Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma

References

• (NCD-RisC) NRFC. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet. 2016 Apr 2;387(10026):1377–1396.
   PubMed Web of Science ®Google Scholar
• Afshin A, Forouzanfar MH, Reitsma MB, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. [2017 Jul 6];377(1):13–27.
   PubMed Web of Science ®Google Scholar
• Masoli M, Fabian D, Holt S, et al. The global burden of asthma: executive summary of the GINA dissemination committee report. Allergy. 2004 May;59(5):469–478.
   PubMed Web of Science ®Google Scholar
• Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018 Apr;141(4):1169–1179.
   PubMed Web of Science ®Google Scholar
• Schatz M, Hsu JW, Zeiger RS, et al. Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma. J Allergy Clin Immunol. 2014 Jun;133(6):1549–1556.
   PubMed Web of Science ®Google Scholar
• Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007 Apr 1; 175(7):661–666.
   PubMed Web of Science ®Google Scholar
• Contreras ZA, Chen Z, Roumeliotaki T, et al. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. Eur Respir J. 2018 Sep;52(3):1800504.
   PubMed Web of Science ®Google Scholar
• Holguin F, Bleecker ER, Busse WW, et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011 Jun;127(6):1486–93 e2.
   PubMed Web of Science ®Google Scholar
• Mosen DM, Schatz M, Magid DJ, et al. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008 Sep;122(3):507–11 e6.
   PubMed Web of Science ®Google Scholar
• Taylor B, Mannino D, Brown C, et al. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008 Jan;63(1):14–20.
   PubMed Web of Science ®Google Scholar
• Scott HA, Gibson PG, Garg ML, et al. Airway inflammation is augmented by obesity and fatty acids in asthma. Eur Respir J. 2011;38(3):594–602.
   PubMed Web of Science ®Google Scholar
• Sideleva O, Suratt BT, Black KE, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012 Oct 1 186(7):598–605.
   PubMed Web of Science ®Google Scholar
• Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013 Feb 14; 368(7):651–662.
   PubMed Web of Science ®Google Scholar
• Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 2013 Oct;13(10):722–737.
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011 Jan 20; 469(7330):323–335.
   PubMed Web of Science ®Google Scholar
• Ryter SW, Nakahira K, Haspel JA, et al. Autophagy in pulmonary diseases. Annu Rev Physiol. 2012;74:377–401.
   PubMed Web of Science ®Google Scholar
• Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004 Dec 23 432(7020):1032–1036.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Maazi H, Sankaranarayanan I, et al. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2016 May;137(5):1382–1389.e9.
   PubMed Web of Science ®Google Scholar
• O’Sullivan TE, Geary CD, Weizman OE, et al. Atg5 is essential for the development and survival of innate lymphocytes. Cell Rep. 2016 May 31 15(9):1910–1919.
   PubMed Web of Science ®Google Scholar
• Galle-Treger L, Hurrell BP, Lewis G, et al. Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function. J Allergy Clin Immunol. 2020 Feb;145(2):502–517 e5.
   PubMed Web of Science ®Google Scholar
• Choi GE, Yoon SY, Kim JY, et al. Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis. J Allergy Clin Immunol. 2017 Dec 7 141(3):938–950.e12.
   PubMed Web of Science ®Google Scholar
• Haspel JA, Choi AM. Autophagy: a core cellular process with emerging links to pulmonary disease. Am J Respir Crit Care Med. 2011 Dec 1; 184(11):1237–1246.
   PubMed Web of Science ®Google Scholar
• Castillo EF, Dekonenko A, Arko-Mensah J, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov 13;109( 46):E3168–76.
   Google Scholar
• Desai D, Newby C, Symon FA, et al. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med. 2013 Sep 15 188(6):657–663.
   PubMed Web of Science ®Google Scholar
• van der Wiel E, Ten Hacken NH, van Den Berge M, et al. Eosinophilic inflammation in subjects with mild-to-moderate asthma with and without obesity: disparity between sputum and biopsies. Am J Respir Crit Care Med. 2014 May 15 189(10):1281–1284.
   PubMed Web of Science ®Google Scholar
• Poon AH, Chouiali F, Tse SM, et al. Genetic and histologic evidence for autophagy in asthma pathogenesis. J Allergy Clin Immunol. 2012;129(2):569–571.
