534
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Safety and efficacy of different doses of intrathecal magnesium sulfate on the acute and chronic postoperative pain in patient undergoing pelvic cancer surgeries - a randomized controlled dose finding clinical study

ORCID Icon, , , &
Pages 828-839 | Received 01 Jul 2023, Accepted 21 Sep 2023, Published online: 22 Oct 2023

References

  • Schwarzkopf E, Boland P. Mesenchymal and Non‐Epithelial tumors of the pelvis. Surgical Mana Adv Pelvic Cancer. 2021;10:283–297.
  • Choong PF. Surgical management of Pelvic Sarcomas. In: Sarcoma. Vol. 2021. Singapore: Springer; 2021pp. 263–279. doi: 10.1007/978-981-15-9414-4_16
  • Winder AA, Davies E, Bagué S, et al. Neoplasms of the abdominal wall. Abdo Trauma Peritoneum Retrop. 2022;10(1):2.
  • Carter P, Baker QF, Adds PJ. Anatomy of the pelvis and perineum. In: Anatomy. CRC Press; 2022pp. 197–233. doi:10.1201/9781003312895-7.
  • Askari R, Salim A, Martin M. Benign colorectal disease trauma of the colon and rectum. In: The ASCRS textbook of colon and rectal surgery 2022. Cham: Springer International Publishing. pp. 729–742. 10.1007/978-3-030-66049-9_42
  • Alman B, Attia S, Baumgarten C, et al. The management of desmoid tumours: a joint global consensus-based guideline approach for adult and paediatric patients. Eur J Cancer. 2020;127:96–107. doi: 10.1016/j.ejca.2019.11.013
  • Carley ME, Chaparro LE, Choinière M, et al. Pharmacotherapy for the prevention of chronic pain after surgery in adults: an updated systematic review and meta-analysis. Anesthesiol. 2021;135(2):304–325. doi: 10.1097/ALN.0000000000003837
  • Shukla U, Singh D, Singh J, et al. Comparative study of epidural dexmedetomidine, fentanyl, and tramadol as adjuvant to levobupivacaine for lower limb orthopedic surgeries. Cureus. 2022;22:14(5): doi: 10.7759/cureus.25225
  • Kido K, Katagiri N, Kawana H, et al. Effects of magnesium sulphate administration in attenuating chronic postsurgical pain in rats. Biochem Biophys Res Commun. 2021;534:395–400. doi: 10.1016/j.bbrc.2020.11.069
  • Morel V, Pickering ME, Goubayon J, et al. Magnesium for pain treatment in 2021? State of the art. Nutrients. 2021;13(5):1397. doi: 10.3390/nu13051397
  • Ma S, Zhang Y, Li Q. Magnesium sulphate reduces postoperative pain in women with cesarean section: a meta‐analysis of randomized controlled trials. Pain Pract. 2022;22(1):8–18. doi: 10.1111/papr.13022
  • Maddali MM, Al Shamsi F, Arora NR, et al. Assessment of stress response attenuation with caudal morphine using a surrogate marker during pediatric cardiac surgery. Ann Card Anaesth. 2022;25(1):61. doi: 10.4103/aca.ACA_6_20
  • Urits I, Jung JW, Amgalan A, et al. Utilization of magnesium for the treatment of chronic pain. Anesth Pain Med. 2021;11(1): Anesthesiology and Pain Medicine. doi: 10.5812/aapm.112348
  • Lewis SA, Shetty S, Gamble S, et al. Intrathecal magnesium delivery for mg+±insensitive NMDA receptor activity due to GRIN1 mutation. Orphanet J Rare Diseases. 2023;18(1): doi: 10.1186/s13023-023-02756-9
  • Treede R, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11). Pain. 2019;160(1):38–44. doi: 10.1097/j.pain.0000000000001384
  • Barke A, Korwisi B, Jakob R, et al. Classification of chronic pain for the international classification of diseases (ICD-11): results of the 2017 international World Health Organization field testing. Pain. 2022;163(2):e310. doi: 10.1097/j.pain.0000000000002287
  • Korwisi B, Suárez BB, Goswami S, et al. Reliability and clinical utility of the chronic pain classification in the 11th revision of the International classification of Diseases from a global perspective: results from India. Cuba, And New Zealand Pain. 2022;163(3):e453–62. doi: 10.1097/j.pain.0000000000002379
  • Carville S, Constanti M, Kosky N, et al. Chronic pain (primary and secondary) in over 16s: summary of NICE guidance. BMJ. 2021;2:373. doi: 10.1136/bmj.n895
  • Caron-Trahan R, Jusseaux AE, Aubin M, et al. Definition and refinement of HYlaDO, a self-hypnosis training program for chronic pain management: a qualitative exploratory study. EXPLORE. 2022;19(3):417–425. doi: 10.1016/j.explore.2022.08.008
  • Strub P, Satink T, Gantschnig BE. How chronic pain changes a person’s life story in relation to participation in occupational roles: a narrative exploration. Scand J Occup Ther. 2022;29(7):578–586. doi: 10.1080/11038128.2021.1945677
  • Valdez CA. Gas chromatography-mass spectrometry analysis of synthetic opioids belonging to the fentanyl class. A Review Crit Rev Anal Chem. 2021;11:1–31.
