Womb transplants with live births: an update and the future

References

• Brännström M, Johannesson L, Bokström H, et al. Live birth after uterus transplantation. Lancet. 2015;385:607–616.
   PubMed Web of Science ®Google Scholar
• Sieunarine K, Zakaria FBP, Boyle DCM, et al. Possibilities for fertility restoration: a new surgical technique. Int Surg. 2005;90:249–256.
   PubMed Web of Science ®Google Scholar
• Racho El-Akouri R, Kurlberg G, Dindelegan G, et al. Heterotopic uterine transplantation by vascular anastomosis in the mouse. J Endocrinol. 2002;174:157–166.
   PubMed Web of Science ®Google Scholar
• Racho El-Akouri R, Kurlberg G, Brännström M. Successful uterine transplantation in the mouse: pregnancy and postnatal development of offspring. Hum Reprod. 2003;18:2018–2023.
   PubMed Web of Science ®Google Scholar
• Racho El-Akouri R, Wranning CA, Mölne J, et al. Pregnancy in transplanted mouse uterus after long-term cold ischaemic preservation. Hum Reprod. 2003;18:2024–2030.
   PubMed Web of Science ®Google Scholar
• Racho El-Akouri R, Groth K, Kurlberg G, et al. Rejection patterns in allogeneic uterus transplantation in the mouse. Hum Reprod. 2006;21:436–442.
   PubMed Web of Science ®Google Scholar
• Groth K, El-Akouri RR, Wranning CA, et al. Rejection of allogenic uterus transplant in the mouse: time-dependent and site-specific infiltration of leukocyte subtype. Hum Reprod. 2009;24:2746–2754.
   PubMed Web of Science ®Google Scholar
• Wranning CA, Akhi SN, Kurlberg G, et al. Uterus transplantation in the rat: model development, surgical learning and morphological evaluation. Acta Obstet Gynecol Scand. 2008;87:1239–1247.
   PubMed Web of Science ®Google Scholar
• Diaz-Garcia C, Akhi SN, Martinez-Varea A, et al. The effect of warm ischemia at uterus transplantation in a rat model. Acta Obstet Gynecol Scand. 2013;92:152–159.
   PubMed Web of Science ®Google Scholar
• Akhi SN, Diaz-Garcia C, El-Akouri RR, et al. Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus. Fertil Steril. 2013;99:862–870.
   PubMed Web of Science ®Google Scholar
• Groth K, Akhi S, Mölne J, et al. Effects of immunosuppression by cyclosporine A on allogenic uterine transplant in the rat. Eur J Obstet Gynecol Reprod Biol. 2012;91:952–958.
   Google Scholar
• Wranning CA, Akhi SN, Diaz-Garcia C, et al. Pregnancy after syngeneic uterus transplantation and spontaneous mating in the rat. Hum Reprod. 2011;26:553–558.
   PubMed Web of Science ®Google Scholar
• Diaz-Garcia C, Akhi SN, Wallin A, et al. First report on fertility after allogeneic uterus transplantation. Acta Obstet Gynecol Scand. 2010;89:1491–1494.
   PubMed Web of Science ®Google Scholar
• Diaz-Garcia C, Johannesson L, Shao R, et al. Pregnancy after allogeneic uterus transplantation in the rat: perinatal outcome and growth trajectory. Fertil Steril. 2014;102:1545–1552.
   PubMed Web of Science ®Google Scholar
• Saso S, Petts G, Chatterjee J, et al. Uterine allotransplantation in a rabbit model using aorta-caval anastomosis: a long-term viability study. Eur J Obstet Gynecol Reprod Biol. 2014;182:185–193.
   PubMed Web of Science ®Google Scholar
• Saso S, Petts G, David AL, et al. Achieving an early pregnancy following allogeneic uterine transplantation in a rabbit model. Eur J Obstet Gynecol Reprod Biol. 2015;185:164–169.
   PubMed Web of Science ®Google Scholar
• Avison DL, DeFaria W, Tryphonopoulos P, et al. Heterotopic uterus transplantation in a swine model. Transplantation. 2009;88:465–469.
