An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders

References

• Kuwano T, Nakao S, Yamamoto H, et al. Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J. 2004 Feb;18(2):300–310. PubMed PMID: 14769824; eng.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick FA. Cyclooxygenase enzymes: regulation and function. Curr Pharm Des. 2004;10(6):577–588. PubMed PMID: 14965321; eng.
   PubMed Web of Science ®Google Scholar
• Seibert K, Masferrer JL. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor. 1994 Spring;4(1):17–23. PubMed PMID: 8038702; eng.
   PubMedGoogle Scholar
• Crofford LJ. COX-1 and COX-2 tissue expression: implications and predictions. J Rheumatol Suppl. 1997 Jul;49:15–19. PubMed PMID: 9249646; eng.
   PubMedGoogle Scholar
• de Leval X, Delarge J, Somers F, et al. Recent advances in inducible cyclooxygenase (COX-2) inhibition. Curr Med Chem. 2000 Oct;7(10):1041–1062. PubMed PMID: 10911017; eng.
   PubMed Web of Science ®Google Scholar
• Oksuz E, Atalar F, Tanirverdi G, et al. Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma. J Neurooncol. 2016 Jan;126(2):271–278. PubMed PMID: 26508095; eng.
   PubMed Web of Science ®Google Scholar
• Botting RM. Mechanism of action of acetaminophen: is there a cyclooxygenase 3? Clin Infect Dis. 2000 Oct;31(Suppl 5):S202–S210. PubMed PMID: 11113024; eng.
   PubMed Web of Science ®Google Scholar
• Zidar N, Odar K, Glavač D, et al. Cyclooxygenase in normal human tissues – is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J Cell Mol Med. 2009 07/24 04/06/received 07/16/accepted;13(9b):3753–3763. PubMed PMID: PMC4516524.
   PubMed Web of Science ®Google Scholar
• Sibbald B. Rofecoxib (Vioxx) voluntarily withdrawn from market. Can Med Assoc J. 2004;171(9):1027–1028. . PubMed PMID: PMC526313.
   PubMed Web of Science ®Google Scholar
• Startup seeking to resurrect Vioxx, arthritis drug pulled from market. Associated Press; 2017. [Cited 2018 Dec 11]. Available from: https://www.statnews.com/2017/11/21/vioxx-startup-comeback/
   Google Scholar
• Hoozemans JJ, Rozemuller AJ, Janssen I, et al. Cyclooxygenase expression in microglia and neurons in Alzheimer’s disease and control brain. Acta Neuropathol. 2001 Jan;101(1):2–8. PubMed PMID: 11194936; eng.
   PubMed Web of Science ®Google Scholar
• Wang H, Ye M, Yu L, et al. Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration. Behav Brain Funct. 2015 02/18 10/26/received 01/21/accepted;11:8. PubMed PMID: PMC4336726.
   PubMed Web of Science ®Google Scholar
• Bosetti F, Choi SH. Rethinking the role of cyclooxygenase-1 in neuroinflammation: more than homeostasis. Cell Cycle. 2010 Aug 1;9(15):2919–2920. PubMed PMID: 20714215; eng.
   PubMed Web of Science ®Google Scholar
• Yermakova A, O’Banion MK. Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. Curr Pharm Des. 2000 Nov;6(17):1755–1776. PubMed PMID: 11203433; eng.
   PubMed Web of Science ®Google Scholar
• Bazan NG. COX-2 as a multifunctional neuronal modulator. Nat Med. 2001 April 01;7:414.
   PubMed Web of Science ®Google Scholar
• Kovacs Z, Dobolyi A, Juhasz G, et al. Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats. Brain Res Bull. 2014 May;104:7–18. PubMed PMID: 24704320; eng.
   PubMed Web of Science ®Google Scholar
• Tu B, Bazan NG. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex. Exp Neurol. 2003 Feb;179(2):167–175. PubMed PMID: 12618123; eng.
   PubMed Web of Science ®Google Scholar
• Dash PK, Mach SA, Moore AN. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J Neurotrauma. 2000 Jan;17(1):69–81. PubMed PMID: 10674759; eng.
   PubMed Web of Science ®Google Scholar
• Tanaka S, Nakamura T, Sumitani K, et al. Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model. Neurosci Res. 2009 Sep;65(1):79–87. PubMed PMID: 19523994; eng.
