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Review

Immunotherapeutic strategies for treating opioid use disorder and overdose

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 77-87 | Received 01 Nov 2022, Accepted 23 Jan 2023, Published online: 12 Feb 2023

References

  • Abuse S. Key substance use and mental health indicators in the United States: results from the 2019 national survey on drug use and health 2020. Accessed at: https://www.samhsa.gov/data/sites/default/files/reports/rpt35325/NSDUHFFRPDFWHTMLFiles2020/2020NSDUHFFR1PDFW102121.pdf August 2022
  • Centers for Disease Control and Prevention. State Unintentional Drug Overdose Reporting System (SUDORS). Atlanta, GA: US department of health and human services, CDC; [2022, June 27]. Accessed at: https://www.cdc.gov/drugoverdose/fatal/dashboard
  • Appa A, Rodda LN, Cawley C, et al. Drug overdose deaths before and after shelter-in-place orders during the COVID-19 pandemic in San Francisco. JAMA network open. 2021;4(5):e2110452–e2110452.
  • DiGennaro C, Garcia GGP, Stringfellow EJ, et al. Changes in characteristics of drug overdose death trends during the COVID-19 pandemic. Int J Drug Policy. 2021;98:103392.
  • Tanz LJ, Dinwiddie AT, Snodgrass S, et al. Drug overdose deaths in 28 states and the District of Columbia: 2020 data from the state unintentional drug overdose reporting system 2022
  • Centers for Disease Control and Prevention. Understanding the opioid overdose epidemic. Atlanta, GA: US department of health and human services, CDC; [2022, June 1]. Accessed at: https://www.cdc.gov/opioids/basics/epidemic.html.August.2022
  • Ciccarone D. The rise of illicit fentanyls, stimulants and the fourth wave of the opioid overdose crisis. Curr Opin Psychiatry. 2021;34(4):344–350.
  • IMS Institute for Healthcare Informatics. Use of opioid recovery medications. IMS institute for healthcare informatics [2016 September]. Accessed at: https://www.iqvia.com/-/media/iqvia/pdfs/institute-reports/use-of-opioid-recovery-medications.pdf.in.August.2022
  • Park TW, Larochelle MR, Saitz R, et al. Associations between prescribed benzodiazepines, overdose death and buprenorphine discontinuation among people receiving buprenorphine. Addiction. 2020;115(5):924–932.
  • Williams AR, Samples H, Crystal S, et al. Acute care, prescription opioid use, and overdose following discontinuation of long-term buprenorphine treatment for opioid use disorder. Am J Psychiatry. 20020;177(2):117–124.
  • Comer SD, Cahill CM. Fentanyl: receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev. 2019;106:49–57.
  • Armenian P, Vo KT, Barr-Walker J, et al. Fentanyl, fentanyl analogs and novel synthetic opioids: a comprehensive review. Neuropharmacology. 2018;134:121–132.
  • Schmid CL, Kennedy NM, Ross NC, et al. Bias factor and therapeutic window correlate to predict safer opioid analgesics. Cell. 2017;171(5):1165–1175.
  • Mattson CL, Tanz LJ, Quinn K, et al. Trends and geographic patterns in drug and synthetic opioid overdose deaths—United States, 2013–2019. Morbidity Mortality Weekly Rep. 2021;70(6):202.
  • Pardo B, Caulkins JP, Kilmer B, et al. The synthetic opioid surge in the United States. 2019 Santa Monica. CA: RAND Corporation. 2019
  • Reuter P, Pardo B, Taylor J. Imagining a fentanyl future: some consequences of synthetic opioids replacing heroin. Int J Drug Policy. 2021;94:103086.
  • US Drug Enforcement Administration. 2020 national drug threat assessment, DEA DCT-DIR-008–21. 2021. Available at: https://www.dea.gov/documents/2021/03/02/2020-national-drug-threat-assessment. cited Aug 2022.
