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Fat mass, weight and body shape changes at menopause – causes and consequences: a narrative review

ORCID Icon, , , &
Pages 381-387 | Received 22 Nov 2022, Accepted 31 Jan 2023, Published online: 09 Mar 2023

References

  • Obesity. World Health Organisation. Available from: https://www.who.int/health-topics/obesity.
  • Fryar CD, Carroll MD, Afful J. Prevalence of overweight, obesity, and severe obesity among adults aged 20 and over: united States, 1960–1962 through 2017–2018. NCHS Health E-Stats. December 2020.
  • Davis SR, Castelo-Branco C, Chedraui P, Writing Group of the International Menopause Society for World Menopause Day 2012, et al. Writing group of the international menopause society for world menopause day 2012. Climacteric. 2012;15(5):419–429.
  • Becker SL, Manson JE. Menopause, the gut microbiome and weight gain: correlation or causation. Menopause. 2020;28(3):327–331.
  • Guthrie JR, Dennerstein L, Dudley EC. Weight gain and the menopause: a 5-year prospective study. Climacteric. 1999;2(3):205–211.
  • Wildman RP, Tepper PG, Crawford S, et al. Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the study of women’s health across the nation. J Clin Endocrinol Metab. 2012;97(9):E1695–1704.
  • Michalakis K, Coppack SW. Primary ovarian insufficiency: relation to changes in body composition and adiposity. Maturitas. 2012;71(4):320–325.
  • Kapoor E, Faubion S, Rocca LG, et al. Trajectories of metabolic parameters after bilateral oophorectomy in premenopausal women. Maturitas. 2022;165:38–46.
  • Goodwin PJ, Ennis M, Pritchard KI, et al. Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol. 1999;17(1):120–129.
  • Gordon AM, Hurwitz S, Shapiro CL, et al. Premature ovarian failure and body composition changes with adjuvant chemotherapy for breast cancer. Menopause. 2011;18(11):1244–1248.
  • Proietto J. Obesity and weight management at menopause. Aust Fam Physician. 2017;46(6):368–370.
  • Stubbins RE, Najjar K, Holcomb VB, et al. Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab. 2012;14(1):58–66.
  • Pedersen SB, Kristensen K, Hermann PA, et al. Estrogen controls lipolysis by up-regulating α2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor α. implications for the female fat distribution. J Clin Endocrinol Metab. 2004;89(4):1869–1878.
  • Juppi HK, Sipilå S, Fachada V, et al. Total and regional adiposity increases during menopause – evidence from a follow-up study. Aging Cell. 2022;21(6):e13621.
  • El Khoudary SR, Shields KJ, Janssen I, et al. Cardiovascular fat, menopause and sex hormones in women: the SWAN cardiovascular fat ancillary study. J Clin Endocrinol Metab. 2015;100(9):3304–3312.
  • Gavin KM, Kohrt W, Klemm DJ, et al. Modulation of energy expenditure by estrogens and exercise in women. Exerc Sport Sci Rev. 2018;46(4):232–239.
  • Kohrt WM, Wierman ME. Preventing fat gain by blocking follicle stimulating hormone. N Engl J Med. 2017;377(3):293–295.
  • Chou T-J, Lu C-W, Liao C-C, et al. Ovariectomy interferes with proteomes of brown adipose tissue in rats. Int J Med Sci. 2022;19(3):499–510.
  • Patel SR, Malhotra A, White DP, et al. Association between reduced sleep and weight gain in women. Am J Epidemiol. 2006;164(10):947–954.
  • Rettberg JR, Yao J, Diaz Brinton R. Estrogen: a master regulator of bioenergetic systems in the brain and body. Front Neuroendocrinol. 2014;35(1):8–30.
  • Kapoor E, Collazo-Clavell ML, Faubion S. Weight gain in women at midlife: a concise review of the pathophysiology and strategies for management. Mayo Clinic Proc. 2017;92(10):1552–1558.
  • Cushman M, Shay CM, Howard VJ, American Heart Association, et al. on behalf of the American heart association. Ten-year differences in women’s awareness related to coronary heart disease: results of the 2019 American heart association national survey: a special report from the American heart association [published online ahead of print september 21, 2020]. Circulation. 2021;143(7):e239–e248.
  • Pu D, Tan R, Yu Q, et al. Metabolic syndrome in menopause and associated factors: a meta-analysis. Climacteric. 2017;20(6):583–591.
  • El Khoudary SR, Chen X, Nasr A, et al. Greater periaortic fat volume at midlife is associated with slower gait speed later in life in women. The SWAN cardiovascular fat ancillary study. J Gerontol A Biol Sci Med Sci. 2019;74(12):1959–1964.
  • Compston JE, Watts NB, Chapurlat R, Glow Investigators, et al. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med. 2011;124(11):1043–1050.
  • Obesity and cancer. National Cancer Institute. April 5, 2022. Available from https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet.
  • Calle E, Rodriguez C, Walker-Thurmond K, et al. Overweight. Obesity and mortality from cancer in a prospectively studied cohort of U.S adults. N Engl J Med. 2003;348(17):1625–1638.