   PubMed Web of Science ®Google Scholar
• Barbalho PG, Carvalho BS, Lopes-Cendes I, et al. Cyclooxygenase-1 as a potential therapeutic target for seizure suppression: evidences from zebrafish pentylenetetrazole-seizure model. Front Neurol. 2016;7:200. PubMed PMID: 27895618; PubMed Central PMCID: PMCPMC5108920. eng.
   PubMed Web of Science ®Google Scholar
• Jiang J, Yang MS, Quan Y, et al. Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. Neurobiol Dis. 2015 Apr;76:126–136. PubMed PMID: 25600211; PubMed Central PMCID: PMCPMC4408774. eng.
   PubMed Web of Science ®Google Scholar
• Okada K, Yuhi T, Tsuji S, et al. Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure. Brain Res. 2001 Mar 16;894(2):332–335. PubMed PMID: 11251211; eng.
   PubMed Web of Science ®Google Scholar
• Parepally JM, Mandula H, Smith QR. Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin. Pharm Res. 2006 May;23(5):873–881. PubMed PMID: 16715377; eng.
   PubMed Web of Science ®Google Scholar
• Dhir A. Pentylenetetrazol (PTZ) kindling model of epilepsy. Curr Protoc Neurosci. 2012;Chapter 9:Unit9.37. PubMed PMID: 23042503; eng.
   PubMedGoogle Scholar
• Kunz T, Oliw EH. The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. Eur J Neurosci. 2001 Feb;13(3):569–575. PubMed PMID: 11168565; eng.
   PubMed Web of Science ®Google Scholar
• Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER); 2005. [Cited 2018 Dec 2011]. Available from: https://www.fda.gov/downloads/drugs/guidances/ucm078932.pdf
   Google Scholar
• Stricker K, Yu S, Krammer G. A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. BMC Musculoskelet Disord. 2008 Sep 8;9:118. PubMed PMID: 18778469; PubMed Central PMCID: PMCPMC2542997. eng.
   PubMed Web of Science ®Google Scholar
• Jung KH, Chu K, Lee ST, et al. Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Neurobiol Dis. 2006 Aug;23(2):237–246. PubMed PMID: 16806953; eng.
   PubMed Web of Science ®Google Scholar
• van der Worp HB, Howells DW, Sena ES, et al. Can animal models of disease reliably inform human studies? PLoS Med. 2010 Mar 30;7(3):e1000245. PubMed PMID: 20361020; PubMed Central PMCID: PMCPMC2846855. eng.
   PubMed Web of Science ®Google Scholar
• Holtman L, van Vliet EA, Edelbroek PM, et al. Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Epilepsy Res. 2010 September 01;91(1):49–56.
   PubMed Web of Science ®Google Scholar
• Suemaru K, Yoshikawa M, Tanaka A, et al. Anticonvulsant effects of acetaminophen in mice: comparison with the effects of nonsteroidal anti-inflammatory drugs. Epilepsy Res. 2018 Feb;140:22–28. PubMed PMID: 29227797; eng.
   PubMed Web of Science ®Google Scholar
• Prescott LF, Balali-Mood M, Critchley JA, et al. Avoidance of mefenamic acid in epilepsy. Lancet. 1981 Aug 22;2(8243):418. PubMed PMID: 6115180; eng.
   PubMed Web of Science ®Google Scholar
• Wallenstein MC. Differential effects of prostaglandin synthetase inhibitors on EEG in rat. Eur J Pharmacol. 1985 May 8;111(2):201–209. PubMed PMID: 3926513; eng.
   PubMed Web of Science ®Google Scholar
• Wallenstein MC. Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. Exp Neurol. 1987 Oct;98(1):152–160. PubMed PMID: 3115810; eng.
   PubMed Web of Science ®Google Scholar
• Wallenstein MC. Attenuation of epileptogenesis by nonsteroidal anti-inflammatory drugs in the rat. Neuropharmacology. 1991 Jun;30(6):657–663. PubMed PMID: 1922684; eng.
   PubMed Web of Science ®Google Scholar
• Arnao V, Riolo M, Fierro B, et al. Seizure following the use of the COX-2 inhibitor etoricoxib. Case Rep Neurol Med. 2017;2017:3. .
