Precision medicine as a predictive factor for risk of hospitalization of recurrent ischemic stroke patients treated with low dose aspirin. A pilot study

References

• Lovett JK, Dennis MS, Sandercock PAG, et al. Very early risk of stroke after a first transient ischemic attack. Stroke. 2003;34(8):e138–40.
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Giles MF, Flossmann E, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005;366(9479):29–36.
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Buchan A, Johnston SC. Recent advances in management of transient ischaemic attacks and minor ischaemic strokes. Lancet Neurol. 2006;5(4):323–331.
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Giles MF, Chandratheva A, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370(9596):1432–1442.
   PubMed Web of Science ®Google Scholar
• Coutts SB, Hill MD, Simon JE, et al. Silent ischemia in minor stroke and TIA patients identified on MR imaging. Neurology. 2005;65(4):513–517.
   PubMed Web of Science ®Google Scholar
• Martinez C, Garcia-Martin E, Blanco G, et al. The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects. Br J Clin Pharmacol. 2005;59(1):62–69.
   PubMed Web of Science ®Google Scholar
• Agundez JA, Garcia-Martin E, Martinez C. Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009;5(6):607–620.
   PubMed Web of Science ®Google Scholar
• Restrepo JG, Garcia-Martin E, Martinez C, et al. Polymorphic drug metabolism in anaesthesia. Curr Drug Metab. 2009;10(3):236–246.
   PubMed Web of Science ®Google Scholar
• Zhou SF, Liu JP, Chowbay B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev. 2009;41(2):89–295.
   PubMed Web of Science ®Google Scholar
• Miners JO, Birkett DJ. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol. 1998;45(6):525–538.
   PubMed Web of Science ®Google Scholar
• Veenstra DL, Blough D, Higashi M, et al. CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes. Clin Pharmacol Ther. 2005;77(5):353–364.
   PubMed Web of Science ®Google Scholar
• Jessup M Abraham W.T., Casey D.T. et al. , et al., 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation, 2009. 119(14): p. 1977–2016.
   Google Scholar
• Chan YH. Biostatistics 102: quantitative data–parametric & non-parametric tests. Singapore Med J. 2003;44(8):391–396.
   PubMedGoogle Scholar
• Chan YH. Biostatistics 103: qualitative data - tests of Independence. Singapore Med J. 2003;44(10):498–503.
   PubMedGoogle Scholar
• Chan YH. Biostatistics 104: correlational analysis. Singapore Med J. 2003;44(12):614–619.
   PubMedGoogle Scholar
• Chan YH. Biostatistics 202: logistic regression analysis. Singapore Med J. 2004;45(4):149–153.
   PubMedGoogle Scholar
• van Oijen MG, Barthélémy C, Janssen MJR, et al. Effect of Genetic Polymorphisms in UDP-Glucuronosyltransferase 1A6 (UGT1A6) on Acetylsalicylic Acid Metabolism in Healthy Female Volunteers. Pharmacology. 2009;83(4):237–242.
   PubMed Web of Science ®Google Scholar
• Garcia-Martin E, Martínez C, Ladero JM, et al. High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population. Eur J Clin Pharmacol. 2001;57(1):47–49.
   PubMed Web of Science ®Google Scholar
• Garcia-Martin E, Martínez C, Ladero JM, et al. Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. Mol Diagn Ther. 2006;10(1):29–40.
   PubMed Web of Science ®Google Scholar
• Shiotani A, Sakakibara T, Yamanaka Y, et al. The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy. J Gastroenterol. 2009;44(7):717–725.
   PubMed Web of Science ®Google Scholar
• Blanco G, Martínez C, Ladero JM, et al. Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding. Pharmacogenet Genomics. 2008;18(1):37–43.
   PubMed Web of Science ®Google Scholar
• Sairanen T, Carpen O, Karjalainen-Lindsberg M-L, et al. Evolution of cerebral tumor necrosis factor-alpha production during human ischemic stroke. Stroke. 2001;32(8):1750–1758.
   PubMed Web of Science ®Google Scholar
• Dixon DA, Tolley ND, Bemis-Standoli K, et al. Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest. 2006;116(10):2727–2738.
   PubMed Web of Science ®Google Scholar
• Schmidt R Bültmann A, Fischel S et al. , et al. Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. Circ Res. 2008;102(3):302–309.
   PubMed Web of Science ®Google Scholar
• Feuerstein N, Goldman S, Feuerstein G. Immune tolerance and stroke: a turning point. Stroke. 2002;33(9):2163–2164.
   PubMed Web of Science ®Google Scholar
• Akasaka Y, Morimoto N, Ishikawa Y, et al. Myocardial apoptosis associated with the expression of proinflammatory cytokines during the course of myocardial infarction. Mod Pathol. 2006;19(4):588–598.
   PubMed Web of Science ®Google Scholar
• Kostulas N, Pelidou SH, Kivisakk P, et al. Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke. 1999;30(10):2174–2179.
   PubMed Web of Science ®Google Scholar
• Welsh P, Lowe GDO, Chalmers J, et al. Associations of proinflammatory cytokines with the risk of recurrent stroke. Stroke. 2008;39(8):2226–2230.
   PubMed Web of Science ®Google Scholar
• Campbell DJ, Woodward M, Chalmers JP, et al. Soluble vascular cell adhesion molecule 1 and N-terminal pro-B-type natriuretic peptide in predicting ischemic stroke in patients with cerebrovascular disease. Arch Neurol. 2006;63(1):60–65.
   PubMedGoogle Scholar
• Al-Bahrani A, Taha S, Shaath H, et al. TNF-α and IL-8 in Acute Stroke and the Modulation of these Cytokines by Antiplatelet Agents. Curr Neurovasc Res. 2007;4(1):31–37.
   PubMed Web of Science ®Google Scholar
• Yang L, Blumbergs PC, Jones NR, et al. Early expression and cellular localization of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injury. Spine (Phila Pa 1976). 2004;29(9):966–971.
   PubMed Web of Science ®Google Scholar
• Lavallee PC, Meseguer E, Abboud H, et al. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol. 2007;6(11):953–960.
   PubMed Web of Science ®Google Scholar
• Luengo-Fernandez R, Gray AM, Rothwell PM. Effect of urgent treatment for transient ischaemic attack and minor stroke on disability and hospital costs (EXPRESS study): a prospective population-based sequential comparison. Lancet Neurol. 2009;8(3):235–243.
   PubMed Web of Science ®Google Scholar