   PubMed Web of Science ®Google Scholar
• Dickinson JD, Alevy Y, Malvin NP, et al. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy. 2016;12(2):397–409.
   PubMed Web of Science ®Google Scholar
• Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature. 2008 Jul 24; 454(7203):445–454.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med. 2012 May;18(5):684–692.
   PubMed Web of Science ®Google Scholar
• Li K, Li M, Li W, et al. Airway epithelial regeneration requires autophagy and glucose metabolism. Cell Death Dis. 2019 Nov 20 10(12):875.
   PubMedGoogle Scholar
• Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
   PubMed Web of Science ®Google Scholar
• Mizushima N. Chapter 2 methods for monitoring autophagy using GFP‐LC3 transgenic mice Methods Enzymol . Autophagy in Mammalian Systems, Part B. Methods in Enzymology. 2009;452:13–23.
   PubMed Web of Science ®Google Scholar
• Pabon MA, Ma KC, Choi AM. Autophagy and obesity-related lung disease. Am J Respir Cell Mol Biol. 2016 May;54(5):636–646.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sowers JR, Ren J. Targeting autophagy in obesity: from pathophysiology to management. Nat Rev Endocrinol. 2018;14(6):356–376.
   PubMed Web of Science ®Google Scholar
• Liu T, Liu Y, Miller M, et al. Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1 313(1):L27–L40.
   PubMed Web of Science ®Google Scholar
• Ban GY, Pham DL, Trinh TH, et al. Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology. 2016 Jan;46(1):48–59.
   PubMed Web of Science ®Google Scholar
• Martin LJ, Gupta J, Jyothula SS, et al. Functional variant in the autophagy-related 5 gene promotor is associated with childhood asthma. PLoS One. 2012;7(4):e33454.
   PubMed Web of Science ®Google Scholar
• Poon AH, Choy DF, Chouiali F, et al. Increased autophagy-related 5 gene expression is associated with collagen expression in the airways of refractory asthmatics. Front Immunol. 2017;8:355.
   PubMed Web of Science ®Google Scholar
• McAlinden KD, Deshpande DA, Ghavami S, et al. Autophagy Activation in Asthma Airways Remodeling. Am J Respir Cell Mol Biol. 2019;60(5):541–553.
   PubMed Web of Science ®Google Scholar
• Farahi N, Loutsios C, Tregay N, et al. In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients. J Allergy Clin Immunol. 2018 Nov;142(5):1659–1662 e8.
   PubMed Web of Science ®Google Scholar
• Painter JD, Galle-Treger L, Akbari O. Role of autophagy in lung inflammation. Front Immunol. 2020;11:1337.
   PubMed Web of Science ®Google Scholar
• Theofani E, Xanthou G. Autophagy: a friend or foe in allergic asthma? Int J Mol Sci. 2021 Jun 12; 22(12):6314.
   PubMed Web of Science ®Google Scholar
• Zeki AA, Yeganeh B, Kenyon NJ, et al. Autophagy in airway diseases: a new frontier in human asthma? Allergy. 2016 Jan;71(1):5–14.
   PubMed Web of Science ®Google Scholar
• Dickinson JD, Sweeter JM, Warren KJ, et al. Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation. Redox Biol. 2018 Apr;14:272–284.
   PubMed Web of Science ®Google Scholar
• Chen YD, Fang YT, Cheng YL, et al. Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells. Sci Rep. 2017 Jul 18 7(1):5676.
   PubMedGoogle Scholar
• Fougeray S, Mami I, Bertho G, et al. Tryptophan depletion and the kinase GCN2 mediate IFN-γ-induced autophagy. J Immunol. 2012 Sep 15;189(6):2954–2964.
   PubMed Web of Science ®Google Scholar
• Wang BF, Cao PP, Wang ZC, et al. Interferon-γ-induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps. Allergy. 2017 Sep;72(9):1384–1397.
   PubMed Web of Science ®Google Scholar
• Chen ZH, Wu YF, Wang PL, et al. Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium. Autophagy. 2016;12(2):297–311.
   PubMed Web of Science ®Google Scholar
• O’Dwyer DN, Ashley SL, Moore BB. Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1; 311(3):L590–601.