   Google Scholar
• What is epilepsy? [Cited 2018 Dec 11]. Available from: https://www.epilepsy.com/learn/about-epilepsy-basics/what-epilepsy.
   Google Scholar
• Kalantaripour TP, Esmaeili-Mahani S, Sheibani V, et al. Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed Pharmacother. 2017 Mar;87:661–668. PubMed PMID: 28088732; eng.
   PubMed Web of Science ®Google Scholar
• Kwon MS, Lee JK, Park SH, et al. Neuroprotective effect of visnagin on kainic acid-induced neuronal cell death in the mice hippocampus. Korean J Physiol Pharmacol. 2010 Oct;14(5):257–263. PubMed PMID: 21165322; PubMed Central PMCID: PMCPMC2997409. eng.
   PubMed Web of Science ®Google Scholar
• Kaminski RM, Rogawski MA, Klitgaard H. The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. Neurotherapeutics. 2014 March 27;11(2):385–400. PubMed PMID: PMC3996125.
   PubMed Web of Science ®Google Scholar
• Loscher W. Animal models of seizures and epilepsy: past, present, and future role for the discovery of antiseizure drugs. Neurochem Res. 2017 Jul;42(7):1873–1888. PubMed PMID: 28290134; eng.
   PubMed Web of Science ®Google Scholar
• Grone BP, Baraban SC. Animal models in epilepsy research: legacies and new directions [Perspective]. Nat Neurosci. 2015 February 24;18:339.
   PubMed Web of Science ®Google Scholar
• Kandratavicius L, Balista PA, Lopes-Aguiar C, et al. Animal models of epilepsy: use and limitations. Neuropsychiatr Dis Treat. 2014 September 09;10:1693–1705. PubMed PMID: PMC4164293.
   PubMed Web of Science ®Google Scholar
• Dey A, Kang X, Qiu J, et al. Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside. Trends Pharmacol Sci. 2016 June 01;37(6):463–484.
   PubMed Web of Science ®Google Scholar
• Vezzani A. Epilepsy and inflammation in the brain: overview and pathophysiology. Epilepsy Curr. 2014 Jan;14(1 Suppl):3–7. PubMed PMID: 24955068; PubMed Central PMCID: PMCPMC3966641. eng.
   PubMed Web of Science ®Google Scholar
• Shimada T, Takemiya T, Sugiura H, et al. Role of inflammatory mediators in the pathogenesis of epilepsy. Mediators Inflamm. 2014;2014:8.
   Google Scholar
• Wetherington J, Serrano G, Dingledine R. Astrocytes in the epileptic brain. Neuron. 2008;58(2):168–178. PubMed PMID: PMC4124883.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim SH, Lim SC, et al. Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy. Neuropsychiatr Dis Treat. 2016 July 28;12:1887–1891. PubMed PMID: PMC4968857.
   PubMed Web of Science ®Google Scholar
• Eyo UB, Murugan M, Wu L-J. Microglia-neuron communication in epilepsy. Glia. 2017 May 18;65(1):5–18. PubMed PMID: PMC5116010.
   PubMed Web of Science ®Google Scholar
• Minghetti L, Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol. 1998 Jan;54(1):99–125. PubMed PMID: 9460796; eng.
   PubMed Web of Science ®Google Scholar
• Iwasa K, Yamamoto S, Yagishita S, et al. Excitotoxicity-induced prostaglandin D2 production induces sustained microglial activation and delayed neuronal death. J Lipid Res. 2017 Apr;58(4):649–655. PubMed PMID: 28174214; PubMed Central PMCID: PMCPMC5392741. eng.
   PubMed Web of Science ®Google Scholar
• Chung JI, Kim AY, Lee SH, et al. Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2alpha. Exp Neurol. 2013 Nov;249:95–103. PubMed PMID: 24005111; eng.
   PubMed Web of Science ®Google Scholar
• Aronica E, Bauer S, Bozzi Y, et al. Neuroinflammatory targets and treatments for epilepsy validated in experimental models. Epilepsia. 2017 Jul;58(Suppl 3):27–38. PubMed PMID: 28675563; PubMed Central PMCID: PMCPMC5873599. eng.
