675
Views
4
CrossRef citations to date
0
Altmetric
Review

Injectable and adhesive hydrogels for dealing with wounds

, , , ORCID Icon, &
Pages 519-533 | Received 06 Mar 2021, Accepted 16 Nov 2021, Published online: 05 Dec 2021

References

  • Kazemzadeh-Narbat M, Annabi N, Khademhosseini A. Surgical sealants and high strength adhesives. Materials Today. 2015;18(4):176–177.
  • Olsson M, Järbrink K, Divakar U, et al. The humanistic and economic burden of chronic wounds: a systematic review. Wound Repair Regener. 2019;27(1):114–125.
  • Saleh B, Dhaliwal HK, Portillo‐Lara R, et al. Local immunomodulation using an adhesive hydrogel loaded with miRNA‐laden nanoparticles promotes wound healing. Small. 2019;15(36):1902232.
  • Dolatshahi-Pirouz A, Skeldal S, Hovgaard MB, et al. Influence of nanoroughness and detailed surface morphology on structural properties and water-coupling capabilities of surface-bound fibrinogen films. J Phys Chem C. 2009;113(11):4406–4412.
  • Hsieh JY, Smith TD, Meli VS, et al. Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater. 2017;47:14–24.
  • Herskovitz I, Macquhae F, Fox JD, et al. Skin movement, wound repair and development of engineered skin. Exp Dermatol. 2016;25(2):99–100.
  • Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr6–265sr6.
  • Feiz S, Navarchian AH, Jazani OM. Poly (vinyl alcohol) membranes in wound-dressing application: microstructure, physical properties, and drug release behavior. Iran Poly J. 2018;27(3):193–205.
  • Duarte AP, Coelho JF, Bordado JC, et al. Surgical adhesives: systematic review of the main types and development forecast. Prog Polym Sci. 2012;37(8):1031–1050. 2012/08/01/;.
  • Guo B, Glavas L, Albertsson A-C. Biodegradable and electrically conducting polymers for biomedical applications. Prog Polym Sci. 2013;38(9):1263–1286.
  • Fan Z, Liu B, Wang J, et al. A novel wound dressing based on Ag/graphene polymer hydrogel: effectively kill bacteria and accelerate wound healing. Adv Funct Mater. 2014;24(25):3933–3943.
  • Yadollahi M, Namazi H, Aghazadeh M. Antibacterial carboxymethyl cellulose/Ag nanocomposite hydrogels cross-linked with layered double hydroxides. Int J Biol Macromol. 2015;79:269–277.
  • Dong Y, Hassan WU, Kennedy R, et al. Performance of an in situ formed bioactive hydrogel dressing from a PEG-based hyperbranched multifunctional copolymer. Acta Biomater. 2014;10(5):2076–2085.
  • Liu Y, Kopelman D, Wu LQ, et al. Biomimetic sealant based on gelatin and microbial transglutaminase: an initial in vivo investigation. J Biomed Mater Res Part B. 2009;91(1):5–16.
  • Lu M, Liu Y, Huang Y-C, et al. Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive. Carbohydr Polym. 2018;181:668–674.
  • Liang D, Lu Z, Yang H, et al. Novel asymmetric wettable AgNPs/chitosan wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces. 2016;8(6):3958–3968.
  • Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004;3(2):115.
  • Meer S. Rook’s textbook of dermatology. Blackwell, Wiley: Blackwell Publishing Ltd; 2010.
  • Griffiths C, Barker J, Bleiker T, et al. Rook’s textbook of dermatology. Blackwell, Wiley: John Wiley & Sons; 2016.
  • Pegoraro C, MacNeil S, Battaglia G. Transdermal drug delivery: from micro to nano. Nanoscale. 2012;4(6):1881–1894.
  • Wiedersberg S, Guy RH. Transdermal drug delivery: 30+ years of war and still fighting! J Control Release. 2014;190:150–156.
  • Amjadi M, Mostaghaci B, Sitti M. Recent advances in skin penetration enhancers for transdermal gene and drug delivery. Curr Gene Ther. 2017;17(2):139–146.
  • Vogt A, Wischke C, Neffe AT, et al. Nanocarriers for drug delivery into and through the skin—do existing technologies match clinical challenges? J Control Release. 2016;242:3–15.
