SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells

References

• Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2(1):16018. doi: 10.1038/nrdp.2016.18
   PubMed Web of Science ®Google Scholar
• Villanueva A, Longo DL. Hepatocellular carcinoma. N Engl J Med. 2019;380(15):1450–1462. doi: 10.1056/NEJMra1713263
   PubMed Web of Science ®Google Scholar
• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492
   PubMed Web of Science ®Google Scholar
• Li Y, Zhao L, Li XF. Hypoxia and the tumor microenvironment. Technol Cancer Res Treat. 2021;20:15330338211036304. doi: 10.1177/15330338211036304
   Web of Science ®Google Scholar
• Petrova V, Annicchiarico-Petruzzelli M, Melino G, et al. The hypoxic tumour microenvironment. Oncogenesis. 2018;7(1):10. doi: 10.1038/s41389-017-0011-9
   PubMed Web of Science ®Google Scholar
• Wu XZ, Xie GR, Chen D. Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma. J Gastroenterol Hepatol. 2007;22(8):1178–1182. doi: 10.1111/j.1440-1746.2007.04997.x
   PubMed Web of Science ®Google Scholar
• Salazar-Roa M, Malumbres M. Fueling the cell division cycle. Trends Cell Biol. 2017;27(1):69–81. doi: 10.1016/j.tcb.2016.08.009
   PubMed Web of Science ®Google Scholar
• Li T, Han J, Jia L, et al. PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation. Protein Cell. 2019;10(8):583–594. doi: 10.1007/s13238-019-0618-z
   PubMed Web of Science ®Google Scholar
• Esteban-Martinez L, Sierra-Filardi E, McGreal RS, et al. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. Embo J. 2017;36:1688–1706. doi: 10.15252/embj.201695916
   PubMed Web of Science ®Google Scholar
• Chang HW, Kim MR, Lee HJ, et al. p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer. Oncogene. 2019;38(19):3729–3742. doi: 10.1038/s41388-019-0697-6
   PubMed Web of Science ®Google Scholar
• Wang SH, Zhu XL, Wang F, et al. LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity. Cell Death Dis. 2021;12(6):557. doi: 10.1038/s41419-021-03821-6
   PubMed Web of Science ®Google Scholar
• Sack MN, Finkel T. Mitochondrial metabolism, sirtuins, and aging. Cold Spring Harb Perspect Biol. 2012;4(12):a013102–a013102. doi: 10.1101/cshperspect.a013102
   PubMed Web of Science ®Google Scholar
• Imai S, Armstrong CM, Kaeberlein M, et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403(6771):795–800. doi: 10.1038/35001622
   PubMed Web of Science ®Google Scholar
• Song CL, Tang H, Ran LK, et al. Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway. Oncogene. 2016;35(5):631–641. doi: 10.1038/onc.2015.121
   PubMed Web of Science ®Google Scholar
• Chang H, Li J, Luo Y, et al. TFB2M activates aerobic glycolysis in hepatocellular carcinoma cells through the NAD + /SIRT3/HIF-1α signaling. J Gastroenterol Hepatol. 2021;36(10):2978–2988. doi: 10.1111/jgh.15548
   PubMed Web of Science ®Google Scholar
• Zhang R, Lin HM, Broering R, et al. RETRACTED ARTICLE: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway. Signal Transduct Target Ther. 2019;4(1):54. doi: 10.1038/s41392-019-0082-5
   PubMedGoogle Scholar
• Kwon M, Firestein BL. DNA transfection: calcium phosphate method. Methods Mol Biol. 2013;1018:107–110.
   PubMedGoogle Scholar
• Sun N, Malide D, Liu J, et al. A fluorescence-based imaging method to measure in vitro and in vivo mitophagy using mt-Keima. Nat Protoc. 2017;12(8):1576–1587. doi: 10.1038/nprot.2017.060
   PubMed Web of Science ®Google Scholar
• Sun N, Yun J, Liu J, et al. Measuring in vivo mitophagy. Mol Cell. 2015;60:685–696. doi: 10.1016/j.molcel.2015.10.009
   PubMed Web of Science ®Google Scholar
• Gao QY, Zhang HF, Tao J, et al. Mitochondrial fission and mitophagy reciprocally orchestrate cardiac fibroblasts activation. Front Cell Dev Biol. 2020;8:629397. doi: 10.3389/fcell.2020.629397
   PubMed Web of Science ®Google Scholar
• Yu EPK, Reinhold J, Yu H, et al. Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness. Arterioscler Thromb Vasc Biol. 2017;37(12):2322–2332. doi: 10.1161/ATVBAHA.117.310042
   PubMed Web of Science ®Google Scholar
• Chen ZT, Zhang HF, Wang M, et al. Long non-coding RNA Linc00092 inhibits cardiac fibroblast activation by altering glycolysis in an ERK-dependent manner. Cell Signal. 2020;74:109708. doi: 10.1016/j.cellsig.2020.109708
   PubMed Web of Science ®Google Scholar
• Tao J, Chen H, Wang YJ, et al. Ketogenic diet suppressed T-Regulatory cells and promoted cardiac fibrosis via reducing mitochondria-associated membranes and inhibiting mitochondrial function. Oxid Med Cell Longev. 2021;2021:5512322. doi: 10.1155/2021/5512322
