277
Views
6
CrossRef citations to date
0
Altmetric
Meta-Analysis

Platelet-rich plasma therapy ensures pain reduction in the management of lateral epicondylitis – a PRISMA-compliant network meta-analysis of randomized controlled trials

ORCID Icon, , , , , & ORCID Icon show all
Pages 535-546 | Received 25 Oct 2021, Accepted 19 Jan 2022, Published online: 31 Jan 2022

References

  • Vaquero-Picado A, Barco R, Antuña SA. Lateral epicondylitis of the elbow. EFORT Open Rev. 2016;1:391.
  • H P, Ms R, D R, et al. Does effectiveness of exercise therapy and mobilisation techniques offer guidance for the treatment of lateral and medial epicondylitis? A systematic review. Br J Sports Med [Internet]. 2013 [cited 2021 Jun 26];47. Available from: https://pubmed.ncbi.nlm.nih.gov/23709519/
  • Coombes BK, Bisset L, Vicenzino B. Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials. Lancet. 2010;376:1751–1767.
  • Kazemi M, Azma K, Tavana B, et al. Autologous blood versus corticosteroid local injection in the short-term treatment of lateral elbow tendinopathy: a randomized clinical trial of efficacy. Am J Phys Med Rehabil. 2010;89:660–667.
  • Martin JI, Atilano L, Merino J, et al. Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial. J Orthop Surg Res [Internet]. 2019[cited 2020 Nov 3];14. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480601/
  • Kaydok E, Ordahan B, Solum S, et al. Short-term efficacy comparison of high-intensity and low-intensity laser therapy in the treatment of lateral epicondylitis: a randomized double-blind clinical study. Arch Rheumatol. 2020;35:60–67.
  • Behazin M, Kachooei AR. Arthroscopic recession technique in the surgery of tennis elbow by sharp cutting the extensor carpi radialis brevis (ECRB) tendon origin. Arch Bone Jt Surg. 2021;9:174–179.
  • Coonrad RW, Hooper WR. Tennis elbow: its course, natural history, conservative and surgical management. J Bone Joint Surg Am. 1973;55:1177–1182.
  • Li A, Wang H, Yu Z, et al. Platelet-rich plasma vs corticosteroids for elbow epicondylitis: a systematic review and meta-analysis. Medicine (Baltimore) [Internet]. 2019 [cited 2021 Jun 26];98:e18358. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940118/
  • Tang S, Wang X, and Wu P, et al. Platelet‐rich plasma vs autologous blood vs corticosteroid injections in the treatment of lateral epicondylitis: a systematic review, pairwise and network meta‐analysis of randomized controlled trials. PM R. 2020;12:397–409.
  • Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777–784.
  • Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. Bmj. 2019;366:l4898.
  • Owen RK, Bradbury N, Xin Y, et al. MetaInsight: an interactive web-based tool for analyzing, interrogating, and visualizing network meta-analyses using R-shiny and netmeta. Res Synth Methods. 2019;10:569–581.
  • Lu G, Ades A. Modeling between-trial variance structure in mixed treatment comparisons. Biostatistics. 2009;10:792–805.
  • Rücker G. Network meta-analysis, electrical networks and graph theory. Res Synth Methods. 2012;3:312–324.
  • Rücker G, Schwarzer G. Ranking treatments in frequentist network meta-analysis works without resampling methods. BMC Med Res Methodol. 2015;15:58.
  • Dias S, Welton NJ, Caldwell DM, et al. Checking consistency in mixed treatment comparison meta-analysis. Stat Med. 2010;29:932–944.
  • Nikolakopoulou A, Higgins JPT, Papakonstantinou T, et al. CINeMA: an approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020;17:e1003082.
  • Papakonstantinou T, Nikolakopoulou A, Higgins JPT, et al. CINeMA: software for semiautomated assessment of the confidence in the results of network meta-analysis. Campbell Syst Rev. 2020;16:e1080.
  • Macdermid JC, Silbernagel KG. Outcome evaluation in tendinopathy: foundations of assessment and a summary of selected measures. J Orthop Sports Phys Ther. 2015;45:950–964.
  • Poltawski L, Watson T. Measuring clinically important change with the Patient-rated Tennis Elbow evaluation. Hand Therapy. 2011;16:52–57.
  • Behera P, Dhillon M, Aggarwal S, et al. Leukocyte-poor platelet-rich plasma versus bupivacaine for recalcitrant lateral epicondylar tendinopathy. J Orthop Surg (Hong Kong). 2015;23:6–10.