  • Xu R, Luo G, Xia H, et al. Novel bilayer wound dressing composed of silicone rubber with particular micropores enhanced wound re-epithelialization and contraction. Biomaterials. 2015;40:1–11.
  • Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature. 2008;453(7193):314.
  • Xue M, Jackson CJ. Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv Wound Care. 2015;4(3):119–136.
  • Radhakumary C, Antonty M, Sreenivasan K. Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing. Carbohydr Polym. 2011;83(2):705–713.
  • Castangia I, Nácher A, Caddeo C, et al. Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. Acta Biomater. 2014;10(3):1292–1300.
  • Ghobril C, Grinstaff M. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial. Chem Soc Rev. 2015;44(7):1820–1835.
  • Yu JR, Navarro J, Coburn JC, et al. Current and future perspectives on skin tissue engineering: Key features of biomedical research, translational assessment, and clinical application. Adv Healthc Mater. 2019;8(5):1801471.
  • Moeini A, Pedram P, Makvandi P, et al. Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: a review. Carbohydr Polym. 2020 2020/04/01/;233:115839.
  • Mehdizadeh M, Yang J. Design strategies and applications of tissue bioadhesives. Macromol Biosci. 2013;13(3):271–288.
  • Quinn JV. Tissue adhesives in clinical medicine. Standford University: PMPH-USA; 2005.
  • Xu Y, Liang K, Ullah W, et al. Chitin nanocrystal enhanced wet adhesion performance of mussel-inspired citrate-based soft-tissue adhesive. Carbohydr Polym. 2018;190:324–330.
  • Pang J, Bi S, Kong T, et al. Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel. Carbohydr Polym. 2020;237:116138.
  • DiStefano TJ, Shmukler JO, Danias G, et al. Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk. Biomaterials. 2020;258:120309.
  • Chen J, Yang J, Wang L, et al. Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration. Bioact Mater. 2021;6(6):1689–1698.
  • Hoseini FS, Taherian R, Manufacturing AA. Properties of Poly vinyl alcohol/fibrin nanocomposite used for wound dressing. Adv Appl NanoBio-Technol. 2021;2(1):6–12.
  • Kang JI, Park KM. Advances in gelatin-based hydrogels for wound management. J Mat Chem B. 2021;9(6):1503–1520.
  • Yang Y, Ritchie AC, Everitt NM. Recombinant human collagen/chitosan-based soft hydrogels as biomaterials for soft tissue engineering. Mater Sci Eng C. 2021;121:111846.
  • Yeoh FH, Lee CS, Kang YB, et al. Production of biodegradable palm oil-based polyurethane as potential biomaterial for biomedical applications. Polymers. 2020;12(8):1842.
  • Bouten PJ, Zonjee M, Bender J, et al. The chemistry of tissue adhesive materials. Prog Polym Sci. 2014;39(7):1375–1405.
  • Annabi N, Tamayol A, Shin SR, et al. Surgical materials: current challenges and nano-enabled solutions. Nano Today. 2014;9(5):574–589.
  • Zhang L, Liu M, Zhang Y, et al. Recent progress of highly adhesive hydrogels as wound dressings. Biomacromolecules. 2020;21(10):3966–3983.
  • Deng J, Tang Y, Zhang Q, et al. A bioinspired medical adhesive derived from skin secretion of Andrias davidianus for wound healing. Adv Funct Mater. 2019;29(31):1809110.
  • Gao Y, Li Z, Huang J, et al. In situ formation of injectable hydrogels for chronic wound healing. J Mat Chem B. 2020;8(38):8768–8780.
  • Tavafoghi M, Sheikhi A, Tutar R, et al. Engineering tough, injectable, naturally derived, bioadhesive composite hydrogels. Adv Healthc Mater. 2020;9(10):1901722.
  • Ercan H, Durkut S, Koc-Demir A, et al. . Novel Biomater Regenerat Med. 2018;163–182.
  • Young DA, Christman KL. Injectable biomaterials for adipose tissue engineering. Biomed Mater. 2012;7(2):024104.
  • Raucci MG, D’Amora U, Ronca A, et al. Injectable functional biomaterials for minimally invasive surgery. Adv Healthc Mater. 2020;9(13):2000349.
