Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 10
346
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Potential inhibitory effect of geraniol isolated from lemongrass (Cymbopogon commutatus Stapf) on tilmicosin-induced oxidative stress in cardiac tissue

ORCID Icon, , ORCID Icon, , ORCID Icon, , ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 1652-1661 | Received 11 Feb 2023, Accepted 08 May 2023, Published online: 24 May 2023

References

  • Abdel-Daim MM, Ghazy EW, Fayez M. 2015. Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice. Can J Physiol Pharmacol. 93(1):45–51.
  • Aboubakr M, Elsayd F, Soliman A, Fadl SE, El-Shafey A, Abdelhiee EY. 2020. L-Carnitine and vitamin E ameliorate cardiotoxicity induced by tilmicosin in rats. Environmental Science and Pollution Research. 27(18):23026–23034.
  • Abou-Zeid SM, Ahmed AI, Awad A, Mohammed WA, Metwally MM, Almeer R, Abdel-Daim MM, Khalil SR. 2021. Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression. Biomed Pharmacother. 133:110997.
  • AlAsmari AF, Ali N, Alharbi M, Alqahtani F, Alasmari F, Almoqbel D, AlSwayyed M, Alshammari A, Alanazi MM, Alhoshani A, et al. 2022. Geraniol ameliorates doxorubicin-mediated kidney injury through alteration of antioxidant status, inflammation, and apoptosis: potential roles of NF-κB and Nrf2/Ho-1. Nutrients. 14(8):1620.
  • Alzahrani AM, Rajendran P, Veeraraghavan VP, Hanieh H. 2021. Cardiac protective effect of kirenol against doxorubicin-induced cardiac hypertrophy in H9c2 cells through Nrf2 signaling via PI3K/AKT pathways. Int J Mol Sci. 22(6):3269.
  • Awad A, Khalil SR, Hendam BM, Abd El-Aziz RM, Metwally MM, Imam TS. 2020. Protective potency of Astragalus polysaccharides against tilmicosin-induced cardiac injury via targeting oxidative stress and cell apoptosis-encoding pathways in rat. Environ Sci Pollut Res Int. 27(17):20861–20875.
  • Bhavaniramya S, Vishnupriya S, Al-Aboody MS, Vijayakumar R, Baskaran D. 2019. Role of essential oils in food safety: Antimicrobial and antioxidant applications. Grain & oil science and technology. 2(2):49–55.
  • Carnesecchi S, Bras-Goncalves R, Bradaia A, Zeisel M, Gosse F, Poupon MF, Raul F. 2004. Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts. Cancer Lett. 215(1):53–59.
  • Cetin N, Boyraz U, Cetin E. 2011. Ghrelin alleviates tilmicosin-induced myocardial oxidative stress in rats. J Anim Vet Adv. 10(15):2038–2042.
  • Chakraborty K, Krishnan S, Joy M. 2019. Macrocyclic lactones from seafood Amphioctopus neglectus: newly described natural leads to attenuate angiotensin-II induced cardiac hypertrophy. Biomed Pharmacother. 110:155–167.
  • Chen W, Viljoen AM. 2010. Geraniol-a review of a commercially important fragrance material. S Afr J.Bot. 76(4):643–651.
  • Cory S, Adams JM. 2002. The Bcl2 family: regulators of the cellular life-or-death switch. Nature Reviews Cancer. 2(9):647–656.
  • El-Bassossy HM, Ghaleb H, Elberry AA, Balamash KS, Ghareib SA, Azhar A, Banjar Z. 2017. Geraniol alleviates diabetic cardiac complications: effect on cardiac ischemia and oxidative stress. Biomed Pharmacother. 88:1025–1030.
  • Farag MR, Elhady WM, Ahmed SY, Taha HS, Alagawany M. 2019. Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway. Res Vet Sci. 124:137–148.
