Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study

References

• Back, S. E., & Jones, J. L. (2018). Alcohol use disorder and posttraumatic stress disorder: An introduction. Alcoholism, Clinical and Experimental Research, 42(5), 836–840. https://doi.org/10.1111/acer.13619
   PubMed Web of Science ®Google Scholar
• Becker, J. B., & Hu, M. (2008). Sex differences in drug abuse. Frontiers in Neuroendocrinology, 29(1), 36–47. https://doi.org/10.1016/j.yfrne.2007.07.003
   PubMed Web of Science ®Google Scholar
• Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Klauminzer, G., Charney, D. S., & Keane, T. M. (1990). A clinician rating scale for assessing current and lifetime PTSD: The CAPS-1. Behavioral Therapy, 13, 187–188.
   Google Scholar
• Bohn, M. J., Krahn, D. D., & Staehler, B. A. (1995). Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcoholism, Clinical and Experimental Research, 19(3), 600–606. https://doi.org/10.1111/j.1530-0277.1995.tb01554.x
   PubMed Web of Science ®Google Scholar
• Brady, K. T., Killeen, T., Saladin, M. E., Dansky, B., & Becker, S. (1994). Comorbid substance-abuse and posttraumatic-stress-disorder - characteristics of women in treatment. The American Journal on Addictions, 3(2), 160–164. https://doi.org/10.1111/j.1521-0391.1994.tb00383.x
   Web of Science ®Google Scholar
• Breese, G. R., Chu, K., Dayas, C. V., Funk, D., Knapp, D. J., Koob, G. F., Le, D. A., O'Dell, L. E., Overstreet, D. H., Roberts, A. J., Sinha, R., Valdez, G. R., & Weiss, F. (2005). Stress enhancement of craving during sobriety: A risk for relapse. Alcoholism, Clinical and Experimental Research, 29(2), 185–195. https://doi.org/10.1097/01.alc.0000153544.83656.3c
   PubMed Web of Science ®Google Scholar
• Bremner, J. D., Krystal, J. H., Southwick, S. M., & Charney, D. S. (1996). Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse, 23(1), 39–51. https://doi.org/10.1002/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I
   PubMed Web of Science ®Google Scholar
• Brinton, R. D., Thompson, R. F., Foy, M. R., Baudry, M., Wang, J., Finch, C. E., Morgan, T. E., Pike, C. J., Mack, W. J., Stanczyk, F. Z., & Nilsen, J. (2008). Progesterone receptors: Form and function in brain. Frontiers in Neuroendocrinology, 29(2), 313–339. https://doi.org/10.1016/j.yfrne.2008.02.001
   PubMed Web of Science ®Google Scholar
• Brown, P. J., Stout, R. L., & Mueller, T. (1999). Substance use disorder and posttraumatic stress disorder comorbidity: Addiction and psychiatric treatment rates. Psychology of Addictive Behaviors, 13(2), 115–122. https://doi.org/10.1037/0893-164X.13.2.115
   Web of Science ®Google Scholar
• Calhoun, P. S., Dennis, M. F., & Beckham, J. C. (2007). Emotional reactivity to trauma stimuli and duration of past smoking cessation attempts in smokers with posttraumatic stress disorder. Experimental and Clinical Psychopharmacology, 15(3), 256–263. https://doi.org/10.1037/1064-1297.15.3.256
   PubMed Web of Science ®Google Scholar
• Chaplin, T. M., Hong, K., Fox, H. C., Siedlarz, K. M., Bergquist, K., & Sinha, R. (2010). Behavioral arousal in response to stress and drug cue in alcohol and cocained addicted individuals versus healthy controls. Human Psychopharmacology, 25(5), 368–376. https://doi.org/10.1002/hup.1127
   PubMed Web of Science ®Google Scholar