  • Zhou H, Liang C, Wei Z, et al. Injectable biomaterials for translational medicine. Mater Today. 2019;28:81–97.
  • Raucci MG, D’Amora U, Ronca A, et al. Injectable functional biomaterials for minimally invasive surgery. Adv Healthc Mater. 2020;9(13):2000349.
  • Haugen HJ, Basu P, Sukul M, et al. Injectable biomaterials for dental tissue regeneration. Int J Mol Sci. 2020;21(10):3442.
  • Van Damme L, Blondeel P, Van Vlierberghe S. Injectable biomaterials as minimal invasive strategy towards soft tissue regeneration–an overview. J Phys Mater. 2020;4:1–19 .
  • Lam J, Clark EC, Fong EL, et al. Evaluation of cell-laden polyelectrolyte hydrogels incorporating poly (l-Lysine) for applications in cartilage tissue engineering. Biomaterials. 2016;83:332–346.
  • Thiele J, Ma Y, Bruekers SM, et al. 25th anniversary article: designer hydrogels for cell cultures: a materials selection guide. Adv Mater. 2014;26(1):125–148.
  • Motealleh A, Kehr NS. Nanocomposite hydrogels and their applications in tissue engineering. Adv Healthc Mater. 2017;6(1):1600938.
  • Capanema NS, Mansur AA, de Jesus AC, et al. Superabsorbent crosslinked carboxymethyl cellulose-PEG hydrogels for potential wound dressing applications. Int J Biol Macromol. 2018;106:1218–1234.
  • Zhu M, Lin S, Sun Y, et al. Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche. Biomaterials. 2016;77:44–52.
  • Schultz KM, Kyburz KA, Anseth KS. Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels. Proc Nat Acad Sci. 2015;112(29):E3757–E3764.
  • Caliari SR, Burdick JA. A practical guide to hydrogels for cell culture. Nat Methods. 2016;13(5):405.
  • Lin J, Zhou W, Han S, et al. Cell-material interactions in tendon tissue engineering. Acta Biomater. 2018;70:1–11.
  • Peak CW, Wilker JJ, Schmidt G. A review on tough and sticky hydrogels [journal article]. Colloid Polym Sci. 2013 September 01;291(9):2031–2047.
  • Xiong Y, Zhang X, Ma X, et al. A review of the properties and applications of bioadhesive hydrogels. Polym Chem. 2021;12(26):3721–3739.
  • Khalil IA, Saleh B, Ibrahim DM, et al. Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications. Biomater Sci. 2020;8(18):5196–5209.
  • Stanisław M, Alina S, Amit J. Biopolymers for hydrogels in cosmetics. J Mater Sci. 2020;31:6.
  • Mittal K, Bakshi IS, Narang JK. Bioadhesives in Drug Delivery. Wiley Online Library; 2020.
  • Badhe RV, Nipate SS. Bioadhes Drug Deliv. 2020;259–305.
  • Zhou J, Wu Y, Zhang X, et al. Enzyme catalyzed hydrogel as versatile bioadhesive for tissue wound hemostasis, bonding, and continuous Repair. Biomacromolecules. 2021;22(4):1346–1356.
  • Berger J, Reist M, Mayer JM, et al. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm. 2004;57(1):35–52.
  • Vernengo J, Fussell G, Smith N, et al. Synthesis and characterization of injectable bioadhesive hydrogels for nucleus pulposus replacement and repair of the damaged intervertebral disc. J Biomed Mater Res Part B. 2010;93(2):309–317.
  • Zahir-Jouzdani F, Wolf JD, Atyabi F, et al. In situ gelling and mucoadhesive polymers: why do they need each other? Expert Opin Drug Deliv. 2018;15(10):1007–1019.
  • Ferreira SBDS, Da Silva JB, Borghi-Pangoni FB, et al. Linear correlation between rheological, mechanical and mucoadhesive properties of polycarbophil polymer blends for biomedical applications. J Mech Behav Biomed Mater. 2017;68:265–275.
  • Johnson TD, Christman KL. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opin Drug Deliv. 2013;10(1):59–72.
  • Rencber S, Karavana SY, Şenyiğit ZA, et al. Mucoadhesive in situ gel formulation for vaginal delivery of clotrimazole: formulation, preparation, and in vitro/in vivo evaluation. Pharm Dev Technol. 2017;22(4):551–561.
