.; Rahimullah, S. Conservation Status and Therapeutic Potential of Saussurea lappa: An Overview. AJPS. 2017, 08(3), 602–614. DOI: 10.4236/ajps.2017.83041.
   Google Scholar
• Telascrea, M.; de Araújo, C. C.; Marques, M. O. M.; Facanali, R.; de Moraes, P. L. R.; Cavalheiro, A. J. Essential Oil from Leaves of Cryptocarya Mandioccana Meisner (Lauraceae): Composition and Intraspecific Chemical Variability. Biochem. Syst. Ecol. 2007, 35(4), 222–232. DOI: 10.1016/j.bse.2006.09.015.
   Web of Science ®Google Scholar
• Fahlbusch, K.; Hammerschmidt, F.; Panten, J.; Pickenhagen, W.; Schatkowski, D.; Bauer, K.; Garbe, D.; Surburg, H. Flavors and Fragrances. In Ullmann’s Encyclopedia of Industrial Chemistry; Wiley, 2003; pp. 1131–1145. DOI:10.1002/14356007.a11_141.
   Google Scholar
• Mahdavi, B.; Ghezi, S.; Maleki, B. Chemical Composition and Bioactivity of Essential Oil and Extracts of Salvia Limbata C.A. Mey (Lamiaceae). Curr. Bioact. Compd. 2020, 16(9), 1299–1305. DOI: 10.2174/1573407216666200218111906.
   Google Scholar
• Salehi, A.; Hazrati, S. How Essential Oil Content and Composition Fluctuate in German Chamomile Flowers During the Day? J. Essent. Oil Bear. Plants. 2017, 20(3), 622–631. DOI: 10.1080/0972060X.2017.1351895.
   Web of Science ®Google Scholar
• Flemming, M.; Kraus, B.; Rascle, A.; Jürgenliemk, G.; Fuchs, S.; Fürst, R.; Heilmann, J. Revisited Anti-Inflammatory Activity of Matricine in Vitro: Comparison with Chamazulene. Fitoterapia. 2015, 106, 122–128. DOI: 10.1016/j.fitote.2015.08.010.
   PubMed Web of Science ®Google Scholar
• Héthelyi, É.; Dános, B.; Tétényi, P. Phytochemical Studies on the Essential Oils of Species Belonging to theAchillea Genus by Gas Chromatography/Mass Spectrometry. Biol. Mass Spectrom. 1989, 18(8), 629–636. DOI: 10.1002/bms.1200180821.
   Google Scholar
• Stanojevic, L. P.; Marjanovic-Balaban, Z. R.; Kalaba, V. D.; Stanojevic, J. S.; Cvetkovic, D. J. Chemical Composition, Antioxidant and Antimicrobial Activity of Chamomile Flowers Essential Oil (Matricaria Chamomilla L.). J. Essent. Oil Bear. Plants. 2016, 19(8), 2017–2028. DOI: 10.1080/0972060X.2016.1224689.
   Web of Science ®Google Scholar
• Rauter, A. P.; Ennis, M.; Hellwich, K.-H.; Herold, B. J.; Horton, D.; Moss, G. P.; Schomburg, I. Nomenclature of flavonoids (IUPAC Recommendations 2017). Pure Appl. Chem. 2018, 90(9), 1429–1486. DOI: 10.1515/pac-2013-0919.
   Web of Science ®Google Scholar
• Redaelli, C.; Formentini, L.; Santaniello, E. Apigenin 7-Glucoside and Its 2″- and 6″-Acetates from Ligulate Flowers of Matricaria Chamomilla. Phytochemistry. 1980, 19(5), 985–986. DOI: 10.1016/0031-9422(80)85160-0.
   Web of Science ®Google Scholar
• Salehi, B.; Venditti, A.; Sharifi-Rad, M.; Kręgiel, D.; Sharifi-Rad, J.; Durazzo, A.; Lucarini, M.; Santini, A.; Souto, E.; Novellino, E., et al. The Therapeutic Potential of Apigenin. Int. J. Mol. Sci. 2019, 20(6), 1305. DOI: 10.3390/ijms20061305.
   PubMed Web of Science ®Google Scholar
• Chen, W.; Viljoen, A. M. Geraniol — a Review of a Commercially Important Fragrance Material. South African J. Bot. 2010, 76(4), 643–651. DOI: 10.1016/j.sajb.2010.05.008.
   Web of Science ®Google Scholar
• Farkoosh, S. S.; Ardakani, M. R. R.; Darzi, F.; Faregh, M. T. Effect of Mycorrhizal Symbiosis and Bacillus Coagolance on Qualitative and Quantitative Traits of Matricaria Chamomilla Under Different Levels of Phosphorus. Middle-East J. Sci. Res. 2011, 8, 01–09.
   Google Scholar
• Yonzon, M.; Lee, D. J.; Yokochi, T.; Kawano, Y.; Nakahara, T. Antimicrobial Activities of Essential Oils of Nepal. J. Essent. Oil Res. 2005, 17(1), 107–111. DOI: 10.1080/10412905.2005.9698846.
   Web of Science ®Google Scholar
• Ekiert, H.; Świątkowska, J.; Knut, E.; Klin, P.; Rzepiela, A.; Tomczyk, M.; Szopa, A. Artemisia Dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Front. Pharmacol. 2021, 12, 383–426. DOI: 10.3389/fphar.2021.653993.
   Web of Science ®Google Scholar
• Molnar, M.; Mendešević, N.; Šubarić, D.; Banjari, I.; Jokić, S. Comparison of Various Techniques for the Extraction of Umbelliferone and Herniarin in Matricaria Chamomilla Processing Fractions. Chem. Cent. J. 2017, 11(1), 78. DOI: 10.1186/s13065-017-0308-y.
   PubMedGoogle Scholar
• Mazimba, O. Umbelliferone: Sources, Chemistry and Bioactivities Review. Bull. Fac. Pharmacy, Cairo Univ. 2017, 55(2), 223–232. DOI: 10.1016/j.bfopcu.2017.05.001.
   Google Scholar
• Ionita, R.; Postu, P. A.; Mihasan, M.; Gorgan, D. L.; Hancianu, M.; Cioanca, O.; Hritcu, L. Ameliorative Effects of Matricaria Chamomilla L. Hydroalcoholic Extract on Scopolamine-Induced Memory Impairment in Rats: A Behavioral and Molecular Study. Phytomedicine. 2018, 47, 113–120. DOI: 10.1016/j.phymed.2018.04.049.
   PubMed Web of Science ®Google Scholar
• Nováková, L.; Vildová, A.; Mateus, J. P.; Gonçalves, T.; Solich, P. Development and Application of UHPLC–MS/MS Method for the Determination of Phenolic Compounds in Chamomile Flowers and Chamomile Tea Extracts. Talanta. 2010, 82(4), 1271–1280. DOI: 10.1016/j.talanta.2010.06.057.
   PubMed Web of Science ®Google Scholar
• Plazas, M.; Andújar, I.; Vilanova, S.; Hurtado, M.; Gramazio, P.; Herraiz, F. J.; Prohens, J. Breeding for Chlorogenic Acid Content in Eggplant: Interest and Prospects. Not. Bot. Horti Agrobot. Cluj-Napoca. 2013, 41(1), 26. DOI: 10.15835/nbha4119036.
   Web of Science ®Google Scholar
• Espíndola, K. M. M.; Ferreira, R. G.; Narvaez, L. E. M.; Silva Rosario, A. C. R.; da Silva, A. H. M.; Silva, A. G. B.; Vieira, A. P. O.; Monteiro, M. C. Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma. Front. Oncol. 2019, 9, 67–77. DOI: 10.3389/fonc.2019.00541.
   PubMed Web of Science ®Google Scholar
• Colunga Biancatelli, R. M. L.; Berrill, M.; Catravas, J. D.; Marik, P. E. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front. Immunol. 2020, 11, 231–255. DOI: 10.3389/fimmu.2020.01451.
   PubMed Web of Science ®Google Scholar
• Jucá, M. M.; Cysne Filho, F. M. S.; de Almeida, J. C.; Mesquita, D. D. S.; Barriga, J. R. D. M.; Dias, K. C. F.; Barbosa, T. M.; Vasconcelos, L. C.; Leal, L. K. A. M.; Ribeiro, J. E., et al. Flavonoids: biological activities and therapeutic potential. Nat. Prod. Res. 2020, 34(5), 692–705. DOI: 10.1080/14786419.2018.1493588.
   PubMed Web of Science ®Google Scholar
• Ganeshpurkar, A.; Saluja, A. K. The Pharmacological Potential of Rutin. Saudi Pharm. J. 2017, 25(2), 149–164. DOI: 10.1016/j.jsps.2016.04.025.
   PubMed Web of Science ®Google Scholar
• Ma, Y.; Li, W.; Mai, J.; Wang, J.; Wei, Y.; Ledesma-Amaro, R.; Ji, X.-J. Engineering Yarrowia Lipolytica for Sustainable Production of the Chamomile Sesquiterpene (−)-α-Bisabolol. Green Chem. 2021, 23(2), 780–787. DOI: 10.1039/D0GC03180A.
   Web of Science ®Google Scholar
• Hajaji, S.; Sifaoui, I.; López-Arencibia, A.; Reyes-Batlle, M.; Jiménez, I. A.; Bazzocchi, I. L.; Valladares, B.; Akkari, H.; Lorenzo-Morales, J.; Piñero, J. E. Leishmanicidal Activity of α-Bisabolol from Tunisian Chamomile Essential Oil. Parasitol. Res. 2018, 117(9), 2855–2867. DOI: 10.1007/s00436-018-5975-7.