• Chesnoy-Marchais, D. (2009). Progesterone and allopregnanolone enhance the miniature synaptic release of glycine in the rat hypoglossal nucleus. The European Journal of Neuroscience, 30(11), 2100–2111. https://doi.org/10.1111/j.1460-9568.2009.07013.x
   PubMed Web of Science ®Google Scholar
• Childress, A. R., Ehrman, R., Mclellan, A. T., Macrae, J., Natale, M., & O'Brien, C. P. (1994). Can induced moods trigger drug-related responses in opiate abuse patients? Journal of Substance Abuse Treatment, 11(1), 17–23. https://doi.org/10.1016/0740-5472(94)90060-4
   PubMed Web of Science ®Google Scholar
• Coffey, S. F., Saladin, M. E., Drobes, D. J., Brady, K. T., Dansky, B. S., & Kilpatrick, D. G. (2002). Trauma and substance cue reactivity in individuals with comorbid posttraumatic stress disorder and cocaine or alcohol dependence. Drug and Alcohol Dependence, 65(2), 115–127. https://doi.org/10.1016/s0376-8716(01)00157-0
   PubMed Web of Science ®Google Scholar
• Coffey, S. F., Stasiewicz, P. R., Hughes, P. M., & Brimo, M. L. (2006). Trauma-focused imaginal exposure for individuals with comorbid posttraumatic stress disorder and alcohol dependence: revealing mechanisms of alcohol craving in a cue reactivity paradigm. Psychology of Addictive Behaviors, 20(4), 425–435. https://doi.org/10.1037/0893-164X.20.4.425
   PubMed Web of Science ®Google Scholar
• Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997). Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men. Journal of Abnormal Psychology, 106(2), 243–250. https://doi.org/10.1037//0021-843x.106.2.243
   PubMed Web of Science ®Google Scholar
• Cruz, D. A., Glantz, L. A., Mcgaughey, K. D., Parke, G., Shampine, L. J., Kilts, J. D., Naylor, J. C., Marx, C. E., & Williamson, D. E. (2019). Neurosteroid levels in the orbital frontal cortex of subjects with PTSD and controls: A preliminary report. Chronic Stress, 3, 247054701983857. 2470547019838570. https://doi.org/10.1177/2470547019838570
   Google Scholar
• Dar, D. E., & Zinder, O. (1997). Short term effect of steroids on catecholamine secretion from bovine adrenal medulla chromaffin cells. Neuropharmacology, 36(11–12), 1783–1788. https://doi.org/10.1016/s0028-3908(97)00150-0
   PubMed Web of Science ®Google Scholar
• First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured clinical interview for DSM-IV axis I disorders (Patient Edition) (SCID-P). Biometric Research, New York State Psychiatric Institute.
   Google Scholar
• Flanagan, J. C., Allan, N. P., Calhoun, C. D., Badour, C. L., Moran-Santa Maria, M., Brady, K. T., & Back, S. E. (2019). Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder. Experimental and Clinical Psychopharmacology, 27(1), 45–54. https://doi.org/10.1037/pha0000232
   PubMed Web of Science ®Google Scholar
• Foa, E. B., & Williams, M. T. (2010). Methodology of a randomized double-blind clinical trial for comorbid posttraumatic stress disorder and alcohol dependence. Mental Health and Substance Use: Dual Diagnosis, 3(2), 131–147. https://doi.org/10.1080/17523281003738661
   PubMedGoogle Scholar
• Fox, H. C., Bergquist, K. L., Hong, K. I., & Sinha, R. (2007). Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. Alcoholism, Clinical and Experimental Research, 31(3), 395–403. https://doi.org/10.1111/j.1530-0277.2006.00320.x
   PubMed Web of Science ®Google Scholar