   PubMedGoogle Scholar
• Holtman L, van Vliet EA, van Schaik R, et al. Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. Epilepsy Res. 2009 Mar;84(1):56–66. PubMed PMID: 19186029; eng.
   PubMed Web of Science ®Google Scholar
• Polascheck N, Bankstahl M, Loscher W. The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Exp Neurol. 2010 Jul;224(1):219–233. PubMed PMID: 20353773; eng.
   PubMed Web of Science ®Google Scholar
• Dhir A, Naidu PS, Kulkarni SK. Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure. 2007 Dec;16(8):691–697. PubMed PMID: 17604186; eng.
   PubMed Web of Science ®Google Scholar
• Dhir A, Naidu PS, Kulkarni SK. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1478–1485. PubMed PMID: 16844276; eng.
   PubMed Web of Science ®Google Scholar
• Dhir A, Naidu PS, Kulkarni SK. Effect of rofecoxib, a cyclo-oxygenase-2 inhibitor, on various biochemical parameters of brain associated with pentylenetetrazol-induced chemical kindling in mice. Fundam Clin Pharmacol. 2006 Jun;20(3):255–261. PubMed PMID: 16671960; eng.
   PubMed Web of Science ®Google Scholar
• Dhir A, Naidu PS, Kulkarni SK. Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action. Indian J Exp Biol. 2006 Apr;44(4):286–291. PubMed PMID: 16629370; eng.
   PubMedGoogle Scholar
• Dhir A, Naidu PS, Kulkarni SK. Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice. Clin Exp Pharmacol Physiol. 2005 Jul;32(7):574–584. PubMed PMID: 16026518; eng.
   PubMed Web of Science ®Google Scholar
• Olsen RE, Svardal A, Eide T, et al. Stress and expression of cyclooxygenases (cox1, cox2a, cox2b) and intestinal eicosanoids, in Atlantic salmon, Salmo salar L. Fish Physiol Biochem. 2012 August 01;38(4):951–962.
   PubMed Web of Science ®Google Scholar
• Ma L, Cui XL, Wang Y, et al. Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. Brain Res. 2012 Aug 21;1469:103–113. PubMed PMID: 22765917; eng.
   PubMed Web of Science ®Google Scholar
• Danzer S. Mossy fiber sprouting in the epileptic brain: taking on the Lernaean Hydra. Epilepsy Curr. 2017 Jan-Feb;17(1):50–51. PubMed PMID: PMC5340559.
   PubMed Web of Science ®Google Scholar
• Abd-Elghafour BA, El-Sayed NM, Ahmed AA, et al. Aspirin and (or) omega-3 polyunsaturated fatty acids protect against corticohippocampal neurodegeneration and downregulate lipoxin A4 production and formyl peptide receptor-like 1 expression in pentylenetetrazole-kindled rats. Can J Physiol Pharmacol. 2017 Apr;95(4):340–348. PubMed PMID: 28060522; eng.
   PubMed Web of Science ®Google Scholar
• Vieira V, Glassmann D, Marafon P, et al. Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. Epilepsy Res. 2016;127:107–113.
   PubMed Web of Science ®Google Scholar
• Taskiran M, Tasdemir A, Ayyildiz N. Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. Brain Res Bull. 2017 Apr;130:42–46. PubMed PMID: 28017780; eng.
   PubMed Web of Science ®Google Scholar
• Rimoli MG, Russo E, Cataldi M, et al. T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin. Neuropharmacology. 2009 Mar;56(3):637–646. PubMed PMID: 19071141; eng.
   PubMed Web of Science ®Google Scholar
• Ho YH, Lin YT, Wu CW, et al. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci. 2015 Jun 24;22:46. PubMed PMID: 26100815; PubMed Central PMCID: PMCPMC4477313. eng.
   PubMed Web of Science ®Google Scholar
• Temp FR, Marafiga JR, Milanesi LH, et al. Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice. Eur J Pharmacol. 2017 Sep 5;810:15–25. PubMed PMID: 28583427; eng.
   PubMed Web of Science ®Google Scholar
• Katyal J, Kumar H, Gupta YK. Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment. Epilepsy Behav. 2015 Mar;44:98–103. PubMed PMID: 25660085; eng.
   PubMed Web of Science ®Google Scholar
• Bingham CO 3rd, Sebba AI, Rubin BR, et al. Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies. Rheumatology (Oxford). 2007 Mar;46(3):496–507. PubMed PMID: 16936327; eng.