   PubMed Web of Science ®Google Scholar
• Shanmuganathan, B.; Suryanarayanan, V.; Sathya, S.; Narenkumar, M.; Singh, S. K.; Ruckmani, K.; Pandima Devi, K. Anti-amyloidogenic and anti-apoptotic effect of α-bisabolol against Aβ induced neurotoxicity in PC12 cells. Eur. J. Med. Chem. 2018, 143, 1196–1207. DOI: 10.1016/j.ejmech.2017.10.017.
   PubMed Web of Science ®Google Scholar
• Nagoor Meeran, M. F.; Azimullah, S.; Laham, F.; Tariq, S.; Goyal, S. N.; Adeghate, E.; Ojha, S. α-Bisabolol Protects Against β-Adrenergic Agonist-Induced Myocardial Infarction in Rats by Attenuating Inflammation, Lysosomal Dysfunction, NLRP3 Inflammasome Activation and Modulating Autophagic Flux. Food Funct. 2020, 11(1), 965–976. DOI: 10.1039/C9FO00530G.
   PubMed Web of Science ®Google Scholar
• Baylac, S. Inhibition of 5-Lipoxygenase by Essential Oils and Other Natural Fragrant Extracts. Int. J. Aromather. 2003, 13(2–3), 138–142. DOI: 10.1016/S0962-4562(03)00083-3.
   Google Scholar
• Shi, T.; Li, Y.; Zhu, L.; Tong, Y.; Yang, J.; Fang, Y.; Wang, M.; Zhang, J.; Jiang, Y.; Yang, S. Engineering the Oleaginous Yeast Yarrowia Lipolytica for β‐Farnesene Overproduction. Biotechnol. J. 2021, 16(7), 63. DOI: 10.1002/biot.202100097.
   Web of Science ®Google Scholar
• Brantner, A. H.; Pfeifhofer, H. W.; Ercegovac, O.; Males, Z.; Plazibat, M. Essential Oil Composition and Antioxidant Activity ofThymus Bracteosus Vis. Ex Benth. Flavour Fragr. J. 2005, 20(6), 596–600. DOI: 10.1002/ffj.1494.
   Web of Science ®Google Scholar
• Qadir, M.; Maurya, A. K.; Agnihotri, V. K.; Shah, W. A. Volatile Composition, Antibacterial and Antioxidant Activities of Artemisia Tournefortiana Reichb. from Kashmir, India. Nat. Prod. Res. 2021, 35(1), 152–156. DOI: 10.1080/14786419.2019.1613990.
   PubMed Web of Science ®Google Scholar
• Oliveira, A.; França, H.; Kuster, R.; Teixeira, L.; Rocha, L. Chemical Composition and Antibacterial Activity of Brazilian Propolis Essential Oil. J. Venom. Anim. Toxins Incl. Trop. Dis. 2010, 16(1), 121–130. DOI: 10.1590/S1678-91992010005000007.
   Web of Science ®Google Scholar
• Qin, Y.; Yang, Z.; Song, D.; Wang, Q.; Gu, S.; Li, W.; Duan, H.; Zhou, J.; Yang, X. Bioactivities of Synthetic Salicylate-Substituted Carboxyl (E)-β-Farnesene Derivatives as Ecofriendly Agrochemicals and Their Binding Mechanism with Potential Targets in Aphid Olfactory System. Pest Manag. Sci. 2020, 76(7), 2465–2472. DOI: 10.1002/ps.5787.
   PubMed Web of Science ®Google Scholar
• Zhang, J.-P.; Qin, Y.-G.; Dong, Y.-W.; Song, D.-L.; Duan, H.-X.; Yang, X.-L. Synthesis and Biological Activities of (E)- β -Farnesene Analogues Containing 1,2,3-Thiadiazole. Chinese Chem. Lett. 2017, 28(2), 372–376. DOI: 10.1016/j.cclet.2016.10.030.
   Web of Science ®Google Scholar
• Qin, Y.-G.; Yang, Z.-K.; Zhou, J.-J.; Zhang, S.-Y.; Pan, S.-X.; Liu, Y.; Gu, S.-H.; Duan, H.-X.; Yang, X.-L. Effects of Carboxyl and Acylamino Linkers in Synthetic Derivatives of Aphid Alarm Pheromone (E)-β-Farnesene on Repellent, Binding and Aphicidal Activity. J. Mol. Struct. 2022, 1268, 133658. DOI: 10.1016/j.molstruc.2022.133658.
   Web of Science ®Google Scholar
• Juteau, F.; Masotti, V.; Bessière, J. M.; Dherbomez, M.; Viano, J. Antibacterial and Antioxidant Activities of Artemisia Annua Essential Oil. Fitoterapia. 2002, 73(6), 532–535. DOI: 10.1016/S0367-326X(02)00175-2.
   PubMed Web of Science ®Google Scholar
• Montanari, R. M.; Barbosa, L. C. A.; Demuner, A. J.; Silva, C. J.; Carvalho, L. S.; Andrade, N. J. Chemical Composition and Antibacterial Activity of Essential Oils from Verbenaceae Species: Alternative Sources of (E)-Caryophyllene and Germacrene-D. Quim. Nova. 2011, 34(9), 1550–1555. DOI: 10.1590/S0100-40422011000900013.
   Web of Science ®Google Scholar
• Laouer, H.; Yabrir, B.; Djeridane, A.; Yousfi, M.; Beldovini, N.; Lamamra, M. Composition, Antioxidant and Antimicrobial Activities of the Essential Oil of Marrubium Deserti. Nat. Prod. Commun. 2009, 4(8), 1934578X0900400. DOI: 10.1177/1934578X0900400824.
   Web of Science ®Google Scholar
• Schepetkin, I.; Özek, G.; Özek, T.; Kirpotina, L.; Khlebnikov, A.; Quinn, M. Chemical Composition and Immunomodulatory Activity of Hypericum Perforatum Essential Oils. Biomolecules. 2020, 10(6), 916. DOI: 10.3390/biom10060916.
   PubMed Web of Science ®Google Scholar
• de Veras, B. O.; de Oliveira, J. R. S.; de Menezes Lima, V. L.; Do Amaral Ferraz Navarro, D. M.; de Oliveira Farias de Aguiar, J. C. R.; de Medeiros Moura, G. M.; da Silva, J. W.; de Assis, C. R. D.; Gorlach-Lira, K.; de Assis, P. A. C., et al. The Essential Oil of the Leaves of Verbesina Macrophylla (Cass.) S.F.Blake Has Antimicrobial, Anti-Inflammatory and Antipyretic Activities and is Toxicologically Safe. J. Ethnopharmacol. 2021, 265, 113248. DOI: 10.1016/j.jep.2020.113248.
   PubMed Web of Science ®Google Scholar
• Pripdeevech, P.; Saansoomchai, J. Antibacterial Activity and Chemical Composition of Essential Oil and Various Extracts of Fagraea Fragrans Roxb. Flowers. Chiang Mai J. Sci. 2013, 40, 214–223.
   Web of Science ®Google Scholar
• Solymosi, P. Herbicidal Activity of Chamazulene. Növényvédelem. 2000, 36, 119–123. DOI: 10.1016/B978-0-12-818188-1.00031-1.
   Google Scholar
• Akram, W.; Tagde, P.; Ahmed, S.; Arora, S.; Emran, T. B.; Babalghith, A. O.; Sweilam, S. H.; Simal-Gandara, J. Guaiazulene and Related Compounds: A Review of Current Perspective on Biomedical Applications. Life. sci. 2023, 316, 121389. DOI: 10.1016/j.lfs.2023.121389.
   PubMed Web of Science ®Google Scholar
• Ornano, L.; Venditti, A.; Ballero, M.; Sanna, C.; Quassinti, L.; Bramucci, M.; Lupidi, G.; Papa, F.; Vittori, S.; Maggi, F.; et al. Chemopreventive and Antioxidant Activity of the Chamazulene‐Rich Essential Oil Obtained from Artemisia Arborescens L. Growing on the Isle of La Maddalena, Sardinia, Italy. Chem. Biodivers. 2013, 10(8), 1464–1474.
   PubMed Web of Science ®Google Scholar
• Capuzzo, A.; Occhipinti, A.; Maffei, M. E. Antioxidant and Radical Scavenging Activities of Chamazulene. Nat. Prod. Res. 2014, 28(24), 2321–2323. DOI: 10.1080/14786419.2014.931393.
   PubMed Web of Science ®Google Scholar
• Safayhi, H.; Sabieraj, J.; Sailer, E.-R.; Ammon, H. Chamazulene: An Antioxidant-Type Inhibitor of Leukotriene B 4 Formation. Planta. med. 1994, 60(5), 410–413. DOI: 10.1055/s-2006-959520.
   PubMed Web of Science ®Google Scholar
• Ali, F.; Rahul, N.; Jyoti, F.; Siddique, S. Health Functionality of Apigenin: A Review. Int. J. Food. Prop. 2017, 20(6), 1197–1238. DOI: 10.1080/10942912.2016.1207188.
   Web of Science ®Google Scholar
• Lapchak, P. A.; Boitano, P. D. Effect of the Pleiotropic Drug CNB-001 on Tissue Plasminogen Activator (tPa) Protease Activity in Vitro: Support for Combination Therapy to Treat Acute Ischemic Stroke. J. Neurol. Neurophysiol. 2014, 5, 1–9. DOI: 10.1155/2014/525141.