• Fox, H. C., Sofuoglu, M., Morgan, P. T., Tuit, K. L., & Sinha, R. (2013). The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology, 38(9), 1532–1544. https://doi.org/10.1016/j.psyneuen.2012.12.022
   PubMed Web of Science ®Google Scholar
• Garcia, N. M., Walker, R. S., & Zoellner, L. A. (2018). Estrogen, progesterone, and the menstrual cycle: A systematic review of fear learning, intrusive memories, and PTSD. Clinical Psychology Review, 66, 80–96. https://doi.org/10.1016/j.cpr.2018.06.005
   PubMed Web of Science ®Google Scholar
• Gilpin, N. W., & Weiner, J. L. (2017). Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder. Genes, Brain, and Behavior, 16(1), 15–43. https://doi.org/10.1111/gbb.12349
   PubMed Web of Science ®Google Scholar
• Gogos, A., Ney, L. J., Seymour, N., VAN Rheenen, T. E., & Felmingham, K. L. (2019). Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link? British Journal of Pharmacology, 176(21), 4119–4135. https://doi.org/10.1111/bph.14584
   PubMed Web of Science ®Google Scholar
• Golden, C. J. (1976). Identification of brain disorders by the stroop color and word test. Journal of Clinical Psychology, 32(3), 654–658. https://doi.org/10.1002/1097-4679(197607)32:3<654::AID-JCLP2270320336>3.0.CO;2-Z
   PubMed Web of Science ®Google Scholar
• Haass-Koffler, C. L., Goodyear, K., Zywiak, W. H., Magill, M., Eltinge, S. E., Wallace, P. M., Long, V. M., Jayaram-Lindström, N., Swift, R. M., Kenna, G. A., & Leggio, L. (2017). Higher pretreatment blood pressure is associated with greater alcohol drinking reduction in alcohol-dependent individuals treated with doxazosin. Drug and Alcohol Dependence, 177, 23–28. https://doi.org/10.1016/j.drugalcdep.2017.03.016
   PubMed Web of Science ®Google Scholar
• Heim, C., Newport, D. J., Heit, S., Graham, Y. P., Wilcox, M., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2000). Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA, 284(5), 592–597. https://doi.org/10.1001/jama.284.5.592
   PubMed Web of Science ®Google Scholar
• Hoffmann, S., Gerhardt, S., Mühle, C., Reinhard, I., Reichert, D., Bach, P., Boroumand-Jazi, R., Kuehner, C., Aguilera, A., Aslan, A., Bahr, N., Belanger, M., Deeken, F., Ebrahimi, C., Fischbach, P., Ganz, M., Garbusow, M., Grosskopf, C., Heigert, M., & Lenz, B. (2022). Progesterone/Estradiol ratio is related to real-life alcohol consumption in alcohol use disorder in a sex- and menstrual cycle phase-dependent manner. medrxiv,org. https://doi.org/10.1101/2022.12.21.22282762
   Google Scholar
• Izard, C. E. (1972). Patterns of emotions: A new analysis of anxiety and depression. Academic Press.
   Google Scholar
• Julian, L. J. (2011). Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Arthritis Care & Research, 63 (Suppl 11), S467–S72. https://doi.org/10.1002/acr.20561
   PubMed Web of Science ®Google Scholar
• Kwako, L. E., George, D. T., Schwandt, M. L., Spagnolo, P. A., Momenan, R., Hommer, D. W., Diamond, C. A., Sinha, R., Shaham, Y., & Heilig, M. (2015). The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: A human experimental study. Psychopharmacology, 232(1), 295–304. https://doi.org/10.1007/s00213-014-3665-4
   PubMed Web of Science ®Google Scholar
• Meisler, A. W. (1996). PTSD and substance abuse in Vietnam. International Society of Traumatic Stress Studies.