  • Fu S, Li Y-L, Wu Y-T, Yue Y, Qian Z-Q, Yang D-L. 2018. Icariside II attenuates myocardial fibrosis by inhibiting nuclear factor-κB and the TGF-β1/Smad2 signalling pathway in spontaneously hypertensive rats. Biomed Pharmacother. 100:64–71.
  • Gallucci N, Casero C, Oliva M, Zygadlo J, Demo M. 2006. Interaction between terpenes and penicillin on bacterial strains resistant to β-lactam antibiotics. Mol Med Chem. 10:30–32.
  • Gustafsson AB, Gottlieb RA. 2007. Bcl-2 family members and apoptosis, taken to heart. American Journal of Physiology-Cell Physiology. 292(1):C45–C51.
  • Ilić BS, Kocić BD, Ćirić VM, Cvetković OG, Miladinović DL. 2014. An in vitro synergistic interaction of combinations of Thymus glabrescens essential oil and its main constituents with chloramphenicol. Sci World J. 2014:1–12.
  • Jayachandran M, Chandrasekaran B, Namasivayam N. 2015a. Effect of geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamsters. Mol Cell Biochem. 398(1–2):39–53.
  • Jayachandran M, Chandrasekaran B, Namasivayam N. 2015b. Geraniol attenuates fibrosis and exerts anti-inflammatory effects on diet induced atherogenesis by NF-κB signaling pathway. Eur J Pharmacol. 762:102–111.
  • Kart A, Karapehlivan M, Yapar K, Citil M, Akpinar A. 2007. Protection through L-Carnitine on tissue oxidant status and sialic acid content in tilmicosin-induced alterations in BALB/c Mice. Acta Vet Brno. 76(2):203–207.
  • Khalil SR, Abdel-Motal SM, Abd-Elsalam M, Abd El-Hameed NE, Awad A. 2020. Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: targeting cell apoptosis-mediated pathways. Gene. 730:144272.
  • Korshunova AY, Blagonravov ML, Neborak EV, Syatkin SP, Sklifasovskaya AP, Semyatov SM, Agostinelli E. 2021. BCL2 regulated apoptotic process in myocardial ischemia reperfusion injury. International journal of molecular medicine. 47(1):23–36.
  • Lei Y, Fu P, Jun X, Cheng P. 2019. Pharmacological properties of geraniol-a review. Planta Med. 85(1):48–55.
  • Li Q, Gao J, Pang X, Chen A, Wang Y. 2020. Molecular mechanisms of action of emodin: As an anti-cardiovascular disease drug. Frontiers in Pharmacology. 11:559607.
  • Li X, Lan Y, Wang Y, Nie M, Lu Y, Zhao E. 2017. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway. Mol Med Rep. 15(5):2574–2582.
  • Lin CY, Tsai SH, Tai DF. 2019. Detection of oxytocin, atrial natriuretic peptide, and brain natriuretic peptide using novel imprinted polymers produced with amphiphilic monomers. Journal of Peptide Science. 25(3):e3150.
  • Mączka W, Wińska K, Grabarczyk M. 2020. One hundred faces of geraniol. Molecules (Basel, Switzerland. 25(14):3303.
  • Maneesai P, Bunbupha S, Potue P, Berkban T, Kukongviriyapan U, Kukongviriyapan V, Prachaney P, Pakdeechote P. 2018. Hesperidin prevents nitric oxide deficiency-induced cardiovascular remodeling in rats via suppressing TGF-β1 and MMPs protein expression. Nutrients. 10(10):1549.
  • Martínez-Cortés I, Acevedo-Domínguez NA, Olguin-Alor R, Cortés-Hernández A, Álvarez-Jiménez V, Campillo-Navarro M, …, Soldevila G. 2019. Tilmicosin modulates the innate immune response and preserves casein production in bovine mammary alveolar cells during Staphylococcus aureus infection. Journal of animal science. 97(2):644–656.
