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Original Articles

ACTN3 R577X polymorphism related to sarcopenia and physical fitness in active older women

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Pages 89-94 | Received 27 Jan 2020, Accepted 26 May 2020, Published online: 30 Jun 2020

References

  • World Health Organization (WHO). Active Aging: A Policy Framework. Madrid: WHO/NMH/NPH/02.8; 2002
  • Wilkin LD, Haddock BL. Health-related variables and fitness among older adults. Int J Aging Hum Dev 2010;70:107–18
  • Gomez-Cabello A, Vicente Rodriguez G, Vila-Maldonado S, Casajus JA, Ara I. [Aging and body composition: the sarcopenic obesity in Spain]. Nutr Hosp 2012;27:22–30
  • Houston DK, Nicklas BJ, Zizza CA. Weighty concerns: the growing prevalence of obesity among older adults. J Am Diet Assoc 2009;109:1886–95
  • Gomez-Cabello A, Pedrero-Chamizo R, Olivares PR, et al. Prevalence of overweight and obesity in non-institutionalized people aged 65 or over from Spain: the elderly EXERNET multi-centre study. Obes Rev 2011;12:583–92
  • Cadore EL, Izquierdo M. How to simultaneously optimize muscle strength, power, functional capacity, and cardiovascular gains in the elderly: an update. Age (Dordr) 2013;35:2329–44
  • Physical Activity Guidelines Advisory Committee Scientific Report. 2018 Physical Activity Guidelines Advisory Committee. Washington, DC: U.S. Department of Health and Human Services; 2018
  • Garatachea N, Lucia A. Genes, physical fitness and ageing. Ageing Res Rev 2013;12:90–102
  • Tan LJ, Liu SL, Lei SF, Papasian CJ, Deng HW. Molecular genetic studies of gene identification for sarcopenia. Hum Genet 2012;131:1–31
  • North KN, Beggs AH. Deficiency of a skeletal muscle isoform of alpha-actinin (alpha-actinin-3) in merosin-positive congenital muscular dystrophy. Neuromuscul Disord 1996;6:229–35
  • Mills M, Yang N, Weinberger R, et al. Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet 2001;10:1335–46
  • Garton FC, Seto JT, Quinlan KG, Yang N, Houweling PJ, North KN. α-Actinin-3 deficiency alters muscle adaptation in response to denervation and immobilization. Hum Mol Genet 2014;23:1879–93
  • Min SK, Lim ST, Kim CS. Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women. J Phys Ther Sci 2016;28:2731–6
  • Cho J, Lee I, Kang H. ACTN3 gene and susceptibility to sarcopenia and osteoporotic status in older Korean adults. Biomed Res Int 2017;2017:4239648
  • Walsh S, Liu D, Metter EJ, Ferrucci L, Roth SM. ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J Appl Physiol 2008;105:1486–91
  • Garatachea N, Fiuza-Luces C, Torres-Luque G, et al. Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians. Eur J Appl Physiol 2012;112:2409–20
  • San Juan AF, Gomez-Gallego F, Cañete S, Santiago C, Pérez M, Lucia A. Does complete deficiency of muscle alpha actinin 3 alter functional capacity in elderly women? A preliminary report. Br J Sports Med 2006;40:e1
  • Delmonico MJ, Kostek MC, Doldo NA, et al. Alpha-actinin-3 (ACTN3) R577X polymorphism influences knee extensor peak power response to strength training in older men and women. J Gerontol A Biol Sci Med Sci 2007;62:206–12
  • Kikuchi N, Zempo H, Fuku N, et al. Association between ACTN3 R577X polymorphism and trunk flexibility in 2 different cohorts. Int J Sports Med 2017;38:402–6
  • Garatachea N, Lucía A. Genes and the ageing muscle: a review on genetic association studies. Age (Dordr) 2013;35:207–33
  • Lopez-Rodriguez C, Laguna M, Gomez-Cabello A, et al. Validation of the self-report EXERNET questionnaire for measuring physical activity and sedentary behavior in elderly. Arch Gerontol Geriatr 2017;69:156–61
  • Rikli RE, Jones CJ. Development and validation of criterion-referenced clinically relevant fitness standards for maintaining physical independence in later years. Gerontologist 2013;53:255–67
  • Lum A, Le Marchand L. A simple mouthwash method for obtaining genomic DNA in molecular epidemiological studies. Cancer Epidemiol Biomarkers Prev 1998;7:719–24
  • Lucia A, Gomez-Gallego F, Santiago C, et al. ACTN3 genotype in professional endurance cyclists. Int J Sports Med 2006;27:880–4
  • Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019;48:16–31
  • Seto JT, Quinlan KG, Lek M, et al. ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling. J Clin Invest 2013;123:4255–63
  • Bustamante-Ara N, Santiago C, Verde Z, et al. ACE and ACTN3 genes and muscle phenotypes in nonagenarians. Int J Sports Med 2010;31:221–4
  • Kikuchi N, Yoshida S, Min SK, et al. The ACTN3 R577X genotype is associated with muscle function in a Japanese population. Appl Physiol Nutr Metab 2015;40:316–22
  • Yang N, MacArthur DG, Gulbin JP, et al. ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 2003;73:627–31
  • Qi B, Liu JQ, Liu GL. Genetic association between ACTN3 polymorphism and risk of non-acute ankle sprain. Genet Mol Res 2016;15:gmr15048962
  • Fiuza-Luces C, Ruiz JR, Rodriguez-Romo G, et al. Are ‘endurance’ alleles ‘survival’ alleles? Insights from the ACTN3 R577X polymorphism. PLoS One 2011;6:e17558
  • Houweling PJ, Papadimitriou ID, Seto JT, et al. Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and disease. Hum Mutat 2018;39:1774–87
  • Lima RM, Leite TK, Pereira RW, Rabelo HT, Roth SM, Oliveira RJ. ACE and ACTN3 genotypes in older women: muscular phenotypes. Int J Sports Med 2011;32:66–72
  • McCauley T, Mastana SS, Folland JP. ACE I/D and ACTN3 R/X polymorphisms and muscle function and muscularity of older Caucasian men. Eur J Appl Physiol 2010;109:269–77

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