Androgens in premenopausal women and women with premature ovarian insufficiency

References

• Webber L, Davies M, Anderson R, et al. ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod 2016;31:926–37
   PubMed Web of Science ®Google Scholar
• Benetti-Pinto CL, Soares PM, Giraldo HP, Yela DA. Role of the different sexuality domains on the sexual function of women with premature ovarian failure. J Sex Med 2015;12:685–9
   PubMed Web of Science ®Google Scholar
• Gartoulla P, Bell RJ, Worsley R, Davis SR. Moderate-severely bothersome vasomotor symptoms are associated with lowered psychological general wellbeing in women at midlife. Maturitas 2015;81:487–92
   PubMed Web of Science ®Google Scholar
• Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long-term health consequences. Maturitas 2010;65:161–6
   PubMed Web of Science ®Google Scholar
• Muka T, Oliver-Williams C, Kunutsor S, et al. Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes, intermediate vascular traits, and all-cause mortality: a systematic review and meta-analysis. JAMA Cardiol 2016;1:767–76
   PubMed Web of Science ®Google Scholar
• Biddle AK, West SL, D'Aloisio AA, Wheeler SB, Borisov NN, Thorp J. Hypoactive sexual desire disorder in postmenopausal women: quality of life and health burden. Value Health 2009;12:763–72
   PubMed Web of Science ®Google Scholar
• Soman M, Huang LC, Cai WH, et al. Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis. Menopause 2019;26:78–93
   PubMed Web of Science ®Google Scholar
• Simpson ER, Davis SR. Minireview: aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 2001;142:4589–94
   PubMed Web of Science ®Google Scholar
• Judd HL, Judd GE, Lucas WE, Yen SSC. Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 1974;39:1020–4
   PubMed Web of Science ®Google Scholar
• Abraham GE. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab 1974;39:340–6
   PubMed Web of Science ®Google Scholar
• Pretorius E, Arlt W, Storbeck KH. A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids. Mol Cell Endocrinol 2017;441:76–85
   PubMed Web of Science ®Google Scholar
• Skiba MA, Bell RJ, Islam RM, Handelsman DJ, Desai R, Davis SR. Androgens during the reproductive years, what's normal for women? J Clin Endocrinol Metab 2019;104:5382–92
   PubMed Web of Science ®Google Scholar
• Nanba AT, Rege J, Ren J, Auchus RJ, Rainey WE, Turcu AF. 11-Oxygenated C19 steroids do not decline with age in women. J Clin Endocrinol Metab 2019;104:2615–22
   PubMed Web of Science ®Google Scholar
• Skiba MA, Bell RJ, Islam RM, Karim N, Davis SR. Distribution of body hair in young Australian women and associations with serum androgen concentrations. J Clin Endocrinol Metab 2020;105:1186–95
   Web of Science ®Google Scholar
• Zheng J, Islam RM, Skiba MA, Bell RJ, Davis SR. Associations between androgens and sexual function in premenopausal women: a cross-sectional study. Lancet Diabetes Endocrinol 2020;8:693–702
   PubMed Web of Science ®Google Scholar
• Sinha-Hikim I, Arver S, Beall G, et al. The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab 1998;83:1312–18
   PubMed Web of Science ®Google Scholar
• Rothman MS, Carlson NE, Xu M, et al. Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry. Steroids 2011;76:177–82
   PubMed Web of Science ®Google Scholar
• Zumoff B, Strain GW, Miller LK, Rosner W. Twenty-four hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 1995;80:1429–30
   PubMed Web of Science ®Google Scholar
• Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847–53
   PubMed Web of Science ®Google Scholar
• Haring R, Hannemann A, John U, et al. Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 2012;97:408–15
   PubMed Web of Science ®Google Scholar
• Goldman AL, Bhasin S, Wu FCW, Krishna M, Matsumoto AM, Jasuja R. A reappraisal of testosterone's binding in circulation: physiological and clinical implications. Endocr Rev 2017;38:302–24
   PubMed Web of Science ®Google Scholar
• Handelsman DJ. Free testosterone: pumping up the tires or ending the free ride? Endocr Rev 2017;38:297–301
   PubMed Web of Science ®Google Scholar
• Davis SR, Baber R, Panay N, et al. Global Consensus Position Statement on the Use of Testosterone Therapy for Women. Climacteric 2019;22:429–34
   PubMed Web of Science ®Google Scholar
• Labrie F. Intracrinology. Mol Cell Endocrinol 1991;78:C113–18
