Extracellular vesicles from Fusobacterium nucleatum: roles in the malignant phenotypes of gastric cancer

References

• Bessède E, Mégraud F. Microbiota and gastric cancer. Seminars in cancer biology. Semin Cancer Biol. 2022 Nov;86(Pt 3):11–17. doi: 10.1016/j.semcancer.2022.05.001
   PubMedGoogle Scholar
• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca A Cancer J Clinicians. 2018 Nov;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• Hsieh YY, Kuo WL, Hsu WT, et al. Fusobacterium nucleatum-induced tumor mutation burden predicts poor survival of gastric cancer patients. Cancers (Basel). 2022 Dec 30;15(1):269. doi: 10.3390/cancers15010269
   PubMed Web of Science ®Google Scholar
• Ajani JA, D’Amico TA, Bentrem DJ, et al. Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2022 Feb;20(2):167–192.
   PubMed Web of Science ®Google Scholar
• Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer. Lancet (London, England). 2020 Aug 29;396(10251):635–648. doi: 10.1016/S0140-6736(20)31288-5
   PubMed Web of Science ®Google Scholar
• Riddell IA. Cisplatin and oxaliplatin: our Current understanding of their actions. Metal ions in life sciences Met Ions Life Sci. 2018 Feb 5;18 1–42.
   Google Scholar
• Martinez-Balibrea E, Martínez-Cardús A, Ginés A, et al. Tumor-related molecular mechanisms of oxaliplatin resistance. Mol Cancer Ther. 2015 Aug;14(8):1767–76.
   PubMed Web of Science ®Google Scholar
• Biagioni A, Skalamera I, Peri S, et al. Update on gastric cancer treatments and gene therapies. Cancer Metastasis Rev. 2019 Sep;38(3):537–548.
   PubMed Web of Science ®Google Scholar
• Turnbaugh PJ, Ley RE, Hamady M, et al. The human microbiome project. Nature. 2007 Oct 18;449(7164):804–10. doi: 10.1038/nature06244
   PubMed Web of Science ®Google Scholar
• Toumazi D, Constantinou C. A fragile balance: the important role of the intestinal microbiota in the prevention and management of colorectal cancer. Oncology. 2020;98(9):593–602. doi: 10.1159/000507959
   PubMed Web of Science ®Google Scholar
• Doocey CM, Finn K, Murphy C, et al. The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development. BMC Microbiol. 2022 Feb 12;22(1):53. doi: 10.1186/s12866-022-02465-6
   PubMed Web of Science ®Google Scholar
• Wu ZF, Zou K, Xiang CJ, et al. Helicobacter pylori infection is associated with the co-occurrence of bacteria in the oral cavity and the gastric mucosa. Helicobacter. 2021 Apr;26(2):e12786.
   PubMed Web of Science ®Google Scholar
• Chang JS, Kuo SH, Chu PY, et al. The epidemiology of gastric cancers in the era of helicobacter pylori eradication: a nationwide cancer registry-based study in Taiwan. CEBP: A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology. 2019 Oct;28(10):1694–1703.
   Google Scholar
• Kabwe M, Brown TL, Dashper S, et al. Genomic, morphological and functional characterisation of novel bacteriophage FNU1 capable of disrupting fusobacterium nucleatum biofilms. Sci Rep. 2019 Jun 24;9(1):9107. doi: 10.1038/s41598-019-45549-6
   PubMedGoogle Scholar
• Habib AM, Islam MS, Sohel M, et al. Mining the proteome of fusobacterium nucleatum subsp. Nucleatum ATCC 25586 for potential therapeutics discovery: an in silico approach. Genomics Inf. 2016 Dec;14(4):255–264.