  • Gilbert M, Dasgupta N. Silicon to syringe: cryptomarkets and disruptive innovation in opioid supply chains. Int J Drug Policy. 2017;46:160–167.
  • Gefen T, Vaya J, Khatib S, et al. The effect of haptens on protein-carrier immunogenicity. Immunology. 2015;144(1):116–126.
  • Heekin RD, Shorter D, Kosten TR. Current status and future prospects for the development of substance abuse vaccines. Expert Rev Vaccines. 2017;16(11):1067–1077.
  • Pravetoni M. Biologics to treat substance use disorders: current status and new directions. Hum Vaccin Immunother. 2016;12(12):3005–3019.
  • Crouse B, Hicks D, Pravetoni M. Investigating the role of interleukin-4 in anti-opioid vaccine efficacy. The Journal of Immunology. 2022; 208 (supplement):123–12.
  • Pulendran B, Arunachalam S, O’Hagan DT. Emerging concepts in the science of vaccine adjuvants. Nat Rev Drug Discov. 2021;20(6):454–475.
  • Cano RLE, Lopera HDE. Introduction to T and B lymphocytes Anaya, Juan-Manuel, Shoenfield, Yehuda, Rojas-Villarraga, Adriana, Levy, Roger, Cervera, Ricard. In: Autoimmunity: from bench to bedside 1 . Bogota, Colombia: El Rosario University Press; 2013:77–97.
  • Pichichero ME. Protein carriers of conjugate vaccines: characteristics, development, and clinical trials. Hum Vaccin Immunother. 2013;9(12):2505–2523.
  • Pravetoni M, Comer SD. Development of vaccines to treat opioid use disorders and reduce incidence of overdose. Neuropharmacology. 2019;158:107662.
  • Shen XY, Orson FM, Kosten TR. Vaccines against drug abuse. Clin Pharmacol Ther. 2012;91(1):60–70.
  • Zimmermann P, Curtis N. Factors that influence the immune response to vaccination. Clin Microbiol Rev. 2019;32(2):e00084–18.
  • Chaudary S, Kaur A, Atri M, et al. Recent advancements in the development of nicotine vaccines: a systematic review. An Public Health Res. 2020;7(2):205–450.
  • Pentel PR, LeSage MG. New directions in nicotine vaccine design and use. Adv Pharmacol. 2014;69:553–580.
  • Kelcher AMH, Baehr CA, Hamid FA, et al. Contribution of antibody-mediated effector functions to the mechanism of efficacy of vaccines for opioid use disorders. J Immunol. 2021;207(3):860–867.
  • Laudenbach M, Baruffaldi F, Vervacke JS, et al., The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse. J Immunol. 2015. 194(12): 5926–5936.
  • Cerny EH, Levy R, Mauel J, et al. Preclinical development of a vaccine ‘against smoking.’ Oncol Res Treat. 2002;25(5):406–411.
  • Desai RI, Bergman J. Effects of the nanoparticle-based vaccine, SEL-068, on nicotine discrimination in squirrel monkeys. Neuropsychopharmacology. 2015;40(9):2207–2216.
  • Maurer P, Jennings GT, Willers J, et al. A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity. Eur J Immunol. 2005;35(7):2031–2040.
  • Pravetoni M, Keyler DE, Raleigh MD, et al. Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats. Biochem Pharmacol. 2011;81(9):1164–1170.
  • Satoskar SD, Keyler DE, LeSage MG, et al. Tissue-dependent effects of immunization with a nicotine conjugate vaccine on the distribution of nicotine in rats. Int Immunopharmacol. 2003;3(7):957–970.
  • Hieda Y, Keyler DE, Ennifar S, et al. Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brain. Int J Immunopharmacol. 2000;22(10):809–819.
  • Lindblom N, De Villiers SHL, Kalayanov G, et al. Active immunization against nicotine prevents reinstatement of nicotine-seeking behavior in rats. Respiration. 2002;69(3):254–260.
  • LeSage MG, Keyler DE, Hieda Y, et al. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology (Berl). 2006;184(3):409–416.