   Google Scholar
• Lee, J.-H.; Zhou, H. Y.; Cho, S. Y.; Kim, Y. S.; Lee, Y. S.; Jeong, C. S. Anti-Inflammatory Mechanisms of Apigenin: Inhibition of Cyclooxygenase-2 Expression, Adhesion of Monocytes to Human Umbilical Vein Endothelial Cells, and Expression of Cellular Adhesion Molecules. Arch. Pharm. Res. 2007, 30(10), 1318–1327. DOI: 10.1007/BF02980273.
   PubMed Web of Science ®Google Scholar
• Telange, D. R.; Patil, A. T.; Pethe, A. M.; Fegade, H.; Anand, S.; Dave, V. S. Formulation and Characterization of an Apigenin-Phospholipid Phytosome (APLC) for Improved Solubility, in vivo Bioavailability, and Antioxidant Potential. Eur. J. Pharm. Sci. 2017, 108, 36–49. DOI: 10.1016/j.ejps.2016.12.009.
   PubMed Web of Science ®Google Scholar
• Miguel, F. G.; Cavalheiro, A. H.; Spinola, N. F.; Ribeiro, D. L.; Barcelos, G. R. M.; Antunes, L. M. G.; Hori, J. I.; Marquele-Oliveira, F.; Rocha, B. A.; Berretta, A. A. Validation of a RP-HPLC-DAD Method for Chamomile (Matricaria Recutita) Preparations and Assessment of the Marker, Apigenin-7-Glucoside, Safety and Anti-Inflammatory Effect. Evidence-Based Complement. Altern. Med. 2015, 2015, 1–9. DOI: 10.1155/2015/828437.
   Web of Science ®Google Scholar
• Pamunuwa, G.; Karunaratne, D. N.; Waisundara, V. Y. Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia Dulcis. Evidence-Based Complement. Altern. Med. 2016, 2016, 1–11. DOI: 10.1155/2016/8243215.
   Web of Science ®Google Scholar
• Shay, J.; Elbaz, H. A.; Lee, I.; Zielske, S. P.; Malek, M. H.; Hüttemann, M. Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. OXID. MED. CELL LONGEV. 2015, 2015, 1–13. DOI: 10.1155/2015/181260.
   Web of Science ®Google Scholar
• Bijani, S.; Dizaji, R.; Sharafi, A.; Hosseini, M.-J. Neuroprotective Effect of Apigenin on Depressive-Like Behavior: Mechanistic Approach. Neurochem. Res. 2022, 47(3), 644–655. DOI: 10.1007/s11064-021-03473-0.
   PubMed Web of Science ®Google Scholar
• Wang, Q.-Q.; Cheng, N.; Yi, W.-B.; Peng, S.-M.; Zou, X.-Q. Synthesis, Nitric Oxide Release, and α-Glucosidase Inhibition of Nitric Oxide Donating Apigenin and Chrysin Derivatives. Bioorg. Med. Chem. 2014, 22(5), 1515–1521. DOI: 10.1016/j.bmc.2014.01.038.
   PubMed Web of Science ®Google Scholar
• Iizumi, Y.; Oishi, M.; Taniguchi, T.; Goi, W.; Sowa, Y.; Sakai, T.; Fei, P. The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9. PLoS One. 2013, 8(8), e73219. DOI: 10.1371/journal.pone.0073219.
   PubMed Web of Science ®Google Scholar
• Maggioni, D.; Garavello, W.; Rigolio, R.; Pignataro, L.; Gaini, R.; Nicolini, G. Apigenin Impairs Oral Squamous Cell Carcinoma Growth in vitro Inducing Cell Cycle Arrest and Apoptosis. Int. J. Oncol. 2013, 43(5), 1675–1682. DOI: 10.3892/ijo.2013.2072.
   PubMed Web of Science ®Google Scholar
• Takagaki, N.; Sowa, Y.; Oki, T.; Nakanishi, R.; Yogosawa, S.; Sakai, T. Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway. Int. J. Oncol. 2005, 25, 5257. DOI: 10.3892/ijo.26.1.185.
   Google Scholar
• SEO, H.-S.; KU, J. M.; CHOI, H.-S.; WOO, J.-K.; JANG, B.-H.; GO, H.; SHIN, Y. C.; KO, S.-G. Apigenin Induces Caspase-Dependent Apoptosis by Inhibiting Signal Transducer and Activator of Transcription 3 Signaling in HER2-Overexpressing SKBR3 Breast Cancer Cells. Mol. Med. Rep. 2015, 12(2), 2977–2984. DOI: 10.3892/mmr.2015.3698.
   PubMed Web of Science ®Google Scholar
• Seo, H.-S.; Choi, H.-S.; Kim, S.-R.; Choi, Y. K.; Woo, S.-M.; Shin, I.; Woo, J.-K.; Park, S.-Y.; Shin, Y. C.; Ko, S.-K. Apigenin Induces Apoptosis via Extrinsic Pathway, Inducing p53 and Inhibiting STAT3 and Nfκb Signaling in HER2-Overexpressing Breast Cancer Cells. Mol. Cell. Biochem. 2012, 366(1–2), 319–334. DOI: 10.1007/s11010-012-1310-2.
   PubMed Web of Science ®Google Scholar
• Chiang, L.-C.; Ng, L. T.; Lin, I.-C.; Kuo, P.-L.; Lin, C.-C. Anti-Proliferative Effect of Apigenin and Its Apoptotic Induction in Human Hep G2 Cells. Cancer Lett. 2006, 237(2), 207–214. DOI: 10.1016/j.canlet.2005.06.002.
   PubMed Web of Science ®Google Scholar
• Avallone, R.; Zanoli, P.; Puia, G.; Kleinschnitz, M.; Schreier, P.; Baraldi, M. Pharmacological Profile of Apigenin, a Flavonoid Isolated from Matricaria Chamomilla. Biochem. Pharmacol. 2000, 59(11), 1387–1394. DOI: 10.1016/S0006-2952(00)00264-1.
   PubMed Web of Science ®Google Scholar
• Zanoli, P.; Avallone, R.; Baraldi, M. Behavioral Characterisation of the Flavonoids Apigenin and Chrysin. Fitoterapia. 2000, 71, S117–S123. DOI: 10.1016/S0367-326X(00)00186-6.
   PubMed Web of Science ®Google Scholar
• Izumi, S.; Takashima, O.; Hirata, T. Geraniol is a Potent Inducer of Apoptosis-Like Cell Death in the Cultured Shoot Primordia of Matricaria Chamomilla. Biochem. Biophys. Res. Commun. 1999, 259(3), 519–522. DOI: 10.1006/bbrc.1999.0813.
   PubMed Web of Science ®Google Scholar
• Lei, Y.; Fu, P.; Jun, X.; Cheng, P. Pharmacological Properties of Geraniol – a Review. Planta. med. 2019, 85(1), 48–55. DOI: 10.1055/a-0750-6907.
   PubMed Web of Science ®Google Scholar
• Chaudhary, S. C.; Siddiqui, M. S.; Athar, M.; Alam, M. S. Geraniol Inhibits Murine Skin Tumorigenesis by Modulating COX‐2 Expression, Ras‐ERK1/2 Signaling Pathway and Apoptosis. J. Appl. Toxicol. 2013, 33(8), 828–837. DOI: 10.1002/jat.2739.
   PubMed Web of Science ®Google Scholar
• Qi, F.; Yan, Q.; Zheng, Z.; Liu, J.; Chen, Y.; Zhang, G. Geraniol and Geranyl Acetate Induce Potent Anticancer Effects in Colon Cancer Colo-205 Cells by Inducing Apoptosis, DNA Damage and Cell Cycle Arrest. J. Buon. 2018, 23(2), 346–352. DOI: 10.1177/1934578X1701200519.
   PubMed Web of Science ®Google Scholar
• Khan, A. Q.; Khan, R.; Qamar, W.; Lateef, A.; Rehman, M. U.; Tahir, M.; Ali, F.; Hamiza, O. O.; Hasan, S. K.; Sultana, S. Geraniol Attenuates 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-Induced Oxidative Stress and Inflammation in Mouse Skin: Possible Role of p38 MAP Kinase and NF-Κb. Exp. Mol. Pathol. 2013, 94(3), 419–429. DOI: 10.1016/j.yexmp.2013.01.006.
   PubMed Web of Science ®Google Scholar
• Wittig, C.; Scheuer, C.; Parakenings, J.; Menger, M. D.; Laschke, M. W.; Addison, C. L. Geraniol Suppresses Angiogenesis by Downregulating Vascular Endothelial Growth Factor (VEGF)/VEGFR-2 Signaling. PLoS One. 2015, 10(7), e0131946. DOI: 10.1371/journal.pone.0131946.
   PubMed Web of Science ®Google Scholar
• Murbach Teles Andrade, B. F.; Conti, B. J.; Santiago, K. B.; Fernandes, A.; Sforcin, J. M. C ymbopogon martinii essential oil and geraniol at noncytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes. J. Pharm. Pharmacol. 2014, 66(10), 1491–1496. DOI: 10.1111/jphp.12278.
   PubMed Web of Science ®Google Scholar
• Su, Y.-W.; Chao, S.-H.; Lee, M.-H.; Ou, T.-Y.; Tsai, Y.-C. Inhibitory Effects of Citronellol and Geraniol on Nitric Oxide and Prostaglandin E 2 Production in Macrophages. Planta. med. 2010, 76(15), 1666–1671. DOI: 10.1055/s-0030-1249947.