  • Truong VX, Ablett MP, Richardson SM, et al. Simultaneous orthogonal dual-click approach to tough, in-situ-forming hydrogels for cell encapsulation. J Am Chem Soc. 2015;137(4):1618–1622.
  • Custódio CA, Del Campo A, Reis RL, et al. . Smart Polym Applicat Chapter 12. Woodhead publishing: Smart Polymers and their Applications (Second Edition). 2019;411–438.
  • Gorgieva S, Kokol V. Synthesis and application of new temperature-responsive hydrogels based on carboxymethyl and hydroxyethyl cellulose derivatives for the functional finishing of cotton knitwear. Carbohydr Polym. 2011;85(3):664–673.
  • Kotsuchibashi Y. Recent advances in multi-temperature-responsive polymeric materials. Polym J. 2020;1–9. DOI:https://doi.org/10.1038/s41428-020-00399-2
  • Yun EJ, Yon B, Joo MK, et al. Cell therapy for skin wound using fibroblast encapsulated poly (ethylene glycol)-poly (L-alanine) thermogel. Biomacromolecules. 2012;13(4):1106–1111.
  • Lee Y, Chung HJ, Yeo S, et al. Thermo-sensitive, injectable, and tissue adhesive sol–gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction. Soft Matter. 2010;6(5):977–983.
  • Atuma C, Strugala V, Allen A, et al. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol. 2001;280(5):G922–G929.
  • Tomić SL, Suljovrujić EH, Filipović JM. Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly (alkylene glycol) s and itaconic acid. Polym Bull. 2006;57(5):691–702.
  • Park KM, Shin YM, Joung YK, et al. In situ forming hydrogels based on tyramine conjugated 4-Arm-PPO-PEO via enzymatic oxidative reaction. Biomacromolecules. 2010;11(3):706–712.
  • Balakrishnan B, Soman D, Payanam U, et al. A novel injectable tissue adhesive based on oxidized dextran and chitosan. Acta Biomater. 2017;53:343–354.
  • Guyot C, Cerruti M, Lerouge S. Injectable, strong and bioadhesive catechol-chitosan hydrogels physically crosslinked using sodium bicarbonate. Mater Sci Eng C. 2021;118:111529.
  • Abou-elnour M, Soliman ME, Skouras A, et al. Microparticles-in-thermoresponsive/bioadhesive hydrogels as a novel integrated platform for effective intra-articular delivery of triamcinolone acetonide. Mol Pharm. 2020;17(6):1963–1978.
  • Le TMD, Duong HTT, Thambi T, et al. Bioinspired pH-and temperature-responsive injectable adhesive hydrogels with polyplexes promotes skin wound healing. Biomacromolecules. 2018;19(8):3536–3548.
  • Zhao L, Niu L, Liang H, et al. pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing. ACS Appl Mater Interfaces. 2017;9(43):37563–37574.
  • He J, Zhang Z, Yang Y, et al. Injectable self-healing adhesive ph-responsive hydrogels accelerate gastric hemostasis and wound healing. Nano-Micro Lett. 2021;13(1):1–17.
  • Giano MC, Ibrahim Z, Medina SH, et al. Injectable bioadhesive hydrogels with innate antibacterial properties. Nat Commun. 2014;5(1):4095.
  • Lokhande G, Carrow JK, Thakur T, et al. Nanoengineered injectable hydrogels for wound healing application. Acta Biomater. 2018;70:35–47.
  • Amjadi M, Sheykhansari S, Nelson BJ, et al. Recent advances in wearable transdermal delivery systems. Adv Mater. 2018;30(7):1704530.
  • Jones A, Vaughan D. Hydrogel dressings in the management of a variety of wound types: a review. J Orthopaed Nurs. 2005;9:S1–S11.
  • Frehner E, Watts R. Evidence summary: wound management-hydrogel dressings without additional therapeutic additives. Wound Pract Res. 2016;24(1):59.
  • Qu J, Zhao X, Ma PX, et al. Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized “smart” drug release. Acta Biomater. 2018;72:55–69.
  • Yadollahi M, Gholamali I, Namazi H, et al. Synthesis and characterization of antibacterial carboxymethylcellulose/CuO bio-nanocomposite hydrogels. Int J Biol Macromol. 2015;73:109–114.