  • Fahim RE, Kessler PD, Kalnik MW. Therapeutic vaccines against tobacco addiction. Expert Rev Vaccines. 2013;12(3):333–342.
  • ClinicalTrials.Gov [Internet]. Bethesda (MD): National Library of Medicine. 2000 Feb 29. identifier nct00633321, study of TA-NIC to assess the efficacy and safety of a vaccine to aid in smoking cessation. and pharmacodynamics of SEL-068 vaccine in smokers and non-smokers, 2008, Mar 12 [cited Aug 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT00633321
  • Tonstad S, Heggen E, Giljam H. Lagerbäck, et al. Niccine®, a nicotine vaccine, for relapse prevention: a phase II, randomized, placebo-controlled. Multicenter Clinical Trial Nicotine Tob Res. 2013;15(9):1492–1501.
  • Cornuz J, Zwahlen S, Jungi WF, et al. A vaccine against nicotine for smoking cessation: a randomized controlled trial. PloS one. 2008;3(6):e2547.
  • Hatsukami DK, Rennard S, Jorenby D, et al. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther. 2005;78(5):456–467.
  • Hatsukami DK, Jorenby DE, Gonzales D, et al. Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeutic. Clin Pharmacol Ther. 2011;89(3):392–399.
  • Wagena EJ, de Vos A, Horwith G, et al. The immunogenicity and safety of a nicotine vaccine in smokers and nonsmokers: results of a randomized, placebo-controlled phase 1/2 trial. Nicotine Tob Res. 2008;10(1):213–218.
  • Hartmann-Boyce J, Stead LF, Cahill K, et al. Efficacy of interventions to combat tobacco addiction: Cochrane update of 2012 reviews. Addiction, 2013. Addiction (Abingdon, England). 2013;108(10):1711–1721.
  • Pryde DC, Jones LH, Gervais DP, et al. Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PloS one. 2013;8(10):e76557.
  • McCluskie MJ, Thorn J, Gervais DP, et al. Anti-nicotine vaccines: comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates. Int Immunopharmacol. 2015;29(2):663–671.
  • ClinicalTrials.Gov [Internet]. Bethesda (MD): National Library of Medicine. 2000 Feb 29. Identifier NCT01478893, Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers, 2011, Nov 23 [cited Aug 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT01478893
  • Kinsey BM, Kosten TR, Orson FM. Anti-cocaine vaccine development. Expert Rev Vaccines. 2010;9(9):1109–1114.
  • Carrera MRA, Ashley JA, Parsons LH, et al. Suppression of psychoactive effects of cocaine by active immunization. Nature. 1995;378(6558):727–730.
  • Carrera MRA, Ashley JA, Wirsching P, et al. A second-generation vaccine protects against the psychoactive effects of cocaine Proceedings of the National Academy of Sciences. 2001 ; 98(4):1988–1992.
  • Carrera MRA, Ashley JA, Zhou B, Wirsching, et al. Cocaine vaccines: antibody protection against relapse in a rat model. Proceedings of the National Academy of Sciences. 2000 ; 97(11),6202–6206.
  • Fox BS, Kantak KM, Edwards MA, et al. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med. 1996;2(10):1129–1132.
  • Kantak KM, Collins SL, Lipman EG, et al. Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model. Psychopharmacology (Berl). 2000;148(3):251–262.
  • Kantak KM, Collins SL, Bond J, et al. Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010. Psychopharmacology (Berl). 2001;153(3):334–340.
  • Koetzner L, Deng S, Sumpter TL, et al. Titer-dependent antagonism of cocaine following active immunization in rhesus monkeys. J Pharmacol Exp Ther. 2001;296(3):789–796.
  • Hrafnkelsdottir K, Valgeirsson J, Gizurarson S. Induction of protective and specific antibodies against cocaine by intranasal immunisation using a glyceride adjuvant. Biol Pharm Bull. 2005;28(6):1038–1042.