   PubMedGoogle Scholar
• Nozawa A, Oshima H, Togawa N, et al. Development of oral care chip, a novel device for quantitative detection of the oral microbiota associated with periodontal disease. PloS One. 2020;15(2):e0229485. doi: 10.1371/journal.pone.0229485
   PubMed Web of Science ®Google Scholar
• Hong M, Li Z, Liu H, et al. Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles. Cell Host Microbe. 2023 May 10;31(5):798–810.e7. doi: 10.1016/j.chom.2023.03.018
   PubMed Web of Science ®Google Scholar
• Xu C, Fan L, Lin Y, et al. Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization. Gut Microbes. 2021 Jan-Dec;13(1):1980347.
   PubMed Web of Science ®Google Scholar
• Hsieh YY, Tung SY, Pan HY, et al. Increased abundance of clostridium and fusobacterium in gastric microbiota of patients with gastric cancer in Taiwan. Sci Rep. 2018 Jan 9;8(1):158. doi: 10.1038/s41598-017-18596-0
   PubMedGoogle Scholar
• Chen WD, Zhang X, Zhang MJ, et al. Salivary fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer. World J Gastroenterol. 2022 Aug 14;28(30):4120–4132. doi: 10.3748/wjg.v28.i30.4120
   PubMed Web of Science ®Google Scholar
• Boehm ET, Thon C, Kupcinskas J, et al. Fusobacterium nucleatum is associated with worse prognosis in lauren’s diffuse type gastric cancer patients. Sci Rep. 2020 Oct 1;10(1):16240. doi: 10.1038/s41598-020-73448-8
   PubMed Web of Science ®Google Scholar
• Xin Y, Li X, Zhang M, et al. Fusobacterium nucleatum-induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis. Cancer Sci. 2023 Jun;114(6):2360–2374.
   PubMed Web of Science ®Google Scholar
• Lu P, Xu M, Xiong Z, et al. Fusobacterium nucleatum prevents apoptosis in colorectal cancer cells via the ANO1 pathway. Cancer Manage Res. 2019;11:9057–9066. doi: 10.2147/CMAR.S185766
   PubMed Web of Science ®Google Scholar
• Capula M, Perán M, Xu G, et al. Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance. Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy. Drug Resist Updat. 2022 Sep;64:100864.
   PubMed Web of Science ®Google Scholar
• Verweij FJ, Balaj L, Boulanger CM, et al. The power of imaging to understand extracellular vesicle biology in vivo. Nat Methods. 2021 Sep;18(9):1013–1026.
   PubMed Web of Science ®Google Scholar
• Crewe C, Funcke JB, Li S, et al. Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab. 2021 Sep 7;33(9):1853–1868.e11. doi: 10.1016/j.cmet.2021.08.002
   PubMed Web of Science ®Google Scholar
• Xie J, Li Q, Haesebrouck F, et al. The tremendous biomedical potential of bacterial extracellular vesicles. Trends Biotechnol. 2022 Oct;40(10):1173–1194.
   PubMed Web of Science ®Google Scholar
• Tarashi S, Zamani MS, Omrani MD, et al. Commensal and pathogenic bacterial-derived extracellular vesicles in host-bacterial and interbacterial dialogues: two sides of the same coin. J Immunol Res. 2022;2022:1–15. doi: 10.1155/2022/8092170
   Web of Science ®Google Scholar
• David L, Taieb F, Pénary M, et al. Outer membrane vesicles produced by pathogenic strains of escherichia coli block autophagic flux and exacerbate inflammasome activation. Autophagy. 2022 Dec;18(12):2913–2925.
   PubMedGoogle Scholar
• Chen G, Gao C, Jiang S, et al. Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis. J Adv Res. 2023 Apr 13;56:167–179. doi: 10.1016/j.jare.2023.04.002
   PubMed Web of Science ®Google Scholar
• Lin LT, Shi YC, Choong CY, et al. The fruits of Paris polyphylla Inhibit colorectal cancer cell migration induced by fusobacterium nucleatum-derived extracellular vesicles. Molecules (Basel, Switzerland). Molecules. 2021 Jul 4;26(13):4081. doi: 10.3390/molecules26134081
   PubMed Web of Science ®Google Scholar
• Kumar S, Paiva B, Anderson KC, et al. International Myeloma working group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016 Aug;17(8):e328–e346.