   Google Scholar
• Milivojevic, V., Charron, L., Fogelman, N., Hermes, G., & Sinha, R. (2022). Pregnenolone reduces stress-induced craving, anxiety, and autonomic arousal in individuals with cocaine use disorder. Biomolecules, 12(11), 1593. https://doi.org/10.3390/biom12111593
   PubMed Web of Science ®Google Scholar
• Milivojevic, V., Fox, H. C., Sofuoglu, M., Covault, J., & Sinha, R. (2016). Effects of progesterone stimulated allopregnanolone on craving and stress response in cocaine dependent men and women. Psychoneuroendocrinology, 65, 44–53. https://doi.org/10.1016/j.psyneuen.2015.12.008
   PubMed Web of Science ®Google Scholar
• Milivojevic, V., Sinha, R., Morgan, P. T., Sofuoglu, M., & Fox, H. C. (2014). Effects of endogenous and exogenous progesterone on emotional intelligence in cocaine-dependent men and women who also abuse alcohol. Human Psychopharmacology, 29(6), 589–598. https://doi.org/10.1002/hup.2446
   PubMed Web of Science ®Google Scholar
• Morrow, A. L., Boero, G., & Porcu, P. (2020). A rationale for allopregnanolone treatment of alcohol use disorders: Basic and clinical studies. Alcoholism, Clinical and Experimental Research, 44(2), 320–339. https://doi.org/10.1111/acer.14253
   PubMedGoogle Scholar
• Nillni, Y. I., Pineles, S. L., Patton, S. C., Rouse, M. H., Sawyer, A. T., & Rasmusson, A. M. (2015). Menstrual cycle effects on psychological symptoms in women with PTSD. Journal of Traumatic Stress, 28(1), 1–7. https://doi.org/10.1002/jts.21984
   PubMed Web of Science ®Google Scholar
• Norman, S. B., Haller, M., Hamblen, J. L., Southwick, S. M., & Pietrzak, R. H. (2018). The burden of co-occurring alcohol use disorder and PTSD in U.S. Military veterans: Comorbidities, functioning, and suicidality. Psychology of Addictive Behaviors, 32(2), 224–229. https://doi.org/10.1037/adb0000348
   PubMed Web of Science ®Google Scholar
• Ouimette, P. C., Finney, J. W., & Moos, R. H. (1999). Two-year posttreatment functioning and coping of substance abuse patients with posttraumatic stress disorder. Psychology of Addictive Behaviors, 13(2), 105–114. https://doi.org/10.1037/0893-164X.13.2.105
   Web of Science ®Google Scholar
• Peart, D. R., Andrade, A. K., Logan, C. N., Knackstedt, L. A., & Murray, J. E. (2022). Regulation of cocaine-related behaviours by estrogen and progesterone. Neuroscience and Biobehavioral Reviews, 135, 104584. https://doi.org/10.1016/j.neubiorev.2022.104584
   PubMed Web of Science ®Google Scholar
• Peltier, M. R., & Sofuoglu, M. (2018). Role of exogenous progesterone in the treatment of men and women with substance use disorders: A narrative review. CNS Drugs, 32(5), 421–435. https://doi.org/10.1007/s40263-018-0525-5
   PubMed Web of Science ®Google Scholar
• Peltier, M. R., Verplaetse, T. L., Mineur, Y. S., Gueorguieva, R., Petrakis, I., Cosgrove, K. P., Picciotto, M. R., & Mckee, S. A. (2021). Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology, 187, 108499. https://doi.org/10.1016/j.neuropharm.2021.108499
   PubMed Web of Science ®Google Scholar
• Petrakis, I. L., & Simpson, T. L. (2017). Posttraumatic stress disorder and alcohol use disorder: A critical review of pharmacologic treatments. Alcoholism, Clinical and Experimental Research, 41(2), 226–237. https://doi.org/10.1111/acer.13297
   PubMed Web of Science ®Google Scholar
• Pierucci-Lagha, A., Covault, J., Feinn, R., Khisti, R. T., Morrow, A. L., Marx, C. E., Shampine, L. J., & Kranzler, H. R. (2006). Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol. Psychopharmacology, 186(3), 451–461. https://doi.org/10.1007/s00213-005-0231-0
   PubMed Web of Science ®Google Scholar
• Pietrzak, R. H., Goldstein, R. B., Southwick, S. M., & Grant, B. F. (2011). Prevalence and Axis I comorbidity of full and partial posttraumatic stress disorder in the United States: Results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Anxiety Disorders, 25(3), 456–465. https://doi.org/10.1016/j.janxdis.2010.11.010
   PubMed Web of Science ®Google Scholar
• Pinna, G. (2018). Biomarkers for PTSD at the interface of the endocannabinoid and neurosteroid axis. Frontiers in Neuroscience, 12, 482. https://doi.org/10.3389/fnins.2018.00482
   PubMed Web of Science ®Google Scholar
