Advanced search
Publication Cover
Climacteric Volume 26, 2023 - Issue 4: Special Issue: Genitourinary syndrome of menopause
Submit an article Journal homepage
1,138
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Expert opinion on the treatment of vulvovaginal atrophy with ospemifene based on new evidence

S. Palaciosa Palacios Institute of Women’s Health and Medicine, Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2229-1200View further author information
ORCID Icon,
R. E. Nappib Unit of Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Pavia, Italy;c Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyORCID Iconhttps://orcid.org/0000-0002-5216-9882View further author information
ORCID Icon,
M. J. Cancelod Gynecology and Obstetrics Department, Hospital Universitario de Guadalajara, University of Alcalá, Guadalajara, SpainORCID Iconhttps://orcid.org/0000-0002-2072-7747View further author information
ORCID Icon,
S. Sáncheze Obstetrics and Gynecology Department, Hospital Universitari General de Catalunya, San Cugat, SpainORCID Iconhttps://orcid.org/0000-0003-4245-5268View further author information
ORCID Icon &
T. Simoncinif Department of Clinical and Experimental Medicine, University of Pisa, ItalyORCID Iconhttps://orcid.org/0000-0002-2971-0079View further author information
ORCID Icon
Pages 388-391 | Received 03 Nov 2022, Accepted 09 Mar 2023, Published online: 05 Apr 2023

References

  • Palacios S, Cancelo MJ, Castelo Branco C, et al. Vulvar and vaginal atrophy as viewed by the spanish REVIVE participants: symptoms, management and treatment perceptions. Climacteric. 2017;20(1):55–61. https://pubmed.ncbi.nlm.nih.gov/28042734/.
  • Portman DJ, Gass MLS. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the international society for the study of women’s sexual health and the North American menopause society. Maturitas. 2014;79(3):349–354.
  • Palacios S, Nappi RE, Bruyniks N, et al. The European vulvovaginal epidemiological survey (EVES): prevalence, symptoms and impact of vulvovaginal atrophy of menopause. Climacteric. 2018;21(3):286–291. https://pubmed.ncbi.nlm.nih.gov/29553288/.
  • Hirschberg AL, Bitzer J, Cano A, et al. Topical estrogens and non-hormonal preparations for postmenopausal vulvovaginal atrophy: an EMAS clinical guide. Maturitas. 2021;148:55–61.
  • Faubion SS, Kingsberg SA, Clark AL, et al. The 2020 genitourinary syndrome of menopause position statement of the North American Menopause Society. Menopause. 2020;27:976–992.
  • Ospemifene | European Public Assessment Report, European Medicines Agency. 2015.
  • Adomaityte J, Farooq M, Qayyum R. Effect of raloxifene therapy on venous thromboembolism in postmenopausal women: a meta-analysis. Thromb Haemost. 2008;99(02):338–342.
  • Ospemifene | European Public Assessment Report, European Medicines Agency. 2022.
  • Aleksovska K, Bassetti CLA, Berger T, et al. Guidelines should be guidelines: time to leave the terms “consensus” and “position” for other purposes. Eur J Neurol. 2021;28:2461–2466.
  • Nordstrom BL, Cai B, De Gregorio F, et al. Risk of venous thromboembolism among women receiving ospemifene: a comparative observational study. Ther Adv Drug Saf. 2022 Nov 19;13. DOI:10.1177/20420986221135931
  • Baquedano L, Sánchez S, Aznar T, et al. Síndrome genitourinario de la menopausia, MenoGuía AEEM. Primera ed. 2020.
  • Palacios S, Cancelo MJ, González S, et al. Síndrome genitourinario de la menopausia: recomendaciones de la Sociedad Española de Ginecología y Obstetricia. Progresos Obstet y Ginecol. 2019;62:141–148.
  • Cagnacci A, Gallo M, Gambacciani M, et al. Joint recommendations for the diagnosis and treatment of vulvo-vaginal atrophy in women in the peri- and post-menopausal phases from the Società Italiana per la Menopausa (SIM) and the Società Italiana della Terza Età (SIGiTE). Minerva Ginecol. 2019;71(5):345–352.
  • Parra M, Lagos N, Levancini M, et al. Menopausia y terapia hormonal de la menopausia las recomendaciones 2018 de la unidad de endocrinología ginecológica de clínica alemana de Santiago-Sociedad Italiana de la menopausia y la sociedad Chilena de endocrinología ginecológica. Rev Chil Obstet Ginecol. 2018;83(5):527–550.
  • Faught BM, Soulban G, Yeaw J, et al. Ospemifene versus local estrogen: adherence and costs in postmenopausal dyspareunia. J Comp Eff Res. 2019;8(13):1111–1123.
  • Portman D, Shulman L, Yeaw J, et al. One-year treatment persistence with local estrogen therapy in postmenopausal women diagnosed as having vaginal atrophy. Menopause. 2015;22(11):1197–1203.
  • Palacios S, Mejía A. Antiresorptives and anabolic therapy in sequence or combination for postmenopausal osteoporosis. Climacteric. 2015;18(4):453–455.
  • Palacios S, Panay N, Sánchez-Borrego R, et al. Earlier treatment of vulvovaginal atrophy in post-menopausal women may improve treatment outcomes. J Gynecol Womens Heal. 2019;16:1–8.
  • Sánchez-Borrego R, Palacios S, Cancelo MJ. Satisfaction and medication adherence in women with vulvovaginal atrophy: the CRETA study. Climacteric. 2023. DOI:10.1080/13697137.2023.2190508
  • Cai B, Paolantonio TD, Calvo JG, et al. No increase in incidence or risk of recurrence of breast cancer in ospemifene-treated patients with vulvovaginal atrophy (VVA) from a 2013 to 2020 US real world data. Maturitas. 2021;152:81. http://www.maturitas.org/article/S0378512221001924/fulltext.
  • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Ministerio de Sanidad Consumo y Bienestar Social. Informe de Posicionamiento Terapéutico de Ospemifeno en el tratamiento de la atrofia vulvovaginal en mujeres postmenopáusicas con síntomas moderados a graves; 2019. p. 1–7.
  • NICE Guidance [NG23] | Menopause: diagnosis and management [Internet]; [cited 2022 May 4]. Available from: https://www.nice.org.uk/guidance/ng23.
  • Scottish Medicines Consortium – ospemifene (Senshio) [Internet]; [cited 2022 May 4]. Available from: https://www.scottishmedicines.org.uk/medicines-advice/ospemifene-senshio-full-smc2170/.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.