  • Gosens T, Peerbooms JC, van Laar W, et al. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med. 2011;39:1200–1208.
  • Gupta PK, Acharya A, Khanna V, et al. PRP versus steroids in a deadlock for efficacy: long-term stability versus short-term intensity-results from a randomised trial. Musculoskelet Surg. 2019;104:285–294.
  • Khaliq A, Khan I, Inam M, et al. Effectiveness of platelets rich plasma versus corticosteroids in lateral epicondylitis. J Pak Med Assoc. 2015;65:S100–104.
  • Krogh TP, Fredberg U, Stengaard-Pedersen K, et al. Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. Am J Sports Med. 2013;41:625–635.
  • Lebiedziński R, Synder M, Buchcic P, et al. A randomized study of autologous conditioned plasma and steroid injections in the treatment of lateral epicondylitis. Int Orthop. 2015;39:2199–2203.
  • Lim W, Park SH, Kim B, et al. Relationship of cytokine levels and clinical effect on platelet-rich plasma-treated lateral epicondylitis. J Orthop Res. 2018;36:913–920.
  • Linnanmäki L, Kanto K, Karjalainen T, et al. Platelet-rich plasma or autologous blood do not reduce pain or improve function in patients with lateral epicondylitis: a randomized controlled trial. Clin Orthop Relat Res. 2020;478:1892–1900.
  • Merolla G, Dellabiancia F, Ricci A, et al. Arthroscopic debridement versus platelet-rich plasma injection: a prospective, randomized, comparative study of chronic lateral epicondylitis with a nearly 2-year follow-up. Arthroscopy. 2017;33:1320–1329.
  • Mishra AK, Skrepnik NV, Edwards SG, et al. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med. 2014;42:463–471.
  • Montalvan B, Le Goux P, Klouche S, et al. Inefficacy of ultrasound-guided local injections of autologous conditioned plasma for recent epicondylitis: results of a double-blind placebo-controlled randomized clinical trial with one-year follow-up. Rheumatology (Oxford). 2016;55:279–285.
  • Palacio EP, Schiavetti RR, Kanematsu M, et al. Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial. Rev Bras Ortop. 2016;51:90–95.
  • Palakuri S, Muthu S. Does leucocyte concentration have a role in the outcome of PRP therapy for lateral epicondylitis – a randomized controlled trial. IP Int J Orthopaedic Rheumatol. 2021;6:84–87.
  • Peerbooms JC, Sluimer J, Bruijn DJ, et al. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010;38:255–262.
  • Raeissadat SA, Rayegani SM, Hassanabadi H, et al. Is platelet-rich plasma superior to whole blood in the management of chronic tennis elbow: one year randomized clinical trial. BMC Sports Sci Med Rehabil. 2014;6:12.
  • Schöffl V, Willauschus W, Sauer F, et al. Autologous conditioned plasma versus placebo injection therapy in lateral epicondylitis of the elbow: a double blind, randomized study. Sportverletz Sportschaden. 2017;31:31–36.
  • Seetharamaiah VB, Gantaguru A, Basavarajanna S. A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow. Indian J Orthop. 2017;51:304–311.
  • Tetschke E, Rudolf M, Lohmann CH, et al. Autologous proliferative therapies in recalcitrant lateral epicondylitis. Am J Phys Med Rehabil. 2015;94:696–706.
  • Thanasas C, Papadimitriou G, Charalambidis C, et al. Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med. 2011;39:2130–2134.
  • Tonk G, Kumar A, Gupta A. Platelet rich plasma versus laser therapy in lateral epicondylitis of elbow. Indian J Orthop. 2014;48:390–393.
  • Vk G, V S, B S, et al. Platelet-rich plasma versus corticosteroid injection for recalcitrant lateral epicondylitis: clinical and ultrasonographic evaluation [Internet]. Journal of orthopaedic surgery (Hong Kong). J Orthop Surg (Hong Kong); 2015 cited 2020 Nov 3]. Available from: https://pubmed.ncbi.nlm.nih.gov/25920633/.
  • Watts AC, Morgan BW, Birch A, et al. Comparing leukocyte-rich platelet-rich plasma injection with surgical intervention for the management of refractory tennis elbow. A prospective randomised trial. Shoulder Elbow. 2020;12:46–53.
  • Yadav R, Kothari SY, Borah D. Comparison of local injection of platelet rich plasma and corticosteroids in the treatment of lateral epicondylitis of humerus. J Clin Diagn Res. 2015;9:RC05–RC07.