   PubMed Web of Science ®Google Scholar
• Doldi N, Belvisi L, Bassan M, Fusi F, Ferrari A. Premature ovarian failure: steroid synthesis and autoimmunity. Gynecol Endocrinol 1998;12:23–8
   PubMed Web of Science ®Google Scholar
• Judd HL, Lucas WE, Yen SSC. Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol 1974;118:793–8
   PubMed Web of Science ®Google Scholar
• Ushiroyama T, Sugimoto O. Endocrine function of the peri- and postmenopausal ovary. Horm Res 1995;44:64–8
   PubMedGoogle Scholar
• Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 2000;85:2832–8
   PubMed Web of Science ®Google Scholar
• Fogle RH, Stanczyk FZ, Zhang X, Paulson RJ. Ovarian androgen production in postmenopausal women. J Clin Endocrinol Metab 2007;92:3040–3
   PubMed Web of Science ®Google Scholar
• Miller K, Sesmilo G, Schiller A, Schonfeld D, Burton S, Klibanski A. Androgen deficiency in women with hypopituitarism. J Clin Endocrinol Metab 2001;86:561–7
   PubMed Web of Science ®Google Scholar
• Slemenda C, Longcope C, Peacock M, Hui S, Johnston CC. Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women. J Clin Invest 1996;97:14–21
   PubMed Web of Science ®Google Scholar
• Rariy CM, Ratcliffe SJ, Weinstein R, et al. Higher serum free testosterone concentration in older women is associated with greater bone mineral density, lean body mass, and total fat mass: the cardiovascular health study. J Clin Endocrinol Metab 2011;96:989–96
   PubMed Web of Science ®Google Scholar
• Lee JS, LaCroix AZ, Wu L, et al. Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women. J Clin Endocrinol Metab 2008;93:1796–803
   PubMed Web of Science ®Google Scholar
• Yuki A, Ando F, Otsuka R, Shimokata H. Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women. Geriatr Gerontol Int 2015;15:326–33
   PubMed Web of Science ®Google Scholar
• Davis SR, McCloud PI, Strauss BJG, Burger HG. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227–36
   PubMed Web of Science ®Google Scholar
• Anasti JN, Kalantaridou SN, Kimzey LM, Defensor RA, Nelson LM. Bone loss in young women with karyotypically normal spontaneous premature ovarian failure. Obstet Gynecol 1998;91:12–15
   PubMed Web of Science ®Google Scholar
• Zuckerman-Levin N, Frolova-Bishara T, Militianu D, Levin M, Aharon-Peretz J, Hochberg Z. Androgen replacement therapy in Turner syndrome: a pilot study. J Clin Endocrinol Metab 2009;94:4820–7
   PubMed Web of Science ®Google Scholar
• Islam MR, Bell RJ, Green S, Page M, Davis SR. Efficacy and safety of testosterone therapy for women: a systematic review and meta-analysis of randomized controlled trial data. Lancet Diabetes Endocrinol 2019;7:754–66
   PubMed Web of Science ®Google Scholar
• Miller KK, Biller BM, Beauregard C, et al. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2006;91:1683–90
   PubMed Web of Science ®Google Scholar
• Popat VB, Calis KA, Kalantaridou SN, et al. Bone mineral density in young women with primary ovarian insufficiency: results of a three-year randomized controlled trial of physiological transdermal estradiol and testosterone replacement. J Clin Endocrinol Metab 2014;99:3418–26
   PubMed Web of Science ®Google Scholar
• Archer JS, Love-Geffen TE, Herbst-Damm KL, Swinney DA, Chang JR. Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women. Menopause 2006;13:528–37
   PubMed Web of Science ®Google Scholar
• Baldassarre M, Perrone AM, Giannone FA, et al. Androgen receptor expression in the human vagina under different physiological and treatment conditions. Int J Impot Res 2013;25:7–11
   PubMed Web of Science ®Google Scholar
• Heard-Davison A, Heiman JR, Kuffel S. Genital and subjective measurement of the time course effects of an acute dose of testosterone vs. placebo in postmenopausal women. J Sex Med 2007;4:209–17
   PubMed Web of Science ®Google Scholar
• Davis SR. Supplementary data-Intra-vaginal testosterone improves sexual satisfaction and vaginal symptoms associated with aromatase inhibitors. 2018.pdf. figshare. Dataset 2018. https://doi.org/https://doi.org/10.26180/5b6517ab522f4
   Google Scholar
• Wahlin-Jacobsen S, Pedersen AT, Kristensen E, et al. Is there a correlation between androgens and sexual desire in women? J Sex Med 2015;12:358–73
   PubMed Web of Science ®Google Scholar
• Pacello PC, Yela DA, Rabelo S, Giraldo PC, Benetti-Pinto CL. Dyspareunia and lubrication in premature ovarian failure using hormonal therapy and vaginal health. Climacteric 2014;17:342–7