  • Jayakumar R, Prabaharan M, Kumar PS, et al. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv. 2011;29(3):322–337.
  • Lu Z, Gao J, He Q, et al. Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing. Carbohydr Polym. 2017;156:460–469.
  • Chen H, Cheng J, Ran L, et al. An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing. Carbohydr Polym. 2018;201:522–531.
  • Qu J, Zhao X, Liang Y, et al. Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing. Chem Eng J. 2019;362:548–560.
  • Zhao X, Wu H, Guo B, et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials. 2017;122:34–47.
  • Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152(8):784–791.
  • Qu J, Zhao X, Liang Y, et al. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. Biomaterials. 2018;183:185–199.
  • Du X, Liu Y, Wang X, et al. Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing. Mater Sci Eng C. 2019;104:109930.
  • Ma M, Zhong Y, Jiang X. Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing. Carbohydr Polym. 2020;236:116096.
  • Wang R, Xu D-L, Liang L, et al. Enzymatically crosslinked epsilon-poly- l -lysine hydrogels with inherent antibacterial properties for wound infection prevention. RSC Adv. 2016;6(11):8620–8627.
  • Hoque J, Prakash RG, Paramanandham K, et al. Biocompatible injectable hydrogel with potent wound healing and antibacterial properties. Mol Pharm. 2017;14(4):1218–1230.
  • Qu J, Zhao X, Liang Y, et al. Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing. Chem Eng J. 2019 2019/01/11/;362:548–560.
  • Mehdizadeh M, Weng H, Gyawali D, et al. Injectable citrate-based mussel-inspired tissue bioadhesives with high wet strength for sutureless wound closure. Biomaterials. 2012;33(32):7972–7983.
  • Resmi R, Unnikrishnan S, Krishnan LK, et al. Synthesis and characterization of silver nanoparticle incorporated gelatin‐hydroxypropyl methacrylate hydrogels for wound dressing applications. J Appl Polym Sci. 2017;134(10):10.
  • Chopra H, Kumar S, Singh I. . Bioadhes Drug Deliv. Vol 6. 2020;147–170.
  • Wachal K, Stachowska E, Korpuścińska K, et al. Physical properties of hydrogel wound dressing and its use in low-level laser therapy (LLLT). Lasers Med Sci. 2018;33:1–9.
  • Gong C, Wu Q, Wang Y, et al. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials. 2013;34(27):6377–6387.
  • Gainza G, Villullas S, Pedraz JL, et al. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomedicine. 2015;11(6):1551–1573.
  • Krausz AE, Adler BL, Cabral V, et al. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 2015;11(1):195–206.
  • Lichtman MK, Otero-Vinas M, Falanga V. Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis. Wound Repair Regener. 2016;24(2):215–222.
  • Goh M, Hwang Y, Tae G. Epidermal growth factor loaded heparin-based hydrogel sheet for skin wound healing. Carbohydr Polym. 2016;147:251–260.
  • Bromberg L, Temchenko M, Alakhov V, et al. Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels. Int J Pharm. 2004;282(1–2):45–60.
  • Wiltsey C, Christiani T, Williams J, et al. Thermogelling bioadhesive scaffolds for intervertebral disk tissue engineering: preliminary in vitro comparison of aldehyde-based versus alginate microparticle-mediated adhesion. Acta Biomater. 2015 2015/04/01/;16:71–80.
  • Jeon O, Samorezov JE, Alsberg E. Single and dual crosslinked oxidized methacrylated alginate/PEG hydrogels for bioadhesive applications. Acta Biomater. 2014;10(1):47–55. 2014/01/01/.
  • Peak CW, Carrow JK, Thakur A, et al. Elastomeric cell-laden nanocomposite microfibers for engineering complex tissues. Cell Mol Bioeng. 2015;8(3):404–415. 2015/09/01.
  • Zhang X, Xu B, Puperi DS, et al. Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering. Acta Biomater. 2015 2015/03/01/;14:11–21.
  • Attalla R, Ling CS, Selvaganapathy PR. Silicon carbide nanoparticles as an effective bioadhesive to bond collagen containing composite gel layers for tissue engineering applications. Adv Healthc Mater. 2018;7(5):1701385.
