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Special Report

Experimental treatments in clinical trials for diabetic foot ulcers: wound healers in the pipeline

, , , , , & show all
Pages 95-99 | Received 08 Nov 2022, Accepted 06 Feb 2023, Published online: 21 Feb 2023

References

  • Hicks CW, Selvarajah S, Mathioudakis N, et al. Burden of infected diabetic foot ulcers on hospital admissions and costs. Annals of Vascular Surgery. 2016;33:149–158.
  • Driver VR, Lavery LA, Reyzelman AM, et al. A clinical trial of integra template for diabetic foot ulcer treatment. Wound Repair Regener. 2015;23(6):891–900.
  • Margolis DJ, Kantor J, Berlin JA. Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis. Diabetes Care. 1999;22(5):692–695.
  • Yazdanpanah L, Nasiri M, Adarvishi S. Literature review on the management of diabetic foot ulcer. World J Diabetes. 2015;6(1):37–53.
  • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736–1743.
  • Xue C, Friedman A, Sen CK. A mathematical model of ischemic cutaneous wounds. Proc Nat Acad Sci. 2009;106(39):16782–16787.
  • Sakakura K, Nakano M, Otsuka F, et al. Pathophysiology of atherosclerosis plaque progression. Heart Lung Circ. 2013;22(6):399–411.
  • Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265). DOI:10.1126/scitranslmed.3009337
  • Wong SL, Demers M, Martinod K, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21(7):815–819.
  • Moura J, Rodrigues J, Gonçalves M, et al. Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol. 2017;14(9):758–769.
  • Sawaya AP, Stone RC, Brooks SR, et al. Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing. Nat Commun. 2020;11(1):4678.
  • Khanna S, Biswas S, Shang Y, et al. Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PloS one. 2010;5(3):e9539.
  • Smith A, Watkins T, Theocharidis G, et al. A novel three-dimensional skin disease model to assess macrophage function in diabetes. Tissue Eng Part C Methods. 2021;27(2):49–58.
  • Theocharidis G, Veves A. Autonomic nerve dysfunction and impaired diabetic wound healing: the role of neuropeptides. Auton Neurosci. 2020;223:102610.
  • Adeghate J, Nurulain S, Tekes K, et al. Novel biological therapies for the treatment of diabetic foot ulcers. Expert Opin Biol Ther. 2017;17(8):979–987.
  • Lavery LA, Fulmer J, Shebetka KA, et al. The efficacy and safety of Grafix(®) for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded, clinical trial. Int Wound J. 2014;11(5):554–560.
  • Ayuk SM, Abrahamse H, Houreld NN. The role of matrix metalloproteinases in diabetic wound healing in relation to photobiomodulation. J Diabetes Res. 2016;2016:1–9.
  • Jones JI, Nguyen TT, Peng Z, et al. Targeting MMP-9 in diabetic foot ulcers. Pharmaceuticals (Basel). 2019 May 22;12(2):79. PMID: 31121851; PMCID: PMC6630664.
  • Meaume S, Truchetet F, Cambazard F, et al; CHALLENGE Study Group. A randomized, controlled, double-blind prospective trial with a lipido-colloid technology-nano-oligosaccharide factor wound dressing in the local management of venous leg ulcers. Wound Repair Regen. 2014;20(4):500–511.
  • Edmonds M, Lázaro-Martínez JL, Alfayate-Garcia JM, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018;6(3):186–196.
  • Santilli JD, Santilli SM. Chronic critical limb ischemia: diagnosis, treatment and prognosis. Am Fam Physician. 1999;59(7):1899–1908.
  • Tay WL, Lo ZJ, Hong Q, et al. Toe pressure in predicting diabetic foot ulcer healing: a systematic review and meta-analysis. Ann Vasc Surg. 2019;60:371–378.
  • Mirza RE, Fang MM, Weinheimer-Haus EM, et al. Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice. Diabetes. 2014;63(3):1103–1114.
  • Al Sadoun H. Macrophage phenotypes in normal and diabetic wound healing and therapeutic interventions. Cells. 2022;11(15):2430.
  • Huang Y, Lin C, Cheng N, et al. Effect of a novel macrophage-regulating drug on wound healing in patients with diabetic foot ulcers: a randomized clinical trial. JAMA Network Open. 2021;4(9):e2122607.
  • Leu WJ, Chen JC, Guh JH. Extract from Plectranthus amboinicusinhibit maturation and release of interleukin 1β through inhibition of NF-κB nuclear translocation and NLRP3 inflammasome activation. Front Pharmacol. 2019;10:573.
  • Sawatdee S, Choochuay K, Chanthorn W, et al. Evaluation of the topical spray containing Centella asiatica extract and its efficacy on excision wounds in rats. Acta Pharm. 2016;66(2):233–244.
  • Theocharidis G, Thomas BE, Sarkar D, et al. Single cell transcriptomic landscape of diabetic foot ulcers. Nat Commun. 2022;13(1):181.
  • Sharma R, Sharma SK, Mudgal SK, et al. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials. Sci Rep. 2021;11(1):2189.
  • Gawdi R, Cooper JS. Hyperbaric Contraindications. Treasure Island, Fl: StatPearls Publishing; 2022.
  • Frykberg R, Franks P, Edmonds M, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical Topical Wound Oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care. 2020;43(3):616–624.
  • Frykberg RG. Topical wound oxygen therapy in the treatment of chronic diabetic foot ulcers. Medicina (B Aires). 2021;57(9):917.
  • Serena TE, Bullock NM, Cole W, et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care. 2021;30(Sup5):S7–S14.
  • Gershater MA, Londahl M, Nyberg P, et al. Complexity of factors related to outcome of neuropathic and neuroischaemic/ischaemic diabetic foot ulcers: a cohort study. Diabetologia. 2009;52(3):398–407.
  • Game F, Jeffcoate W, Tarnow L, et al. LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial. Lancet Diabetes Endocrinol. 2018;6(11):870–878.

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