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Research in Sports Medicine
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Volume 32, 2024 - Issue 3
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Research Article

The effects of a multi-day cross-country mountain bike race on myocardial function, stress, inflammation and cardiac biomarkers in amateur master athletes

, , , &
Pages 425-442 | Received 20 Jan 2022, Accepted 13 Sep 2022, Published online: 22 Sep 2022

References

  • Aagaard, P., Sahlen, A., Bergfeldt, L., & Braunschweig, F. (2014). Heart rate and its variability in response to running-associations with troponin. Medicine and Science in Sports and Exercise, 46(8), 1624–1630. https://doi.org/10.1249/MSS.0000000000000270
  • Aengevaeren, V. L., Hopman, M. T. E., Thijssen, D. H. J., van Kimmenade, R. R., de Boer, M. J., & Eijsvogels, T. M. H. (2017). Endurance exercise-induced changes in BNP concentrations in cardiovascular patients versus healthy controls. International Journal of Cardiology, 227, 430–435. https://doi.org/10.1016/j.ijcard.2016.11.016
  • Aengevaeren, V. L., Mosterd, A., Braber, T. L., Prakken, N. H. J., Doevendans, P. A., Grobbee, D. E., Thompson, P. D., Eijsvogels, T. M. H., & Velthuis, B. K. (2017). Relationship between lifelong exercise volume and coronary atherosclerosis in athletes. Circulation, 136(2), 138–148. https://doi.org/10.1161/CIRCULATIONAHA.117.027834
  • Andersen, K., Farahmand, B., Ahlbom, A., Held, C., Ljunghall, S., Michaelsson, K., & Sundstrom, J. (2013). Risk of arrhythmias in 52 755 long-distance cross-country skiers: A cohort study. European Heart Journal, 34(47), 3624–3631. https://doi.org/10.1093/eurheartj/eht188
  • Armstrong, L. E. (2005). Hydration assessment techniques. Nutrition Reviews, 63(6 Pt 2), S40–54. https://doi.org/10.1111/j.1753-4887.2005.tb00153.x
  • Baggish, A. L., & Levine, B. D. (2017). Coronary artery calcification among endurance athletes: “hearts of stone”. Circulation, 136(2), 149–151. https://doi.org/10.1161/CIRCULATIONAHA.117.028750
  • Baker, P., Leckie, T., Harrington, D., & Richardson, A. (2019). Exercise-Induced cardiac troponin elevation: An update on the evidence, mechanism and implications. International Journal of Clinical Cardiology, 22, 181–186. https://doi.org/10.1016/j.ijcha.2019.03.001
  • Belval, L. N., Hosokawa, Y., Casa, D. J., Adams, W. M., Armstrong, L. E., Baker, L. B., Burke, L., Cheuvront, S., Chiampas, G., Gonzalez-Alonso, J., Huggins, R. A., Kavouras, S. A., Lee, E. C., McDermott, B. P., Miller, K., Schlader, Z., Sims, S., Stearns, R. L., Troyanos, C., & Wingo, J. (2019). Practical hydration solutions for sports. Nutrients, 11(7). https://doi.org/10.3390/nu11071550
  • Bessa, A. L., Oliveira, V. N., Agostini, G. G., Oliveira, R. J., Oliveira, A. C., White, G. E., Wells, G. D., Teixeira, D. N., & Espindola, F. S. (2016). Exercise intensity and recovery: Biomarkers of injury, inflammation, and oxidative stress. Journal of Strength and Conditioning Research / National Strength & Conditioning Association, 30(2), 311–319. https://doi.org/10.1519/JSC.0b013e31828f1ee9
  • Bolados, C. C., López, P. R., Valenzuela, T. H., Diaz, P. O., Antonio, G. H., & Anthony, C. H. (2019). Testosterone, and cortisol responses to HIIT and continuous aerobic exercise in active young men. Sustainabilit 11, 6096.