   PubMed Web of Science ®Google Scholar
• Citraro R, Leo A, Marra R, et al. Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. Brain Res Bull. 2015 Apr;113:1–7. PubMed PMID: 25701797; eng.
   PubMed Web of Science ®Google Scholar
• Mishra CB, Kumari S, Prakash A, et al. Discovery of novel methylsulfonyl phenyl derivatives as potent human cyclooxygenase-2 inhibitors with effective anticonvulsant action: design, synthesis, in-silico, in-vitro and in-vivo evaluation. Eur J Med Chem. 2018 May 10;151:520–532. PubMed PMID: 29655084; eng.
   PubMed Web of Science ®Google Scholar
• Kwon YS, Pineda E, Auvin S, et al. Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain. J Neuroinflammation. 2013 Feb 26;10:30. PubMed PMID: 23442201; PubMed Central PMCID: PMCPMC3599749. eng.
   PubMed Web of Science ®Google Scholar
• Farrell JS, Colangeli R, Wolff MD, et al. Postictal hypoperfusion/hypoxia provides the foundation for a unified theory of seizure-induced brain abnormalities and behavioral dysfunction. Epilepsia. 2017 Sep;58(9):1493–1501. PubMed PMID: 28632329; eng.
   PubMed Web of Science ®Google Scholar
• Farrell JS, Gaxiola-Valdez I, Wolff MD, et al. Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent. eLife. 2016 11/22 07/04/received 11/21/accepted;5:e19352. PubMed PMID: PMC5154758.
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhou L, Su LD, et al. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. J Neurosci. 2018 Mar 28;38(13):3346–3357. PubMed PMID: 29491011; PubMed Central PMCID: PMCPMC5884462. eng.
   PubMed Web of Science ®Google Scholar
• Tang XH, Wu XY, Xu L, et al. Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy. Chin Med J (Engl). 2013;126(10):1900–1905. PubMed PMID: 23673107; eng.
   PubMed Web of Science ®Google Scholar
• Xu L, Hao Y, Wu X, et al. Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy. Neurol Res. 2013 Jul;35(6):561–567. PubMed PMID: 23561319; eng.
   PubMed Web of Science ®Google Scholar
• Eslami SM, Moradi MM, Ghasemi M, et al. Anticonvulsive effects of licofelone on status epilepticus induced by lithium-pilocarpine in Wistar rats: a role for inducible nitric oxide synthase. J Epilepsy Res. 2016 Dec;6(2):51–58. PubMed PMID: 28101475; PubMed Central PMCID: PMCPMC5206100. eng.
   PubMedGoogle Scholar
• Payandemehr B, Khoshneviszadeh M, Varastehmoradi B, et al. A COX/5-LOX inhibitor licofelone revealed anticonvulsant properties through iNOS diminution in mice. Neurochem Res. 2015 Sep;40(9):1819–1828. PubMed PMID: 26216049; eng.
   PubMed Web of Science ®Google Scholar
• Schlichtiger J, Pekcec A, Bartmann H, et al. Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. Br J Pharmacol. 2010 09/21/received 11/06/revised 11/19/accepted;160(5):1062–1071. PubMed PMID: PMC2936016.
   PubMed Web of Science ®Google Scholar
• Zibell G, Unkruer B, Pekcec A, et al. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology. 2009 Apr;56(5):849–855. PubMed PMID: 19371577; eng.
   PubMed Web of Science ®Google Scholar
• Song TT, Li D, Huang SP, et al. Effects of cyclooxygenase-2 selective inhibitor celecoxib on the expression of major vault protein in rats with status epilepticus. Zhongguo Dang Dai Er Ke Za Zhi. 2016 May;18(5):440–445. PubMed PMID: 27165595; chi.
   PubMedGoogle Scholar
• Liu B, Wang T, Wang L, et al. Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy. J Neurol Sci. 2011 Sep 15;308(1–2):88–93. PubMed PMID: 21683962; eng.
   PubMed Web of Science ®Google Scholar
• van Vliet EA, Zibell G, Pekcec A, et al. COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology. 2010 February 01;58(2):404–412.
   PubMed Web of Science ®Google Scholar