  • Mehta J, Rayalam S, Wang X. 2018. Cytoprotective effects of natural compounds against oxidative stress. Antioxidants. 7(10):147.
  • Muhammad I, Wang X, Li S, Li R, Zhang X. 2018. Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway. Molecular biology reports. 45(6):1775–1785.
  • Omoigui S. 2007. The Interleukin-6 inflammation pathway from cholesterol to aging–Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Immun Ageing. 4:1–22.
  • Pavan B, Dalpiaz A, Marani L, Beggiato S, Ferraro L, Canistro D, Paolini M, Vivarelli F, Valerii MC, Comparone A, et al. 2018. Geraniol pharmacokinetics, bioavailability and its multiple effects on the liver antioxidant and xenobiotic-metabolizing enzymes. Front Pharmacol. 9:18.
  • Pillai VB, Samant S, Sundaresan NR, Raghuraman H, Kim G, Bonner MY, Arbiser JL, Walker DI, Jones DP, Gius D, et al. 2015. Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun. 6(1):16.
  • Polo MP, Crespo R, de Bravo MG. 2011. Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line. Cell Biochem Funct. 29(6):452–458.
  • Prasad SN. 2014. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. J Insect Physiol. 60:7–16.,
  • Rababa’h AM, Guillory AN, Mustafa R, Hijjawi T. 2018. Oxidative stress and cardiac remodeling: an updated edge. Curr Cardiol Rev. 14(1):53–59.
  • Rajendran P, Ben Ammar R, Al-Saeedi FJ, Mohamed ME, ElNaggar MA, Al-Ramadan SY, Bekhet GM, Soliman AM. 2020. Kaempferol inhibits zearalenone-induced oxidative stress and apoptosis via the PI3K/Akt-mediated Nrf2 signaling pathway: in vitro and in vivo studies. Int J Mol Sci. 22(1):217.
  • Ramachandra CJ, Cong S, Chan X, Yap EP, Yu F, Hausenloy DJ. 2021. Oxidative stress in cardiac hypertrophy: from molecular mechanisms to novel therapeutic targets. Free Radic Biol Med. 166:297–312.
  • Saito Y. 2010. Roles of atrial natriuretic peptide and its therapeutic use. J Cardiol. 56(3):262–270.
  • Shoff SM, Grummer M, Yatvin MB, Elson CE. 1991. Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene geraniol. Cancer Res. 51(1):37–42.
  • Sinha AK. 1972. Colorimetric assay of catalase. Anal Biochem. 47(2):389–394.
  • Solorzano-Santos F, Miranda-Novales MG. 2012. Essential oils from aromatic herbs as antimicrobial agents. Curr Opin Biotechnol. 23(2):136–141.
  • Turina ADV, Nolan M, Zygadlo J, Perillo M. 2006. Natural terpenes: self-assembly and membrane partitioning. Biophys Chem. 122(2):101–113.
  • Unsal V, Dalkıran T, Çiçek M, Kölükçü E. 2020. The role of natural antioxidants against reactive oxygen species produced by cadmium toxicity: a review. Advanced pharmaceutical bulletin. 10(2):184.
  • Watson CJ, Horgan S, Neary R, Glezeva N, Tea I, Corrigan N, McDonald K, Ledwidge M, Baugh J. 2016. Epigenetic therapy for the treatment of hypertension-induced cardiac hypertrophy and fibrosis. J Cardiovasc Pharmacol Ther. 21(1):127–137.
  • Whang WK, Park HS, Ham I, Oh M, Namkoong H, Kim HK, Hwang DW, Hur SY, Kim TE, Park YG, et al. 2005. Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 37(5):436–446.
  • Younis NS, Abduldaium MS, Mohamed ME. 2020. Protective effect of geraniol on oxidative, inflammatory and apoptotic alterations in isoproterenol-induced cardiotoxicity: role of the Keap1/Nrf2/HO-1 and PI3K/Akt/mTOR pathways. Antioxidants 9(10): 977.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.