   PubMed Web of Science ®Google Scholar
• Li G, Sun Y, Huang Y, et al. Fusobacterium nucleatum-derived small extracellular vesicles facilitate tumor growth and metastasis via TLR4 in breast cancer. BMC Cancer. 2023 May 23;23(1):473. doi: 10.1186/s12885-023-10844-z
   PubMed Web of Science ®Google Scholar
• Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012 Feb;22(2):299–306.
   PubMed Web of Science ®Google Scholar
• Bachurski D, Schuldner M, Nguyen PH, et al. Extracellular vesicle measurements with nanoparticle tracking analysis - an accuracy and repeatability comparison between NanoSight NS300 and ZetaView. J Extracell Vesicles. 2019;8(1):1596016. doi: 10.1080/20013078.2019.1596016
   PubMed Web of Science ®Google Scholar
• Hu PS, Xia QS, Wu F, et al. NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of all-trans retinoic acid via targeting RDH16 in malignant glioma. Oncogene. 2017 Aug 17;36(33):4706–4718. doi: 10.1038/onc.2017.34
   PubMed Web of Science ®Google Scholar
• Yang Q, Yu W, Han X. Overexpression of microRNA‑101 causes anti‑tumor effects by targeting CREB1 in colon cancer. Mol Med Rep. 2019 Apr;19(4):3159–3167. doi: 10.3892/mmr.2019.9952
   PubMed Web of Science ®Google Scholar
• Zhu M, Gong Z, Wu Q, et al. Sanguinarine suppresses migration and metastasis in colorectal carcinoma associated with the inversion of EMT through the Wnt/β-catenin signaling. Clin Transl Med. 2020 Jan;10(1):1–12.
   PubMed Web of Science ®Google Scholar
• Qu X, Liu B, Wang L, et al. Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer. Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy. Drug Resist Updat. 2023 May;68:100936.
   PubMedGoogle Scholar
• Sadrekarimi H, Gardanova ZR, Bakhshesh M, et al. Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora. J Transl Med. 2022 Jul 6;20(1):301. doi: 10.1186/s12967-022-03492-7
   PubMed Web of Science ®Google Scholar
• Parhi L, Alon-Maimon T, Sol A, et al. Breast cancer colonization by fusobacterium nucleatum accelerates tumor growth and metastatic progression. Nat Commun. 2020 Jun 26;11(1):3259. doi: 10.1038/s41467-020-16967-2
   PubMed Web of Science ®Google Scholar
• Sepich-Poore GD, Zitvogel L, Straussman R, et al. The microbiome and human cancer. Science. 2021 Mar 26;371(6536). doi: 10.1126/science.abc4552
   PubMed Web of Science ®Google Scholar
• Ianiro G, Molina-Infante J, Gasbarrini A. Gastric microbiota. Helicobacter. 2015 Sep;20(Suppl 1):68–71. doi: 10.1111/hel.12260
   PubMedGoogle Scholar
• Hutton ML, Kaparakis-Liaskos M, Turner L, et al. Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells. Infect Immun. 2010 Nov;78(11):4523–4531.
   PubMed Web of Science ®Google Scholar
• Brennan CA, Garrett WS. Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nature Rev Microbiol. 2019 Mar;17(3):156–166. doi: 10.1038/s41579-018-0129-6
   PubMed Web of Science ®Google Scholar
• Hong J, Guo F, Lu SY, et al. F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Gut. 2021 Nov;70(11):2123–2137.