   PubMed Web of Science ®Google Scholar
• Davis M, Ventura JL, Wieners M, et al. The psychosocial transition associated with spontaneous 46,XX primary ovarian insufficiency: illness uncertainty, stigma, goal flexibility, and purpose in life as factors in emotional health. Fertil Steril 2010;93:2321–9
   PubMed Web of Science ®Google Scholar
• Schmidt PJ, Luff JA, Haq NA, et al. Depression in women with spontaneous 46,XX primary ovarian insufficiency. J Clin Endocrinol Metab 2011;96:E278–87
   PubMed Web of Science ®Google Scholar
• Spoletini I, Vitale C, Pelliccia F, Fossati C, Rosano GM. Androgens and cardiovascular disease in postmenopausal women: a systematic review. Climacteric 2014;17:625–34
   PubMed Web of Science ®Google Scholar
• Jones RD, Hugh Jones T, Channer KS. The influence of testosterone upon vascular reactivity. Eur J Endocrinol 2004;151:29–37
   PubMed Web of Science ®Google Scholar
• Worboys S, Kotsopoulos D, Teede H, McGrath BP, Davis SR. Evidence that parenteral testosterone may improve endothelium-dependent and -independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001;86:158–61
   PubMed Web of Science ®Google Scholar
• Navarro-Dorado J, Orensanz LM, Recio P, et al. Mechanisms involved in testosterone-induced vasodilatation in pig prostatic small arteries. Life Sci 2008;83:569–73
   PubMed Web of Science ®Google Scholar
• Davison S, Thipphawong J, Blanchard J, et al. Pharmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J Clin Pharmacol 2005;45:177–84
   PubMed Web of Science ®Google Scholar
• Sievers C, Klotsche J, Pieper L, et al. Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients. Eur J Endocrinol 2010;163:699–708
   PubMed Web of Science ®Google Scholar
• Davis SR, Wahlin-Jacobsen S. Testosterone in women–the clinical significance. Lancet Diabetes Endocrinol 2015;3:980–92
   PubMed Web of Science ®Google Scholar
• Schaffrath G, Kische H, Gross S, et al. Association of sex hormones with incident 10-year cardiovascular disease and mortality in women. Maturitas 2015;82:424–30
   PubMed Web of Science ®Google Scholar
• Azziz R, Carmina E, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 2009;91:456–88
   PubMed Web of Science ®Google Scholar
• Clayton AH, Goldstein I, Kim NN, et al. The International Society for the Study of Women's Sexual Health process of care for management of hypoactive sexual desire disorder in women. Mayo Clin Proc 2018;93:467–87
   PubMed Web of Science ®Google Scholar
• Floter A, Carlstrom K, von Schoultz B, Nathorst BJ. Administration of testosterone undecanoate in postmenopausal women: effects on androgens, estradiol, and gonadotrophins. Menopause 2000;7:251–6
   PubMed Web of Science ®Google Scholar
• Buckler HM, Kalsi PK, Cantrill JA, Anderson DC. An audit of oestradiol levels and implant frequency in women undergoing subcutaneous implant therapy. Clin Endocrinol (Oxf) 1995;42:445–50
   PubMed Web of Science ®Google Scholar
• Advisory Committee Briefing Document Intrinsa® (testosterone transdermal system) 2 December 2004. NDA No. 21-769 Procter & Gamble Pharmaceuticals, Inc. Advisory Committee for Reproductive Health Drugs. 2009. Available from: https://wayback.archive-it.org/7993/20170405114619/ https://www.fda.gov/ohrms/dockets/ac/04/briefing/2004-4082B1_01_A-P&G-Intrinsa.pdf [accessed 20 April 2019]
   Google Scholar
• Davis SR, Moreau M, Kroll R, et al. Testosterone for low libido in menopausal women not taking estrogen therapy. N Engl J Med 2008;359:2005–17
   PubMed Web of Science ®Google Scholar
• Panay N, Al-Azzawi F, Bouchard C, et al. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric 2010;13:121–31
   PubMed Web of Science ®Google Scholar
• Shifren J, Davis SR, Moreau M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 study. Menopause 2006;13:770–9
   PubMed Web of Science ®Google Scholar
• Wierman ME, Arlt W, Basson R, et al. Androgen therapy in women: a reappraisal: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2014;99:3489–510
   PubMed Web of Science ®Google Scholar
• Bachelot A, Nicolas C, Gricourt S, et al. Poor compliance to hormone therapy and decreased bone mineral density in women with premature ovarian insufficiency. PLoS One 2016;11:e0164638
   PubMed Web of Science ®Google Scholar