  • Bordelon, L. A., & Ferreira, S. L. A. (2019). Mountain biking is for (white, wealthy, middle-aged) men: The cape epic mountain bike race. Journal Sport Tour, 23(1), 41–59. https://doi.org/10.1080/14775085.2019.1654906
  • Ciampricotti, R., & el Gamal, M. (1989). Recurrent myocardial infarction and sudden death after sport. American Heart Journal, 117(1), 188–191. https://doi.org/10.1016/0002-8703(89)90676-5
  • Costello, J. T., Rendell, R. A., Furber, M., Massey, H. C., Tipton, M. J., Young, J. S., & Corbett, J. (2018). Effects of acute or chronic heat exposure, exercise and dehydration on plasma cortisol, IL-6 and CRP levels in trained males. Cytokine, 110, 277–283. https://doi.org/10.1016/j.cyto.2018.01.018
  • Donaldson, J. A., Wiles, J. D., Coleman, D. A., Papadakis, M., Sharma, R., & O’Driscoll, J. M. (2019). Left ventricular function and cardiac biomarker release-the influence of exercise intensity, duration and mode: A systematic review and meta-analysis. Sports Medicine, 49(8), 1275–1289. https://doi.org/10.1007/s40279-019-01142-5
  • Eijsvogels, T. M., Fernandez, A. B., & Thompson, P. D. (2016). Are there deleterious cardiac effects of acute and chronic endurance exercise? Physiological Reviews, 96(1), 99–125. https://doi.org/10.1152/physrev.00029.2014
  • Eijsvogels, T. M., Molossi, S., Lee, D. C., Emery, M. S., & Thompson, P. D. (2016). Exercise at the extremes: The amount of exercise to reduce cardiovascular events. Journal of the American College of Cardiology, 67(3), 316–329. https://doi.org/10.1016/j.jacc.2015.11.034
  • Gaskill, S. E., Ruby, B. C., Walker, A. J., Sanchez, O. A., Serfass, R. C., & Leon, A. S. (2001). Validity and reliability of combining three methods to determine ventilatory threshold. Medicine and Science in Sports and Exercise, 33(11), 1841–1848. https://doi.org/10.1097/00005768-200111000-00007
  • Hackney, A. C., Davis, H. C., & Lane, A. R. (2016). Growth hormone-insulin-like growth factor axis, thyroid axis, prolactin, and exercise. Frontiers of Hormone Research, 47, 1–11. https://doi.org/10.1159/000445147
  • Harnish, C. R., Ferguson, H. A., & Swinand, G. P. (2021). Racing demands of off-road triathlon: A case study of a national champion masters triathlete. Sports (Basel), 9(10). https://doi.org/10.3390/sports9100136
  • Hewing, B., Schattke, S., Spethmann, S., Sanad, W., Schroeckh, S., Schimke, I., Halleck, F., Peters, H., Brechtel, L., Lock, J., Baumann, G., Dreger, H., Borges, A. C., & Knebel, F. (2015). Cardiac and renal function in a large cohort of amateur marathon runners. Cardiovascular Ultrasound, 13, 13. https://doi.org/10.1186/s12947-015-0007-6
  • Hubert, A., Le Rolle, V., Leclercq, C., Galli, E., Samset, E., Casset, C., Mabo, P., Hernandez, A., & Donal, E. (2018). Estimation of myocardial work from pressure-strain loops analysis: An experimental evaluation. European Heart Journal Cardiovascular Imaging, 19(12), 1372–1379. https://doi.org/10.1093/ehjci/jey024
  • Jorres, M., Gunga, H. C., & Steinach, M. (2021). Physiological changes, activity, and stress during a 100-km-24-h walking-march. Frontiers in Physiology, 12, 640710. https://doi.org/10.3389/fphys.2021.640710
  • Kim, J. H., & Baggish, A. L. (2017). Strenuous exercise and cardiovascular disease outcomes. Current Atherosclerosis Reports, 19(1), 1. https://doi.org/10.1007/s11883-017-0636-3
  • Konig, D., Neubauer, O., Nics, L., Kern, N., Berg, A., Bisse, E., & Wagner, K. H. (2007). Biomarkers of exercise-induced myocardial stress in relation to inflammatory and oxidative stress. Exercise Immunology Review, 13(1), 15–36.