   PubMed Web of Science ®Google Scholar
• Yu T, Guo F, Yu Y, et al. Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy. Cell. 2017 Jul 27;170(3):548–563.e16. doi: 10.1016/j.cell.2017.07.008
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen Y, Zhang J, et al. Fusobacterium nucleatum promotes metastasis in colorectal cancer by activating autophagy signaling via the upregulation of CARD3 expression. Theranostics. 2020;10(1):323–339. doi: 10.7150/thno.38870
   PubMed Web of Science ®Google Scholar
• Hsieh YY, Tung SY, Pan HY, et al. Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients. World J Gastroenterol. 2021 Nov 14;27(42):7311–7323. doi: 10.3748/wjg.v27.i42.7311
   PubMed Web of Science ®Google Scholar
• Liu D, Lu M, Li J, et al. The patterns and timing of recurrence after curative resection for gastric cancer in China. World J Surg Oncol. 2016 Dec 8;14(1):305. doi: 10.1186/s12957-016-1042-y
   PubMedGoogle Scholar
• Charalampakis N, Economopoulou P, Kotsantis I, et al. Medical management of gastric cancer: a 2017 update. Cancer Med. 2018 Jan;7(1):123–133.
   PubMed Web of Science ®Google Scholar
• Ñahui Palomino RA, Vanpouille C, Laghi L, et al. Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues. Nat Commun. 2019 Dec 11;10(1):5656. doi: 10.1038/s41467-019-13468-9
   PubMedGoogle Scholar
• Toyofuku M, Nomura N, Eberl L. Types and origins of bacterial membrane vesicles. Nature Rev Microbiol. 2019 Jan;17(1):13–24. doi: 10.1038/s41579-018-0112-2
   PubMed Web of Science ®Google Scholar
• Schwechheimer C, Kuehn MJ. Outer-membrane vesicles from gram-negative bacteria: biogenesis and functions. Nature Rev Microbiol. 2015 Oct;13(10):605–619. doi: 10.1038/nrmicro3525
   PubMed Web of Science ®Google Scholar
• Orench-Rivera N, Kuehn MJ. Environmentally controlled bacterial vesicle-mediated export. Cell Microbiol. 2016 Nov;18(11):1525–1536. doi: 10.1111/cmi.12676
   PubMed Web of Science ®Google Scholar
• Yang Z, Gao Z, Yang Z, et al. Lactobacillus plantarum-derived extracellular vesicles protect against ischemic brain injury via the microRNA-101a-3p/c-Fos/TGF-β axis. Pharmacol Res. 2022 Aug;182:106332.
   PubMed Web of Science ®Google Scholar
• Wang X, Li H, Wang J, et al. Staphylococcus aureus extracellular vesicles induce apoptosis and restrain mitophagy-mediated degradation of damaged mitochondria. Microbiol Res. 2023 Aug;273:127421.
   PubMedGoogle Scholar
• Engevik MA, Danhof HA, Ruan W, et al. Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation. MBio. 2021 Mar 2;12(2). doi: 10.1128/mBio.02706-20
   PubMed Web of Science ®Google Scholar
• Liu L, Liang L, Yang C, et al. Extracellular vesicles of fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway. Gut Microbes. 2021 Jan-Dec;13(1):1–20.
   Web of Science ®Google Scholar
• Chen S, Zhang L, Li M, et al. Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis. Nat Commun. 2022 Mar 10;13(1):1248. doi: 10.1038/s41467-022-28913-5
   PubMed Web of Science ®Google Scholar
• Zhang R, Liu L, Wang F, et al. AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA. Cell Death Dis. 2022 Dec 15;13(12):1041. doi: 10.1038/s41419-022-05502-4
   PubMed Web of Science ®Google Scholar
• Petroni G, Buqué A, Zitvogel L, et al. Immunomodulation by targeted anticancer agents. Cancer Cell. 2021 Mar 8;39(3):310–345. doi: 10.1016/j.ccell.2020.11.009
   PubMed Web of Science ®Google Scholar
• Huang T, Song X, Xu D, et al. Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics. 2020;10(19):8721–8743. doi: 10.7150/thno.41648
   PubMed Web of Science ®Google Scholar
• Zhang T, Wang B, Su F, et al. TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. Int J Biol Sci. 2022;18(11):4560–4577. doi: 10.7150/ijbs.69933
   PubMed Web of Science ®Google Scholar