  • Kumar D, Das RN, Sinha PK. Clinical Characteristics of Individuals Receiving intrathecal bupivacaine with clonidine or bupivacaine with fentanyl spinal anaesthesia. Ann Card Anaesth. 2022;25(1):61.
  • Weitzman ER, Kossowsky J, Blakemore LM, et al. Acceptability of a fentanyl vaccine to prevent opioid overdose and need for personalized decision-making. Clin Infect Dis. 2022;75(Supplement_1):S98–S109. doi: 10.1093/cid/ciac344
  • O’Donnell J, Gladden RM, Kariisa M, et al. Using death scene and toxicology evidence to define involvement of heroin, pharmaceutical morphine, illicitly manufactured fentanyl and pharmaceutical fentanyl in opioid overdose deaths, 38 states and the District of Columbia, January 2018–December 2019. Addiction. 2022;117(5):1483–1490. doi: 10.1111/add.15768
  • Papsun DM, Krotulski AJ, Logan BK. Proliferation of Novel Synthetic opioids in postmortem investigations after core-structure scheduling for fentanyl-related substances. Am J Forensic Med Pathol. 2022;43(4):315–327. doi: 10.1097/PAF.0000000000000787
  • Martinez-Taboada F, Sun TC, Redondo JI. Onset of action of bupivacaine administered via dural puncture epidural versus spinal, lumbosacral, and sacrococcygeal epidural injections in dogs: randomised clinical trial. Animals. 2021;11(10):2996. doi: 10.3390/ani11102996
  • Pani N, Sahu P, Swain D, et al. Effects of fentanyl and dexmedetomidine as adjuvants to bupivacaine in paravertebral block for postoperative analgesia in patients undergoing modified radical mastectomy: a prospective randomised double-blind study. Indian J Anaesth. 2022;66:S193.
  • Sarkar P, Singh Y, Patel N, et al. Safety and efficacy of low-dose selective spinal anesthesia with bupivacaine and fentanyl as compared to intravenous sedation and port-site infiltration for outpatient laparoscopic tubal ligation: a randomized controlled trial. Anesth Essays Res. 2021;15(3):290. doi: 10.4103/aer.aer_121_21
  • Zainab F. Early and late haemodynamic effects after adding fentanyl to bupivacaine-lignocaine mixtures in supraclavicular brachial plexus block: a randomized control trial. J Bangladesh Coll Phys Surg. 2022;40(1):17–22. doi: 10.3329/jbcps.v40i1.57052
  • Rao YV, Nadimpalli HK, Kutikuppala LV. Comparative study of epidural fentanyl with bupivacaine and epidural tramadol with bupivacaine for postoperative pain management in orthopedic lower limb surgeries. MGM J Med Sci. 2022;9(3):351. doi: 10.4103/mgmj.mgmj_35_22
  • Lenz H, Høiseth LØ, Comelon M, et al. Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study. Br J Anaesth. 2021;126(5):1038–1045. doi: 10.1016/j.bja.2020.12.045
  • Caballero-Lozada AF, Gómez JM, Torres-Mosquera A, et al. Impacts of intrathecal fentanyl on the incidence of postoperative nausea/vomiting: systematic review and meta-analysis of randomized studies. J Anaesthesiol Clin Pharmacol. 2022;38(3):391–398. doi: 10.4103/joacp.JOACP_443_20
  • Lee SC, Kim TH, Choi SR, et al. No difference between spinal anesthesia with hyperbaric ropivacaine and intravenous dexmedetomidine sedation with and without intrathecal fentanyl: a randomized noninferiority trial. Pain Res Manag. 2022;13:2022. doi: 10.1155/2022/3395783
  • Cavalcanti IL, Lima FL, Silva MJ, et al. Use profile of magnesium sulfate in anesthesia in Brazil. Front Pharmacol. 2019;26(10):429. doi: 10.3389/fphar.2019.00429
  • Rajabi M, Razavizade MR, Hamidi-Shad M, et al. Magnesium sulfate and clonidine; effects on hemodynamic factors and depth of general anesthesia in cesarean section. Anesth Pain Med. 2020;10(5): Anesthesiology and Pain Medicine. doi: 10.5812/aapm.100563
  • Rehman AU, Khaleeq S, Ahmed A, et al. Effects of magnesium sulphate on the onset and duration of neuromuscular blockade by cisatracurium in adult patients undergoing transpedicular screw fixation surgery under general anesthesia. Ann Punjab Med Coll(apmc). 2021;15(2):113–117.