   PubMed Web of Science ®Google Scholar
• El Azab, F.; Elguindy, E.; Yacout, N. M.; Elgamal, G. A. Hepatoprotective Impact of Geraniol Against CCl4-Induced Liver Fibrosis in Rats. Pakistan J. Biol. Sci. 2020, 23(12), 1650–1658. DOI: 10.3923/pjbs.2020.1650.1658.
   PubMedGoogle Scholar
• Chen, J.; Fan, X.; Zhou, L.; Gao, X. Treatment with Geraniol Ameliorates Methionine‐Choline‐Deficient Diet‐Induced Non‐Alcoholic Steatohepatitis in Rats. J. Gastroenterol. Hepatol. 2016, 31(7), 1357–1365. DOI: 10.1111/jgh.13272.
   PubMed Web of Science ®Google Scholar
• Ibrahim, S. M.; El- Denshary, E. S.; Abdallah, D. M.; Hribal, M. L. Geraniol, Alone and in Combination with Pioglitazone, Ameliorates Fructose-Induced Metabolic Syndrome in Rats via the Modulation of Both Inflammatory and Oxidative Stress Status. PLoS One. 2015, 10(2), e0117516. DOI: 10.1371/journal.pone.0117516.
   PubMed Web of Science ®Google Scholar
• Galle, M.; Kladniew, B. R.; Castro, M. A.; Villegas, S. M.; Lacunza, E.; Polo, M.; de Bravo, M. G.; Crespo, R. Modulation by Geraniol of Gene Expression Involved in Lipid Metabolism Leading to a Reduction of Serum-Cholesterol and Triglyceride Levels. Phytomedicine. 2015, 22(7–8), 696–704. DOI: 10.1016/j.phymed.2015.04.005.
   PubMed Web of Science ®Google Scholar
• Singh, S.; Fatima, Z.; Ahmad, K.; Hameed, S.; Sturtevant, J. Fungicidal action of geraniol against Candida albicans is potentiated by abrogated CaCdr1p drug efflux and fluconazole synergism. PLoS One. 2018, 13(8), e0203079. DOI: 10.1371/journal.pone.0203079.
   PubMed Web of Science ®Google Scholar
• Singh, S.; Fatima, Z.; Hameed, S. Insights into the Mode of Action of Anticandidal Herbal Monoterpenoid Geraniol Reveal Disruption of Multiple MDR Mechanisms and Virulence Attributes in Candida albicans. Arch. Microbiol. 2016, 198(5), 459–472. DOI: 10.1007/s00203-016-1205-9.
   PubMed Web of Science ®Google Scholar
• Sharma, Y.; Khan, L. A.; Manzoor, N. Anti-Candida Activity of Geraniol Involves Disruption of Cell Membrane Integrity and Function. J. Med. Mycol. 2016, 26(3), 244–254. DOI: 10.1016/j.mycmed.2016.04.004.
   PubMed Web of Science ®Google Scholar
• Leite, M. C. A.; de Brito Bezerra, A. P.; de Sousa, J. P.; de Oliveira Lima, E. Investigating the Antifungal Activity and Mechanism(s) of Geraniol Against Candida albicans Strains. Med. Mycol. 2015, 53(3), 275–284. DOI: 10.1093/mmy/myu078.
   PubMed Web of Science ®Google Scholar
• Asgharzade, S.; Khorrami, M. B.; Forouzanfar, F. Neuroprotective Effect of Herniarin Following Transient Focal Cerebral Ischemia in Rats. Metab. Brain Dis. 2021, 36(8), 2505–2510. DOI: 10.1007/s11011-021-00841-1.
   PubMed Web of Science ®Google Scholar
• Shaibani, Z. The Effect of Herniarin on Oxidative Stress in the Hippocampus in Streptozotocin-Induced Diabetic Rats. J. Anim. Biol. 2021, 14, 55–63. DOI: 10.22034/ASCIJ.2021.684776.
   Google Scholar
• Salehcheh, M.; Safari, O.; Khodayar, M. J.; Mojiri-Forushani, H.; Cheki, M. The Protective Effect of Herniarin on Genotoxicity and Apoptosis Induced by Cisplatin in Bone Marrow Cells of Rats. Drug Chem. Toxicol. 2022, 45(4), 1470–1475. DOI: 10.1080/01480545.2020.1842883.
   PubMed Web of Science ®Google Scholar
• Sim, M.-O.; Lee, H.-I.; Ham, J. R.; Seo, K.-I.; Kim, M.-J.; Lee, M.-K. Anti-Inflammatory and Antioxidant Effects of Umbelliferone in Chronic Alcohol-Fed Rats. Nutr. Res. Pract. 2015, 9(4), 364. DOI: 10.4162/nrp.2015.9.4.364.
   PubMed Web of Science ®Google Scholar
• Boulebd, H. Are Thymol, Rosefuran, Terpinolene and Umbelliferone Good Scavengers of Peroxyl Radicals? Phytochemistry. 2021, 184, 112670. DOI: 10.1016/j.phytochem.2021.112670.
   PubMed Web of Science ®Google Scholar
• Alotaibi, M. F.; Al-Joufi, F.; Abou Seif, H. S.; Alzoghaibi, M. A.; Djouhri, L.; Ahmeda, A. F.; Mahmoud, A. M. Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling. Drug Des. Devel. Ther. 2020, 14, 4003–4019. DOI: 10.2147/DDDT.S265636.
   PubMed Web of Science ®Google Scholar
• Wang, D.; Wang, X.; Tong, W.; Cui, Y.; Li, X.; Sun, H. Umbelliferone Alleviates Lipopolysaccharide-Induced Inflammatory Responses in Acute Lung Injury by Down-Regulating TLR4/MyD88/NF-Κb Signaling. Inflammation. 2019, 42(2), 440–448. DOI: 10.1007/s10753-018-00953-4.
   PubMed Web of Science ®Google Scholar
• Wang, H.-Q.; Wang, S.-S.; Chiufai, K.; Wang, Q.; Cheng, X.-L. Umbelliferone Ameliorates Renal Function in Diabetic Nephropathy Rats Through Regulating Inflammation and TLR/NF-Κb Pathway. Chin. J. Nat. Med. 2019, 17(5), 346–354. DOI: 10.1016/S1875-5364(19)30040-8.
   PubMed Web of Science ®Google Scholar
• Kundu, M.; Chatterjee, S.; Ghosh, N.; Manna, P.; Das, J.; Sil, P. C. Tumor Targeted Delivery of Umbelliferone via a Smart Mesoporous Silica Nanoparticles Controlled-Release Drug Delivery System for Increased Anticancer Efficiency. Mater. Sci. Eng. C. 2020, 116, 111239. DOI: 10.1016/j.msec.2020.111239.
   PubMed Web of Science ®Google Scholar
• Hassanein, E. H. M.; Ali, F. E. M.; Kozman, M. R.; Abd El-Ghafar, O. A. M. Umbelliferone Attenuates Gentamicin-Induced Renal Toxicity by Suppression of TLR-4/nf-Κb-p65/NLRP-3 and JAK1/STAT-3 Signaling Pathways. Environ. Sci. Pollut. Res. 2021, 28(9), 11558–11571. DOI: 10.1007/s11356-020-11416-5.
   PubMed Web of Science ®Google Scholar
• Sotiropoulou, N. S.; Megremi, S. F.; Tarantilis, P. Evaluation of Antioxidant Activity, Toxicity, and Phenolic Profile of Aqueous Extracts of Chamomile (Matricaria Chamomilla L.) and Sage (Salvia Officinalis L.) Prepared at Different Temperatures. Appl. Sci. 2020, 10(7), 2270. DOI: 10.3390/app10072270.
   Google Scholar
• Gao, W.; Wang, C.; Yu, L.; Sheng, T.; Wu, Z.; Wang, X.; Zhang, D.; Lin, Y.; Gong, Y. Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice Through MAPK/ERK/JNK Pathway. Biomed Res. Int. 2019, 2019, 1–14. DOI: 10.1155/2019/6916189.
   Web of Science ®Google Scholar
• Kováčik, J.; Klejdus, B. Dynamics of Phenolic Acids and Lignin Accumulation in Metal-Treated Matricaria Chamomilla Roots. Plant Cell Rep. 2008, 27(3), 605–615. DOI: 10.1007/s00299-007-0490-9.
   PubMed Web of Science ®Google Scholar
• Ye, X.; Liu, Y.; Hu, J.; Gao, Y.; Ma, Y.; Wen, D. Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia. Front. Endocrinol. (Lausanne). 2021, 12, 237–244. DOI: 10.3389/fendo.2021.762691.
   Web of Science ®Google Scholar
• Bhandarkar, N. S.; Brown, L.; Panchal, S. K. Chlorogenic acid attenuates high-carbohydrate, high-fat diet–induced cardiovascular, liver, and metabolic changes in rats. Nutr. Res. 2019, 62, 78–88. DOI: 10.1016/j.nutres.2018.11.002.
   PubMed Web of Science ®Google Scholar
• Ma, Y.; Gao, M.; Liu, D. Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. Pharm. Res. 2015, 32(4), 1200–1209. DOI: 10.1007/s11095-014-1526-9.
   PubMed Web of Science ®Google Scholar
• Huang, S.; Wang, L.-L.; Xue, N.-N.; Li, C.; Guo, H.-H.; Ren, T.-K.; Zhan, Y.; Li, W.-B.; Zhang, J.; Chen, X.-G., et al. Chlorogenic Acid Effectively Treats Cancers Through Induction of Cancer Cell Differentiation. Theranostics. 2019, 9(23), 6745–6763. DOI: 10.7150/thno.34674.