• Ralevski, E., Southwick, S., Jackson, E., Jane, J. S., Russo, M., & Petrakis, I. (2016). Trauma- and stress-induced response in veterans with alcohol dependence and comorbid post-traumatic stress disorder. Alcoholism, Clinical and Experimental Research, 40(8), 1752–1760. https://doi.org/10.1111/acer.13120
   PubMed Web of Science ®Google Scholar
• Ralevski, E., Southwick, S., & Petrakis, I. (2020). Trauma- and stress-induced craving for alcohol in individuals without PTSD. Alcohol and Alcoholism 55(1), 37–43. https://doi.org/10.1093/alcalc/agz092
   PubMed Web of Science ®Google Scholar
• Raskind, M. A., Millard, S. P., Petrie, E. C., Peterson, K., Williams, T., Hoff, D. J., Hart, K., Holmes, H., Hill, J., Daniels, C., Hendrickson, R., & Peskind, E. R. (2016). Higher pretreatment blood pressure is associated with greater posttraumatic stress disorder symptom reduction in soldiers treated with prazosin. Biological Psychiatry, 80(10), 736–742. https://doi.org/10.1016/j.biopsych.2016.03.2108
   PubMed Web of Science ®Google Scholar
• Rasmusson, A. M., Pinna, G., Paliwal, P., Weisman, D., Gottschalk, C., Charney, D., Krystal, J., & Guidotti, A. (2006). Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biological Psychiatry, 60(7), 704–713. https://doi.org/10.1016/j.biopsych.2006.03.026
   PubMed Web of Science ®Google Scholar
• Raudales, A. M., Weiss, N. H., Schmidt, N. B., & Short, N. A. (2020). The role of emotion dysregulation in negative affect reactivity to a trauma cue: Differential associations through elicited posttraumatic stress disorder symptoms. Journal of Affective Disorders, 267, 203–210. https://doi.org/10.1016/j.jad.2020.02.028
   PubMed Web of Science ®Google Scholar
• Read, J. P., Brown, P. J., & Kahler, C. W. (2004). Substance use and posttraumatic stress disorders: Symptom interplay and effects on outcome. Addictive Behaviors, 29(8), 1665–1672. https://doi.org/10.1016/j.addbeh.2004.02.061
   PubMed Web of Science ®Google Scholar
• Russo, S. J., Sun, W. L., Minerly, A. C., Weierstall, K., Nazarian, A., Festa, E. D., Niyomchai, T., Akhavan, A., Luine, V., Jenab, S., & Quiñones-Jenab, V. (2008). Progesterone attenuates cocaine-induced conditioned place preference in female rats. Brain Research, 1189, 229–235. https://doi.org/10.1016/j.brainres.2007.10.057
   PubMed Web of Science ®Google Scholar
• Sarkola, T., Mäkisalo, H., Fukunaga, T., & Eriksson, C. J. (1999). Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcoholism, Clinical and Experimental Research, 23(6), 976–982.
   PubMed Web of Science ®Google Scholar
• Seal, K. H., Cohen, G., Waldrop, A., Cohen, B. E., Maguen, S., & Ren, L. (2011). Substance use disorders in Iraq and Afghanistan veterans in VA healthcare, 2001–2010: Implications for screening, diagnosis and treatment. Drug and Alcohol Dependence, 116(1-3), 93–101. https://doi.org/10.1016/j.drugalcdep.2010.11.027
   PubMed Web of Science ®Google Scholar
• Seligowski, A. V., Hurly, J., Mellen, E., Ressler, K. J., & Ramikie, T. S. (2020). Translational studies of estradiol and progesterone in fear and PTSD. European Journal of Psychotraumatology, 11(1), 1723857. https://doi.org/10.1080/20008198.2020.1723857
   PubMed Web of Science ®Google Scholar
• Sinha, R. (2009). Modeling stress and drug craving in the laboratory: Implications for addiction treatment development. Addiction Biology, 14(1), 84–98. https://doi.org/10.1111/j.1369-1600.2008.00134.x
   PubMed Web of Science ®Google Scholar
• Sinha, R., Fox, H., Hong, K. I., Sofuoglu, M., Morgan, P. T., & Bergquist, K. T. (2007). Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: Implications for relapse susceptibility. Experimental and Clinical Psychopharmacology, 15(5), 445–452. https://doi.org/10.1037/1064-1297.15.5.445
   PubMed Web of Science ®Google Scholar
• Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009). Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology, 34(5), 1198–1208. https://doi.org/10.1038/npp.2008.78
   PubMed Web of Science ®Google Scholar
• Sinha, R., Garcia, M., Kemp, K., Krystal, J. H., & O'Malley, S. S. (2005). Alcohol craving and subjective emotional state during stress and alcohol cue exposure in alcoholics and social drinkers. Alcoholism: Clinical & Experimental Research, 29, 150A.
