Repression of autocrine pheromone signaling leads to fusaric acid over-production

References

• Arumugam T, Ghazi T, Abdul NS, Chuturgoon AA. 2021. A review on the oxidative effects of the fusariotoxins: fumonisin B1 and fusaric acid. In: Patel VB, Preedy VR, editors. Toxicology. Cambridge, MA: Elsevier Inc.; p. 181–190. doi: 10.1016/B978-0-12-819092-0.00019-4.
   Google Scholar
• Bacon CW, Hinton DM, Hinton A., Jr. 2006. Growth‐inhibiting effects of concentrations of fusaric acid on the growth of Bacillus mojavensis and other biocontrol Bacillus species. J Appl Microbiol. 100(1):185–194. doi: 10.1111/j.1365-2672.2005.02770.x.
   PubMed Web of Science ®Google Scholar
• Brown DW, Butchko RA, Busman M, Proctor RH. 2012. Identification of gene clusters associated with fusaric acid, fusarin, and perithecial pigment production in Fusarium verticillioides. Fungal Genet Biol. 49(7):521–532. doi: 10.1016/j.fgb.2012.05.010.
   PubMed Web of Science ®Google Scholar
• Brown DW, Lee SH, Kim LH, Ryu JG, Lee S, Seo Y, Kim YH, Busman M, Yun SH, Proctor RH, et al. 2015. Identification of a 12-gene fusaric acid biosynthetic gene cluster in Fusarium species through comparative and functional genomics. Mol Plant Microbe Interact. 28(3):319–332. doi: 10.1094/MPMI-09-14-0264-R.
   PubMed Web of Science ®Google Scholar
• Capasso R, Evidente A, Cutignano A, Vurro M, Zonno MC, Bottalico A. 1996. Fusaric and 9, 10-dehydrofusaric acids and their methyl esters from Fusarium nygamai. Phytochemistry. 41(4):1035–1039. doi: 10.1016/0031-9422(95)00716-4.
   Web of Science ®Google Scholar
• D’Alton A, Etherton B. 1984. Effects of fusaric acid on tomato root hair membrane potentials and ATP levels. Plant Physiol. 74(1):39–42. doi: 10.1104/pp.74.1.39.
   PubMed Web of Science ®Google Scholar
• Ding Z, Li M, Sun F, Xi P, Sun L, Zhang L, Jiang Z. 2015. Mitogen-activated protein kinases are associated with the regulation of physiological traits and virulence in Fusarium oxysporum f. sp. cubense. PLoS One. 10(4):e0122634. doi: 10.1371/journal.pone.0122634.
   PubMed Web of Science ®Google Scholar
• Gäumann E. 1957. Fusaric acid as a wilt toxin. Phytopathology. 47:342–357.
   Web of Science ®Google Scholar
• Keller NP. 2019. Fungal secondary metabolism: regulation, function and drug discovery. Nat Rev Microbiol. 17(3):167–180. doi: 10.1038/s41579-018-0121-1.
   PubMed Web of Science ®Google Scholar
• López-Díaz C, Rahjoo V, Sulyok M, Ghionna V, Martín-Vicente A, Capilla J, Di Pietro A, López-Berges MS. 2018. Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts. Mol Plant Pathol. 19(2):440–453. doi: 10.1111/mpp.12536.
   PubMed Web of Science ®Google Scholar
• Marrè MT, Vergani P, Albergoni FG. 1993. Relationship between fusaric acid uptake and its binding to cell structures by leaves of Egeria densa and its toxic effects on membrane permeability and respiration. Physiol Mol Plant Pathol. 42(2):141–157. doi: 10.1006/pmpp.1993.1012.
   Web of Science ®Google Scholar
• Niehaus EM, von Bargen KW, Espino JJ, Pfannmüller A, Humpf HU, Tudzynski B. 2014. Characterization of the fusaric acid gene cluster in Fusarium fujikuroi. Appl Microbiol Biotechnol. 98(4):1749–1762. doi: 10.1007/s00253-013-5453-1.
   PubMed Web of Science ®Google Scholar
• Palmieri D, Segorbe D, López-Berges MS, De Curtis F, Lima G, Di Pietro A, Turrà D. 2023. Alkaline pH, low iron availability, poor nitrogen sources and CWI MAPK signaling are associated with increased fusaric acid production in Fusarium oxysporum. Toxins (Basel). 15(1):50. doi: 10.3390/toxins15010050.
   PubMed Web of Science ®Google Scholar
• Pavlovkin J. 1998. Effect of fusaric acid on the electrical properties of maize root hairs plasmalemma. Agriculture. 44:350–355.
   Google Scholar
• Porter JK, Bacon CW, Wray EM, Hagler WM.Jr. 1995. Fusaric acid in Fusarium moniliforme cultures, corn, and feeds toxic to livestock and the neurochemical effects in the brain and pineal gland of rats. Nat Toxins. 3(2):91–100. doi: 10.1002/nt.2620030206.
   PubMedGoogle Scholar
• Ruiz JA, Bernar EM, Jung K. 2015. Production of siderophores increases resistance to fusaric acid in Pseudomonas protegens Pf‐5. PLoS One. 10(1):e0117040. doi: 10.1371/journal.pone.0117040.
   PubMed Web of Science ®Google Scholar
• Spitellek G. 1967. Mass spectrometry of heterocyclic compounds. In: Katritzky AR, Boulton AJ, editors. Advances in heterocyclic chemistry. Vol. 7. Cambridge, MA: Elsevier Inc.; p. 301–376. doi: 10.1016/s0065-2725(08)60593-0.
   Google Scholar
• Turrà D, El Ghalid M, Rossi F, Di Pietro A. 2015. Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals. Nature. 527(7579):521–524. doi: 10.1038/nature15516.
   PubMed Web of Science ®Google Scholar
• Vitale S, Di Pietro A, Turrà D. 2019. Autocrine pheromone signalling regulates community behaviour in the fungal pathogen Fusarium oxysporum. Nat Microbiol. 4(9):1443–1449. doi: 10.1038/s41564-019-0456-z.
   PubMed Web of Science ®Google Scholar
• Wang J, Li GW, Lin YC, Zhou S, Ng SW. 2005. 5-(But-3-enyl) pyridinium-2-carboxylate–5-butylpyridine-2-carboxylic acid (1/1), a co-crystal from Fusarium moniliforme. Acta Crystallogr E Struct Rep Online. 61(5):o1515–o1516. doi: 10.1107/S1600536805012675.
   Google Scholar
• Yabuta T, Kambe K, Hayashi T. 1937. Biochemistry of the bakanae fungus. I. Fusarinic acid, a new product of the bakanae fungus. J Agric Chem Soc Jpn. 10:1059–1068.
   Google Scholar
• Yin ES, Rakhmankulova M, Kucera K, de Sena Filho JG, Portero CE, Narvaez‐Trujillo A, Holley SA, Strobel SA. 2015. Fusaric acid induces a notochord malformation in zebrafish via copper chelation. Biometals. 28(4):783–789. doi: 10.1007/s10534-015-9855-7.
   PubMed Web of Science ®Google Scholar