  • Yerlikaya M, Talay Çaliş H, Tomruk Sütbeyaz S, et al. Comparison of effects of leukocyte-rich and leukocyte-poor platelet-rich plasma on pain and functionality in patients with lateral epicondylitis. Arch Rheumatol. 2018;33:73–79.
  • Creaney L, Wallace A, Curtis M, et al. Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections. Br J Sports Med. 2011;45:966–971.
  • Da H, Mj K, and Lb T, et al. Treatment of lateral epicondylitis with autologous blood, platelet-rich plasma, or corticosteroid injections: a systematic review of overlapping meta-analyses. Orthop J Sports Med [Internet]. 2019 [cited 2021 Oct 19];7. Available from: https://pubmed.ncbi.nlm.nih.gov/30899764/
  • Muthu S, Patel S, and Selvaraj P, et al. Comparative analysis of leucocyte poor vs leucocyte rich platelet-rich plasma in the management of lateral epicondylitis: systematic review & meta-analysis of randomised controlled trials. J Clinl Orthopaedics Trauma. 2021;19:96–107.
  • Oudelaar BW, Peerbooms JC, Huis In ’t Veld R, et al. Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature. Am J Sports Med. 2019;47:479–487.
  • Dj M, Pa E, Rm S, et al. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus. Journal of orthopaedic research : official publication of the Orthopaedic Research Society [Internet]. 2008 cited 2021 Jun 27;26. Available from: https://pubmed.ncbi.nlm.nih.gov/17960651/.
  • Kobayashi Y, Saita Y, Nishio H, et al. Leukocyte concentration and composition in platelet-rich plasma (PRP) influences the growth factor and protease concentrations. J Orthop Sci. 2016;21:683–689.
  • Moraes VY, Lenza M, and Tamaoki MJ, et al. Platelet-rich therapies for musculoskeletal soft tissue injuries. Cochrane Database Syst Rev. 2013;12:CD010071.
  • Fitzpatrick J, Bulsara M, Zheng MH. The effectiveness of platelet-rich plasma in the treatment of tendinopathy: a meta-analysis of randomized controlled clinical trials. Am J Sports Med. 2017;45:226–233.
  • Majewski M, Ochsner PE, Liu F, et al. Accelerated healing of the rat Achilles tendon in response to autologous conditioned serum. Am J Sports Med. 2009;37:2117–2125.
  • Cf K, G M-T. Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice. J Pain [Internet]. 2011 [cited 2021 Jun 27];12. Available from: https://pubmed.ncbi.nlm.nih.gov/20889388/
  • Nadeau S, Filali M, Zhang J, et al. Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J Neurosci. 2011;31:12533–12542.
  • Alsousou J, Ali A, Willett K, et al. The role of platelet-rich plasma in tissue regeneration. Platelets. 2013;24:173–182.
  • Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004;103:2096–2104.
  • Arirachakaran A, Sukthuayat A, Sisayanarane T, et al. Platelet-rich plasma versus autologous blood versus steroid injection in lateral epicondylitis: systematic review and network meta-analysis. J Orthop Traumatol. 2016;17:101–112.
  • Shakeel H, Ahmad TS. Steroid injection versus NSAID injection for trigger finger: a comparative study of early outcomes. J Hand Surg Am. 2012;37:1319–1323.
  • Oxlund H. Long term local cortisol treatment of tendons and the indirect effect on skin. An experimental study in rats. Scand J Plast Reconstr Surg. 1982;16:61–66.
  • Smidt N, Assendelft WJJ, van der Windt DAWM, et al. Corticosteroid injections for lateral epicondylitis: a systematic review. Pain. 2002;96:23–40.
  • Huang K, Giddins G, Wu L-D. Platelet-rich plasma versus corticosteroid injections in the management of elbow epicondylitis and plantar fasciitis: an updated systematic review and meta-analysis. Am J Sports Med. 2020;48:2572–2585.
  • Dojode CM. A randomised control trial to evaluate the efficacy of autologous blood injection versus local corticosteroid injection for treatment of lateral epicondylitis. Bone Joint Res. 2012;1:192–197.
  • Ozturan KE, Yucel I, Cakici H, et al. Autologous blood and corticosteroid injection and extracorporeal shock wave therapy in the treatment of lateral epicondylitis. Orthopedics. 2010;33:84–91.
  • Shim S, Yoon B-H, Shin I-S, et al. Network meta-analysis: application and practice using Stata. Epidemiol Health. 2017;39:e2017047.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.