   PubMed Web of Science ®Google Scholar
• Santana-Gálvez, J.; Villela Castrejón, J.; Serna-Saldívar, S. O.; Jacobo-Velázquez, D. A. Anticancer potential of dihydrocaffeic acid: a chlorogenic acid metabolite. CyTA - J. Food. 2020, 18(1), 245–248. DOI: 10.1080/19476337.2020.1743762.
   Web of Science ®Google Scholar
• Rebai, O.; Belkhir, M.; Sanchez-Gomez, M. V.; Matute, C.; Fattouch, S.; Amri, M. Differential Molecular Targets for Neuroprotective Effect of Chlorogenic Acid and Its Related Compounds Against Glutamate Induced Excitotoxicity and Oxidative Stress in Rat Cortical Neurons. Neurochem. Res. 2017, 42(12), 3559–3572. DOI: 10.1007/s11064-017-2403-9.
   PubMed Web of Science ®Google Scholar
• Heitman, E.; Ingram, D. K. Cognitive and neuroprotective effects of chlorogenic acid. Nutr. Neurosci. 2017, 20(1), 32–39. DOI: 10.1179/1476830514Y.0000000146.
   PubMed Web of Science ®Google Scholar
• Shan, S.; Tian, L.; Fang, R. Chlorogenic Acid Exerts Beneficial Effects in 6-Hydroxydopamine-Induced Neurotoxicity by Inhibition of Endoplasmic Reticulum Stress. Med. Sci. Monit. 2019, 25, 453–459. DOI: 10.12659/MSM.911166.
   PubMed Web of Science ®Google Scholar
• Kumar, G.; Mukherjee, S.; Paliwal, P.; Singh, S. S.; Birla, H.; Singh, S. P.; Krishnamurthy, S.; Patnaik, R. Neuroprotective Effect of Chlorogenic Acid in Global Cerebral Ischemia-Reperfusion Rat Model. Naunyn Schmiedebergs Arch. Pharmacol. 2019, 392(10), 1293–1309. DOI: 10.1007/s00210-019-01670-x.
   PubMed Web of Science ®Google Scholar
• Liu, D.; Wang, H.; Zhang, Y.; Zhang, Z. Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway. Nutr. Neurosci. 2020, 20, 32–39. DOI: 10.1179/1476830514Y.0000000146
   Google Scholar
• Alam, M.; Ahmed, S.; Elasbali, A. M.; Adnan, M.; Alam, S.; Hassan, M. I.; Pasupuleti, V. R. Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases. Front. Oncol. 2022, 12, 989–1010. DOI: 10.3389/fonc.2022.860508.
   Web of Science ®Google Scholar
• Kępa, M.; Miklasińska-Majdanik, M.; Wojtyczka, R. D.; Idzik, D.; Korzeniowski, K.; Smoleń-Dzirba, J.; Wąsik, T. J. Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains. Biomed Res. Int. 2018, 2018, 1–9. DOI: 10.1155/2018/7413504.
   Web of Science ®Google Scholar
• Rezaei-Seresht, H.; Cheshomi, H.; Falanji, F.; Movahedi-Motlagh, F.; Hashemian, M.; Mireskandari, E. Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells: An in silico and in vitro study. Avicenna J. Phytomedicine. 2019, 9, 574–586. DOI: 10.22038/AJP.2019.13475.
   PubMed Web of Science ®Google Scholar
• Niu, Y.; Wang, K.; Zheng, S.; Wang, Y.; Ren, Q.; Li, H.; Ding, L.; Li, W.; Zhang, L. Antibacterial Effect of Caffeic Acid Phenethyl Ester on Cariogenic Bacteria and Streptococcus mutans Biofilms. Antimicrob. Agents Chemother. 2020, 64(9), 789. DOI: 10.1128/AAC.00251-20.
   Web of Science ®Google Scholar
• Malik, J. A.; Ahmed, S.; Mir, A.; Shinde, M.; Bender, O.; Alshammari, F.; Ansari, M.; Anwar, S. The SARS-CoV-2 Mutations versus Vaccine Effectiveness: New Opportunities to New Challenges. J. Infect Public Health. 2022, 15(2), 228–240. DOI: 10.1016/j.jiph.2021.12.014.
   PubMed Web of Science ®Google Scholar
• Adem, Ş.; Eyupoglu, V.; Sarfraz, I.; Rasul, A.; Zahoor, A. F.; Ali, M.; Abdalla, M.; Ibrahim, I. M.; Elfiky, A. A. Caffeic Acid Derivatives (CAFDs) as Inhibitors of SARS-CoV-2: CAFDs-Based Functional Foods as a Potential Alternative Approach to Combat COVID-19. Phytomedicine. 2021, 85, 153310. DOI: 10.1016/j.phymed.2020.153310.
   PubMed Web of Science ®Google Scholar
• Cook, M. T. Mechanism of Metastasis Suppression by Luteolin in Breast Cancer. Breast Cancer Targets Ther. 2018, 10, 89–100. DOI: 10.2147/BCTT.S144202.
   PubMed Web of Science ®Google Scholar
• Imran, M.; Rauf, A.; Abu-Izneid, T.; Nadeem, M.; Shariati, M. A.; Khan, I. A.; Imran, A.; Orhan, I. E.; Rizwan, M.; Atif, M.; et al. Luteolin, a Flavonoid, as an Anticancer Agent: A Review. Biomed. Pharmacother. 2019, 112, 108612. DOI: 10.1016/j.biopha.2019.108612.
   PubMed Web of Science ®Google Scholar
• Ashokkumar, P.; Sudhandiran, G. Luteolin Inhibits Cell Proliferation During Azoxymethane-Induced Experimental Colon Carcinogenesis via Wnt/β-Catenin Pathway. Invest. New Drugs. 2011, 29(2), 273–284. DOI: 10.1007/s10637-009-9359-9.
   PubMed Web of Science ®Google Scholar
• Xu, H.; Yu, W.; Sun, S.; Li, C.; Zhang, Y.; Ren, J. Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy. Front. Physiol. 2020, 11, 10990–10998. DOI: 10.3389/fphys.2020.00113.
   Web of Science ®Google Scholar
• Guimarães, R.; Calhelha, R. C.; Froufe, H. J. C.; Abreu, R. M. V.; Carvalho, A. M.; Queiroz, M. J.; Ferreira, R. P. Wild Roman Chamomile Extracts and Phenolic Compounds: Enzymatic Assays and Molecular Modelling Studies with VEGFR-2 Tyrosine Kinase. Food Funct. 2016, 7(1), 79–83. DOI: 10.1039/C5FO00586H.
   PubMed Web of Science ®Google Scholar
• Gendrisch, F.; Esser, P. R.; Schempp, C. M.; Wölfle, U. Luteolin as a Modulator of Skin Aging and Inflammation. BioFactors. 2021, 47(2), 170–180. DOI: 10.1002/biof.1699.
   PubMed Web of Science ®Google Scholar
• Kempuraj, D.; Thangavel, R.; Kempuraj, D. D.; Ahmed, M. E.; Selvakumar, G. P.; Raikwar, S. P.; Zaheer, S. A.; Iyer, S. S.; Govindarajan, R.; Chandrasekaran, P. N., et al. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. BioFactors. 2021, 47(2), 190–197. DOI: 10.1002/biof.1687.
   PubMed Web of Science ®Google Scholar
• Salehi, B.; Machin, L.; Monzote, L.; Sharifi-Rad, J.; Ezzat, S. M.; Salem, M. A.; Merghany, R. M.; El Mahdy, N. M.; Kılıç, C. S.; Sytar, O., et al. Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health. ACS Omega. 2020, 5(20), 11849–11872. DOI: https://doi.org/10.1021/acsomega.0c01818.
   PubMed Web of Science ®Google Scholar
• Patel, R. V.; Mistry, B. M.; Shinde, S. K.; Syed, R.; Singh, V.; Shin, H.-S. Therapeutic potential of quercetin as a cardiovascular agent. Eur. J. Med. Chem. 2018, 155, 889–904. DOI: 10.1016/j.ejmech.2018.06.053.
   PubMed Web of Science ®Google Scholar
• Lesjak, M.; Beara, I.; Simin, N.; Pintać, D.; Majkić, T.; Bekvalac, K.; Orčić, D.; Mimica-Dukić, N. Antioxidant and Anti-Inflammatory Activities of Quercetin and Its Derivatives. J. Funct. Foods. 2018, 40, 68–75. DOI: 10.1016/j.jff.2017.10.047.
   Web of Science ®Google Scholar
• Azeem, M.; Hanif, M.; Mahmood, K.; Ameer, N.; Chughtai, F. R. S.; Abid, U. An Insight into Anticancer, Antioxidant, Antimicrobial, Antidiabetic and Anti-Inflammatory Effects of Quercetin: A Review. Polym. Bull. 2023, 80(1), 241–262. DOI: 10.1007/s00289-022-04091-8.
   PubMed Web of Science ®Google Scholar
• Wiczkowski, W.; Szawara-Nowak, D.; Topolska, J.; Olejarz, K.; Zieliński, H.; Piskuła, M. K. Metabolites of Dietary Quercetin: Profile, Isolation, Identification, and Antioxidant Capacity. J. Funct. Foods. 2014, 11, 121–129. DOI: 10.1016/j.jff.2014.09.013.
   Web of Science ®Google Scholar
• Rauf, A.; Imran, M.; Khan, I. A.; Ur‐Rehman, M.; Gilani, S. A.; Mehmood, Z.; Mubarak, M. S. Anticancer potential of quercetin: A comprehensive review. Phyther. Res. 2018, 32(11), 2109–2130. DOI: 10.1002/ptr.6155.