  • Hicks MJ, Kaminsky SM, De BP, et al. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Hum Gene Ther Clin Dev. 2014;25(1):40–49.
  • Maoz A, Hicks MJ, Vallabhjosula S, et al. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology. 2013;38(11):2170–2178.
  • Wee S, Hicks MJ, De BP, et al. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology. 2012;37(5):1083–1091.
  • Kosten TR, Gonsai K, St Clair Roberts J, et al. Phase II human study of cocaine vaccine TA-CD. 2002, June. In CPDD Annual Meeting, Quebec City.
  • Kosten TR, Biegel D. Therapeutic vaccines for substance dependence. Expert Rev Vaccines. 2002;1(3):365–371.
  • Martell BA, Mitchell E, Poling J, et al. Vaccine pharmacotherapy for the treatment of cocaine dependence. Biol Psychiatry. 2005;58(2):158–164.
  • Martell BA, Orson FM, Poling J, et al. Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial. Arch Gen Psychiatry. 2009;66(10):1116–1123.
  • Haney M, Gunderson EW, Jiang H, et al. Cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans. Biol Psychiatry. 2010;67(1):59–65.
  • ClinicalTrials.Gov [Internet]. Bethesda (MD): National Library of Medicine. 2000 Feb 29. Identifier NCT02455479, Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-Dependent Individuals, 2015, May 27 7 [cited Aug 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT02455479
  • Shen XY, Kosten TA, Lopez AY, et al. A vaccine against methamphetamine attenuates its behavioral effects in mice. Drug Alcohol Depend. 2013;129(1–2):41–48.
  • Haile CN, Kosten TA, Shen XY, et al. Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine. Am J Addict. 2015;24(8):748–755.
  • Keller CM, Spence AL, Stevens MW, et al. Effects of a methamphetamine vaccine, IXT-v100, on methamphetamine-related behaviors. Psychopharmacology (Berl). 2020;237(3):655–667.
  • Miller ML, Moreno AY, Aarde SM, et al. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats. Biol Psychiatry. 2013;73(8):721–728.
  • Miller ML, Aarde SM, Moreno AY, et al. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats. Drug Alcohol Depend. 2015;153:29–36.
  • Moreno AY, Mayorov AV, Janda KD. Impact of distinct chemical structures for the development of a methamphetamine vaccine. J Am Chem Soc. 2011;133(17):6587–6595.
  • Collins KC, Schlosburg JE, Lockner JW, et al. Lipid tucaresol as an adjuvant for methamphetamine vaccine development. Chem Comm. 2014;50(31):4079–4081.
  • Collins KC, Schlosburg JE, Bremer PT, et al. Methamphetamine vaccines: improvement through hapten design. J Med Chem. 2016;59(8):3878–3885.
  • Stevens MW, Gunnell MG, Tawney R, et al. Optimization of a methamphetamine conjugate vaccine for antibody production in mice. Int Immunopharmacol. 2016;35:137–141.
  • Spector S, Berkowitz B, Flynn EJ, et al. Antibodies to morphine, barbiturates, and serotonin. Pharmacol Rev. 1973;25(2):281–291.
  • Bonese KF, Wainer BH, Fitch FW, et al. Changes in heroin self-administration by a rhesus monkey after morphine immunisation. Nature. 1974;252(5485):708–710.
  • Kosten TA, Shen XY, O’Malley PW. Kinsey, et al. A Morphine Conjugate Vaccine Attenuates the Behavioral Effects of Morphine in Rats Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013;45:223–229.
  • Raleigh MD, Pentel PR. Vaccines for opioid addiction Montoya, Ivan. In: Biologics to treat substance use disorders (Cham: Springer). 2016. p. 37–63.
  • Truong TT, Kosten TR. Current status of vaccines for substance use disorders: a brief review of human studies. J Neurol Sci. 2021;434:120098.
  • Schlosburg JE, Vendruscolo LF, Bremer PT, et al. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences. 110(22),9036–9041.