  • Lee C-W, Kim H, Nam M, et al. Obesity and abdominal obesity are risk factors for airway obstructive diseases in korean women: a nationwide population-based cohort study. Menopause. 2022;29(6):734–740.
  • Tang R, Fan Y, Luo M, et al. General and Central obesity are associated with increased severity of the VMS and sexual symptoms of menopause among chinese women: a longitudinal study. Front Endocrinol (Lausanne). 2022;13:814872.
  • Esposito K, Giugliano F, Ciotola M, et al. Obesity and sexual dysfunction, male and female. Int J Impot Res. 2008;20(4):358–365.
  • Esfahani SB, Pal S. Obesity, mental health, and sexual dysfunction: a critical review. Health Psychol Open. 2018;5(2)July-September :2055102918786867–2055102918786813.
  • Pileggi CA, Blondin DP, Hooks BG, et al. Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. Ebio Medicine. 2022;83:104192.
  • Knight M, Anekwe C, Washington K, et al. Weight regulation in menopause. Menopause. 2021;28(8):960–965.
  • Gould L, Gordon A, Cabre H, et al. Metabolic effects of menopause: a cross sectional characterization of body composition and exercise metabolism. Menopause. 2022;29(4):377–389.
  • Donnelly JE, Blair SN, Jakicic JM, et al. American college of sports medicine. American college of sports medicine position stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41:459–471.
  • Pugliese G, Barrea L, Laudisio D, et al. Mediterranean diet as tool to manage obesity in menopause: a narrative review. Nutrition. 2020;79-80:110991–110998.
  • Howard B, Manson J, Stefanick M, et al. Low-fat dietary pattern and weight change over 7 years: the women’s health initiative dietary modification trial. JAMA. 2006;295(1):39–49.
  • Kawano Y, Edwards M, Huang Y, et al. Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. Cell. 2022;185(19):3501–3519.e20.
  • Cantor A, Nelson H, Pappas M, et al. Preventing obesity in midlife women: a systematic review for the women’s preventive services initiative. Ann Intern Med. 2022;175(9):1275–1284.
  • Moliver N, Mika E, Chartrand M, et al. Increased hatha yoga experience predicts lower body mass index and reduced medication use in women over 45years. Int J Yoga. 2011;4(2):77–86.
  • Sui Y, Zhao HL, Wong VC, et al. A systematic review on use of chinese medicine and acupuncture for treatment of obesity. Obes Rev. 2012;13(5):409–430.
  • Margolis KL, Bonds DE, Rodabough RJ, Women’s Health Initiative Investigators, et al. For the women’s health initiative investigators. Effect of Oestrogen plus Progestin on the Incidence of Diabetes in Postmenopausal Women: results from the Women’s Health Initiative Hormone Trial Diabetologia. 2004;47(7):1175–1187.
  • Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and estrogen/progestin replacement study (HERS) Research group. JAMA. 1998;199280(7):605–613.
  • Manson J, Rimm E, Colditz G, et al. A prospective study of postmenopausal estrogen therapy and subsequent incidence of non-insulin-dependent diabetes mellitus. Ann Epidemiol. 1992;2(5):665–673.
  • Espeland MA, Stefanick M, Kritz-Silverstein  , et al. Effect of postmenopausal hormone therapy on body weight and waist and hip girths. JCEM. 1997;82:1549–1556.
  • Yanowski S, Yanowski Y. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311(1):74–86.
  • Pi-Sunyer X, Astrup A, Fujioka K, SCALE Obesity and Prediabetes NN8022-1839 Study Group, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med. 2015;373(1):11–22.
  • Wilding J, Batterham R, Calanna S, STEP 1 Study Group, et al. Once-Weekly semaglutide in adults with overweight or obesity. N Engl J Med. 2021;384(11):989–1002. Mar 18
  • Kramer CK, Leitão CB, Pinto LC, et al. Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trial. Obes Rev. 2011; May12(5):e338-347–e347.
  • Yerevanian A, Soukas A. Metformin: mechanisms in human obesity and weight loss. Curr Obes Rep. 2019;8(2):156–164.
  • Tek C. Naltrexone HCI/bupropion HCI for chronic weight management in obese adults: patient selection and perspectives. Patient Prefer Adherence. 2016;10:751–759.
  • Medsafe Medicine Information. New Zealand Medicine and Medical Devices Safety Authority. 2023. Available from: https://www.medsafe.govt.nz/Medicines/infoSearch.asp.
  • Picot J, Jones J, Colquitt J, et al. The clinical effectiveness and cost effectiveness of bariatric surgery for obesity: a systematic review and economic evaluation. Health Technol Assess. 2009;13(41):1–190.
  • NWCR Facts. National weight control registry. Available from: http://www.nwcr.ws/Research/default.htm.
  • Markovic TP, Proietto J, Dixon JB, et al. The Australian obesity management algorithm: a simple tool to guide the management of obesity in primary care. Obes Res Clin Pract. 2022;16(5):353–363.
  • Garvey WT, Mechanick JI, Brett EM, et al. American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. AACE/ACE Guidelines. 2016;22(3):1–203.

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