  • Han L, Lu X, Wang M, et al. A mussel‐inspired conductive, self‐adhesive, and self‐healable tough hydrogel as cell stimulators and implantable bioelectronics. Small. 2017;13(2):1601916.
  • Feng Q, Wei K, Lin S, et al. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials. 2016;101:217–228.
  • Hoque J, Bhattacharjee B, Prakash RG, et al. Dual function injectable hydrogel for controlled release of antibiotic and local antibacterial therapy. Biomacromolecules. 2017;19(2):267–278.
  • Mi L, Xue H, Li Y, et al. A thermoresponsive antimicrobial wound dressing hydrogel based on a cationic betaine ester. Adv Funct Mater. 2011;21(21):4028–4034.
  • Wu D-Q, Zhu J, Han H, et al. Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: in vitro and in vivo study. Acta Biomater. 2018;65:305–316.
  • Croisfelt FM, Ataide JA, Tundisi LL, et al. Characterization of PNIPAAm-co-AAm hydrogels for modified release of bromelain. Eur Polym J. 2018;105:48–54.
  • Ding C, Tian M, Feng R, et al. Novel self-healing hydrogel with injectable, ph-responsive, strain-sensitive, promoting wound-healing, and hemostatic properties based on collagen and chitosan. ACS Biomater Sci Eng. 2020;6(7):3855–3867.
  • Gao Q, Zhang C, Wang M, et al. Injectable pH-responsive poly (γ-glutamic acid)-silica hybrid hydrogels with high mechanical strength, conductivity and cytocompatibility for biomedical applications. Polymer. 2020;197:122489.
  • Wu M, Chen J, Huang W, et al. Injectable and self-healing nanocomposite hydrogels with ultrasensitive pH-responsiveness and tunable mechanical properties: implications for controlled drug delivery. Biomacromolecules. 2020;21(6):2409–2420.
  • Kennedy J, Bunko K, Santhini E, et al. The use of ‘smart’textiles for wound care. Woodhead publishing: Advanced textiles for wound care: Elsevier; 2019. p. 289–311.
  • Wade RJ, Bassin EJ, Rodell CB, et al. Protease-degradable electrospun fibrous hydrogels. Nat Commun. 2015;6(1):1–10.
  • Wu M, Zhang Y, Liu Q, et al. A smart hydrogel system for visual detection of glucose. Biosens Bioelectron. 2019;142:111547.
  • Dong Y, Wang W, Veiseh O, et al. Injectable and glucose-responsive hydrogels based on boronic acid–glucose complexation. Langmuir. 2016;32(34):8743–8747.
  • Zheng D, Gao Z, Xu T, et al. Responsive peptide-based supramolecular hydrogels constructed by self-immolative chemistry. Nanoscale. 2018;10(45):21459–21465.
  • Chen N, Wang H, Ling C, et al. Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery. Carbohydr Polym. 2019;225:115207.
  • Liu Q, Liu M, Li H. A transient simulation to predict the kinetic behavior of magnetic-sensitive hydrogel responsive to magnetic stimulus. Int J Mech Sci. 2020;182:105765.
  • Furth ME, Atala A, Van Dyke ME. Smart biomaterials design for tissue engineering and regenerative medicine. Biomaterials. 2007;28(34):5068–5073. .
  • Ning C, Zhou L, Tan G. Fourth-generation biomedical materials. Mater Today. 2016;19(1):2–3. 2016/01/01/.
  • Omer AM, Tamer TM, Khalifa RE, et al. Smart biopolymer hydrogels developments for biotechnological applications. Cellul Based Superabsorbent Hydrogels. 2018;1–21.
  • Zhou J, Yao D, Qian Z, et al. Bacteria-responsive intelligent wound dressing: simultaneous In situ detection and inhibition of bacterial infection for accelerated wound healing. Biomaterials. 2018;161:11–23.
  • Rasool A, Ata S, Islam A. Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application. Carbohydr Polym. 2019;203:423–429. 2019/01/01/.
  • Hu C, Zhang F, Long L, et al. Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing. J Control Release. 2020;324:204–217.
  • Ajovalasit A, Sabatino MA, Todaro S, et al. Xyloglucan-basedhydrogel films for wound dressing: structure-property relationships. Carbohydr Polym. 2018 2018/01/01/;179:262–272.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.