  • Raleigh MD, Peterson SJ, Laudenbach M, et al. Safety and efficacy of an oxycodone vaccine: addressing some of the unique considerations posed by opioid abuse. PLoS One. 2017;12(12):e0184876.
  • Bremer PT, Kimishima A, Schlosburg JE, et al. Combatting synthetic designer opioids: a conjugate vaccine ablates lethal doses of fentanyl class drugs. Angew Chem. 2016;128(11):3836–3839.
  • Tenney RD, Blake S, Bremer PT, et al. Vaccine blunts fentanyl potency in male rhesus monkeys. Neuropharmacology. 2019;158:107730.
  • Stone AE, Scheuermann SE, Haile CN, et al. Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. Npj Vaccines. 2021;6(1):1–11.
  • Hwang CS, Smith LC, Natori Y, et al. Efficacious vaccine against heroin contaminated with fentanyl. ACS Chem Neurosci. 2018;9(6):1269.
  • Raleigh MD, Baruffaldi F, Peterson SJ, et al. A fentanyl vaccine alters fentanyl distribution and protects against fentanyl-induced effects in mice and rats. J Pharmacol Exp Ther. 2019;368(2):282–291.
  • Eubanks LM, Blake S, Natori Y, et al. A highly efficacious carfentanil vaccine that blunts opioid-induced antinociception and respiratory depression. ACS Chem Biol. 2021;16(2):277–282.
  • Baehr C, Robinson C, Kassick A. et al. Preclinical efficacy and selectivity of vaccines targeting fentanyl, alfentanil, sufentanil, and acetylfentanyl in rats. ACS omega. 2022;7(19): 16584–92.
  • Sulima A, Jalah R, Antoline JF, et al. A stable heroin analogue that can serve as a vaccine hapten to induce antibodies that block the effects of heroin and its metabolites in rodents and that cross-react immunologically with related drugs of abuse. J Med Chem. 2018;61(1):329–343.
  • Torres OB, Matyas GR, Rao M, et al. Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant. Npj Vaccines. 2017;2(1):1–8.
  • Beck Z, Torres OB, Matyas GR, et al. Immune response to antigen adsorbed to aluminum hydroxide particles: effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex. J Control Release. 2018;275:12–19.
  • Bremer PT, Janda KD, Barker EL. Conjugate vaccine immunotherapy for substance use disorder. Pharmacol Rev. 2017;69(3):298–315.
  • Raleigh MD, Pravetoni M, Harris AC, et al. Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats. J Pharmacol Exp Ther. 2013;344(2):397–406.
  • Raleigh MD, Pentel PR, LeSage MG. Pharmacokinetic correlates of the effects of a heroin vaccine on heroin self-administration in rats. PLoS One. 2014;9(12):e115696.
  • Raleigh MD, Laudenbach M, Baruffaldi F, et al. Opioid dose-and route-dependent efficacy of oxycodone and heroin vaccines in rats. J Pharmacol Exp Ther. 2018;365(2):346–353.
  • Pravetoni M, Le Naour M, Tucker AM, et al. Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens. J Med Chem. 2013;56(3):915–923.
  • Kimishima A, Wenthur CJ, Zhou B, et al. An advance in prescription opioid vaccines: overdose mortality reduction and extraordinary alteration of drug half-life. ACS Chem Biol. 2017;12(1):36–40.
  • Nguyen JD, Hwang CS, Grant Y, et al. Prophylactic vaccination protects against the development of oxycodone self-administration. Neuropharmacology. 2018;138:292–303.
  • Pravetoni M, Pentel PR, Potter DN, et al., Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats. PloS one. 2014. 9(7): e101807.
  • Laudenbach M, Baruffaldi F, Robinson C, et al. Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose. Sci Rep. 2018;8(1):1–12.
  • Akbarzadeh A, Mehraby M, Zarbakhsh M, et al. Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development. Biotechnol Appl Biochem. 1999;30(2):139–145.
