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Original Articles

Metabolite Profiling of [14C]hexahydro-1, 3, 5-trinitro-1,3,5-triazine (RDX) in Yucatan Miniature Pigs

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Pages 1191-1202 | Received 04 May 2006, Accepted 06 Sep 2006, Published online: 15 Jun 2007

REFERENCES

  • Agency for Toxic Substances and Disease Registry . 1995 . Toxicological profile for RDX , Atlanta, GA : U.S. Department of Health and Human Service, Public Health Service, ATSDR .
  • Bhushan , B. , Halasz , A. , Spain , J. C. and Hawari , J. 2002 . Diaphorase catalyzed biotransformation of RDX via N-denitration mechanism . Biochem. Biophys. Res. Commun. , 296 : 779 – 784 .
  • Bhushan , B. , Trott , S. , Spain , J. C. , Halasz , A. , Paquet , L. and Hawari , J. 2003 . Biotransformation of hexahydro-1, 3, 5-triazine (RDX) by rabbit liver cytochrome P450: Insight into the mechanism of RDX biodegradation by Rhodococcus sp. DN22 . Am. Soc. Microbiol. , 69 : 1347 – 1351 .
  • Fournier , D. , Halasz , A. , Spain , J. C. , Fiurasek , P. and Hawari , J. 2002 . Determination of key metabolites during biodegradation of hexahydro-1,3,5-trinitro-1,3,5-triazine with Rhodococcus sp. strain DN22 . Appl. Environ. Microbiol. , 68 : 166 – 172 .
  • George , S. E. , Huggins-Clark , G. and Brooks , L. R. 2001 . Use of Salmonella microsuspension bioassay to detect the mutagenicity of munitions compounds at low concentrations . Mutat. Res. , 490 : 45 – 56 .
  • Halasz , A. , Spain , J. C. , Paquet , L. , Beaulieu , C. and Hawari , J. 2002 . Insights into the formation and degradation mechanisms of methylenedinitramine during the incubation of RDX with anaerobic sludge . Environ Sci. Technol. , 36 : 633 – 638 .
  • Hart , E.R. 1976 . Two year feeding study in rats , Litton Bionetics Inc. : Kensington, MD, Office of Naval Research contract N00014–73-C-0162. ADAO40161 .
  • Hawari , J. , Halasz , A. , Sheremata , T. , Beaudet , S. , Groom , C. , Paquet , L. , Rhofir , C. , Ampleman , G. and Thiboutot , S. 2000 . Characterization of metabolites during biodegradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) with municipal anaerobic sludge . Appl. Environ. Microbiol. , 66 : 2652 – 2657 .
  • Levine, B. S., Furedi-Machacek, E. M., Rac, V. S., Gordon, D. E., and Lish, P.M. 1983. Determination of the chronic mammalian toxicological effects of RDX: Twenty-four month chronic toxicity/carcinogenicity study of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in Fischer 344 rat. Phase V, Vol. 1. Contract DAMD 17–79-C-9161. IIT Research Institue, Chicago. ADA 160774. U.S. Army Medical Research and Development Command, Fort Detrick, MD.
  • Lish, P. M., Levine, B. S., Furedi-Machacek, E. M., Sagartz, E. M., and Rac. Y. S. 1984 Determination of the chronic mammalian toxicological effects of RDX: Twenty-four month chronic toxicity/carcinogenicity study of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in the B6C3F1 hybrid mouse. Phase VI, Vol. I. Contract DAMD 17–79-C-9161. IIT Research Institue, Chicago. ADA 160774. U.S. Army Medical Research and Development Command, Fort Detrick, MD
  • McCormick , N. G. , Cornell , J. H. and Kaplan , A. M. 1981 . Biodegradation of hexahydro-1,3,5-trinitro-1,3,5-triazine . Appl. Environ. Microbiol. , 42 : 817 – 823 .
  • McLellan , W. L. , Hartley , W. R. and Brower , M. E. 1992 . “ Hexahydro-1,3,5-trinitro-1,3,5 triazine (RDX) ” . In Drinking water health advisory: Munitions , Edited by: Roberts , W. C. and Hartley , W. R. 133 – 179 . U.S. Environmental Protection Agency, Office of Drinking Water Health Advisories. Boca Raton, FL : Lewis .
  • National Research Council . 1996 . Guide for the care and use of laboratory animals , Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council. Washington, DC : National Academy Press .
  • Reddy , G. , Eisenhut , K. , Morrison , S. A. and Kelly , J. A. 1989 . Toxicokinetics of 14-C RDX (cyclotrimethylenetrinitramine) in rats after intratracheal administration . Toxicologist , 9 : 83 (abstract)
  • Reddy , G. , Erexson , G. I. , Cifone , M. A. , Major , M. A. and Leac , h. G. J. 2005 . Genotoxicity assessment of RDX . Int. J. Toxicol. , 24 : 427 – 434 .
  • Schneider , N. R. , Bradley , S. L. and Anderson , M. E. 1977 . Toxicology of cyclotrimethylenetrinitramine: Distribution and metabolism in rats and the miniature swine . Toxicol. Appl. Pharmacol. , 39 : 531 – 541 .
  • Schneider , N. R. , Bradley , S. L. and Anderson , M. E. 1978 . The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration . Toxicol. Appl. Pharmacol. , 46 : 163 – 171 .
  • U.S. Envirnmental Protection Agency. 2006. Integrated Risk Information System (IRIS). National Center for Environmental Assessment, Cincinnati, OH www.epa.gov/IRIS/subst/0313.htm
  • Walsh , M. E. and Jenkins , T. F. Identification of TNT transformation products in soil . Special report 92–16 . 1992 . Hanover, NH: Cold Regions Research and Engineering Laboratory, U.S. Army Corps of Engineers

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