   PubMed Web of Science ®Google Scholar
• Zaplatic, E.; Bule, M.; Shah, S. Z. A.; Sahab Uddin, M.; Niaz, K. Corrigendum to “Molecular Mechanisms Underlying Protective Role of Quercetin in Attenuating Alzheimer’s disease” [Life Sci. 221 (2019) 109–119]. Life. sci. 2019, 231(231), 116616. DOI: 10.1016/j.lfs.2019.116616.
   PubMedGoogle Scholar
• Nouri, Z.; Fakhri, S.; Nouri, K.; Wallace, C. E.; Farzaei, M. H.; Bishayee, A. Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach. Cancers (Basel). 2020, 12(8), 2276. DOI: 10.3390/cancers12082276.
   PubMed Web of Science ®Google Scholar
• Enogieru, A. B.; Haylett, W.; Hiss, D. C.; Bardien, S.; Ekpo, O. E. Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. OXID. MED. CELL LONGEV. 2018, 2018, 1–17. DOI: 10.1155/2018/6241017.
   Web of Science ®Google Scholar
• Irfan, F.; Jameel, F.; Khan, I.; Aslam, R.; Faizi, S.; Salim, A. Role of Quercetin and Rutin in Enhancing the Therapeutic Potential of Mesenchymal Stem Cells for Cold Induced Burn Wound. Regen. Ther. 2022, 21, 225–238. DOI: 10.1016/j.reth.2022.07.011.
   PubMed Web of Science ®Google Scholar
• Imani, A.; Maleki, N.; Bohlouli, S.; Kouhsoltani, M.; Sharifi, S.; Maleki Dizaj, S. Molecular mechanisms of anticancer effect of rutin. Phyther. Res. 2021, 35(5), 2500–2513. DOI: 10.1002/ptr.6977.
   PubMed Web of Science ®Google Scholar
• Sun, X.; Li, L.; Dong, Q.-X.; Zhu, J.; Huang, Y.; Hou, S.; Yu, X.; Liu, R. Rutin Prevents Tau Pathology and Neuroinflammation in a Mouse Model of Alzheimer’s Disease. J. Neuroinflammation. 2021, 18(1), 131. DOI: 10.1186/s12974-021-02182-3.
   PubMed Web of Science ®Google Scholar
• Satyal, P.; Shrestha, S.; Setzer, W. N. Composition and Bioactivities of an (E)-β-Farnesene Chemotype of Chamomile (Matricaria Chamomilla) Essential Oil from Nepal. Nat. Prod. Commun. 2015, 10(8), 1934578X1501000. DOI: 10.1177/1934578X1501000835.
   Web of Science ®Google Scholar
• Roby, M. H. H.; Sarhan, M. A.; Selim, K. A.-H.; Khalel, K. I. Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.). Ind. Crops Prod. 2013, 44, 437–445. DOI: 10.1016/j.indcrop.2012.10.012.
   Web of Science ®Google Scholar
• Seyedjavadi, S. S.; Khani, S.; Zare‐Zardini, H.; Halabian, R.; Goudarzi, M.; Khatami, S.; Imani Fooladi, A. A.; Amani, J.; Razzaghi‐Abyaneh, M. Isolation, Functional Characterization, and Biological Properties of MCh‐AMP1, a Novel Antifungal Peptide from Matricaria Chamomilla L. Chem. Biol. Drug Des. 2019, 93(5), 949–959. DOI: 10.1111/cbdd.13500.
   PubMed Web of Science ®Google Scholar
• Tolouee, M.; Alinezhad, S.; Saberi, R.; Eslamifar, A.; Zad, S. J.; Jaimand, K.; Taeb, J.; Rezaee, M.-B.; Kawachi, M.; Shams-Ghahfarokhi, M.; et al. Effect of Matricaria Chamomilla L. Flower Essential Oil on the Growth and Ultrastructure of Aspergillus Niger van Tieghem. Int. J. Food Microbiol. 2010, 139(3), 127–133.
   PubMed Web of Science ®Google Scholar
• Enas, M. A. Phytochemical Composition, Antifungal, Antiaflatoxigenic, Antioxidant, and Anticancer Activities of Glycyrrhiza Glabra L. and Matricaria Chamomilla L. Essential Oils. J. Med. Plants Res. 2013, 7(29), 2197–2207. DOI: 10.5897/JMPR12.5134.
   Google Scholar
• EL-Hefny, M.; Abo Elgat, W.; Al-Huqail, A.; Ali, H. Essential and Recovery Oils from Matricaria Chamomilla Flowers as Environmentally Friendly Fungicides Against Four Fungi Isolated from Cultural Heritage Objects. Processes. 2019, 7(11), 809. DOI: 10.3390/pr7110809.
   Web of Science ®Google Scholar
• Dadashpour, M.; Firouzi-Amandi, A.; Pourhassan-Moghaddam, M.; Maleki, M. J.; Soozangar, N.; Jeddi, F.; Nouri, M.; Zarghami, N.; Pilehvar-Soltanahmadi, Y. Biomimetic Synthesis of Silver Nanoparticles Using Matricaria Chamomilla Extract and Their Potential Anticancer Activity Against Human Lung Cancer Cells. Mater. Sci. Eng. C. 2018, 92, 902–912. DOI: 10.1016/j.msec.2018.07.053.
   PubMed Web of Science ®Google Scholar
• Kamali, A. M.; Nikseresht, M.; Delaviz, H.; Barmak, M. J. S.; Ardakani, M.; Mahmoudi, M. T. In vitro Cytotoxic Activity of Matricaria Chamomilla Root Extract in Human Breast Cancer Cell Line MCF-7. Life Sci. J. 2014, 11, 403–406.
   Google Scholar
• Nikseresht, M.; Kamali, A.; Rahimi, H.; Delaviz, H.; Toori, M.; Kashani, I.; Mahmoudi, R. The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer MDA-MB-468 and MCF-7 Cell Lines. Pharmacognosy. Res. 2017, 9(1), 87. DOI: 10.4103/0974-8490.199778.
   PubMed Web of Science ®Google Scholar
• Shaaban, M.; El-Hagrassi, A. M.; Osman, A. F.; Soltan, M. M. Bioactive Compounds from Matricaria Chamomilla: Structure Identification, in vitro Antiproliferative, Antimigratory, Antiangiogenic, and Antiadenoviral Activities. Zeitschrift für Naturforsch. C. 2022, 77(3–4), 85–94. DOI: 10.1515/znc-2021-0083.
   PubMed Web of Science ®Google Scholar
• Mitoshi, M.; Kuriyama, I.; Nakayama, H.; Miyazato, H.; Sugimoto, K.; Kobayashi, Y.; Jippo, T.; Kanazawa, K.; Yoshida, H.; Mizushina, Y. Effects of Essential Oils from Herbal Plants and Citrus Fruits on DNA Polymerase Inhibitory, Cancer Cell Growth Inhibitory, Antiallergic, and Antioxidant Activities. J. Agric. Food. Chem. 2012, 60(45), 11343–11350. DOI: 10.1021/jf303377f.
   PubMed Web of Science ®Google Scholar
• El Joumaa, M. M.; Taleb, R. I.; Rizk, S.; Borjac, J. M. Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice. J. Complement Integr. Med. 2020, 17(3), 20190143. DOI: 10.1515/jcim-2019-0143.
   Google Scholar
• Shebbo, S.; El Joumaa, M.; Kawach, R.; Borjac, J. Hepatoprotective Effect of Matricaria Chamomilla Aqueous Extract Against 1,2-Dimethylhydrazine-Induced Carcinogenic Hepatic Damage in Mice. Heliyon. 2020, 6(6), e04082. DOI: 10.1016/j.heliyon.2020.e04082.
   PubMed Web of Science ®Google Scholar
• Hassanpour, H.; Ghanbarzadeh, M. Induction of cell division and antioxidative enzyme activity of Matricaria chamomilla L. cell line under clino-rotation. Plant Cell Tissue Organ Cult. 2021, 146(2), 215–224. DOI: 10.1007/s11240-021-02060-z.
   Web of Science ®Google Scholar
• Ranjbar, A.; Mohsenzadeh, F.; Chehregani, A.; Khajavi, F.; Zijoud, S.-M.; Ghasemi, H. Ameliorative Effect of Matricaria Chamomilla.L on Paraquat: Induced Oxidative Damage in Lung Rats. Pharmacognosy. Res. 2014, 6(3), 199. DOI: 10.4103/0974-8490.132595.
   PubMedGoogle Scholar
• Kolodziejczyk-Czepas, J.; Bijak, M.; Saluk, J.; Ponczek, M. B.; Zbikowska, H. M.; Nowak, P.; Tsirigotis-Maniecka, M.; Pawlaczyk, I. Radical Scavenging and Antioxidant Effects of Matricaria Chamomilla Polyphenolic–Polysaccharide Conjugates. Int. J. Biol. Macromol. 2015, 72, 1152–1158. DOI: 10.1016/j.ijbiomac.2014.09.032.
   PubMed Web of Science ®Google Scholar
• Aksoy, L.; Sözbilir, N. B. Effects of Matricaria Chamomilla L. on Lipid Peroxidation, Antioxidant Enzyme Systems, and Key Liver Enzymes in CCl 4 -Treated Rats. Toxicol. Environ. Chem. 2012, 94(9), 1780–1788. DOI: 10.1080/02772248.2012.729837.