  • Kosowski, M., Mlynarska, K., Chmura, J., Kustrzycka-Kratochwil, D., Sukiennik-Kujawa, M., Todd, J. A., Jankowska, E. A., Banasiak, W., Reczuch, K., & Ponikowski, P. (2019). Cardiovascular stress biomarker assessment of middle-aged non-athlete marathon runners. European Journal of Preventive Cardiology, 26(3), 318–327. https://doi.org/10.1177/2047487318819198
  • La Gerche, A., Connelly, K. A., Mooney, D. J., MacIsaac, A. I., & Prior, D. L. (2008). Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise. Heart, 94(7), 860–866. https://doi.org/10.1136/hrt.2006.101063
  • Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., Lancellotti, P., Muraru, D., Picard, M. H., Rietzschel, E. R., Rudski, L., Spencer, K. T., Tsang, W., & Voigt, J. U. (2015). Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American society of echocardiography and the European association of cardiovascular imaging. European Heart Journal Cardiovascular Imaging, 16(3), 233–270. https://doi.org/10.1093/ehjci/jev014
  • Lee, E. C., Fragala, M. S., Kavouras, S. A., Queen, R. M., Pryor, J. L., & Casa, D. J. (2017). Biomarkers in sports and exercise: Tracking health, performance, and recovery in athletes. Journal of Strength and Conditioning Research / National Strength & Conditioning Association, 31(10), 2920–2937. https://doi.org/10.1519/JSC.0000000000002122
  • Legaz-Arrese, A., George, K., Carranza-Garcia, L. E., Munguia-Izquierdo, D., Moros-Garcia, T., & Serrano-Ostariz, E. (2011). The impact of exercise intensity on the release of cardiac biomarkers in marathon runners. European Journal of Applied Physiology, 111(12), 2961–2967. https://doi.org/10.1007/s00421-011-1922-3
  • Lemez, S., & Baker, J. (2015). Do elite athletes live longer? A systematic review of mortality and longevity in elite athletes. Sports Medicine Open, 1(1), 16. https://doi.org/10.1186/s40798-015-0024-x
  • Lord, R. N., Utomi, V., Oxborough, D. L., Curry, B. A., Brown, M., & George, K. P. (2018). Left ventricular function and mechanics following prolonged endurance exercise: An update and meta-analysis with insights from novel techniques. European Journal of Applied Physiology, 118(7), 1291–1299. https://doi.org/10.1007/s00421-018-3906-z
  • Maron, B. J., Epstein, S. E., & Roberts, W. C. (1986). Causes of sudden death in competitive athletes. Journal of the American College of Cardiology, 7(1), 204–214. https://doi.org/10.1016/s0735-1097(86)80283-2
  • McGarvey, J., Thompson, J., Hanna, C., Noakes, T. D., Stewart, J., & Speedy, D. (2010). Sensitivity and specificity of clinical signs for assessment of dehydration in endurance athletes. British Journal of Sports Medicine, 44(10), 716–719. https://doi.org/10.1136/bjsm.2008.053249
  • Merghani, A., Maestrini, V., Rosmini, S., Cox, A. T., Dhutia, H., Bastiaenan, R., David, S., Yeo, T. J., Narain, R., Malhotra, A., Papadakis, M., Wilson, M. G., Tome, M., AlFakih, K., Moon, J. C., & Sharma, S. (2017). Prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk profile. Circulation, 136(2), 126–137. https://doi.org/10.1161/CIRCULATIONAHA.116.026964
  • Middleton, N., Shave, R., George, K., Whyte, G., Hart, E., & Atkinson, G. (2006). Left ventricular function immediately following prolonged exercise: A meta-analysis. Medicine and Science in Sports and Exercise, 38(4), 681–687. https://doi.org/10.1249/01.mss.0000210203.10200.12
  • Middleton, N., Shave, R., George, K., Whyte, G., Simpson, R., Florida-James, G., & Gaze, D. (2007). Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. Medicine and Science in Sports and Exercise, 39(1), 83–90. https://doi.org/10.1249/01.mss.0000239395.93578.60
  • Mohlenkamp, S., Lehmann, N., Breuckmann, F., Brocker-Preuss, M., Nassenstein, K., Halle, M., Budde, T., Mann, K., Barkhausen, J., Heusch, G., Jockel, K. H., Erbel, R., Marathon Study, I., & Heinz Nixdorf Recall Study, I. (2008). Running: The risk of coronary events : Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. European Heart Journal, 29(15), 1903–1910. https://doi.org/10.1093/eurheartj/ehn163
  • Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F., 3rd, Dokainish, H., Edvardsen, T., Flachskampf, F. A., Gillebert, T. C., Klein, A. L., Lancellotti, P., Marino, P., Oh, J. K., Popescu, B. A., & Waggoner, A. D. (2016). Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American society of echocardiography and the European association of cardiovascular imaging. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography, 29(4), 277–314. https://doi.org/10.1016/j.echo.2016.01.011
  • Nieman, D. C., Henson, D. A., Dumke, C. L., Oley, K., McAnulty, S. R., Davis, J. M., Murphy, E. A., Utter, A. C., Lind, R. H., McAnulty, L. S., & Morrow, J. D. (2006). Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. Brain, Behavior, and Immunity, 20(6), 578–584. https://doi.org/10.1016/j.bbi.2006.02.001
  • Nieman, D. C., Konrad, M., Henson, D. A., Kennerly, K., Shanely, R. A., & Wallner-Liebmann, S. J. (2012). Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity. Journal of Interferon & Cytokine Research : The Official Journal of the International Society for Interferon and Cytokine Research, 32(1), 12–17. https://doi.org/10.1089/jir.2011.0038
  • Oosthuyse, T., Avidon, I., Likuwa, I., & Woodiwiss, A. J. (2012). Progression of changes in left ventricular function during four days of simulated multi-stage cycling. European Journal of Applied Physiology, 112(6), 2243–2255. https://doi.org/10.1007/s00421-011-2201-z
  • Parry-Williams, G., Gati, S., & Sharma, S. (2021). The heart of the ageing endurance athlete: The role of chronic coronary stress. European Heart Journal, 42(28), 2737–2744. https://doi.org/10.1093/eurheartj/ehab095
  • Parry-Williams, G., & Sharma, S. (2020). The effects of endurance exercise on the heart: Panacea or poison? Nature Reviews Cardiology, 17(7), 402–412. https://doi.org/10.1038/s41569-020-0354-3
  • Pedersen, B. K., & Febbraio, M. A. (2008). Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiological Reviews, 88(4), 1379–1406. https://doi.org/10.1152/physrev.90100.2007
  • Pelliccia, A., & Sharma, S. (2021). The 2020 ESC guidelines on sport cardiology. European Heart Journal, 42(1), 5–6. https://doi.org/10.1093/eurheartj/ehaa734
  • Peritz, D. C., Catino, A. B., Csecs, I., Kaur, G., Kheirkhahan, M., Loveless, B., Wasmund, S., Kholmovski, E., Morris, A., & Marrouche, N. F. (2020). High-Intensity endurance training is associated with left atrial fibrosis. American Heart Journal, 226, 206–213. https://doi.org/10.1016/j.ahj.2020.05.015
  • Regwan, S., Hulten, E. A., Martinho, S., Slim, J., Villines, T. C., Mitchell, J., & Slim, A. M. (2010). Marathon running as a cause of troponin elevation: A systematic review and meta-analysis. Journal of Interventional Cardiology, 23(5), 443–450. https://doi.org/10.1111/j.1540-8183.2010.00575.x
  • Scheer, V. (2019). Participation trends of ultra endurance events. Sports Medicine and Arthroscopy Review, 27(1), 3–7. https://doi.org/10.1097/JSA.0000000000000198
  • Scherr, J., Braun, S., Schuster, T., Hartmann, C., Moehlenkamp, S., Wolfarth, B., Pressler, A., & Halle, M. (2011). 72-H kinetics of high-sensitive troponin T and inflammatory markers after marathon. Medicine and Science in Sports and Exercise, 43(10), 1819–1827. https://doi.org/10.1249/MSS.0b013e31821b12eb
  • Sedaghat-Hamedani, F., Kayvanpour, E., Frankenstein, L., Mereles, D., Amr, A., Buss, S., Keller, A., Giannitsis, E., Jensen, K., Katus, H. A., & Meder, B. (2015). Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury–a metaanalysis of 45 studies. Clinical Chemistry, 61(10), 1246–1255. https://doi.org/10.1373/clinchem.2015.240796
  • Serrano Ostariz, E., Lopez Ramon, M., Cremades Arroyos, D., Izquierdo Alvarez, S., Catalan Edo, P., Baquer Sahun, C., & Legaz Arrese, A. (2013). Post-Exercise left ventricular dysfunction measured after a long-duration cycling event. BMC Research Notes, 6(1), 211. https://doi.org/10.1186/1756-0500-6-211
  • Sharwood, K. A., Collins, M., Goedecke, J. H., Wilson, G., & Noakes, T. D. (2004). Weight changes, medical complications, and performance during an Ironman triathlon. British Journal of Sports Medicine, 38(6), 718–724. https://doi.org/10.1136/bjsm.2003.007187