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang H, Zheng Y, et al. Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-κB-dependent mechanism. Cell Death Dis. 2020;11(3):188. doi: 10.1038/s41419-020-2378-3
   PubMed Web of Science ®Google Scholar
• Schneider CA, Rasband WS, Eliceiri KW. NIH image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9(7):671–675. doi: 10.1038/nmeth.2089
   PubMed Web of Science ®Google Scholar
• Li W, Huang K, Wen F, et al. LINC00184 silencing inhibits glycolysis and restores mitochondrial oxidative phosphorylation in esophageal cancer through demethylation of PTEN. EBioMedicine. 2019;44:298–310. doi: 10.1016/j.ebiom.2019.05.055
   PubMed Web of Science ®Google Scholar
• Wu NN, Zhang Y, Mitophagy RJ. Mitochondrial dynamics, and homeostasis in cardiovascular aging. Oxid Med Cell Longev. 2019;2019:9825061. doi: 10.1155/2019/9825061
   PubMed Web of Science ®Google Scholar
• Zhang J. Autophagy and mitophagy in cellular damage control. Redox Biol. 2013;1(1):19–23. doi: 10.1016/j.redox.2012.11.008
   PubMed Web of Science ®Google Scholar
• Qin M, Meng Y, Luo C, et al. lncRNA PRR34-AS1 promotes HCC development via modulating Wnt/beta-catenin pathway by absorbing miR-296-5p and upregulating E2F2 and SOX12. Mol Ther Nucleic Acids. 2021;25:37–52. doi: 10.1016/j.omtn.2021.04.016
   PubMedGoogle Scholar
• Liu L, Zhu XD, Wang WQ, et al. Activation of β-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res. 2010;16(10):2740–2750. doi: 10.1158/1078-0432.CCR-09-2610
   PubMed Web of Science ®Google Scholar
• Jiang W, He T, Liu S, et al. The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer. J Hematol Oncol. 2018;11(1):139. doi: 10.1186/s13045-018-0674-5
   PubMedGoogle Scholar
• Zhao H, Luo Y, Chen L, et al. Sirt3 inhibits cerebral ischemia-reperfusion injury through normalizing Wnt/β-catenin pathway and blocking mitochondrial fission. Cell Stress Chaperones. 2018;23(5):1079–1092. doi: 10.1007/s12192-018-0917-y
   PubMed Web of Science ®Google Scholar
• Guo X, Yan F, Shan X, et al. SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through beta-catenin/PPAR-gamma signaling. Life Sci. 2017;186:111–117. doi: 10.1016/j.lfs.2017.07.030
   PubMed Web of Science ®Google Scholar
• Li R, Quan Y, Xia W. SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/β-catenin pathway. Exp Cell Res. 2018;364(2):143–151. doi: 10.1016/j.yexcr.2018.01.036
   PubMed Web of Science ®Google Scholar
• Song LL, Zhang Y, Zhang XR, et al. Theacrine attenuates myocardial fibrosis after myocardial infarction via the SIRT3/β-catenin/PPARγ pathway in estrogen-deficient mice. Eur Rev Med Pharmacol Sci. 2019;23(12):5477–5486. doi: 10.26355/eurrev_201906_18217
   PubMed Web of Science ®Google Scholar
• Cui Y, Qin L, Wu J, et al. SIRT3 enhances glycolysis and proliferation in SIRT3-expressing gastric cancer cells. PLoS One. 2015;10(6):e0129834. doi: 10.1371/journal.pone.0129834
   PubMed Web of Science ®Google Scholar
• He X, Zeng H, Chen ST, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104–113. doi: 10.1016/j.yjmcc.2017.09.007
   PubMed Web of Science ®Google Scholar
• Srivastava SP, Li J, Kitada M, et al. SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis. Cell Death Dis. 2018;9(10):997. doi: 10.1038/s41419-018-1057-0
   PubMedGoogle Scholar
• Yang YY, Zhou YM, Xu JZ, et al. Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β-catenin pathway. J Bone Miner Res. 2021;36(8):1605–1620. doi: 10.1002/jbmr.4321
   PubMed Web of Science ®Google Scholar
• Jiang Y, Han Q, Zhao H, et al. Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis. J Exp Clin Cancer Res. 2021;40(1):13. doi: 10.1186/s13046-020-01808-3
   PubMed Web of Science ®Google Scholar
• Yang X, Shao F, Guo D, et al. WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis. Cell Death Dis. 2021;12(5):462. doi: 10.1038/s41419-021-03739-z
   PubMed Web of Science ®Google Scholar
• Cheung KG, Cole LK, Xiang B, et al. Sirtuin-3 (SIRT3) protein attenuates doxorubicin-induced oxidative stress and improves mitochondrial respiration in H9c2 cardiomyocytes. J Biol Chem. 2015;290(17):10981–10993. doi: 10.1074/jbc.M114.607960
   PubMed Web of Science ®Google Scholar
• Li C, Zhou Y, Kim JT, et al. Regulation of SIRT2 by Wnt/β-catenin signaling pathway in colorectal cancer cells. Biochim Biophys Acta, Mol Cell Res. 2021;1868(4):118966. doi: 10.1016/j.bbamcr.2021.118966
   PubMed Web of Science ®Google Scholar
• Lehwald N, Tao GZ, Jang KY, et al. β-catenin regulates hepatic mitochondrial function and energy balance in mice. Gastroenterology. 2012;143(3):754–764. doi: 10.1053/j.gastro.2012.05.048
   PubMed Web of Science ®Google Scholar