   Web of Science ®Google Scholar
• Iverson, C. D.; Zahid, S.; Li, Y.; Shoqafi, A. H.; Ata, A.; Samarasekera, R. Glutathione S-Transferase Inhibitory, Free Radical Scavenging, and Anti-Leishmanial Activities of Chemical Constituents of Artocarpus Nobilis and Matricaria Chamomilla. Phytochem. Lett. 2010, 3(4), 207–211. DOI: 10.1016/j.phytol.2010.07.008.
   Web of Science ®Google Scholar
• Ortiz, M. I.; Cariño‐Cortés, R.; Ponce‐Monter, H. A.; González‐García, M. P.; Castañeda‐Hernández, G.; Salinas‐Caballero, M. Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan‐Induced Paw Inflammation in Rats. Drug Dev. Res. 2017, 78(7), 360–367. DOI: 10.1002/ddr.21401.
   PubMed Web of Science ®Google Scholar
• El Mihyaoui, A.; Esteves da Silva, J. C. G.; Charfi, S.; Candela Castillo, M. E.; Lamarti, A.; Arnao, M. B. Chamomile (Matricaria Chamomilla L.): A Review of Ethnomedicinal Use. Phytochemistry And Pharmacological Uses. Life. 2022, 12(4), 479. DOI: 10.3390/life12040479.
   Google Scholar
• Wu, Y.; Xu, Y.; Yao, L. Anti-inflammatory and Anti-allergic Effects of German Chamomile (Matricaria chamomilla L.). J. Essent. Oil Bear. Plants. 2012, 15(1), 75–83. DOI: 10.1080/0972060X.2012.10644022.
   Web of Science ®Google Scholar
• Sayyar, Z.; Yazdinezhad, A.; Hassan, M.; Jafari Anarkooli, I. Protective Effect of Matricaria Chamomilla Ethanolic Extract on Hippocampal Neuron Damage in Rats Exposed to Formaldehyde. OXID. MED. CELL LONGEV. 2018, 2018, 1–10. DOI: 10.1155/2018/6414317.
   Web of Science ®Google Scholar
• Asgharzade, S.; Rabiei, Z.; Rafieian-Kopaei, M. Effects of Matricaria Chamomilla Extract on Motor Coordination Impairment Induced by Scopolamine in Rats. Asian Pac. J. Trop. Biomed. 2015, 5(10), 829–833. DOI: 10.1016/j.apjtb.2015.06.006.
   Google Scholar
• Alibabaei, Z.; Rabiei, Z.; Rahnama, S.; Mokhtari, S.; Rafieian-Kopaei, M. Matricaria Chamomilla Extract Demonstrates Antioxidant Properties Against Elevated Rat Brain Oxidative Status Induced by Amnestic Dose of Scopolamine. Biomed. Aging Pathol. 2014, 4(4), 355–360. DOI: 10.1016/j.biomag.2014.07.003.
   Google Scholar
• Amsterdam, J. D.; Li, Q. S.; Xie, S. X.; Mao, J. J. Putative Antidepressant Effect of Chamomile (Matricaria Chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression. J. Altern. Complement. Med. 2020, 26(9), 815–821. DOI: 10.1089/acm.2019.0252.
   Web of Science ®Google Scholar
• Abbasinia, H.; Alizadeh, Z.; Vakilian, K.; Jafari, Z.; Poor, P. M.; Ranjbaran, M. Effect of Chamomile Extract on Sleep Disorder in Menopausal Women. Iran. J. Obstet. Gynecol. Infertil. 2016, 19, 1–7. DOI: 10.22038/IJOGI.2016.7631.
   Google Scholar
• Abad, A. N. A.; Nouri, M. H. K.; Gharjanie, A.; Tavakoli, F. Effect of Matricaria chamomilla Hydroalcoholic Extract on Cisplatin-induced Neuropathy in Mice. Chin. J. Nat. Med. 2011, 9, 126–131. DOI: 10.3724/SP.J.1009.2011.00126.
   Google Scholar
• Nouri, K. Antinociceptive effect of Matricaria chamomilla on vincristine-induced peripheral neuropathy in mice. Afr J. Pharm. Pharmacol. 2012, 6(1), 24–29. DOI: 10.5897/AJPP11.340.
   Google Scholar
• Ioniță, R. Anxiolytic and Antidepressant Effects of Matricaria Chamomilla Hydroalcoholic Extract in a Rat Model of Scopolamine. Farmacia. 2019, 67(1), 68–72. DOI: 10.31925/farmacia.2019.1.9.
   Web of Science ®Google Scholar
• Reis, L. S. L. D. S.; Pardo, P. E.; Oba, E.; Kronka, S. D. N.; Frazatti-Gallina, N. M. Matricaria chamomilla CH 12 decreases handling stress in Nelore calves. J. Vet. Sci. 2006, 7(2), 189. DOI: 10.4142/jvs.2006.7.2.189.
   PubMed Web of Science ®Google Scholar
• Moore, E.; Lockwood, D. Treatment of Visceral Leishmaniasis. J. Glob. Infect. Dis. 2010, 2(2), 151. DOI: 10.4103/0974-777X.62883.
   PubMedGoogle Scholar
• Karam, T. K.; Ortega, S.; Ueda Nakamura, T.; Auzély-Velty, R.; Nakamura, C. V. Development of Chitosan Nanocapsules Containing Essential Oil of Matricaria Chamomilla L. for the Treatment of Cutaneous Leishmaniasis. Int. J. Biol. Macromol. 2020, 162, 199–208. DOI: 10.1016/j.ijbiomac.2020.06.149.
   PubMed Web of Science ®Google Scholar
• Luize, P. S.; Tiuman, T. S.; Morello, L. G.; Maza, P. K.; Ueda-Nakamura, T.; Dias Filho, B. P.; Cortez, D. A. G.; Mello, J. C. P. D.; Nakamura, C. V. Effects of Medicinal Plant Extracts on Growth of Leishmania (L.) Amazonensis and Trypanosoma Cruzi. Rev. Bras. Cienc. Farm. 2005, 41(1), 85–94. DOI: 10.1590/S1516-93322005000100010.
   Google Scholar
• Macchioni, F.; Perrucci, S.; Cecchi, F.; Cioni, P. L.; Morelli, I.; Pampiglione, S. Acaricidal activity of aqueous extracts of camomile flowers, Matricaria chamomilla, against the mite Psoroptes cuniculi. Med. Vet. Entomol. 2004, 18(2), 205–207. DOI: 10.1111/j.0269-283X.2004.00488.x.
   PubMed Web of Science ®Google Scholar
• Bahmani, M.; Saki, K.; Gholami-Ahangaran, M.; Parsaei, P.; Mohsenzadegan, A.; Zia-Jahromi, N. Evaluating the Anti-Leech Activity of Methanolic Extract of Matricaria Chamomilla L. Comparing with Ivermectin, Mebendasole, Praziquantel, Rafoxanide, Febantel and Albendasole. Middle-East J. Sci. Res. 2012, 12, 260–263. DOI: 10.5829/idosi.mejsr.2012.12.2.6446.
   Google Scholar
• Mollabashi, E. N.; Ziaie, T.; Khalesi, Z. B.; Leili, E. K.; Bekhradi, R. Effect of Chamomile capsule on premenstrual syndrome symptoms relief. Iran. J. Obstet. Gynecol. Infertil. 2018, 21, 72–80. DOI: 10.22038/IJOGI.2018.11799.
   Google Scholar
• Johari, H.; Khavarian, M.; Mokhtari, M.; Kamali, M.; Kargar Jahromi, H. The Effects of Hydro Alcoholic Extract of Matricaria Chamomilla Flower on Testosterone and Gonadotropins Hormone in Adult Male Rat. Pars Jahrom Univ. Med. Sci. 2014, 12(4), 37–41. DOI: 10.29252/jmj.12.4.6.
   Google Scholar
• Karbalay-Doust, S.; Noorafshan, A.; Dehghani, F.; Panjehshahin, M. R.; Monabati, A. Effects of Hydroalcoholic Extract of Matricaria Chamomilla on Serum Testosterone and Estradiol Levels, Spermatozoon Quality, and Tail Length in Rat. Iran. J. Med. Sci. 2010, 35, 122–128.
   Google Scholar
• Shadi, T. Z.; Talal, A. Z. A Review of Four Common Medicinal Plants Used to Treat Eczema. J. Med. Plants Res. 2015, 9(24), 702–711. DOI: 10.5897/JMPR2015.5831.
   Google Scholar
• Dolati, S. A Review of the Therapeutic Effects of Chamomile (Matricaria Chamomile) in Traditional and Modern Medicine. Res. Sport Sci. Med. Plants. 2021, 1, 1–12. DOI: 10.30495/VARZESH.2021.1918705.1003.
   Google Scholar
• Boroujeni, H.; Parvin, N.; Mirzaeian, P.; Marandi, S. Formulation and Clinical Trial Study of AJMT Cream in Treatment of Eczema. Iioab. J. 2017, 8, 46–50.
   Google Scholar
• Niknam, S.; Tofighi, Z.; Faramarzi, M. A.; Abdollahifar, M. A.; Sajadi, E.; Dinarvand, R.; Toliyat, T. Polyherbal Combination for Wound Healing: Matricaria Chamomilla L. and Punica Granatum L. DARU J. Pharm. Sci. 2021, 29(1), 133–145. DOI: 10.1007/s40199-021-00392-x.