  • Shave, R., George, K., & Gaze, D. (2007). The influence of exercise upon cardiac biomarkers: A practical guide for clinicians and scientists. Current Medicinal Chemistry, 14(13), 1427–1436. https://doi.org/10.2174/092986707780831177
  • Stohr, E. J., Gonzalez-Alonso, J., Pearson, J., Low, D. A., Ali, L., Barker, H., & Shave, R. (2011). Dehydration reduces left ventricular filling at rest and during exercise independent of twist mechanics. Journal of Applied Physiology (1985), 111(3), 891–897. https://doi.org/10.1152/japplphysiol.00528.2011
  • Tabata, I., Nishimura, K., Kouzaki, M., Hirai, Y., Ogita, F., Miyachi, M., & Yamamoto, K. (1996). Effects of moderate-intensity endurance and high-intensity intermittent training on anaerobic capacity and VO2max. Medicine and Science in Sports and Exercise, 28(10), 1327–1330. https://doi.org/10.1097/00005768-199610000-00018
  • Tidball, J. G. (2005). Inflammatory processes in muscle injury and repair. American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 288(2), R345–353. https://doi.org/10.1152/ajpregu.00454.2004
  • Traiperm, N., Chaunchaiyakul, R., Burtscher, M., & Gatterer, H. (2021). Cardiac biomarkers following marathon running: Is running time a factor for biomarker change? International Journal of Sports Physiology and Performance, 1–8. https://doi.org/10.1123/ijspp.2020-0352
  • Trivax, J. E., Franklin, B. A., Goldstein, J. A., Chinnaiyan, K. M., Gallagher, M. J., deJong, A. T., Colar, J. M., Haines, D. E., & McCullough, P. A. (2010). Acute cardiac effects of marathon running. Journal of Applied Physiology (1985), 108(5), 1148–1153. https://doi.org/10.1152/japplphysiol.01151.2009
  • Vitti, A., Nikolaidis, P. T., Villiger, E., Onywera, V., & Knechtle, B. (2020). The “New York city marathon”: Participation and performance trends of 1.2M runners during half-century. Research in Sports Medicine, 28(1), 121–137. https://doi.org/10.1080/15438627.2019.1586705
  • Voigt, J. U., Pedrizzetti, G., Lysyansky, P., Marwick, T. H., Houle, H., Baumann, R., Pedri, S., Ito, Y., Abe, Y., Metz, S., Song, J. H., Hamilton, J., Sengupta, P. P., Kolias, T. J., D’Hooge, J., Aurigemma, G. P., Thomas, J. D., & Badano, L. P. (2015). Definitions for a common standard for 2D speckle tracking echocardiography: Consensus document of the EACVI/ASE/Industry task force to standardize deformation imaging. European Heart Journal Cardiovascular Imaging, 16(1), 1–11. https://doi.org/10.1093/ehjci/jeu184
  • Wang, T. J., Larson, M. G., Levy, D., Vasan, R. S., Leip, E. P., Wolf, P. A., D’Agostino, R. B., Murabito, J. M., Kannel, W. B., & Benjamin, E. J. (2003). Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: The Framingham heart study. Circulation, 107(23), 2920–2925. https://doi.org/10.1161/01.CIR.0000072767.89944.6E
  • Watanabe, K., Stohr, E. J., Akiyama, K., Watanabe, S., & Gonzalez-Alonso, J. (2020). Dehydration reduces stroke volume and cardiac output during exercise because of impaired cardiac filling and venous return, not left ventricular function. Physiological Reports, 8(11), e14433. https://doi.org/10.14814/phy2.14433
  • Wilson, M., O’Hanlon, R., Prasad, S., Deighan, A., Macmillan, P., Oxborough, D., Godfrey, R., Smith, G., Maceira, A., Sharma, S., George, K., & Whyte, G. (2011). Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. Journal of Applied Physiology (1985), 110(6), 1622–1626. https://doi.org/10.1152/japplphysiol.01280.2010
  • Wilson, M., O’Hanlon, R., Prasad, S., Oxborough, D., Godfrey, R., Alpendurada, F., Smith, G., Wong, J., Basavarajaiah, S., Sharma, S., Nevill, A., Gaze, D., George, K., & Whyte, G. (2011). Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise. British Journal of Sports Medicine, 45(10), 780–784. https://doi.org/10.1136/bjsm.2009.064089
  • Wirnitzer, K. C., & Kornexl, E. (2008). Exercise intensity during an 8-day mountain bike marathon race. European Journal of Applied Physiology, 104(6), 999–1005. https://doi.org/10.1007/s00421-008-0855-y
  • Zaryski, C., & Smith, D. J. (2005). Training principles and issues for ultra-endurance athletes. Current Sports Medicine Reports, 4(3), 165–170. https://doi.org/10.1097/01.csmr.0000306201.49315.73

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