  • Akbarzadeh A, Norouzian D, Farhangi A, et al. Immunotherapy of 347 volunteer outpatient morphine addicts by human therapeutic morphine vaccine in Kermanshah province of Iran. J Pharmacol Toxicol. 2009;4(1):30–35.
  • ClinicalTrials.Gov [Internet]. Bethesda (MD): National Library of Medicine. 2000 Feb 29. Identifier NCT04458545, Clinical Trials of Multivalent Opioid Vaccine Components, 2020, Jul 7 [cited Aug 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT04458545
  • Carrera MRA, Ashley JA, Hoffman TZ, et al. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem. 2004;12(3):563–570.
  • Keyler DE, Roiko SA, Benlhabib E, et al. Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: dose-and affinity-response relationships. Drug Metab Dispos. 2005;33(7):1056–1061.
  • Carrera MRA, Trigo JM, Wirsching P, et al. Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. Pharmacol Biochem Behav. 2005;81(4):709–714.
  • Norman AB, Norman MK, Buesing WR, et al. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. J Pharmacol Exp Ther. 2009;328(3):873–881.
  • Gentry WB, Laurenzana EM, Williams DK, et al. Safety and efficiency of an anti-(+)-methamphetamine monoclonal antibody in the protection against cardiovascular and central nervous system effects of (+)-methamphetamine in rats. Int Immunopharmacol. 2006;6(6):968–977.
  • Baehr C, Kelcher AH, Khaimraj A, et al. Monoclonal antibodies counteract opioid-induced behavioral and toxic effects in mice and rats. J Pharmacol Exp Ther. 2020;375(3):469–477.
  • Bogen IL, Boix F, Nerem E, et al. A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice. J Pharmacol Exp Ther. 2014;349(3):568–576.
  • Kvello AMS, Andersen JM, Øiestad EL, et al. Pharmacological effects of a monoclonal antibody against 6-monoacetylmorphine upon heroin-induced locomotor activity and pharmacokinetics in mice. J Pharmacol Exp Ther. 2016;358(2):181–189.
  • Hardin JS, Wessinger WD, Wenger GR, et al. A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats. J Pharmacol Exp Ther. 2002;302(1):119–126.
  • Stevens MW, Henry RL, Owens SM, et al. First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers. MAbs. 2014;6(6):1649–1656.
  • ClinicalTrials.Gov [Internet]. Bethesda (MD): National Library of Medicine. 2000 Feb 29. Identifier NCT03336866, Study of Antibody for Methamphetamine Outpatient Therapy (STAMPOUT), 2017, Nov 8 [cited Sept 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT03336866
  • Baehr CA, Wu MM, Pandit SG, et al. Pharmacological profiling of antifentanyl monoclonal antibodies in combination with naloxone in pre-and postexposure models of fentanyl toxicity. J Pharmacol Exp Ther. 2022;381(2):129–136.
  • Shaffer L (2021). Using vaccines to harness the immune system and fight drugs of abuse Proceedings of the National Academy of Sciences. 118(52), e2121094118.
  • Baruffaldi F, Kelcher AH, Laudenbach M, et al. Preclinical efficacy and characterization of candidate vaccines for treatment of opioid use disorders using clinically viable carrier proteins. Mol Pharm. 2018;15(11):4947–4962.
  • Crouse B, Zhang L, Robinson C, et al. Housing conditions and microbial environment do not affect the efficacy of vaccines for treatment of opioid use disorders in mice and rats. Hum Vaccin Immunother. 2021;17(11):4383–4392.
  • O’Connor AM, Cousins G, Durand L, et al. Retention of patients in opioid substitution treatment: a systematic review. PloS one. 2020;15(5):e0232086.
  • Timko C, Schultz NR, Cucciare MA, et al. Retention in medication-assisted treatment for opiate dependence: a systematic review. J Addict Dis. 2016;35(1):22–35.
  • Wu LT, Zhu H, Swartz MS. Treatment utilization among persons with opioid use disorder in the United States. Drug Alcohol Depend. 2016;169:117–127.

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