   PubMed Web of Science ®Google Scholar
• Dahm-Kähler P, Wranning CA, Lundmark C, et al. Transplantation of the uterus in the sheep: methodology and early reperfusion events. J Obstet Gynaecol Res. 2008;34:784–793.
   PubMed Web of Science ®Google Scholar
• Wranning CA, Marcickiewicz J, Enskog A, et al. Fertility after autologous ovine uterine-tubal-ovarian transplantation by vascular anastomosis to the external iliac vessels. Hum Reprod. 2010;25:1973–1979.
   PubMed Web of Science ®Google Scholar
• Ramirez ER, Ramirez DK, Pillari VT, et al. Modified uterine transplant procedure in the sheep model. J Minim Invasive Gynecol. 2008;15:311–314.
   PubMed Web of Science ®Google Scholar
• Gauthier T, Bertin F, Fourcade L, et al. Uterine allotransplantation in ewes using an aortocava patch. Hum Reprod. 2011;11:3028–3036.
   Web of Science ®Google Scholar
• Gonzales-Pinto IM, Tryphonopoulos P, Avison DL, et al. Uterus transplantation model in the sheep with heterotopic whole graft and aorta and cava anastomosis. Transpl Proc. 2013;45:1802–1804.
   PubMed Web of Science ®Google Scholar
• Wei L, Xue T, Yang T, et al. Modified uterine allotransplantation and immunosuppression procedure in the sheep model. PLOS One. 2013;8:e81300.
   PubMed Web of Science ®Google Scholar
• Ramirez ER, Ramirez-Nessetti DK, Nessetti MB, et al. Pregnancy and outcome of uterine allotransplantation and assisted reproduction in sheep. J Minim Invasive Gynecol. 2011;18:238–245.
   PubMed Web of Science ®Google Scholar
• Enskog A, Johannesson L, Chai DC, et al. Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation. Hum Reprod. 2010;25:1980–1987.
   PubMed Web of Science ®Google Scholar
• Johannesson L, Enskog A, Dahm-Kähler P, et al. Uterus transplantation in a non-human primate: long-term follow up after autologous transplantation. Hum Reprod. 2012;27:1640–1648.
   PubMed Web of Science ®Google Scholar
• Johannesson L, Enskog A, Mölne J, et al. Preclinical report on allogeneic uterus transplantation in non-human primates. Hum Reprod. 2013;28:189–198.
   PubMed Web of Science ®Google Scholar
• Tryphonopoulos P, Tzakis AG, Tekin A, et al. Allogeneic uterus transplantation in baboons: surgical technique and challenges to long-term graft survival. Transplantation. 2014;98:51–56.
   Web of Science ®Google Scholar
• Kisu I, Mihara M, Banno K, et al. A new surgical technique of uterine auto-transplantation in cynomolgus monkey: preliminary report about two cases. Arch Gynecol Obstet. 2012;285:129–137.
   PubMed Web of Science ®Google Scholar
• Mihara M, Kisu I, Hara H, et al. Uterus transplantation in cynomolgus macaques: intraoperative evaluation of uterine blood flow using indocyanine green. Hum Reprod. 2011;11:3019–3027.
   Web of Science ®Google Scholar
• Obara H, Kisu I, Kato Y, et al. Surgical technique for allogeneic transplantation in macaques. Sci Rep. 2016;6:35989.
   PubMed Web of Science ®Google Scholar
• Adachi M, Kisu I, Nagai T, et al. Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation. Acta Obstet Gynecol Scand. 2016;95:991–998.
   PubMed Web of Science ®Google Scholar
• Mihara M, Kisu I, Hara H, et al. Uterine autotransplantation in cynomolgus macaques: the first case of pregnancy and delivery. Hum Reprod. 2012;27:2332–2340.
   PubMed Web of Science ®Google Scholar
• Fageeh W, Raffa H, Jabbah H, et al. Transplantation of the human uterus. Int J Gynaecol Obstet. 2002;76:245–251.
   PubMed Web of Science ®Google Scholar
• Özkan Ö, Akar ME, Özkan Ö, et al. Preliminary results of the first human uterus transplantation from a multiorgan donor. Fertil Steril. 2013;99:470–476.
