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The Journal of Maternal-Fetal & Neonatal Medicine Volume 37, 2024 - Issue 1
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Original Article

Role of recombinant factor VIIa in the clinical management of severe postpartum hemorrhage: consensus among European experts

D. Surbeka Department of Obstetrics and Gynecology, University Hospital Bern, University of Bern, Bern, SwitzerlandCorrespondence[email protected]
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J. Blatnýb Department of Paediatric Haematology and Biochemistry, Children’s University Hospital Brno and Medical School of Masaryk University, Brno, Czech RepublicView further author information
,
M. Wielgosc Medical Faculty, Lazarski University, Warsaw, PolandView further author information
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N. Acsd Department of Obstetrics and Gynecology, Semmelweis University, Budapest, HungaryView further author information
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H. Edwardse Department of Obstetrics and Gynecology, Herlev Hospital, University of Copenhagen, Copenhagen, DenmarkView further author information
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O. Erezf Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer Sheva, Israel;g Department of Obstetrics and Gynecology, Hutzel Women’s Hospital, Wayne State University, Detroit, MI, USAView further author information
,
J. L. Barthah Department of Maternal Fetal Medicine, Hospital Universitario La Paz, Madrid, SpainView further author information
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H. Madari Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, FranceView further author information
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F. J. Mercierj Department of Anaesthesia and Critical Care Medicine, APHP Université Paris-Saclay University, Clamart, FranceView further author information
,
D. Schlembachk Clinic of Obstetric Medicine, Vivantes Network of Health GmbH, Clinicum Berlin-Neukoelln, Berlin, GermanyView further author information
&
G. C. Di Renzol Centre of Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy;m PREIS International and European School of Perinatal, Neonatal and Reproductive Medicine, Florence, Italy;n Department of Obstetrics, Gynecology and Perinatology, I.M. Sechenov First State University of Moscow, Moscow, RussiaView further author information
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Article: 2332794 | Received 16 Feb 2024, Accepted 13 Mar 2024, Published online: 27 Mar 2024

References

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  • Committee for Medicinal Products for Human Use (CHMP). CHMP extension of indication variation assessment report (rFVII®, Eptacog Alfa), European Public Assessment Report (EPAR); 2022 [cited 2022 Apr 22]. Procedure No. EMEA/H/C/000074/II/0116.
  • NovoSeven (Eptacog Alfa) Summary of Product Characteristics; 2023; [cited 2023 Nov]. Available from: https://www.ema.europa.eu/en/documents/product-information/novoseven-epar-product-information_en.pdf
  • Monroe DM, Hoffman M, Oliver JA, et al. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol. 1997;99(3):542–547. doi: 10.1046/j.1365-2141.1997.4463256.x.
  • Lavigne-Lissalde G, Aya AG, Mercier FJ, et al. Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial. J Thromb Haemost. 2015;13(4):520–529. doi: 10.1111/jth.12844.
  • Sørensen B, Dargaud Y, Kenet G, et al. On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII. Haemophilia. 2012;18(2):255–262. doi: 10.1111/j.1365-2516.2011.02612.x.
  • Lusher JM. Early treatment with recombinant factor VIIa results in greater efficacy with less product. Eur J Haematol Suppl. 1998;63:7–10. doi: 10.1111/j.1600-0609.1998.tb01103.x.

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