   PubMed Web of Science ®Google Scholar
• Diaz J, Warren L, Helfner L, et al. Obesity shifts house dust mite-induced airway cellular infiltration from eosinophils to macrophages: effects of glucocorticoid treatment. Immunol Res. 2015 Dec;63(1–3):197–208.
   PubMed Web of Science ®Google Scholar
• Lambrecht BN, Hammad H, Fahy JV. The Cytokines of Asthma. Immunity. 2019 Apr 16; 50(4):975–991.
   PubMed Web of Science ®Google Scholar
• Walker JA, McKenzie ANJ. TH2 cell development and function. Nat Rev Immunol. 2018 Feb;18(2):121–133.
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012 May 4; 18(5):716–725.
   PubMed Web of Science ®Google Scholar
• Choi Y, Bowman JW, Jung JU. Autophagy during viral infection - a double-edged sword. Nat Rev Microbiol. 2018 Jun;16(6):341–354.
   PubMed Web of Science ®Google Scholar
• Wang E, Liu X, Tu W, et al. Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)-induced epithelial cytokine release through aryl hydrocarbon receptor in asthma. Allergy. 2019 Sep;74(9):1675–1690.
   PubMed Web of Science ®Google Scholar
• Rashid HO, Yadav RK, Kim HR, et al. ER stress: autophagy induction, inhibition and selection. Autophagy. 2015 Nov 2 11(11):1956–1977.
   PubMed Web of Science ®Google Scholar
• Senft D, Ronai ZA. UPR, autophagy, and mitochondria crosstalk underlies the ER stress response. Trends Biochem Sci. 2015 Mar;40(3):141–148.
   PubMed Web of Science ®Google Scholar
• Green DR, Galluzzi L, Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (New York, NY). 2011 Aug 26; 333(6046):1109–1112.
   Google Scholar
• Li CY, Erickson SR, Wu CH. Metformin use and asthma outcomes among patients with concurrent asthma and diabetes. Respirology. 2016 Oct;21(7):1210–1218.
   PubMed Web of Science ®Google Scholar
• Yin Y, Mitson-Salazar A, Wansley DL, et al. Rapamycin preferentially inhibits human IL-5(+) T(H)2-cell proliferation via an mTORC1/S6 kinase-1-dependent pathway. J Allergy Clin Immunol. 2017 May;139(5):1701–1704.e10.
   PubMed Web of Science ®Google Scholar
• Mushaben EM, Kramer EL, Brandt EB, et al. Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma. J Immunol. 2011 Dec 1;187(11):5756–5763.
   PubMed Web of Science ®Google Scholar
• Hua W, Liu H, Xia LX, et al. Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice. Respirology. 2015 Oct;20(7):1055–1065.
   PubMed Web of Science ®Google Scholar
• Gu W, Cui R, Ding T, et al. Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. Respirology. 2017 Apr;22(3):533–541.
   PubMed Web of Science ®Google Scholar
• Liu JN, Suh DH, Trinh HK, et al. The role of autophagy in allergic inflammation: a new target for severe asthma. Exp Mol Med. 2016 Jul 1 48(7):e243.
   PubMedGoogle Scholar
• Bates JH. Physiological mechanisms of airway hyperresponsiveness in obese asthma. Am J Respir Cell Mol Biol. 2016 May;54(5):618–623.
   PubMed Web of Science ®Google Scholar
• Dixon AE, Poynter ME. Mechanisms of asthma in obesity. Pleiotropic aspects of obesity produce distinct asthma phenotypes. Am J Respir Cell Mol Biol. 2016 May;54(5):601–608.
   PubMed Web of Science ®Google Scholar
• Shore SA, Cho Y. Obesity and asthma: microbiome-metabolome interactions. Am J Respir Cell Mol Biol. 2016 May;54(5):609–617.
   PubMed Web of Science ®Google Scholar
• Galle-Treger L, Suzuki Y, Patel N, et al. Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity. Nat Commun. 2016 Oct 18;7:13202.
   PubMed Web of Science ®Google Scholar
• Tong J, Bandulwala HS, Clay BS, et al. Fas-positive T cells regulate the resolution of airway inflammation in a murine model of asthma. J Exp Med. 2006 May 15 203(5):1173–1184.
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Suda T, Furuhashi K, et al. Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro. Am J Respir Cell Mol Biol. 2012 Jun;46(6):773–780.
   PubMed Web of Science ®Google Scholar