   PubMed Web of Science ®Google Scholar
• Smith-Hoerter, K., Stasiewicz, P. R., & Bradizza, C. M. (2004). Subjective reactions to alcohol cue exposure: a qualitative analysis of patients’ self-reports. Psychology of Addictive Behaviors, 18(4), 402–406. https://doi.org/10.1037/0893-164X.18.4.402
   PubMed Web of Science ®Google Scholar
• Smith, N., & Cottler, L. (2018). The epidemiology of post-traumatic stress disorder and alcohol use disorder. Alcohol Research: Current Reviews, 39(2), 113–120.
   PubMed Web of Science ®Google Scholar
• Sobell, L. C., & Sobell, M. B. (1992). Timeline follow-back: A technique for assessing self-reported alcohol consumption. In R. Z. Litten & J. Allen (Eds.) Measuring alcohol consumption: psychosoical and biological methods. Humana Press.
   Google Scholar
• Sofuoglu, M., Mouratidis, M., & Mooney, M. (2011). Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers. Psychoneuroendocrinology, 36(1), 123–132. https://doi.org/10.1016/j.psyneuen.2010.07.005
   PubMed Web of Science ®Google Scholar
• Stasiewicz, P. R., Gulliver, S. B., Bradizza, C. M., Rohsenow, D. J., Torrisi, R., & Monti, P. M. (1997). Exposure to negative emotional cues and alcohol cue reactivity with alcoholics: A preliminary investigation. Behaviour Research and Therapy, 35(12), 1143–1149.
   PubMed Web of Science ®Google Scholar
• Tomaselli, G., & Vallée, M. (2019). Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway. Frontiers in Neuroendocrinology, 55, 100789. https://doi.org/10.1016/j.yfrne.2019.100789
   PubMed Web of Science ®Google Scholar
• van der Kolk, B. (2004). Psychobiology of posttraumatic stress disorder. In J. Panksepp (Ed.), Textbook of biological psychiatry. Wiley-Liss.
   Google Scholar
• Vujanovic, A. A., Lebeaut, A., Zegel, M., Smit, T., & Berenz, E. C. (2019). Post-traumatic stress and alcohol use disorders: Recent advances and future directions in cue reactivity. Current Opinion in Psychology, 30, 109–116. https://doi.org/10.1016/j.copsyc.2019.04.003
   PubMed Web of Science ®Google Scholar
• Weinland, C., Mühle, C., Kornhuber, J., & Lenz, B. (2021). Progesterone serum levels correlate negatively with craving in female postmenopausal in-patients with alcohol use disorder: A sex- and menopausal status-separated study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 110, 110278. https://doi.org/10.1016/j.pnpbp.2021.110278
   PubMed Web of Science ®Google Scholar
• Zambrano-Vazquez, L., Levy, H. C., Belleau, E. L., Dworkin, E. R., Howard Sharp, K. M., Pittenger, S. L., Schumacher, J. A., & Coffey, S. F. (2017). Using the research domain criteria framework to track domains of change in comorbid PTSD and SUD. Psychological Trauma: Theory, Research, Practice and Policy, 9(6), 679–687. https://doi.org/10.1037/tra0000257
   PubMed Web of Science ®Google Scholar