   Web of Science ®Google Scholar
• Soltani, M.; Moghimian, M.; Abtahi-Eivari, S. H.; Shoorei, H.; Khaki, A.; Shokoohi, M. Protective Effects of Matricaria Chamomilla Extract on Torsion/detorsion-Induced Tissue Damage and Oxidative Stress in Adult Rat Testis. Int. J. Fertil. Steril. 2018, 12(3), 242–248. DOI: 10.22074/ijfs.2018.5324.
   PubMed Web of Science ®Google Scholar
• Jarrahi, M. An Experimental Study of the Effects of Matricaria Chamomilla Extract on Cutaneous Burn Wound Healing in Albino Rats. Nat. Prod. Res. 2008, 22(5), 422–427. DOI: 10.1080/14786410701591713.
   PubMed Web of Science ®Google Scholar
• Cemek, M.; Kağa, S.; Şimşek, N.; Büyükokuroğlu, M. E.; Konuk, M. Antihyperglycemic and Antioxidative Potential of Matricaria Chamomilla L. in Streptozotocin-Induced Diabetic Rats. J. Nat. Med. 2008, 62(3), 284–293. DOI: 10.1007/s11418-008-0228-1.
   PubMed Web of Science ®Google Scholar
• Mahadeva Rao, U. S.; Subramanian, S. Biochemical Evaluation of Antihyperglycemic and Antioxidative Effects of Morinda Citrifolia Fruit Extract Studied in Streptozotocin-Induced Diabetic Rats. Med. Chem. Res. 2009, 18(6), 433–446. DOI: 10.1007/s00044-008-9140-1.
   Web of Science ®Google Scholar
• Najla, O. A.; Olfat, A. K.; Kholoud, S. R.; Enas, N. D.; Hanan, I. Hypoglycemic and Biochemical Effects of Matricaria Chamomilla Leave Extract in Streptozotocin-Induced Diabetic Rats. J. Heal. Sci. 2012, 2, 43–48. DOI: 10.5923/j.health.20120205.01.
   Google Scholar
• Soliman, G. A. The Potential Cardioprotective Effect of Matricaria Chamomilla Extract Against Diabetes-Induced Oxidative Stress in Rats. Farmacia. 2020, 68(2), 269–279. DOI: 10.31925/farmacia.2020.2.12.
   Web of Science ®Google Scholar
• Heidarianpour, A.; Mohammadi, F.; Keshvari, M.; Mirazi, N. Ameliorative Effects of Endurance Training and Matricaria Chamomilla Flowers Hydroethanolic Extract on Cognitive Deficit in Type 2 Diabetes Rats. Biomed. Pharmacother. 2021, 135, 111230. DOI: 10.1016/j.biopha.2021.111230.
   PubMed Web of Science ®Google Scholar
• Hajizadeh-Sharafabad, F.; Varshosaz, P.; Jafari-Vayghan, H.; Alizadeh, M.; Maleki, V. Chamomile (Matricaria recutita L.) and diabetes mellitus, current knowledge and the way forward: A systematic review. Complement Ther. Med. 2020, 48, 102284. DOI: 10.1016/j.ctim.2019.102284.
   PubMed Web of Science ®Google Scholar
• Tavakol, H.; Farzad, K.; Fariba, M.; Abdolkarim, C.; Hassan, G.; Seyed-Mostafa, H.; Akram, R. Hepatoprotective Effect of Matricaria Chamomilla.L in Paraquat Induced Rat Liver Injury. Drug Res. (Stuttg). 2014, 65(2), 61–64. DOI: 10.1055/s-0033-1363999.
   PubMedGoogle Scholar
• Madrigal-Santillán, E. Review of Natural Products with Hepatoprotective Effects. World J. Gastroenterol. 2014, 20(40), 14787. DOI: 10.3748/wjg.v20.i40.14787.
   PubMed Web of Science ®Google Scholar
• Chani, J. M.; Jasim, N. Z. Hepatoprotective Effect of Matricaria Chamomilla Hot Aqueous Extract Against Methomyl 90%- Induced Hepatotoxicity in Mice. Al-Kufa Univ. J. Biol. 2016, 8, 185–195.
   Google Scholar
• Salama, R. M. Matricaria chamomilla attenuates cisplatin nephrotoxicity. Saudi J. Kidney Dis. Transplant. 2012, 23(4), 765. DOI: 10.4103/1319-2442.98158.
   PubMedGoogle Scholar
• Salama, R. H. M.; Abd-El-Hameed, N. A.; Abd-El-Ghaffar, S. K.; Mohammed, Z. T.; Ghandour, N. M. A. Nephroprotective Effect of Nigella Sativa and Matricaria Chamomilla in Cisplatin Induced Renal Injury—Supportive Treatments in Cisplatin Nephrotoxicity. Int. J. Clin. Med. 2011, 02(3), 185–195. DOI: 10.4236/ijcm.2011.23031.
   Google Scholar
• Mehmood, M. H.; Munir, S.; Khalid, U. A.; Asrar, M.; Gilani, A. H. Antidiarrhoeal, Antisecretory and Antispasmodic Activities of Matricaria Chamomilla are Mediated Predominantly Through K±channels Activation. BMC Complement. Altern. Med. 2015, 15(1), 75. DOI: 10.1186/s12906-015-0595-6.
   PubMedGoogle Scholar
• Romero, M. D. C.; Valero, A.; Martín-Sánchez, J.; Navarro-Moll, M. C. Activity of Matricaria Chamomilla Essential Oil Against Anisakiasis. Phytomedicine. 2012, 19(6), 520–523. DOI: 10.1016/j.phymed.2012.02.005.
   PubMed Web of Science ®Google Scholar
• Bahrami, A. M.; Doosti, A.; Moosavi, A. B. Effect of Matricaria Chamomilla L. Plant Extraction on Experimental Infected Lamb with Ostertagia Ostertagi Parasits. Int. J. Pharmacol. 2010, 6(5), 712–718. DOI: 10.3923/ijp.2010.712.718.
   Google Scholar
• Hajaji, S.; Sifaoui, I.; López-Arencibia, A.; Reyes-Batlle, M.; Jiménez, I. A.; Bazzocchi, I. L.; Valladares, B.; Pinero, J. E.; Lorenzo-Morales, J.; Akkari, H. Correlation of Radical-Scavenging Capacity and Amoebicidal Activity of Matricaria Recutita L. (Asteraceae). Exp. Parasitol. 2017, 183, 212–217. DOI: 10.1016/j.exppara.2017.09.011.
   PubMed Web of Science ®Google Scholar
• Váradyová, Z.; Pisarčíková, J.; Babják, M.; Hodges, A.; Mravčáková, D.; Kišidayová, S.; Königová, A.; Vadlejch, J.; Várady, M. Ovicidal and Larvicidal Activity of Extracts from Medicinal-Plants Against Haemonchus Contortus. Exp. Parasitol. 2018, 195, 71–77. DOI: 10.1016/j.exppara.2018.10.009.
   PubMed Web of Science ®Google Scholar
• Cemek, M.; Yilmaz, E.; Büyükokuroğlu, M. E. Protective Effect of Matricaria Chamomilla on Ethanol-Induced Acute Gastric Mucosal Injury in Rats. Pharm. Biol. 2010, 48(7), 757–763. DOI: 10.3109/13880200903296147.
   PubMed Web of Science ®Google Scholar
• Morshedi, M.; Gol, A.; Mohammadzadeh, A. The Effect of Matricaria Chamomilla on the Treatment of Ibuprofen-Induced Gastric Ulcers in Male Rats. Hormozgan Med. J. 2014, 20, 270–275.
   Google Scholar
• Karbalay-Doust, S.; Noorafshan, A. Antiulcerogenic Effects of Matricaria Chamomilla Extract in Experimental Gastric Ulcer in Mice. Iran. J. Med. Sci. 2009, 34, 198–203.
   Google Scholar
• Naema, F.; J, N.; Ali, A.; Ahmed, A. Effect of the Aqueous Extract of Matricaria Chamomilla on Stress-Ethanol Induced Acute Gastric Ulceration in Rabbits. Med. J. Basrah Univ. 2006, 24(1), 66–69. DOI: 10.33762/mjbu.2006.46423.
   Google Scholar
• El Souda, S. S. E. D.; Ahmed, K. M.; Grace, M. H.; Elkherassy, E. E. A.; Farrag, A. R. H.; Abdelwahab, S. M. Flavonoids and Gastroprotective Effect of Matricaria Chamomilla Against Indomethacin-Induced Ulcer in Rats. J. Herbs. Spices Med. Plants. 2015, 21(2), 111–117. DOI: 10.1080/10496475.2014.919372.
   Google Scholar
• Gomaa, A.; Hashem, T.; Mohamed, M.; Ashry, E. Matricaria Chamomilla Extract Inhibits Both Development of Morphine Dependence and Expression of Abstinence Syndrome in Rats. J. Pharmacol. Sci. 2003, 92(1), 50–55. DOI: 10.1254/jphs.92.50.
   PubMed Web of Science ®Google Scholar
• de Souza Reis, L. S. L.; Frazatti-Gallina, N. M.; de Lima Paoli, R.; Giuffrida, R.; Albas, A.; Oba, E.; Pardo, P. E. Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle. J. Vet. Sci. 2008, 9(4), 433. DOI: 10.4142/jvs.2008.9.4.433.
   PubMed Web of Science ®Google Scholar
• Dada, R.; Toghyani, M.; Tabeidian, S. A. The Effect of Chamomile Flower (Matricaria Chamomilla L.) Extract and Powder as Growth Promoter on Growth Performance and Digestive Organs of Broiler Chickens. Res. Opin. Anim. Vet. Sci. 2015, 5, 290–294.
   Google Scholar