  • Mir AH, Wani JG, Yousuf A, et al. Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirement: a prospective randomized double blind placebo controlled study. IJCA. 2019;6(3):355–358. doi: 10.18231/j.ijca.2019.068
  • Zhang J, Wang Y, Xu H, et al. Influence of magnesium sulfate on hemodynamic responses during laparoscopic cholecystectomy: a meta-analysis of randomized controlled studies. J Med. 2018;97(45):e12747. doi: 10.1097/MD.0000000000012747
  • de Almeida CE, de Carvalho LR, Andrade CV, et al. Effects of magnesium sulphate on the onset time of rocuronium at different doses: a randomized clinical trial. Braz J Anesthesiol. 2021;71(5):482–488. English Edition. doi: 10.1016/j.bjane.2021.07.023
  • Omar H, Aboella WA, Hassan MM, et al. Comparative study between intrathecal dexmedetomidine and intrathecal magnesium sulfate for the prevention of post-spinal anesthesia shivering in uroscopic surgery. (RCT) BMC Anesthesiol. 2019;19(1):1–0. doi: 10.1186/s12871-019-0853-0
  • Lehoczky L, Southworth AB, Zamudio Martínez G, et al. Magnesium sulfate titration reduces maternal complications following fetoscopic closure of spina bifida. Prenat Diagn. 2021;41(8):983–988. doi: 10.1002/pd.5923
  • Ahmed OH, Ali WM, Kamel YM. Magnesium sulfate versus fentanyl as adjuvant to epidural levobupivacaine in surgeries below umbilicus. Egypt J Hosp Med. 2019;77(2):4987–4992. doi: 10.21608/ejhm.2019.48134
  • Mostafa MF, Herdan R, Fathy GM, et al. Intrathecal dexmedetomidine versus magnesium sulphate for postoperative analgesia and stress response after caesarean delivery; randomized controlled double‐blind study. European J Pain. 2020;24(1):182–191. doi: 10.1002/ejp.1476
  • El Mourad MB, Arafa SK. Effect of intravenous versus intraperitoneal magnesium sulfate on hemodynamic parameters and postoperative analgesia during laparoscopic sleeve gastrectomy–A prospective randomized study. J Anaesthesiol Clin Pharmacol. 2019;35(2):242. doi: 10.4103/joacp.JOACP_208_18
  • Hamdy Salman O, Mohamed Ali AE, Gad GS. The effect of epidural magnesium sulphate on postoperative nociception and serum B endorphin levels in high tibial osteotomy orthopedic surgery. Egypt J Anaesth. 2021;37(1):107–112. doi: 10.1080/11101849.2021.1894816
  • Li LQ, Fang MD, Wang C, et al. Comparative evaluation of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia: a meta-analysis of randomized controlled trials. BMC Anesthesiol. 2020;20(1):1–2. BMC Anesthesiology. doi: 10.1186/s12871-020-0947-8
  • Prasad D, Ali I, Chaudhary P. A Comparative study on effect of intravenous MGSO4 on spinal anaesthesia with bupivacaine and buprenorphine. Eur J Mol Clin Med. 2022 Jan 1;9(1):1366–1375.
  • Saraswathi C, Krishnaprasad P. To compare the effects of intrathecal dexmedetomidine versus magnesium sulphate as adjuvants to hyperbaric bupivacaine for lower limb orthopedic surgeries. Indian J Clin Anaesth. 2019 Jul;6(3): 355–358.
  • Tuteja S, Gupta A, Choudhary S, et al. Comparison of two different doses of magnesium sulfate as an adjuvant to intrathecal bupivacaine in patients with pre-eclampsia undergoing elective cesarean section: a prospective double-blind randomized study. J Obstet Anaesth Crit Care. 2023 Jan 1;13(1):51. doi: 10.4103/JOACC.JOACC_35_22
  • Soleimanpour H, Imani F, Dolati S, et al. Management of pain using magnesium sulphate: a narrative review. Postgrad Med. 2022;134(3):260–266. doi: 10.1080/00325481.2022.2035092
  • Shin HJ, Na HS, Do SH. Magnesium and pain. Nutrients. 2020;12(8):2184. doi: 10.3390/nu12082184
  • Sain A, Jain T, Sood M. Analgesic effect of magnesium sulphate as an adjuvant to levobupivacaine in lower abdominal and pelvic surgeries under epidural anaesthesia: a randomized double blind controlled interventional study. J Anaesth Clin Pharmacol. 2018;34(3):328.
  • Elsharkawy RA, Farahat TE, Abdelhafez MS. Analgesic effect of adding magnesium sulfate to epidural levobupivacaine in patients with pre-eclampsia undergoing elective cesarean section. J Anaesthesiol Clin Pharmacol. 2018;34(3):328. doi: 10.4103/joacp.JOACP_1_18
  • Alipour M, Tabari M, Sharifian Attar A, et al. Nausea and vomiting after spinal anesthesia with two drugs combinations of bupivacaine-fentanyl and bupivacaine-sufentanil during cesarean section. Iran J Obstet Gynecol Infertil. 2021;24(2):1–7.
  • Schwartz J, Gan TJ. Management of postoperative nausea and vomiting in the context of an enhanced recovery after surgery program. Best Pract Res Clin Anaesthesiol. 2020;34(4):687–700. doi: 10.1016/j.bpa.2020.07.011
  • Zhang C, Huang D, Zeng W, et al. Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil–based anesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial. BMC Anesthesiol. 2022;22(1):1–7. doi: 10.1186/s12871-022-01671-z