   PubMed Web of Science ®Google Scholar
• Brännström M, Diaz-Garcia C, Olausson M, et al. Uterus transplantation: animal research and human possibilities. Fertil Steril. 2012;97:169–1276.
   PubMed Web of Science ®Google Scholar
• Moore FD. Ethical problems special to surgery. Arch Surg. 2000;135:14–16.
   PubMed Web of Science ®Google Scholar
• McCulloch P, Altman DG, Campbell WB, et al. No surgical innovation without evaluation: the IDEAL recommendations. Lancet. 2009;374:1105–1112.
   PubMed Web of Science ®Google Scholar
• Wranning CA, Mölne J, Racho El-Akouri R, et al. Short-term ischaemic storage of human uterine myometrium – basic studies towards uterine transplantation”. Human Reprod. 2005;20:2736–2744.
   PubMed Web of Science ®Google Scholar
• Del Priore G, Stega J, Sieunarine K, et al. Human uterus retrieval from a multi-organ donor. Obstet Gynecol. 2007;109:101–104.
   PubMed Web of Science ®Google Scholar
• Gauthier T, Piver P, Pichon N, et al. Uterus retrieval process from brain dead donors. Fertil Steril. 2014;102:476–482.
   PubMed Web of Science ®Google Scholar
• Brännström M, Johannesson L, Dahm-Kähler P, et al. The first clinical uterus transplantation trial: a six months report. Fertil Steril. 2014;101:1228–1236.
   PubMed Web of Science ®Google Scholar
• Johannesson L, Diaz-Garcia C, Leonhardt H, et al. Vascular pedicle lengths after hysterectomy: toward future human uterus transplantation. Obstet Gynecol. 2012;119:1219–1225.
   PubMed Web of Science ®Google Scholar
• Erman Akar M, Özkan Ö, Aydinuraz B, et al. Clinical pregnancy after uterus transplantation. Fertil Steril. 2013;100:1358–1363.
   PubMed Web of Science ®Google Scholar
• Järvholm S, Johannesson L, Brännström M. Psychological aspects in pre-transplantation assessments of patients prior to entering the first uterus transplantation trial. Acta Obstet Gynecol Scand. 2015;94:1035–1038.
   PubMed Web of Science ®Google Scholar
• Kvarnström N, Järvholm S, Johannesson L, et al. Live uterus donors of the initial observational study of uterus transplantation – psychological and medical follow-up until 1 year after surgery in the 9 cases. Transplantation. 2017;101:664–670.
   PubMed Web of Science ®Google Scholar
• Johannesson L, Kvarnström N, Mölne J, et al. Uterus transplantation trial: 1-year outcome. Fertil Steril. 2015;103:199–204.
   PubMed Web of Science ®Google Scholar
• Mölne J, Broecker V, Ekberg J, et al. Monitoring of human uterus transplantation with cervical biopsies: a provisional scoring system for rejection. Am J Transpl. 2017;17:1628–1636.
   PubMed Web of Science ®Google Scholar
• Johannesson L, Clarke A, Brännström M. Uterus transplantation trial: psychological evaluation of recipients and partners during the post-transplantation year. Fertil Steril. 2015;104:1010–1015.
   PubMed Web of Science ®Google Scholar
• Brännström M, Bokström M, Dahm-Kähler P, et al. One uterus bridging three generations; first live birth after mother-to-daughter uterus transplantation. Fertil Steril. 2016;107:261–266.
   PubMed Web of Science ®Google Scholar
• Flyckt RL, Farrell RM, Perni UC, et al. Deceased donor uterine transplantation; innovation and adaption. Obstet Gynecol. 2016;128:837–842.
   PubMed Web of Science ®Google Scholar
• Hellström M, Bandstein S, Brännström M. Uterine tissue engineering and the future of uterus transplantation. Ann Biomed Eng. 2016 Dec 19. epub
   PubMed Web of Science ®Google Scholar
• Hellström M, Moreno-Moya JM, Bandstein S, et al. Bioengineered uterine tissue supports pregnancy in a rat model. Fertil Steril. 2016;106:487–496.
   PubMed Web of Science ®Google Scholar
• Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–1410.
   PubMed Web of Science ®Google Scholar